Heart Failure Clinical Trials

150 studies are recruiting for heart failure in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Barostim-Enabled NEurohormonal Intervention For Improving Treatment of Heart Failure

   The purpose of BENEFIT-HF is to demonstrate the safety and effectiveness of Baroreflex Activation Therapy (BAT) with the Barostim System in participants with heart failure, defined as NYHA Functional Class II or III, LVEF < 50% and NT-proBNP < 5,000 pg/mL despite being treated with Guideline-Direct…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Cardiology Associates of Mobile, Mobile, Alabama

   Locations

   21 in total

   Run by

   CVRx, Inc.

   See if you can join NCT07232030 on ClinicalTrials.gov

2. Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)

   This study aims to compare the efficacy of vericiguat versus placebo on change in n-terminal pro-brain natriuretic peptide (NTproBNP) from baseline to Week 16 of the Base Period. The primary hypothesis is that vericiguat is superior to placebo in reducing NT-proBNP at Week 16 of the Base Period.

   Stage

   Phase 2

   Ages

   0 to 17

   Site

   The Regents of the University of California - Los Angeles (UCLA Pediatrics) ( Site 0002), Los Angeles, California

   Locations

   111 in total

   Run by

   Merck Sharp & Dohme LLC

   See if you can join NCT05714085 on ClinicalTrials.gov

3. A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure

   This study is open to adults aged 18 or above legal age with heart failure. People can join the study if they have heart failure symptoms and a left ventricular ejection fraction (LVEF) of 40% or more. The purpose of this study is to find out whether vicadrostat (BI 690517) in combination with empa…

   Stage

   Phase 3

   Ages

   18 and older

   Site

   Diagnostic and Medical Clinic, Mobile, Alabama

   Locations

   671 in total

   Run by

   Boehringer Ingelheim

   See if you can join NCT06424288 on ClinicalTrials.gov

4. A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart

   This study is open to adults with chronic heart failure (HF) who have a reduced left ventricular ejection fraction (LVEF) of less than 40%. People can join the study if they have been diagnosed with chronic HF at least 3 months before they start on the study. The purpose of this study is to find ou…

   Stage

   Phase 3

   Ages

   18 and older

   Site

   Valley Clinical Trials, Inc., Covina, California

   Locations

   594 in total

   Run by

   Boehringer Ingelheim

   See if you can join NCT06935370 on ClinicalTrials.gov

5. CCM OPEN HF Registry

   The registry has been designed to evaluate the long-term safety and efficacy of CCM therapy in a real-world setting.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Cardiovascular Associates of Mesa, Mesa, Arizona

   Locations

   30 in total

   Run by

   Impulse Dynamics

   See if you can join NCT07112924 on ClinicalTrials.gov

6. Voice-based Outcome Identification and Clinical Evaluation in Heart Failure

   VOICE-HF is a clinical study designed to evaluate the performance of a novel non-invasive software device (Noah Labs Vox) that uses vocal characteristics to estimate DHF risk and has strong potential for clinical success. This study will compare the performance of Noah Labs Vox with the contemporar…

   Stage

   Not phased

   Ages

   22 and older

   Site

   Brigham and Women's Hospital, Boston, Massachusetts

   Run by

   Noah Labs

   See if you can join NCT07870395 on ClinicalTrials.gov

7. Changes in Skeletal Muscle Thickness in Patients With Acute Heart Failure

   This study aims to determine, via skeletal muscle ultrasound (US), the extent, timing and relationship between skeletal muscle mass loss and outcomes after orthotropic heart transplantation (OHT) and left ventricular assist device (LVAD) implantation amongst patients with cardiogenic shock. Advance…

   Stage

   Not phased

   Ages

   18 to 100

   Site

   Tufts Medical Center, Boston, Massachusetts

   Run by

   Tufts Medical Center

   See if you can join NCT06253104 on ClinicalTrials.gov

8. Assessment of CCM in HF With Higher Ejection Fraction

   The AIM HIGHer Clinical Trial will evaluate the safety and efficacy of Cardiac Contractility Modulation (CCM) therapy in patients with heart failure with LVEF ≥40% and ≤70%.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Grandview Medical Group Research, LLC, Birmingham, Alabama

   Locations

   67 in total

   Run by

   Impulse Dynamics

   See if you can join NCT05064709 on ClinicalTrials.gov

9. A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF)

   The purpose of this study is to learn about the safety and effects of the study medicine (PF-07328948) for the possible treatment of heart failure (HF).

