Heart Failure Clinical Trials

151 studies are recruiting for heart failure in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 5

1. Urine Sodium-Driven Diuretic Adjustment Strategy in Acute Decompensated Heart Failure

   The goal of this clinical trial is to learn if increasing the dose of diuretics to achieve a higher urine sodium target produces better clinical results when treating patients hospitalized with acute heart failure when compared to lower urine sodium target and standard of care. The main questions i…

   Stage

   Phase 4

   Ages

   18 and older

   Site

   Lakeland Regional Hospital, Lakeland, Florida

   Run by

   Lakeland Regional Health Systems, Inc.

   See if you can join NCT07263035 on ClinicalTrials.gov

2. CardioMEMS HF System Coverage With Evidence Development Study

   The purpose of the CardioMEMS CED Study is to determine if pulmonary artery (PA) pressure-guided heart failure management using the CardioMEMS™ HF System improves long-term health outcomes in heart failure (HF) patients in the real-world setting.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Abbott, Pleasanton, California

   Run by

   Abbott Medical Devices

   See if you can join NCT06779552 on ClinicalTrials.gov

3. Forge AHEAD: Feasibility of Yoga to Improve Cognitive Function

   The investigators will conduct a two-phase pilot study to test the feasibility and acceptability of a 12-week Chair Yoga intervention for 20 heart-failure patients. Using a patient-centered approach, investigators will involve stakeholders in designing the protocol, gather patient feedback, and ref…

   Stage

   Not phased

   Ages

   55 and older

   Site

   Auburn University, Auburn, Alabama

   Run by

   Auburn University

   See if you can join NCT07489105 on ClinicalTrials.gov

4. Precision Rehabilitation for Veterans With (HFpEF)

   This study is being completed because there is conflicting information regarding the value of monitored exercise in patients with heart failure with preserved ejection fraction (HFpEF). The purpose of this study is to collect baseline information necessary for researchers to pursue a larger study e…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Columbia VA Health Care System, Columbia, South Carolina

   Run by

   Columbia VA Health Care System

   See if you can join NCT07493915 on ClinicalTrials.gov

5. Sotagliflozin to Slow Kidney Function Decline in Persons With Type 1 Diabetes and Diabetic Kidney Disease

   Powerful new drugs that can prevent or delay end stage kidney disease (ESKD) - so called sodium-glucose cotransporter-2 inhibitors (SGLT2i) - are now available for patients with type 2 diabetes. Whether these drugs have similar effects in patients with type 1 diabetes (T1D) remains unknown because …

   Stage

   Phase 3

   Ages

   18 to 75

   Site

   Stanford University Medical Center, Stanford, California

   Locations

   19 in total

   Run by

   Alessandro Doria

   See if you can join NCT06217302 on ClinicalTrials.gov

6. XVIVO Heart Box (XHB) With Supplemented XVIVO Heart Solution (SXHS) Continued Access Protocol (CAP)

   The purpose of this study is to evaluate if Non-Ischemic Heart Preservation (NIHP) of extended criteria donor hearts using the XVIVO Heart Preservation System (XHPS) is a safe and effective way to preserve and transport hearts for transplantation.

   Stage

   Not phased

   Ages

   18 and older

   Site

   UC San Diego Health, La Jolla, California

   Locations

   14 in total

   Run by

   XVIVO Perfusion

   See if you can join NCT06895070 on ClinicalTrials.gov

7. Home Hospital for Suddenly Ill Adults

   The investigators propose a home hospital model of care that substitutes for treatment in an acute care hospital. Limited studies of the home hospital model have demonstrated that a sizeable proportion of acute care can be delivered in the home with equal quality and safety, reduced cost, and impro…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Brigham and Women's Hospital, Boston, Massachusetts

   Locations

   2 in total

   Run by

   Brigham and Women's Hospital

   See if you can join NCT03524222 on ClinicalTrials.gov

8. Hemodynamic Monitoring to Prevent Adverse Events foLlowing cardiOgenic Shock Trial

   Pilot Prospective Randomized Unblinded Pragmatic Trial of Pulmonary Artery Hemodynamic Monitoring Following Hospitalization for Cardiogenic Shock

