Heart Failure Clinical Trials

150 studies are recruiting for heart failure in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 4

1. Quantifying New Heart Muscle Cells

   Regenerative therapies could provide new ways of treating heart failure. Unlike many organs in the human body, such as the skin and the GI tract, the ability to regenerate heart muscle decreases after birth, but the precise timing of this decrease and how this decrease is altered in heart disease a…

   Stage

   Not phased

   Ages

   0 to 1

   Site

   Weill Cornell Medicine, New York, New York

   Locations

   4 in total

   Run by

   Weill Medical College of Cornell University

   See if you can join NCT06587165 on ClinicalTrials.gov

2. Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure

   The purpose of TEAM-HF IDE clinical trial is to evaluate safety and effectiveness of the HeartMate 3 LVAS compared to guideline directed medical therapy (GDMT) in a population of ambulatory advanced heart failure patients who are not dependent on intravenous inotrope.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Banner-University Medical Center Phoenix, Phoenix, Arizona

   Locations

   68 in total

   Run by

   Abbott Medical Devices

   See if you can join NCT06526195 on ClinicalTrials.gov

3. Gator SCALES-WHF: SubCutaneous Administration of Lasix to Eliminate Symptoms of Worsening Heart Failure

   The primary objective of the study is to develop, implement, and evaluate a site-specific clinical pathway for at-home treatment of eligible patients presenting to the clinic with worsening heart failure. The secondary objectives are: 1. To evaluate patient factors related to parenteral decongestio…

   Stage

   Phase 4

   Ages

   18 to 80

   Site

   University of Florida, Gainesville, Florida

   Run by

   University of Florida

   See if you can join NCT06979726 on ClinicalTrials.gov

4. CALM Study: Cardiomems Assisted Lvad Management

   This prospective, open label, randomized, single-center pilot clinical trial will determine if the rate of heart failure related (HFR) hospitalizations is less in LVAD patients whose PAP is monitored with the CardioMEMS device vs the control patients receiving standard of care treatment.

   Stage

   Not phased

   Ages

   21 to 85

   Site

   Baylor Scott & White The Heart Hospital - Plano, Plano, Texas

   Run by

   Baylor Research Institute

   See if you can join NCT07096544 on ClinicalTrials.gov

5. Home-based Cardiac Rehabilitation in Heart Failure

   This study evaluates a mobile health (mHealth) home-based cardiac rehabilitation program for patients with heart failure. We will stratify randomization between rural and urban populations, with the goal to assess implementation of cardiac rehabilitation across these two geographic areas. . The stu…

   Stage

   Phase 3

   Ages

   18 and older

   Site

   University of Texas Southwestern Medical Center, Dallas, Texas

   Locations

   2 in total

   Run by

   University of Texas Southwestern Medical Center

   See if you can join NCT06349941 on ClinicalTrials.gov

6. AI-Enabled Direct-from-ECG Ejection Fraction (EF) Severity Assessment Using COR ECG Wearable Monitor

   This prospective, multicenter, cluster-randomized controlled study aims to evaluate the accuracy of an investigational artificial intelligence (AI) Software as a Medical Device (SaMD) designed to compute ejection fraction (EF) severity categories based on the American Society of Echocardiography's …

   Stage

   Not phased

   Ages

   18 and older

   Site

   Orange County Heart Institute, Orange, California

   Locations

   8 in total

   Run by

   Peerbridge Health, Inc

   See if you can join NCT06699056 on ClinicalTrials.gov

7. IEEM-Heat and Heart Failure

   We will test the hypothesis that increasing skin wetness, and thus evaporative cooling, will attenuate the increase in core body temperature and accompanying cardiac stress during heat wave conditions in individuals with congestive heart failure. Secondly, we propose that wearing a water-saturated …

   Stage

   Not phased

   Ages

   45 and older

   Site

   Institute for Exercise and Environmental Medicine - Texas Health Presbyterian Hospital Dallas, Dallas, Texas

   Run by

   University of Texas Southwestern Medical Center

   See if you can join NCT06961929 on ClinicalTrials.gov

8. Mechanisms of Diuretic Resistance in Heart Failure, Aim 1

   This study will employ a randomized order, double-blind, repeated measures dose ranging design. This design was chosen in order to generate multiple within-subject serial loop diuretic dose response exposures. The overall study schema will include 75 heart failure (HF) patients.

