Heart Failure Clinical Trials in Minneapolis, Minnesota

21 studies are recruiting for heart failure in Minneapolis, Minnesota right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

  1. A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure

    This study is open to adults aged 18 or above legal age with heart failure. People can join the study if they have heart failure symptoms and a left ventricular ejection fraction (LVEF) of 40% or more. The purpose of this study is to find out whether vicadrostat (BI 690517) in combination with empa…

    Stage
    Phase 3
    Ages
    18 and older
    Site
    Minneapolis VA Health Care System, Minneapolis, Minnesota
    Locations
    671 in total
    Run by
    Boehringer Ingelheim

    See if you can join NCT06424288 on ClinicalTrials.gov

  2. A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart

    This study is open to adults with chronic heart failure (HF) who have a reduced left ventricular ejection fraction (LVEF) of less than 40%. People can join the study if they have been diagnosed with chronic HF at least 3 months before they start on the study. The purpose of this study is to find ou…

    Stage
    Phase 3
    Ages
    18 and older
    Site
    Minneapolis VA Health Care System, Minneapolis, Minnesota
    Locations
    594 in total
    Run by
    Boehringer Ingelheim

    See if you can join NCT06935370 on ClinicalTrials.gov

  3. CCM OPEN HF Registry

    The registry has been designed to evaluate the long-term safety and efficacy of CCM therapy in a real-world setting.

    Stage
    Not phased
    Ages
    18 and older
    Site
    Minneapolis Heart Institute Research Foundation, Minneapolis, Minnesota
    Locations
    30 in total
    Run by
    Impulse Dynamics

    See if you can join NCT07112924 on ClinicalTrials.gov

  4. Assessment of CCM in HF With Higher Ejection Fraction

    The AIM HIGHer Clinical Trial will evaluate the safety and efficacy of Cardiac Contractility Modulation (CCM) therapy in patients with heart failure with LVEF ≥40% and ≤70%.

    Stage
    Not phased
    Ages
    18 and older
    Site
    Minneapolis Heart Institute at Abbott Northwestern Hospital, Minneapolis, Minnesota
    Locations
    67 in total
    Run by
    Impulse Dynamics

    See if you can join NCT05064709 on ClinicalTrials.gov

  5. Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin

    Participants include men and women ≥ 40 years of age with T2DM, established CV disease, a history of HTN with an SBP of at least 130 mmHg at screening, who meet the predefined serum potassium level, and with at least one additional risk factor for HF. The study will include an optional pre-screenin…

    Stage
    Phase 3
    Ages
    40 and older
    Site
    Research Site, Minneapolis, Minnesota
    Locations
    977 in total
    Run by
    AstraZeneca

    See if you can join NCT06677060 on ClinicalTrials.gov

  6. Advancing Clinical Heart Failure Outcomes Leveraging Defibrillation Lead Implant System for Left Bundle Branch Area Pacing

    This 2x2 randomized crossover feasibility study will evaluate the therapeutic value of adding pacing from the left ventricular lead to Left Bundle Branch Area Pacing (LBBAP) using a cardiac resynchronization therapy defibrillator (CRT-D). This combined therapy is known as Left Bundle Branch Optimiz…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Minneapolis Heart Institute Foundation, Minneapolis, Minnesota
    Run by
    Medtronic Cardiac Rhythm and Heart Failure

    See if you can join NCT07526896 on ClinicalTrials.gov

  7. INitiation and Titration of Guideline Directed Medical TheRApy in HearT Failure Cardiogenic Shock With ImpElla 5.5 for Cardiac Recovery

    The study will evaluate the impact of a combined device-drug strategy with Impella 5.5 with best practices and optimized GDMT on heart recovery outcomes in patients with decompensated heart failure and cardiogenic shock.

    Stage
    Not phased
    Ages
    18 to 80
    Site
    Abbott Northwestern, Minneapolis, Minnesota
    Locations
    17 in total
    Run by
    Abiomed Inc.

