Heart Failure Clinical Trials in Dallas, Texas

33 studies are recruiting for heart failure in Dallas, Texas right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)

   This study aims to compare the efficacy of vericiguat versus placebo on change in n-terminal pro-brain natriuretic peptide (NTproBNP) from baseline to Week 16 of the Base Period. The primary hypothesis is that vericiguat is superior to placebo in reducing NT-proBNP at Week 16 of the Base Period.

   Stage

   Phase 2

   Ages

   0 to 17

   Site

   Children's Health-The Heart Center ( Site 0015), Dallas, Texas

   Locations

   111 in total

   Run by

   Merck Sharp & Dohme LLC

   See if you can join NCT05714085 on ClinicalTrials.gov

2. A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure

   This study is open to adults aged 18 or above legal age with heart failure. People can join the study if they have heart failure symptoms and a left ventricular ejection fraction (LVEF) of 40% or more. The purpose of this study is to find out whether vicadrostat (BI 690517) in combination with empa…

   Stage

   Phase 3

   Ages

   18 and older

   Site

   Texas Health Research and Education Institute, Dallas, Texas

   Locations

   671 in total

   Run by

   Boehringer Ingelheim

   See if you can join NCT06424288 on ClinicalTrials.gov

3. A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart

   This study is open to adults with chronic heart failure (HF) who have a reduced left ventricular ejection fraction (LVEF) of less than 40%. People can join the study if they have been diagnosed with chronic HF at least 3 months before they start on the study. The purpose of this study is to find ou…

   Stage

   Phase 3

   Ages

   18 and older

   Site

   Texas Health Research and Education Institute, Dallas, Texas

   Locations

   594 in total

   Run by

   Boehringer Ingelheim

   See if you can join NCT06935370 on ClinicalTrials.gov

4. Assessment of CCM in HF With Higher Ejection Fraction

   The AIM HIGHer Clinical Trial will evaluate the safety and efficacy of Cardiac Contractility Modulation (CCM) therapy in patients with heart failure with LVEF ≥40% and ≤70%.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Baylor Scott and White Research Institute, Dallas, Texas

   Locations

   67 in total

   Run by

   Impulse Dynamics

   See if you can join NCT05064709 on ClinicalTrials.gov

5. Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin

   Participants include men and women ≥ 40 years of age with T2DM, established CV disease, a history of HTN with an SBP of at least 130 mmHg at screening, who meet the predefined serum potassium level, and with at least one additional risk factor for HF. The study will include an optional pre-screenin…

   Stage

   Phase 3

   Ages

   40 and older

   Site

   Research Site, Dallas, Texas

   Locations

   977 in total

   Run by

   AstraZeneca

   See if you can join NCT06677060 on ClinicalTrials.gov

6. NORM-HF Pivotal Study

   This is an international, multi-center, prospective, randomized, open-label blinded endpoint study designed to demonstrate that use of the FIRE1 NORM™ System in the management of New York Heart Association Class II/III HF patients is superior for reducing the combined endpoint of worsening HF event…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Baylor Scott & White - Dallas, Dallas, Texas

   Locations

   25 in total

   Run by

   Foundry Innovation & Research 1, Limited (FIRE1)

   See if you can join NCT07574593 on ClinicalTrials.gov

7. Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction

   The purpose of this study is to find out if the investigational drug called omecamtiv mecarbil can reduce the risk of the effects of heart failure, like hospitalization, transplantation, or death in patients with heart failure and severely reduced ejection fraction.

   Stage

   Phase 3

   Ages

   18 to 85

   Site

   Baylor University Medical Center, Dallas, Texas

   Locations

   209 in total

   Run by

   Cytokinetics

   See if you can join NCT06736574 on ClinicalTrials.gov

8. INitiation and Titration of Guideline Directed Medical TheRApy in HearT Failure Cardiogenic Shock With ImpElla 5.5 for Cardiac Recovery

   The study will evaluate the impact of a combined device-drug strategy with Impella 5.5 with best practices and optimized GDMT on heart recovery outcomes in patients with decompensated heart failure and cardiogenic shock.

   Stage

   Not phased

   Ages

   18 to 80

   Site

   Medical City Heart Hospital Dallas, Dallas, Texas

   Locations

   17 in total

   Run by

   Abiomed Inc.

