Heart Failure Clinical Trials

148 studies are recruiting for heart failure in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 4

1. Improving Medication Adherence Using Family-focused and Literacy-sensitive Strategies

   People with heart failure who do not take their medications as prescribed are at high risk of complications leading to hospitalization, death and poor quality of life. In the proposed intervention, nurses will use easy-to-understand language to coach patients and their care partners to help them wo…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Jia-Rong Wu, Lexington, Kentucky

   Run by

   Jia-Rong Wu

   See if you can join NCT05548413 on ClinicalTrials.gov

2. Ultra-High Frequency - Electrocardiogram (UHF-ECG) for the Diagnosis of Ventricular Electrical Dyssynchrony (VED)

   The purpose of this study is to demonstrate the safety and effectiveness of the VDI UHF-ECG System in the diagnosis of ventricular dyssynchrony when compared to the 12-lead ECG in patients with bradycardia and heart failure indicated for pacemaker implantation.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Peak Heart and Vascular, Avondale, Arizona

   Locations

   12 in total

   Run by

   VDI Technologies

   See if you can join NCT06641362 on ClinicalTrials.gov

3. Splanchnic X: Splanchnic Nerve Block in Heart Failure With Reduced Ejection Fraction

   Heart failure (HF) affects more than 6 million adults in the U.S. alone, with increasing prevalence. Cardiovascular congestion with resultant limitation in physical activity is the hallmark of chronic and decompensated HF. The current HF physiologic model suggests that congestion is the result of v…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Duke, Durham, North Carolina

   Run by

   Duke University

   See if you can join NCT06733012 on ClinicalTrials.gov

4. The Salt Study for Heart Failure

   The purpose of this study is to understand if low sodium (cardiac) diet is indeed necessary for better health outcomes in patients who suffered heart failure. This study will investigate the association between sodium intake and risk for 30-day re-admission in Heart Failure (HF) patients.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Robert Wood Johnson Barnabas Hospital - New Brunswick, New Brunswick, New Jersey

   Run by

   Maya Guglin, MD

   See if you can join NCT07560592 on ClinicalTrials.gov

5. Cardiovascular Health Improvement Project

   The goal of this project is to establish a biobank of clinical information, DNA, plasma, and aortic tissue samples from patients with cardiovascular disease as well as healthy controls.

   Stage

   Not phased

   Ages

   Any age

   Site

   University of Michigan, Ann Arbor, Michigan

   Run by

   University of Michigan

   See if you can join NCT02306200 on ClinicalTrials.gov

6. CCM OPEN HF Registry

   The registry has been designed to evaluate the long-term safety and efficacy of CCM therapy in a real-world setting.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Cardiovascular Associates of Mesa, Mesa, Arizona

   Locations

   28 in total

   Run by

   Impulse Dynamics

   See if you can join NCT07112924 on ClinicalTrials.gov

7. A Study of Paramedic HF Management

   The purpose of this research is to see if having community paramedic (CP) visit patients at home to manage their heart failure help them stay out of the hospital and improve their overall health compared to standard care. The investigators want to find out if their approach is better for patients i…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Mayo Clinic, Rochester, Minnesota

   Run by

   Mayo Clinic

   See if you can join NCT06874556 on ClinicalTrials.gov

8. Promoting Well-being and Health in Heart Failure

   The focus of this study is to test the efficacy of a 12-week, phone-delivered Positive Psychology-Motivational Interviewing (PP-MI) intervention, with additional twice weekly PP and health behavior text messages for a total of 24 weeks (with interactive, algorithm-driven, goal-focused text messages…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Massachusetts General Hospital, Boston, Massachusetts

   Run by

   Massachusetts General Hospital

   See if you can join NCT04829617 on ClinicalTrials.gov

9. The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR

   The objective of this prospective, randomized, double- blinded (patient and assessors), sham-controlled clinical trial is to assess the safety and efficacy of the CMCS in treating heart failure with functional regurgitation (FMR).

   Stage

   Not phased

   Ages

   18 and older

   Site

   Dignity Health Research Institute at Mercy Gilbert and Chandler Regional Medical Centers, Gilbert, Arizona

   Locations

   92 in total

   Run by

   Cardiac Dimensions, Inc.