    See if you can join NCT06965504 on ClinicalTrials.gov

  8. CSP #2025 - Geriatric OUt-of-hospital Randomized MEal Trial in Heart Failure: Veterans Affairs (GOURMET-VA)

    The purpose of this multi-center clinical trial is to study the efficacy and safety of providing nutritional support added to the study-defined standard of care which consists of standardized dietary education and a single dietary counseling session shortly after discharge, versus study-defined sta…

    Stage
    Not phased
    Ages
    60 and older
    Site
    Minneapolis VA Health Care System, Minneapolis, MN, Minneapolis, Minnesota
    Locations
    21 in total
    Run by
    VA Office of Research and Development

    See if you can join NCT05996328 on ClinicalTrials.gov

  9. Alleviant ALLAY-HFrEF Study

    Prospective, multicenter, randomized, sham-controlled, double blind (patient and observer), study designed to evaluate the safety and efficacy of a percutaneously created interatrial shunt using the Alleviant ALV1 System in patients with HFrEF.

    Stage
    Not phased
    Ages
    18 and older
    Site
    Minneapolis Heart Institute Foundation, Minneapolis, Minnesota
    Locations
    70 in total
    Run by
    Alleviant Medical, Inc.

    See if you can join NCT06812533 on ClinicalTrials.gov

  10. A Research Study Comparing Different Doses of CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Preserved Ejection Fraction and Left Ventricular Hypertrophy

    This study will look into how CDR132L (a potential new medicine) works on the structure and function of the heart in people living with heart failure. Participants will either get CDR132L or placebo (a medicine which has no effect on the body), which treatment the participants get is decided by cha…

    Stage
    Phase 2
    Ages
    40 to 84
    Site
    University of Minnesota_Minneapolis_1, Minneapolis, Minnesota
    Locations
    118 in total
    Run by
    Novo Nordisk A/S

    See if you can join NCT06979362 on ClinicalTrials.gov

  11. Early Feasibility Study - Edwards APTURE Transcatheter Shunt System

    The purpose of this study is to evaluate initial clinical safety, device functionality and effectiveness of the Edwards APTURE transcatheter shunt system.

    Stage
    Not phased
    Ages
    18 and older
    Site
    Abbott Northwestern, Minneapolis, Minnesota
    Locations
    19 in total
    Run by
    Edwards Lifesciences

    See if you can join NCT03523416 on ClinicalTrials.gov

  12. A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients

    Finerenone will be compared to placebo to determine efficacy and safety of treatment in patients hospitalized with acute decompensated heart failure (HF) and mildly reduced or preserved left ventricular ejection fraction.

    Stage
    Phase 3
    Ages
    18 and older
    Site
    Minneapolis, MN Investigative Site 10091, Minneapolis, Minnesota
    Locations
    356 in total
    Run by
    Colorado Prevention Center

    See if you can join NCT06008197 on ClinicalTrials.gov

  13. A Study to Determine the Efficacy and Safety of Finerenone and SGLT2i in Combination in Hospitalized Patients With Heart Failure (CONFIRMATION-HF)

    Combination therapy of finerenone plus empagliflozin will be compared to usual care to determine the efficacy and safety of treatment in patients hospitalized with heart failure.

    Stage
    Phase 3
    Ages
    18 and older
    Site
    Minneapolis, MN Investigative Site CON-10035, Minneapolis, Minnesota
    Locations
    140 in total
    Run by
    Colorado Prevention Center

    See if you can join NCT06024746 on ClinicalTrials.gov

  14. Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failure

    The goal of this study is to evaluate the safety and efficacy of the BrioVAD System by demonstrating non-inferiority to the HeartMate 3 Left Ventricular Assist System when used for the treatment of advanced, refractory, left ventricular heart failure.

    Stage
    Not phased
    Ages
    18 to 100
    Site
    Abbott Northwestern Hospital, Minneapolis, Minnesota
    Locations
    47 in total
    Run by
    BrioHealth Solutions, Inc.