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Yale University, New Haven, Connecticut

   Run by

   Yale University

   See if you can join NCT05323487 on ClinicalTrials.gov

9. Mechanisms of Diuretic Resistance in Heart Failure, Aim 3

   Randomized double-blind placebo-controlled crossover study design

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Yale University, New Haven, Connecticut

   Run by

   Yale University

   See if you can join NCT06209359 on ClinicalTrials.gov

10. CV Imaging of Metabolic Interventions

    Cardiovascular disease is the leading cause of death worldwide. It is becoming clearer that heart failure (HF) is closely associated with body's metabolism. Even before the heart becomes weaker, it responds to the stresses by changing the fuels it burns, which results in a reduction in the heart's …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Cardiovascular Innovation Research Center, Cleveland, Ohio

    Run by

    The Cleveland Clinic

    See if you can join NCT05650307 on ClinicalTrials.gov

11. Development of CIRC Technologies

    Cardiovascular disease is the leading cause of death worldwide. Advanced cardiovascular imaging using Magnetic Resonance Imaging (MRI) has proven to be effective in providing gold standard myocardial tissue characterization. Moreover, the intrinsic advantage of MRI's lack of exposure to ionizing ra…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Cardiovascular Innovation Research Center, Cleveland, Ohio

    Run by

    The Cleveland Clinic

    See if you can join NCT05654272 on ClinicalTrials.gov

12. Early Assessment and Initiation of GuideLine-Directed Evidence-Based Management-HF

    EAGLE-HF (Early Assessment and initiation of GuideLine-directed Evidence-based management-HF) is a prospective single site study of a multinational, unblinded, randomized-controlled, longitudinal trial called SYMPHONY. Primary, secondary and exploratory outcomes that are part of SYMPHONY are not de…

    Stage

    Not phased

    Ages

    40 and older

    Site

    Cleveland Clinic, Cleveland, Ohio

    Run by

    The Cleveland Clinic

    See if you can join NCT06849752 on ClinicalTrials.gov

13. Using Ultromics EchoGo HFpEF Algorithm to Identify and Treat High Heart Failure Risk in Patients With Type 2 Diabetes

    A pragmatic electronic health record (EHR) based randomized controlled trial to evaluate the utility of providing Ultromics EchoGo analysis results and recommendations for HF risk prevention therapies using an EHR embedded clinical decision support tool.

    Stage

    Not phased

    Ages

    Any age

    Site

    UT Southwestern Medical Center, Dallas, Texas

    Run by

    University of Texas Southwestern Medical Center

    See if you can join NCT06593314 on ClinicalTrials.gov

14. Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiometabolic, and Musculoskeletal Disorder Research (VALD)

    The purpose of this research study is to validate (check the accuracy of) laboratory assays, intravenous catheter insertion, and equipment or devices and their reproducibility, which is necessary to perform high quality research on chronic diseases, nutrition, and metabolism (the process by which a…

    Stage

    Not phased

    Ages

    18 to 100

    Site

    University of Missouri-Columbia, Columbia, Missouri

    Run by

    Bettina Mittendorfer

    See if you can join NCT07083557 on ClinicalTrials.gov

15. The Inorganic Nitrate and eXercise Performance in Heart Failure (iNIX-HF)

    The goals of this project are to determine the effectiveness of acute (2 hours after a single dose) and chronic (after 6 weeks of once-a-day dosing) KNO3 treatment (10mmol) vs. placebo on quadriceps muscle power and on aerobic exercise performance (V̇O2peak) in patients with HFrEF (left ventricular…

    Stage

    Phase 2

    Ages

    19 to 79

    Site

    Washington University School of Medicine, St Louis, Missouri

    Run by

    Washington University School of Medicine

    See if you can join NCT05562167 on ClinicalTrials.gov

16. Improving Medication Adherence Using Family-focused and Literacy-sensitive Strategies

    People with heart failure who do not take their medications as prescribed are at high risk of complications leading to hospitalization, death and poor quality of life. In the proposed intervention, nurses will use easy-to-understand language to coach patients and their care partners to help them wo…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Jia-Rong Wu, Lexington, Kentucky

