Heart Failure Clinical Trials

148 studies are recruiting for heart failure in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 5

1. Efficacy of LoDoCo in Improving Exercise Capacity Among Patients With HFpEF and Inflammation

   The purpose of this research study is to determine the effectiveness of low dose colchicine (LoDoCo) on measures of exercise capacity, physical function, frailty, and quality of life, among patients with heart failure with chronic stable preserved ejection fraction (HFpEF) and systemic inflammation…

   Stage

   Phase 2

   Ages

   50 and older

   Site

   UT Southwestern Medical Center, Dallas, Texas

   Run by

   University of Texas Southwestern Medical Center

   See if you can join NCT06130059 on ClinicalTrials.gov

2. NT-ProBNP-based Heart Failure Screening and Prevention Trial in Patients With Type 2 Diabetes: STRONG-DM Study

   A pragmatic, randomized clinical trial to evaluate the effect of a heart failure (HF) risk assessment and prevention strategy incorporating HF clinical risk scores (WATCH-DM) with cardiac biomarker (NT-proBNP) paired with a clinical decision support tool to implement an intensive prevention strateg…

   Stage

   Not phased

   Ages

   Any age

   Site

   University of Texas Southwestern Medical Center, Dallas, Texas

   Run by

   University of Texas Southwestern Medical Center

   See if you can join NCT06593327 on ClinicalTrials.gov

3. AI-Guided Left Bundle Branch Area Pacing

   The purpose of this study is to compare the effectiveness of AI-guided LBBAP versus conventional LBBAP (not AI-guided) in improving CRT response rates and clinical outcomes.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Mayo Clinic in Rochester, Rochester, Minnesota

   Run by

   Mayo Clinic

   See if you can join NCT07206602 on ClinicalTrials.gov

4. Identifying Markers of Exercise Training in Heart Failure

   The heart failure syndrome that occurs when the heart is too sick to properly do its job. One of the main symptoms is difficulty with exercise. One way to improve symptoms is to start patients in a 12 week exercise program called cardiac rehabilitation. Cardiac rehabilitation been shown to improve …

   Stage

   Not phased

   Ages

   18 to 89

   Site

   Stanford Health Care, Stanford, California

   Run by

   Stanford University

   See if you can join NCT05696652 on ClinicalTrials.gov

5. Cardiovascular Kidney and Metabolic Health Assessment and Patient Empowerment

   The primary objective of CHAPERONE solution is to evaluate the efficacy of engaging, assessing, and enabling long term treatment strategy with Health Artificial Intelligence (AI) Chatbot, Copilot, Large Language Model (LLM) and vital sign monitoring device in reducing CKM disease burden using an al…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Gilbert Cardiology, Gilbert, Arizona

   Locations

   5 in total

   Run by

   Aventyn, Inc.

   See if you can join NCT07403669 on ClinicalTrials.gov

6. Heart Failure Precision Medicine Study

   The study aims to test the hypothesis that multi-omics studies can identify Heart Failure profiles at risk of adverse outcomes and evaluate a telemonitoring intervention in the optimization of guideline-directed medical therapy.

   Stage

   Not phased

   Ages

   21 and older

   Site

   UC Davis Medical Center, Sacramento, California

   Run by

   University of California, Davis

   See if you can join NCT04196842 on ClinicalTrials.gov

7. His-Bundle Corrective Pacing in Heart Failure

   The investigators aim to prospectively evaluate the efficacy and mechanism of benefit of His-bundle pacing enhanced cardiac resynchronization therapy (His-CRT) vs. cardiac resynchronization therapy (BIV-CRT) in patients with heart failure and right bundle branch block (RBBB).

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Arizona, Phoenix, Arizona

   Locations

   14 in total

   Run by

   University of Rochester

   See if you can join NCT05265520 on ClinicalTrials.gov

8. iCardia4HF: Multi-component mHealth Intervention for Patients With Heart Failure

   The goal of this factorial randomized trial is to examine the independent and synergistic efficacies of two mobile health technology interventions in people with chronic heart failure. The first intervention involves the use of multiple consumer mHealth apps and sensor devices (MyApps) for heart fa…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Rush University Medical Center, Chicago, Illinois

   Locations

   2 in total

   Run by

   University of Illinois at Chicago

   See if you can join NCT06205225 on ClinicalTrials.gov

9. Transplant of Redeemed Organs by Judicious Administration of New Direct-Acting Antivirals for Hepatitis-C Heart Recipients

   This phase II, multi-center, open-label study will evaluate the safety and efficacy of utilizing HCV-positive donors for heart transplant in HCV-negative recipients treated with sofosbuvir 400 mg / velpatasvir 100 mg (Epclusa®).