   See if you can join NCT06965504 on ClinicalTrials.gov

9. CSP #2025 - Geriatric OUt-of-hospital Randomized MEal Trial in Heart Failure: Veterans Affairs (GOURMET-VA)

   The purpose of this multi-center clinical trial is to study the efficacy and safety of providing nutritional support added to the study-defined standard of care which consists of standardized dietary education and a single dietary counseling session shortly after discharge, versus study-defined sta…

   Stage

   Not phased

   Ages

   60 and older

   Site

   VA North Texas Health Care System Dallas VA Medical Center, Dallas, TX, Dallas, Texas

   Locations

   21 in total

   Run by

   VA Office of Research and Development

   See if you can join NCT05996328 on ClinicalTrials.gov

10. A Research Study Comparing Different Doses of CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Preserved Ejection Fraction and Left Ventricular Hypertrophy

    This study will look into how CDR132L (a potential new medicine) works on the structure and function of the heart in people living with heart failure. Participants will either get CDR132L or placebo (a medicine which has no effect on the body), which treatment the participants get is decided by cha…

    Stage

    Phase 2

    Ages

    40 to 84

    Site

    University of Texas Southwestern Medical Center, Dallas, Texas

    Locations

    118 in total

    Run by

    Novo Nordisk A/S

    See if you can join NCT06979362 on ClinicalTrials.gov

11. NT-ProBNP-based Heart Failure Screening and Prevention Trial in Patients With Type 2 Diabetes: STRONG-DM Study

    A pragmatic, randomized clinical trial to evaluate the effect of a heart failure (HF) risk assessment and prevention strategy incorporating HF clinical risk scores (WATCH-DM) with cardiac biomarker (NT-proBNP) paired with a clinical decision support tool to implement an intensive prevention strateg…

    Stage

    Not phased

    Ages

    Any age

    Site

    University of Texas Southwestern Medical Center, Dallas, Texas

    Locations

    3 in total

    Run by

    University of Texas Southwestern Medical Center

    See if you can join NCT06593327 on ClinicalTrials.gov

12. Evaluation of Liver Stiffness Performance, by FibroScan®, to Detect Elevated Central Venous Pressure (CVP)

    This is a pivotal, global, prospective, cross-sectional, multicentric clinical investigation designed to explore a non-invasive, reliable alternative to invasive, catheter-based hemodynamic assessments, which are associated with procedural risks and limited applicability in certain participant popu…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Texas Southwestern Medical Center - Clinical Heart and Vascular Center - West Campus Building 3 Location, Dallas, Texas

    Locations

    7 in total

    Run by

    Echosens

    See if you can join NCT07222813 on ClinicalTrials.gov

13. A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients

    Finerenone will be compared to placebo to determine efficacy and safety of treatment in patients hospitalized with acute decompensated heart failure (HF) and mildly reduced or preserved left ventricular ejection fraction.

    Stage

    Phase 3

    Ages

    18 and older

    Site

    Dallas, TX Investigative Site 10042, Dallas, Texas

    Locations

    356 in total

    Run by

    Colorado Prevention Center

    See if you can join NCT06008197 on ClinicalTrials.gov

14. Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failure

    The goal of this study is to evaluate the safety and efficacy of the BrioVAD System by demonstrating non-inferiority to the HeartMate 3 Left Ventricular Assist System when used for the treatment of advanced, refractory, left ventricular heart failure.

    Stage

    Not phased

    Ages

    18 to 100

    Site

    Baylor University Medical Center, part of Baylor Scott & White Health, Dallas, Texas

    Locations

    47 in total

    Run by

    BrioHealth Solutions, Inc.

    See if you can join NCT06310031 on ClinicalTrials.gov

15. Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)

    The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the most safe and effective dose for children. The primary objective of this study is to evaluate the PK…

    Stage

    Not phased

    Ages

    0 to 20

    Site

    University of Texas-Southwestern Medical Center Dallas, Dallas, Texas

    Locations

    52 in total

    Run by

    Duke University

    See if you can join NCT04278404 on ClinicalTrials.gov

16. Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products

    The main purpose of the Product Performance Report (formerly referred to as System Longevity Study) is to evaluate long-term performance of Medtronic market-released cardiac rhythm products by analyzing product survival probabilities.

    Stage

    Not phased

    Ages

    Any age

    Site

    Research site, Dallas, Texas

    Locations

    333 in total

    Run by

    Medtronic

    See if you can join NCT00271180 on ClinicalTrials.gov

17. A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity

    This study is being done to look at the safety and effect of NNC0487-0111 in people with Heart Failure with preserved Ejection Fraction (HFpEF) or Heart Failure with mildly reduced Ejection Fraction (HFmrEF) and excess body weight when compared to placebo. The purpose of this clinical study is to f…

    Stage

    Phase 3

    Ages

    18 and older

    Site

    Renal Disease Research Institute, Dallas, Texas

    Locations

    838 in total

    Run by

    Novo Nordisk A/S

    See if you can join NCT07567001 on ClinicalTrials.gov

18. Alleviant ALLAY-HF Study

    Prospective, multicenter, randomized, sham-controlled, double blinded, adaptive study designed to evaluate the safety and efficacy of a percutaneously created interatrial shunt using the Alleviant ALV1 System in patients with HFpEF/HFmrEF.