   Stage

   Phase 2

   Ages

   18 to 79

   Site

   Comprehensive Cardiovascular Care, Santa Maria, California

   Locations

   150 in total

   Run by

   Pfizer

   See if you can join NCT06991257 on ClinicalTrials.gov

10. Mobile Health Intervention to Increase Activity in Heart Failure Study

    Physical activity is known to help patients with heart failure feel better and live longer though few patients with heart failure are sufficiently active. This study is evaluating whether a mobile health intervention can help patients with heart failure increase physical activity levels and remain …

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Michigan, Ann Arbor, Michigan

    Run by

    University of Michigan

    See if you can join NCT07750262 on ClinicalTrials.gov

11. Rural Community Peer Partnerships for Improving Methamphetamine-Associated Heart Failure Screening and Engagement

    The goal of PEER-Heart is to implement and assess feasibility and preliminary effectiveness of a community peer-facilitated screening for methamphetamine-associated heart failure (MAHF) and linkage to evidence-based cardiology care for people who use methamphetamine in rural areas.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Oregon Health & Science University, Portland, Oregon

    Run by

    Oregon Health and Science University

    See if you can join NCT06461962 on ClinicalTrials.gov

12. Magnetic Resonance Elastography as a Method to Estimate Stiffness of Soft Tissues

    Magnetic resonance elastography is a novel non-invasive MRI technique to obtain stiffness of soft tissues such as liver, heart, kidneys, etc. In this imaging technique a person is laid in an MR scanner and a paddle (plastic drum) is put on the area of interest to send sound vibration via a speaker …

    Stage

    Not phased

    Ages

    18 and older

    Site

    The Ohio State University Wexner Medical Center, Columbus, Ohio

    Run by

    Arunark Kolipaka

    See if you can join NCT01757730 on ClinicalTrials.gov

13. Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin

    Participants include men and women ≥ 40 years of age with T2DM, established CV disease, a history of HTN with an SBP of at least 130 mmHg at screening, who meet the predefined serum potassium level, and with at least one additional risk factor for HF. The study will include an optional pre-screenin…

    Stage

    Phase 3

    Ages

    40 and older

    Site

    Research Site, Birmingham, Alabama

    Locations

    977 in total

    Run by

    AstraZeneca

    See if you can join NCT06677060 on ClinicalTrials.gov

14. Fluid Guided Heart Failure Treatment at the Cleveland Clinic

    FIGHT-HF is an exploratory non-randomized open-label study evaluating a heart failure management intervention. The goal of this pilot is to assess the performance of a fluid-guided heart failure management program and Alert Response Guide (ARG) using the Bodyport Cardiac Scale and Congestion Index …

    Stage

    Not phased

    Ages

    21 and older

    Site

    The Cleveland Clinic, Cleveland, Ohio

    Run by

    Bodyport Inc.

    See if you can join NCT07205120 on ClinicalTrials.gov

15. A Randomized Placebo-procedure Controlled Trial of the Enhancor System (PULmonary Artery Denervation) to Evaluate Safety and Efficacy in Patients With Combined Pre- and Post-capillary Pulmonary Hypertension Associated With Left Heart Disease

    The goal of this clinical study is to evaluate the safety and efficacy of percutaneous pulmonary artery denervation with the Multi-Pole Pulmonary Artery Radiofrequency Ablation Enhancor System in patients with combined pre- and post-capillary pulmonary hypertension (CpcPH) associated with left hear…

    Stage

    Not phased

    Ages

    18 to 85

    Site

    Banner - University Medical Center Tucson, Tucson, Arizona

    Locations

    18 in total

    Run by

    Pulnovo Medical, Inc.

    See if you can join NCT07214376 on ClinicalTrials.gov

16. Advancing Clinical Heart Failure Outcomes Leveraging Defibrillation Lead Implant System for Left Bundle Branch Area Pacing

    This 2x2 randomized crossover feasibility study will evaluate the therapeutic value of adding pacing from the left ventricular lead to Left Bundle Branch Area Pacing (LBBAP) using a cardiac resynchronization therapy defibrillator (CRT-D). This combined therapy is known as Left Bundle Branch Optimiz…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Minneapolis Heart Institute Foundation, Minneapolis, Minnesota

    Run by

    Medtronic Cardiac Rhythm and Heart Failure

    See if you can join NCT07526896 on ClinicalTrials.gov

17. The HEARTFELT Study

    This pragmatic randomized crossover trial looks at the effect(s) of using a remote patient monitoring device (Heartfelt device) with health alerts to monitor the development of peripheral edema in patients with heart failure (HF). The hypothesis is that this passive measurement method will lead to …

    Stage

    Not phased

    Ages

    22 and older

    Site

    HealthArc, Hackensack, New Jersey

    Locations

    3 in total

    Run by

    Heartfelt Technologies

    See if you can join NCT06222099 on ClinicalTrials.gov

18. The WiSE®-UP Study (The WiSE System Utilization & Performance Study)

    Observe to understand product performance, including patient safety, clinical outcomes, and CRT response information associated with the use of the market-released WiSE System

    Stage

    Not phased

    Ages

    22 and older

    Site

    CardioVascular Associates of Mesa (CVAM), Mesa, Arizona

    Locations

    12 in total

    Run by

    EBR Systems, Inc.