   Stage

   Phase 2

   Ages

   18 to 90

   Site

   Cedars-Sinai Medical Center, Los Angeles, California

   Locations

   3 in total

   Run by

   Baylor Research Institute

   See if you can join NCT03383419 on ClinicalTrials.gov

10. Cardiopulmonary Stress Testing (CPET) AlloSure Study

    1. Cell-free DNA does not vary significantly as a function of the activity of immunologically quiescent cardiac transplant recipients, despite the metabolic demands of the transplanted organ. (The implication of the null result would be that no restrictions to patient activity, nor modification of …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Baylor Scott & White health research institute, Dallas, Texas

    Run by

    Baylor Research Institute

    See if you can join NCT04656080 on ClinicalTrials.gov

11. Sensor-controlled Digital Game for Heart Failure Self-management: A Clinical Trial

    This study evaluates a sensor-controlled digital game (SCDG) to motivate self-management behaviors of weight monitoring and physical activity in adults with heart failure (HF). Half of the participants will receive the SCDG app and weight monitoring and physical activity sensors and the other half …

    Stage

    Not phased

    Ages

    45 and older

    Site

    The University of Texas Austin, Austin, Texas

    Run by

    University of Texas at Austin

    See if you can join NCT05056129 on ClinicalTrials.gov

12. Effect of Music on Cardiopulmonary Exercise Capacity in Heart Failure Patients

    The study aims to assess the effect of music on the heart resulting in a change in their exercise capacity among systolic heart failure patients undergoing Cardiopulmonary Exercise testing.

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Kentucky, Lexington, Kentucky

    Run by

    Maya Ignaszewski

    See if you can join NCT05537467 on ClinicalTrials.gov

13. Diffusion MRI in Heart Failure

    The development of symptomatic heart failure is frequently preceded by a pre-clinical period of structural remodeling in the heart. The remodeling process driving this transition, however, remains poorly understood. The investigators hypothesize that imaging the diffusion of water in the heart with…

    Stage

    EARLY_Phase 1

    Ages

    18 to 85

    Site

    Massachusetts General Hospital, Charlestown, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT02973633 on ClinicalTrials.gov

14. His Bundle Pacing in Bradycardia and Heart Failure

    Participants in this study will either have heart failure (HF) and are scheduled to undergo pace maker (PM) implantation, cardiac resynchronization therapy pacemaker (CRT-P), cardiac resynchronization therapy defibrillator (CRT-D) implantation, His bundle pacing (HIBP) or left bundle area pacing (L…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Mayo Clinic, Rochester, Minnesota

    Run by

    Yong-Mei Cha

    See if you can join NCT03008291 on ClinicalTrials.gov

15. Remote Ischemic Preconditioning for Renal and Cardiac Protection in Congestive Heart Failure (RICH) Trial

    This is a prospective, double-blind, sham-controlled, multicenter, randomized clinical trial is to study the effects of remote ischemic preconditioning on contrast-associated acute kidney injury, functional capacity, and major adverse kidney events in in patients with congestive heart failure under…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA, Pittsburgh, Pennsylvania

    Locations

    3 in total

    Run by

    VA Office of Research and Development

    See if you can join NCT04982419 on ClinicalTrials.gov

16. A SkeleTal Muscle Recovery Intervention With Dietary Protein in Heart Failure

    Severe skeletal wasting and catabolic weight loss are highly common among patients with heart failure with reduced ejection fraction (HFrEF). This prospective randomized controlled trial will compare changes in the muscle mass in the arms and the legs (appendicular lean mass) in patients with HFrEF…

    Stage

    Not phased

    Ages

    18 to 100

    Site

    Tufts Medical Center, Boston, Massachusetts

    Locations

    2 in total

    Run by

    Tufts Medical Center

    See if you can join NCT05627440 on ClinicalTrials.gov

17. Real World Effectiveness of the Cordella Pulmonary Artery Sensor System in Patients With Chronic Heart Heart Failure

    This retrospective, non-randomized cohort study will evaluate how well the Cordella PA Sensor System works compared to standard medication treatment in people with chronic heart failure. The study will track patients for two years to see if those using the Cordella system have fewer deaths and hosp…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Endotronix, Naperville, Illinois

    Run by

    Endotronix, Inc.