   See if you can join NCT03142152 on ClinicalTrials.gov

10. HeartShare: Combining Omics, Deep Phenotyping, and Electronic Health Records for Heart Failure Subtypes and Treatment Targets

    HeartShare is a comprehensive study of heart failure, a common and serious medical condition which occurs when the heart is unable to keep up with the demands of the body, resulting in shortness of breath, fluid retention, and fatigue. HeartShare aims to better classify heart failure into subtypes …

    Stage

    Not phased

    Ages

    30 and older

    Site

    University of California Davis, Sacramento, California

    Locations

    6 in total

    Run by

    Northwestern University

    See if you can join NCT05873634 on ClinicalTrials.gov

11. Smartphone Twelve-Lead ECG Utility In ST-Elevation Myocardial Infarction II

    AliveCor (www.alivecor.com) has developed several electrocardiogram (ECG) devices that interface with iOS and Android smartphones and tablets via various Kardia apps. The current Kardia family of devices can measure single lead and six limb-lead ECGs, depending on the device. KardiaMobile, KardiaMo…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Mayo Clinic, Rochester, Minnesota

    Locations

    4 in total

    Run by

    AliveCor

    See if you can join NCT06271577 on ClinicalTrials.gov

12. Myocardial Mechanisms in Heart Failure With Preserved Ejection Fraction

    The purpose of this study is to identify changes in heart tissue structure and biological function in patients with heart failure by performing an endomyocardial biopsy (EMB or heart biopsy) during a right heart catheterization (RHC). The ultimate goal is to use this information to develop new trea…

    Stage

    Not phased

    Ages

    30 and older

    Site

    Northwestern University, Chicago, Illinois

    Locations

    6 in total

    Run by

    Northwestern University

    See if you can join NCT06517186 on ClinicalTrials.gov

13. Urine Sodium-Driven Diuretic Adjustment Strategy in Acute Decompensated Heart Failure

    The goal of this clinical trial is to learn if increasing the dose of diuretics to achieve a higher urine sodium target produces better clinical results when treating patients hospitalized with acute heart failure when compared to lower urine sodium target and standard of care. The main questions i…

    Stage

    Phase 4

    Ages

    18 and older

    Site

    Lakeland Regional Hospital, Lakeland, Florida

    Run by

    Lakeland Regional Health Systems, Inc.

    See if you can join NCT07263035 on ClinicalTrials.gov

14. CardioMEMS HF System Coverage With Evidence Development Study

    The purpose of the CardioMEMS CED Study is to determine if pulmonary artery (PA) pressure-guided heart failure management using the CardioMEMS™ HF System improves long-term health outcomes in heart failure (HF) patients in the real-world setting.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Abbott, Pleasanton, California

    Run by

    Abbott Medical Devices

    See if you can join NCT06779552 on ClinicalTrials.gov

15. Forge AHEAD: Feasibility of Yoga to Improve Cognitive Function

    The investigators will conduct a two-phase pilot study to test the feasibility and acceptability of a 12-week Chair Yoga intervention for 20 heart-failure patients. Using a patient-centered approach, investigators will involve stakeholders in designing the protocol, gather patient feedback, and ref…

    Stage

    Not phased

    Ages

    55 and older

    Site

    Auburn University, Auburn, Alabama

    Run by

    Auburn University

    See if you can join NCT07489105 on ClinicalTrials.gov

16. Precision Rehabilitation for Veterans With (HFpEF)

    This study is being completed because there is conflicting information regarding the value of monitored exercise in patients with heart failure with preserved ejection fraction (HFpEF). The purpose of this study is to collect baseline information necessary for researchers to pursue a larger study e…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Columbia VA Health Care System, Columbia, South Carolina

    Run by

    Columbia VA Health Care System

    See if you can join NCT07493915 on ClinicalTrials.gov

17. Sotagliflozin to Slow Kidney Function Decline in Persons With Type 1 Diabetes and Diabetic Kidney Disease

    Powerful new drugs that can prevent or delay end stage kidney disease (ESKD) - so called sodium-glucose cotransporter-2 inhibitors (SGLT2i) - are now available for patients with type 2 diabetes. Whether these drugs have similar effects in patients with type 1 diabetes (T1D) remains unknown because …

    Stage

    Phase 3

    Ages

    18 to 75

    Site

    Stanford University Medical Center, Stanford, California

    Locations

    19 in total

    Run by

    Alessandro Doria

    See if you can join NCT06217302 on ClinicalTrials.gov

18. XVIVO Heart Box (XHB) With Supplemented XVIVO Heart Solution (SXHS) Continued Access Protocol (CAP)

    The purpose of this study is to evaluate if Non-Ischemic Heart Preservation (NIHP) of extended criteria donor hearts using the XVIVO Heart Preservation System (XHPS) is a safe and effective way to preserve and transport hearts for transplantation.