   Stage

   Not phased

   Ages

   18 and older

   Site

   Inova Fairfax Medical Campus, Falls Church, Virginia

   Run by

   Inova Health Care Services

   See if you can join NCT04419480 on ClinicalTrials.gov

9. Proof-of-concept of a Behavioral Intervention to Improve the Cardiovascular Health of People Living With HIV

   Heart failure (HF) is a growing health and economic burden around the globe, and it remains a leading cause of morbidity and mortality among the general population. HIV is recognized as an independent risk factor for HF, due to direct and indirect effects. Furthermore, people living with HIV (PLWH)…

   Stage

   Not phased

   Ages

   40 and older

   Site

   University of Washington, Seattle, Washington

   Locations

   2 in total

   Run by

   University of Washington

   See if you can join NCT07105007 on ClinicalTrials.gov

10. Sodium-Glucose Cotransporter-2 Inhibitor for Patients With Acute Cardiorenal Syndrome

    The overall objective of this study is to determine whether the addition of SGLT2 inhibitors to usual care in hospitalized patients with heart failure associated acute kidney injury is safe and efficacious. Investigators will assess if SGLT2 inhibition improves a composite cardio-renal outcome (mor…

    Stage

    Phase 2

    Ages

    18 to 85

    Site

    Yale New Haven Hospital-St. Raphael Campus, New Haven, Connecticut

    Locations

    2 in total

    Run by

    Yale University

    See if you can join NCT07273838 on ClinicalTrials.gov

11. Utility of Thenar Near Infrared Spectroscopy (NIRS) in Pediatric Patients With Heart Failure

    This is a single-center, non-randomized study.The study staff will use the InSpectraTM tissue oxygen saturation (StO2) monitor manufactured by Hutchinson Technology to measure baseline StO2 levels after applying the noninvasive probe to the thenar eminence. After a stable reading is obtained, a blo…

    Stage

    Not phased

    Ages

    Up to 25

    Site

    University of Florida, Gainesville, Florida

    Run by

    University of Florida

    See if you can join NCT02368041 on ClinicalTrials.gov

12. Real-Time Monitoring of Heart Failure Across the Yale New Haven Health System

    The Yale HF Registry is a live EHR based registry that allows for retrospective and real-time monitoring of Heart Failure case across the Yale New Haven Health System.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Yale New Haven Health System, New Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT04237701 on ClinicalTrials.gov

13. Voice Analysis to Detect Pulmonary Arterial Pressure Changes in Heart Failure

    VAPP-HF is a prospective, multi-center, observational study assessing whether daily voice recordings analyzed by a machine learning algorithm can detect changes in pulmonary arterial (PA) pressure in heart failure patients with implanted PA pressure sensors (e.g., CardioMEMS, Cordella). Patients ac…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of California, San Francisco (UCSF), San Francisco, California

    Locations

    3 in total

    Run by

    Noah Labs

    See if you can join NCT07443670 on ClinicalTrials.gov

14. Efficacy of LoDoCo in Improving Exercise Capacity Among Patients With HFpEF and Inflammation

    The purpose of this research study is to determine the effectiveness of low dose colchicine (LoDoCo) on measures of exercise capacity, physical function, frailty, and quality of life, among patients with heart failure with chronic stable preserved ejection fraction (HFpEF) and systemic inflammation…

    Stage

    Phase 2

    Ages

    50 and older

    Site

    UT Southwestern Medical Center, Dallas, Texas

    Run by

    University of Texas Southwestern Medical Center

    See if you can join NCT06130059 on ClinicalTrials.gov

15. AI-Guided Left Bundle Branch Area Pacing

    The purpose of this study is to compare the effectiveness of AI-guided LBBAP versus conventional LBBAP (not AI-guided) in improving CRT response rates and clinical outcomes.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Mayo Clinic in Rochester, Rochester, Minnesota

    Run by

    Mayo Clinic

    See if you can join NCT07206602 on ClinicalTrials.gov

16. Identifying Markers of Exercise Training in Heart Failure

    The heart failure syndrome that occurs when the heart is too sick to properly do its job. One of the main symptoms is difficulty with exercise. One way to improve symptoms is to start patients in a 12 week exercise program called cardiac rehabilitation. Cardiac rehabilitation been shown to improve …

    Stage

    Not phased

    Ages

    18 to 89

    Site

    Stanford Health Care, Stanford, California

    Run by

    Stanford University

    See if you can join NCT05696652 on ClinicalTrials.gov

17. Cardiovascular Kidney and Metabolic Health Assessment and Patient Empowerment

    The primary objective of CHAPERONE solution is to evaluate the efficacy of engaging, assessing, and enabling long term treatment strategy with Health Artificial Intelligence (AI) Chatbot, Copilot, Large Language Model (LLM) and vital sign monitoring device in reducing CKM disease burden using an al…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Gilbert Cardiology, Gilbert, Arizona

    Locations

    5 in total

    Run by

    Aventyn, Inc.