    Run by

    Jia-Rong Wu

    See if you can join NCT05548413 on ClinicalTrials.gov

17. Ultra-High Frequency - Electrocardiogram (UHF-ECG) for the Diagnosis of Ventricular Electrical Dyssynchrony (VED)

    The purpose of this study is to demonstrate the safety and effectiveness of the VDI UHF-ECG System in the diagnosis of ventricular dyssynchrony when compared to the 12-lead ECG in patients with bradycardia and heart failure indicated for pacemaker implantation.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Peak Heart and Vascular, Avondale, Arizona

    Locations

    12 in total

    Run by

    VDI Technologies

    See if you can join NCT06641362 on ClinicalTrials.gov

18. Splanchnic X: Splanchnic Nerve Block in Heart Failure With Reduced Ejection Fraction

    Heart failure (HF) affects more than 6 million adults in the U.S. alone, with increasing prevalence. Cardiovascular congestion with resultant limitation in physical activity is the hallmark of chronic and decompensated HF. The current HF physiologic model suggests that congestion is the result of v…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Duke, Durham, North Carolina

    Run by

    Duke University

    See if you can join NCT06733012 on ClinicalTrials.gov

19. The Salt Study for Heart Failure

    The purpose of this study is to understand if low sodium (cardiac) diet is indeed necessary for better health outcomes in patients who suffered heart failure. This study will investigate the association between sodium intake and risk for 30-day re-admission in Heart Failure (HF) patients.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Robert Wood Johnson Barnabas Hospital - New Brunswick, New Brunswick, New Jersey

    Run by

    Maya Guglin, MD

    See if you can join NCT07560592 on ClinicalTrials.gov

20. Cardiovascular Health Improvement Project

    The goal of this project is to establish a biobank of clinical information, DNA, plasma, and aortic tissue samples from patients with cardiovascular disease as well as healthy controls.

    Stage

    Not phased

    Ages

    Any age

    Site

    University of Michigan, Ann Arbor, Michigan

    Run by

    University of Michigan

    See if you can join NCT02306200 on ClinicalTrials.gov

21. A Study of Paramedic HF Management

    The purpose of this research is to see if having community paramedic (CP) visit patients at home to manage their heart failure help them stay out of the hospital and improve their overall health compared to standard care. The investigators want to find out if their approach is better for patients i…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Mayo Clinic, Rochester, Minnesota

    Run by

    Mayo Clinic

    See if you can join NCT06874556 on ClinicalTrials.gov

22. Promoting Well-being and Health in Heart Failure

    The focus of this study is to test the efficacy of a 12-week, phone-delivered Positive Psychology-Motivational Interviewing (PP-MI) intervention, with additional twice weekly PP and health behavior text messages for a total of 24 weeks (with interactive, algorithm-driven, goal-focused text messages…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT04829617 on ClinicalTrials.gov

23. The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR

    The objective of this prospective, randomized, double- blinded (patient and assessors), sham-controlled clinical trial is to assess the safety and efficacy of the CMCS in treating heart failure with functional regurgitation (FMR).

    Stage

    Not phased

    Ages

    18 and older

    Site

    Dignity Health Research Institute at Mercy Gilbert and Chandler Regional Medical Centers, Gilbert, Arizona

    Locations

    92 in total

    Run by

    Cardiac Dimensions, Inc.

    See if you can join NCT03142152 on ClinicalTrials.gov

24. Smartphone Twelve-Lead ECG Utility In ST-Elevation Myocardial Infarction II

    AliveCor (www.alivecor.com) has developed several electrocardiogram (ECG) devices that interface with iOS and Android smartphones and tablets via various Kardia apps. The current Kardia family of devices can measure single lead and six limb-lead ECGs, depending on the device. KardiaMobile, KardiaMo…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Mayo Clinic, Rochester, Minnesota

    Locations

    4 in total

    Run by

    AliveCor

    See if you can join NCT06271577 on ClinicalTrials.gov

25. Urine Sodium-Driven Diuretic Adjustment Strategy in Acute Decompensated Heart Failure

    The goal of this clinical trial is to learn if increasing the dose of diuretics to achieve a higher urine sodium target produces better clinical results when treating patients hospitalized with acute heart failure when compared to lower urine sodium target and standard of care. The main questions i…

    Stage

    Phase 4

    Ages

    18 and older

    Site

    Lakeland Regional Hospital, Lakeland, Florida

    Run by

    Lakeland Regional Health Systems, Inc.

    See if you can join NCT07263035 on ClinicalTrials.gov