Heart Failure Clinical Trials in Detroit, Michigan

12 studies are recruiting for heart failure in Detroit, Michigan right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction

   The purpose of this study is to find out if the investigational drug called omecamtiv mecarbil can reduce the risk of the effects of heart failure, like hospitalization, transplantation, or death in patients with heart failure and severely reduced ejection fraction.

   Stage

   Phase 3

   Ages

   18 to 85

   Site

   Henry Ford Hospital, Detroit, Michigan

   Locations

   205 in total

   Run by

   Cytokinetics

   See if you can join NCT06736574 on ClinicalTrials.gov

2. Diuretics Alone vs. Aortix Endovascular Device for Acute Heart Failure

   Aortix is a circulatory support device for chronic heart failure patients on medical management who have been hospitalized for acute decompensated heart failure (ADHF) and have persistent congestion despite usual medical therapy. Eligible ADHF patients with diuretic resistance (irrespective of ejec…

   Stage

   Not phased

   Ages

   21 and older

   Site

   Henry Ford, Detroit, Michigan

   Locations

   50 in total

   Run by

   Procyrion

   See if you can join NCT05677100 on ClinicalTrials.gov

3. A Study of LY3971297 in Participants With Heart Failure

   The main purpose of this study is to assess how well LY3971297 is tolerated and what side effects may occur in participants with heart failure with preserved ejection fraction (HFpEF) and participants with heart failure with reduced ejection fraction (HFrEF). Blood tests will be performed to invest…

   Stage

   Phase 1

   Ages

   18 to 65

   Site

   Henry Ford Health System, Detroit, Michigan

   Locations

   12 in total

   Run by

   Eli Lilly and Company

   See if you can join NCT07547540 on ClinicalTrials.gov

4. A Randomized Placebo-procedure Controlled Trial of the Enhancor System (PULmonary Artery Denervation) to Evaluate Safety and Efficacy in Patients With Combined Pre- and Post-capillary Pulmonary Hypertension Associated With Left Heart Disease

   The goal of this clinical study is to evaluate the safety and efficacy of percutaneous pulmonary artery denervation with the Multi-Pole Pulmonary Artery Radiofrequency Ablation Enhancor System in patients with combined pre- and post-capillary pulmonary hypertension (CpcPH) associated with left hear…

   Stage

   Not phased

   Ages

   18 to 85

   Site

   Henry Ford Hospital, Detroit, Michigan

   Locations

   6 in total

   Run by

   Pulnovo Medical, Inc.

   See if you can join NCT07214376 on ClinicalTrials.gov

5. Alleviant ALLAY-HF Study

   Prospective, multicenter, randomized, sham-controlled, double blinded, adaptive study designed to evaluate the safety and efficacy of a percutaneously created interatrial shunt using the Alleviant ALV1 System in patients with HFpEF/HFmrEF.

   Stage

   Not phased

   Ages

   40 and older

   Site

   Ascension St. John Hospital, Detroit, Michigan

   Locations

   93 in total

   Run by

   Alleviant Medical, Inc.

   See if you can join NCT05685303 on ClinicalTrials.gov

6. Assessment of CCM in HF With Higher Ejection Fraction

   The AIM HIGHer Clinical Trial will evaluate the safety and efficacy of Cardiac Contractility Modulation (CCM) therapy in patients with heart failure with LVEF ≥40% and ≤70%.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Henry Ford St. John Hospital, Detroit, Michigan

   Locations

   105 in total

   Run by

   Impulse Dynamics

   See if you can join NCT05064709 on ClinicalTrials.gov

7. A Research Study Comparing Different Doses of CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Preserved Ejection Fraction and Left Ventricular Hypertrophy

   This study will look into how CDR132L (a potential new medicine) works on the structure and function of the heart in people living with heart failure. Participants will either get CDR132L or placebo (a medicine which has no effect on the body), which treatment the participants get is decided by cha…

   Stage

   Phase 2

   Ages

   40 to 84

   Site

   Henry Ford Hospital_Detroit, Detroit, Michigan

   Locations

   117 in total

   Run by

   Novo Nordisk A/S

   See if you can join NCT06979362 on ClinicalTrials.gov

8. Project 4: ACHIEVE PATHFINDER

   ACHIEVE-P4: PATHFINDER is a randomized, blinded clinical trial of portable air cleaners (PAC) provided at the time of hospital discharge to Heart Failure (HF) patients. It will be carried out at Henry Ford Hospitals. This project is part of the ACHIEVE GREATER (Addressing Cardiometabolic Health In …

   Stage

   Not phased

   Ages

   18 and older

   Site

   Henry Ford Health, Detroit, Michigan

   Run by

   Henry Ford Health System

   See if you can join NCT06070428 on ClinicalTrials.gov

9. UPBEAT: Using Polygenic Scores to Guide BB Therapy in HF With Mildly Reduced EF

   This study will use polygenic scores, a tool which describes differences in genetics, to examine effectiveness of beta blocker medication in heart failure patients with ejection fraction of 41-50 percent. The study will also assess beta blockers' effect on the changes in left ventricular end-systol…

   Stage

   Not phased

   Ages

   18 to 89

   Site

   Henry Ford Health, Detroit, Michigan

   Run by

   David Lanfear

   See if you can join NCT07054489 on ClinicalTrials.gov

10. Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure

    The purpose of TEAM-HF IDE clinical trial is to evaluate safety and effectiveness of the HeartMate 3 LVAS compared to guideline directed medical therapy (GDMT) in a population of ambulatory advanced heart failure patients who are not dependent on intravenous inotrope.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Henry Ford Hospital, Detroit, Michigan

    Locations

    68 in total

    Run by

    Abbott Medical Devices

    See if you can join NCT06526195 on ClinicalTrials.gov

11. AI-Enabled Direct-from-ECG Ejection Fraction (EF) Severity Assessment Using COR ECG Wearable Monitor

    This prospective, multicenter, cluster-randomized controlled study aims to evaluate the accuracy of an investigational artificial intelligence (AI) Software as a Medical Device (SaMD) designed to compute ejection fraction (EF) severity categories based on the American Society of Echocardiography's …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Henry Ford Hospital, Detroit, Michigan

    Locations

    8 in total

    Run by

    Peerbridge Health, Inc

    See if you can join NCT06699056 on ClinicalTrials.gov

12. Home-Based Exercise Program Using Mobile Technology After Left Ventricular Assist Device Implantation

    The goal of this clinical trial is to evaluate the effects of a home-based exercise program using mobile technology on physical activity and capacity, frailty and muscle mass, and quality of life in patients with a newly implanted HeartMate 3 left ventricular assist device (HM3 LVAD). Researchers w…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Henry Ford Health, Detroit, Michigan

    Locations

    4 in total

    Run by

    University of Pennsylvania

    See if you can join NCT06291922 on ClinicalTrials.gov