    See if you can join NCT07403669 on ClinicalTrials.gov

18. Heart Failure Precision Medicine Study

    The study aims to test the hypothesis that multi-omics studies can identify Heart Failure profiles at risk of adverse outcomes and evaluate a telemonitoring intervention in the optimization of guideline-directed medical therapy.

    Stage

    Not phased

    Ages

    21 and older

    Site

    UC Davis Medical Center, Sacramento, California

    Run by

    University of California, Davis

    See if you can join NCT04196842 on ClinicalTrials.gov

19. His-Bundle Corrective Pacing in Heart Failure

    The investigators aim to prospectively evaluate the efficacy and mechanism of benefit of His-bundle pacing enhanced cardiac resynchronization therapy (His-CRT) vs. cardiac resynchronization therapy (BIV-CRT) in patients with heart failure and right bundle branch block (RBBB).

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Arizona, Phoenix, Arizona

    Locations

    14 in total

    Run by

    University of Rochester

    See if you can join NCT05265520 on ClinicalTrials.gov

20. iCardia4HF: Multi-component mHealth Intervention for Patients With Heart Failure

    The goal of this factorial randomized trial is to examine the independent and synergistic efficacies of two mobile health technology interventions in people with chronic heart failure. The first intervention involves the use of multiple consumer mHealth apps and sensor devices (MyApps) for heart fa…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Rush University Medical Center, Chicago, Illinois

    Locations

    2 in total

    Run by

    University of Illinois at Chicago

    See if you can join NCT06205225 on ClinicalTrials.gov

21. Transplant of Redeemed Organs by Judicious Administration of New Direct-Acting Antivirals for Hepatitis-C Heart Recipients

    This phase II, multi-center, open-label study will evaluate the safety and efficacy of utilizing HCV-positive donors for heart transplant in HCV-negative recipients treated with sofosbuvir 400 mg / velpatasvir 100 mg (Epclusa®).

    Stage

    Phase 2

    Ages

    18 to 90

    Site

    Cedars-Sinai Medical Center, Los Angeles, California

    Locations

    3 in total

    Run by

    Baylor Research Institute

    See if you can join NCT03383419 on ClinicalTrials.gov

22. Cardiopulmonary Stress Testing (CPET) AlloSure Study

    1. Cell-free DNA does not vary significantly as a function of the activity of immunologically quiescent cardiac transplant recipients, despite the metabolic demands of the transplanted organ. (The implication of the null result would be that no restrictions to patient activity, nor modification of …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Baylor Scott & White health research institute, Dallas, Texas

    Run by

    Baylor Research Institute

    See if you can join NCT04656080 on ClinicalTrials.gov

23. Sensor-controlled Digital Game for Heart Failure Self-management: A Clinical Trial

    This study evaluates a sensor-controlled digital game (SCDG) to motivate self-management behaviors of weight monitoring and physical activity in adults with heart failure (HF). Half of the participants will receive the SCDG app and weight monitoring and physical activity sensors and the other half …

    Stage

    Not phased

    Ages

    45 and older

    Site

    The University of Texas Austin, Austin, Texas

    Run by

    University of Texas at Austin

    See if you can join NCT05056129 on ClinicalTrials.gov

24. Effect of Music on Cardiopulmonary Exercise Capacity in Heart Failure Patients

    The study aims to assess the effect of music on the heart resulting in a change in their exercise capacity among systolic heart failure patients undergoing Cardiopulmonary Exercise testing.

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Kentucky, Lexington, Kentucky

    Run by

    Maya Ignaszewski

    See if you can join NCT05537467 on ClinicalTrials.gov

25. Diffusion MRI in Heart Failure

    The development of symptomatic heart failure is frequently preceded by a pre-clinical period of structural remodeling in the heart. The remodeling process driving this transition, however, remains poorly understood. The investigators hypothesize that imaging the diffusion of water in the heart with…

    Stage

    EARLY_Phase 1

    Ages

    18 to 85

    Site

    Massachusetts General Hospital, Charlestown, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT02973633 on ClinicalTrials.gov