    Stage

    Not phased

    Ages

    40 and older

    Site

    UT Southwestern, Dallas, Texas

    Locations

    93 in total

    Run by

    Alleviant Medical, Inc.

    See if you can join NCT05685303 on ClinicalTrials.gov

19. Multicenter Trial of ECMO in Children With Severe Cardiac Failure Using the Cardiohelp System

    There are two primary goals of this multicenter clinical trial that combines an FDA device trial and a phase II drug trial in the same study cohort. These two goals are to: 1. To evaluate the safety and effectiveness of the Cardiohelp Device for VA-ECMO (heart-lung support) for up to 30 days of sup…

    Stage

    Phase 2

    Ages

    0 to 16

    Site

    Children's Health Dallas, Dallas, Texas

    Locations

    5 in total

    Run by

    Stanford University

    See if you can join NCT06080074 on ClinicalTrials.gov

20. PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III

    This is a prospective, multi-center, open label, randomized control clinical trial evaluating the safety and efficacy of the Cordella™ Pulmonary Artery Sensor System in NYHA Class II-III Heart Failure Patients (PROACTIVE-HF-2 Trial). The study contains of 5 arms: NYHA II Cohort - To demonstrate saf…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Medical City Healthcare Dallas, Dallas, Texas

    Locations

    48 in total

    Run by

    Endotronix, Inc.

    See if you can join NCT05934487 on ClinicalTrials.gov

21. Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure

    The purpose of TEAM-HF IDE clinical trial is to evaluate safety and effectiveness of the HeartMate 3 LVAS compared to guideline directed medical therapy (GDMT) in a population of ambulatory advanced heart failure patients who are not dependent on intravenous inotrope.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Baylor University Hospital, Dallas, Texas

    Locations

    68 in total

    Run by

    Abbott Medical Devices

    See if you can join NCT06526195 on ClinicalTrials.gov

22. Home-based Cardiac Rehabilitation in Heart Failure

    This study evaluates a mobile health (mHealth) home-based cardiac rehabilitation program for patients with heart failure. We will stratify randomization between rural and urban populations, with the goal to assess implementation of cardiac rehabilitation across these two geographic areas. . The stu…

    Stage

    Phase 3

    Ages

    18 and older

    Site

    University of Texas Southwestern Medical Center, Dallas, Texas

    Locations

    2 in total

    Run by

    University of Texas Southwestern Medical Center

    See if you can join NCT06349941 on ClinicalTrials.gov

23. IEEM-Heat and Heart Failure

    We will test the hypothesis that increasing skin wetness, and thus evaporative cooling, will attenuate the increase in core body temperature and accompanying cardiac stress during heat wave conditions in individuals with congestive heart failure. Secondly, we propose that wearing a water-saturated …

    Stage

    Not phased

    Ages

    45 and older

    Site

    Institute for Exercise and Environmental Medicine - Texas Health Presbyterian Hospital Dallas, Dallas, Texas

    Run by

    University of Texas Southwestern Medical Center

    See if you can join NCT06961929 on ClinicalTrials.gov

24. Using Ultromics EchoGo HFpEF Algorithm to Identify and Treat High Heart Failure Risk in Patients With Type 2 Diabetes

    A pragmatic electronic health record (EHR) based randomized controlled trial to evaluate the utility of providing Ultromics EchoGo analysis results and recommendations for HF risk prevention therapies using an EHR embedded clinical decision support tool.

    Stage

    Not phased

    Ages

    Any age

    Site

    UT Southwestern Medical Center, Dallas, Texas

    Run by

    University of Texas Southwestern Medical Center

    See if you can join NCT06593314 on ClinicalTrials.gov

25. Sotagliflozin to Slow Kidney Function Decline in Persons With Type 1 Diabetes and Diabetic Kidney Disease

    Powerful new drugs that can prevent or delay end stage kidney disease (ESKD) - so called sodium-glucose cotransporter-2 inhibitors (SGLT2i) - are now available for patients with type 2 diabetes. Whether these drugs have similar effects in patients with type 1 diabetes (T1D) remains unknown because …

    Stage

    Phase 3

    Ages

    18 to 75

    Site

    University of Texas Southwestern, Dallas, Texas

    Locations

    19 in total

    Run by

    Alessandro Doria

    See if you can join NCT06217302 on ClinicalTrials.gov