    Stage

    Not phased

    Ages

    18 and older

    Site

    UC San Diego Health, La Jolla, California

    Locations

    14 in total

    Run by

    XVIVO Perfusion

    See if you can join NCT06895070 on ClinicalTrials.gov

19. Home Hospital for Suddenly Ill Adults

    The investigators propose a home hospital model of care that substitutes for treatment in an acute care hospital. Limited studies of the home hospital model have demonstrated that a sizeable proportion of acute care can be delivered in the home with equal quality and safety, reduced cost, and impro…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Brigham and Women's Hospital, Boston, Massachusetts

    Locations

    2 in total

    Run by

    Brigham and Women's Hospital

    See if you can join NCT03524222 on ClinicalTrials.gov

20. Hemodynamic Monitoring to Prevent Adverse Events foLlowing cardiOgenic Shock Trial

    Pilot Prospective Randomized Unblinded Pragmatic Trial of Pulmonary Artery Hemodynamic Monitoring Following Hospitalization for Cardiogenic Shock

    Stage

    Not phased

    Ages

    18 and older

    Site

    Inova Fairfax Medical Campus, Falls Church, Virginia

    Run by

    Inova Health Care Services

    See if you can join NCT04419480 on ClinicalTrials.gov

21. Proof-of-concept of a Behavioral Intervention to Improve the Cardiovascular Health of People Living With HIV

    Heart failure (HF) is a growing health and economic burden around the globe, and it remains a leading cause of morbidity and mortality among the general population. HIV is recognized as an independent risk factor for HF, due to direct and indirect effects. Furthermore, people living with HIV (PLWH)…

    Stage

    Not phased

    Ages

    40 and older

    Site

    University of Washington, Seattle, Washington

    Locations

    2 in total

    Run by

    University of Washington

    See if you can join NCT07105007 on ClinicalTrials.gov

22. Sodium-Glucose Cotransporter-2 Inhibitor for Patients With Acute Cardiorenal Syndrome

    The overall objective of this study is to determine whether the addition of SGLT2 inhibitors to usual care in hospitalized patients with heart failure associated acute kidney injury is safe and efficacious. Investigators will assess if SGLT2 inhibition improves a composite cardio-renal outcome (mor…

    Stage

    Phase 2

    Ages

    18 to 85

    Site

    Yale New Haven Hospital-St. Raphael Campus, New Haven, Connecticut

    Locations

    2 in total

    Run by

    Yale University

    See if you can join NCT07273838 on ClinicalTrials.gov

23. Utility of Thenar Near Infrared Spectroscopy (NIRS) in Pediatric Patients With Heart Failure

    This is a single-center, non-randomized study.The study staff will use the InSpectraTM tissue oxygen saturation (StO2) monitor manufactured by Hutchinson Technology to measure baseline StO2 levels after applying the noninvasive probe to the thenar eminence. After a stable reading is obtained, a blo…

    Stage

    Not phased

    Ages

    Up to 25

    Site

    University of Florida, Gainesville, Florida

    Run by

    University of Florida

    See if you can join NCT02368041 on ClinicalTrials.gov

24. Real-Time Monitoring of Heart Failure Across the Yale New Haven Health System

    The Yale HF Registry is a live EHR based registry that allows for retrospective and real-time monitoring of Heart Failure case across the Yale New Haven Health System.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Yale New Haven Health System, New Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT04237701 on ClinicalTrials.gov

25. Voice Analysis to Detect Pulmonary Arterial Pressure Changes in Heart Failure

    VAPP-HF is a prospective, multi-center, observational study assessing whether daily voice recordings analyzed by a machine learning algorithm can detect changes in pulmonary arterial (PA) pressure in heart failure patients with implanted PA pressure sensors (e.g., CardioMEMS, Cordella). Patients ac…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of California, San Francisco (UCSF), San Francisco, California

    Locations

    3 in total

    Run by

    Noah Labs

    See if you can join NCT07443670 on ClinicalTrials.gov