    See if you can join NCT07098858 on ClinicalTrials.gov

19. NORM-HF Pivotal Study

    This is an international, multi-center, prospective, randomized, open-label blinded endpoint study designed to demonstrate that use of the FIRE1 NORM™ System in the management of New York Heart Association Class II/III HF patients is superior for reducing the combined endpoint of worsening HF event…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Cardiovascular Institute of San Diego, Chula Vista, California

    Locations

    25 in total

    Run by

    Foundry Innovation & Research 1, Limited (FIRE1)

    See if you can join NCT07574593 on ClinicalTrials.gov

20. Understanding and Addressing Risks of Low Socioeconomic Status and Diabetes for Heart Failure

    This study aims to determine whether a 6-month multilevel intervention involving problem-solving training, exercise training and support from community health workers is more effective in improving outcomes for individuals with low socioeconomic status, type 2 diabetes, obesity, and early cardiac d…

    Stage

    Not phased

    Ages

    30 to 70

    Site

    Johns Hopkins Center for Health Equity, Baltimore, Maryland

    Locations

    2 in total

    Run by

    Johns Hopkins University

    See if you can join NCT06364644 on ClinicalTrials.gov

21. Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction

    The purpose of this study is to find out if the investigational drug called omecamtiv mecarbil can reduce the risk of the effects of heart failure, like hospitalization, transplantation, or death in patients with heart failure and severely reduced ejection fraction.

    Stage

    Phase 3

    Ages

    18 to 85

    Site

    Advanced Cardiovascular, LLC, Alexander City, Alabama

    Locations

    209 in total

    Run by

    Cytokinetics

    See if you can join NCT06736574 on ClinicalTrials.gov

22. INitiation and Titration of Guideline Directed Medical TheRApy in HearT Failure Cardiogenic Shock With ImpElla 5.5 for Cardiac Recovery

    The study will evaluate the impact of a combined device-drug strategy with Impella 5.5 with best practices and optimized GDMT on heart recovery outcomes in patients with decompensated heart failure and cardiogenic shock.

    Stage

    Not phased

    Ages

    18 to 80

    Site

    Tampa General Hospital, Tampa, Florida

    Locations

    17 in total

    Run by

    Abiomed Inc.

    See if you can join NCT06965504 on ClinicalTrials.gov

23. CSP #2025 - Geriatric OUt-of-hospital Randomized MEal Trial in Heart Failure: Veterans Affairs (GOURMET-VA)

    The purpose of this multi-center clinical trial is to study the efficacy and safety of providing nutritional support added to the study-defined standard of care which consists of standardized dietary education and a single dietary counseling session shortly after discharge, versus study-defined sta…

    Stage

    Not phased

    Ages

    60 and older

    Site

    Birmingham VA Medical Center, Birmingham, AL, Birmingham, Alabama

    Locations

    21 in total

    Run by

    VA Office of Research and Development

    See if you can join NCT05996328 on ClinicalTrials.gov

24. Home-Based Exercise Program Using Mobile Technology After Left Ventricular Assist Device Implantation

    The goal of this clinical trial is to evaluate the effects of a home-based exercise program using mobile technology on physical activity and capacity, frailty and muscle mass, and quality of life in patients with a newly implanted HeartMate 3 left ventricular assist device (HM3 LVAD). Researchers w…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Henry Ford Health, Detroit, Michigan

    Locations

    4 in total

    Run by

    University of Pennsylvania

    See if you can join NCT06291922 on ClinicalTrials.gov

25. Alleviant ALLAY-HFrEF Study

    Prospective, multicenter, randomized, sham-controlled, double blind (patient and observer), study designed to evaluate the safety and efficacy of a percutaneously created interatrial shunt using the Alleviant ALV1 System in patients with HFrEF.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Keck Medical Center of USC, Los Angeles, California

    Locations

    70 in total

    Run by

    Alleviant Medical, Inc.

    See if you can join NCT06812533 on ClinicalTrials.gov