    See if you can join NCT06783335 on ClinicalTrials.gov

18. Supporting Health in Veterans With Heart Failure

    This study will test the effectiveness of a culturally-sensitive, telephone-based, tailored problem-solving intervention to improve physical and mental health in Veterans with heart failure (HF). Veterans will be recruited from VA clinics throughout the United States. As a component of this study, …

    Stage

    Not phased

    Ages

    18 and older

    Site

    VA Clinic - Gainesville, Gainesville, Florida

    Locations

    4 in total

    Run by

    Florida State University

    See if you can join NCT05839067 on ClinicalTrials.gov

19. Fluid Guided Heart Failure Treatment at the Cleveland Clinic

    FIGHT-HF is an exploratory non-randomized open-label study evaluating a heart failure management intervention. The goal of this pilot is to assess the performance of a fluid-guided heart failure management program and Alert Response Guide (ARG) using the Bodyport Cardiac Scale and Congestion Index …

    Stage

    Not phased

    Ages

    21 and older

    Site

    The Cleveland Clinic, Cleveland, Ohio

    Run by

    Bodyport Inc.

    See if you can join NCT07205120 on ClinicalTrials.gov

20. Enhanced Nutritional Optimization in LVAD Trial

    The goal of this clinical trial is to assess whether a peri-operative intervention with nutritional immune modulating intervention (Ensure Surgery Immunonutrition shake) has beneficial effects on the complex interplay between gut microbiome, systemic inflammation and malnutrition that is commonly p…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Columbia University Medical Center, New York, New York

    Run by

    Columbia University

    See if you can join NCT05655910 on ClinicalTrials.gov

21. Pulmonary Artery Catheter in Cardiogenic Shock Trial

    The primary objective of the PACCS trial is to assess if early invasive hemodynamic assessment and ongoing management with a PAC in patients with cardiogenic shock due to acutely decompensated heart failure (AHDF-CS) is associated with lower in-hospital mortality risk compared to the current standa…

    Stage

    Not phased

    Ages

    18 to 90

    Site

    Tufts Medical Center, Boston, Massachusetts

    Run by

    Tufts Medical Center

    See if you can join NCT05485376 on ClinicalTrials.gov

22. Ertugliflozin in Chronic Heart Failure

    The purpose of this study is to determine the effects on heart failure signs and symptoms of the use of either ertugliflozin, metolazone or placebo, in conjunction with intravenous loop diuretic use in acute settings and chronic oral loop diuretic therapy. There are two general purposes for this st…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Yale School of Medicine, New Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT04438213 on ClinicalTrials.gov

23. Left vs Left Randomized Clinical Trial

    The investigators aim to prospectively test the comparative effectiveness of His or Left bundle branch pacing in relation to patient centered outcomes (quality of life, physical activity, heart failure hospitalization, mortality) and comparative safety in relation to device-related complications an…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Mercy Gilbert & Chandler Regional Medical Centers, Gilbert AZ, Gilbert, Arizona

    Locations

    71 in total

    Run by

    Baylor College of Medicine

    See if you can join NCT05650658 on ClinicalTrials.gov

24. : Vascular Function in Health and Disease

    Many control mechanisms exist which successfully match the supply of blood with the metabolic demand of various tissues under wide-ranging conditions. One primary regulator of vasomotion and thus perfusion to the muscle tissue is the host of chemical factors originating from the vascular endotheliu…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    George E Wahlen VA Medical Center, Salt Lake City, Utah

    Run by

    Russell Richardson

    See if you can join NCT02966665 on ClinicalTrials.gov

25. Home-Based Exercise Program Using Mobile Technology After Left Ventricular Assist Device Implantation

    The goal of this clinical trial is to evaluate the effects of a home-based exercise program using mobile technology on physical activity and capacity, frailty and muscle mass, and quality of life in patients with a newly implanted HeartMate 3 left ventricular assist device (HM3 LVAD). Researchers w…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Henry Ford Health, Detroit, Michigan

    Locations

    4 in total

    Run by

    University of Pennsylvania

    See if you can join NCT06291922 on ClinicalTrials.gov