    See if you can join NCT06310031 on ClinicalTrials.gov

  15. Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)

    The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the most safe and effective dose for children. The primary objective of this study is to evaluate the PK…

    Stage
    Not phased
    Ages
    0 to 20
    Site
    University of Minnesota, Minneapolis, Minnesota
    Locations
    52 in total
    Run by
    Duke University

    See if you can join NCT04278404 on ClinicalTrials.gov

  16. Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products

    The main purpose of the Product Performance Report (formerly referred to as System Longevity Study) is to evaluate long-term performance of Medtronic market-released cardiac rhythm products by analyzing product survival probabilities.

    Stage
    Not phased
    Ages
    Any age
    Site
    Research site, Minneapolis, Minnesota
    Locations
    333 in total
    Run by
    Medtronic

    See if you can join NCT00271180 on ClinicalTrials.gov

  17. Alleviant ALLAY-HF Study

    Prospective, multicenter, randomized, sham-controlled, double blinded, adaptive study designed to evaluate the safety and efficacy of a percutaneously created interatrial shunt using the Alleviant ALV1 System in patients with HFpEF/HFmrEF.

    Stage
    Not phased
    Ages
    40 and older
    Site
    Minneapolis Heart Institute Foundation, Minneapolis, Minnesota
    Locations
    93 in total
    Run by
    Alleviant Medical, Inc.

    See if you can join NCT05685303 on ClinicalTrials.gov

  18. A Study to Evaluate Finerenone on Clinical Efficacy and Safety in Patients With Heart Failure Who Are Intolerant or Not Eligible for Treatment With Steroidal Mineralocorticoid Receptor Antagonists

    Finerenone will be compared to placebo to determine efficacy and safety of treatment in patients with heart failure and reduced ejection fraction (HFrEF) who are intolerant or ineligible to receive treatment with steroidal mineralocorticoid receptor antagonists (sMRA).

    Stage
    Phase 3
    Ages
    18 and older
    Site
    Minneapolis, MN Investigative Site FIN-10035, Minneapolis, Minnesota
    Locations
    176 in total
    Run by
    Colorado Prevention Center

    See if you can join NCT06033950 on ClinicalTrials.gov

  19. PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III

    This is a prospective, multi-center, open label, randomized control clinical trial evaluating the safety and efficacy of the Cordella™ Pulmonary Artery Sensor System in NYHA Class II-III Heart Failure Patients (PROACTIVE-HF-2 Trial). The study contains of 5 arms: NYHA II Cohort - To demonstrate saf…

    Stage
    Not phased
    Ages
    18 and older
    Site
    University of Minnesota, Minneapolis, Minnesota
    Locations
    48 in total
    Run by
    Endotronix, Inc.

    See if you can join NCT05934487 on ClinicalTrials.gov

  20. Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure

    The purpose of TEAM-HF IDE clinical trial is to evaluate safety and effectiveness of the HeartMate 3 LVAS compared to guideline directed medical therapy (GDMT) in a population of ambulatory advanced heart failure patients who are not dependent on intravenous inotrope.

    Stage
    Not phased
    Ages
    18 and older
    Site
    Minneapolis Heart Institute, Minneapolis, Minnesota
    Locations
    68 in total
    Run by
    Abbott Medical Devices

    See if you can join NCT06526195 on ClinicalTrials.gov

  21. HF2 Registry - Hemodynamic Frontiers in Heart Failure Registry

    The purpose of the HF2 (Hemodynamic Frontiers in Heart Failure) registry is to collect relevant patient-level demographic, clinical, laboratory, and hemodynamic data from patients implanted with pulmonary artery pressure sensor at participating centers to advance scientific knowledge about ambulato…

    Stage
    Not phased
    Ages
    18 to 100
    Site
    Minneapolis Heart Institute Foundation/ Allina Health, Minneapolis, Minnesota
    Locations
    12 in total
    Run by
    University of Kansas Medical Center

    See if you can join NCT06425848 on ClinicalTrials.gov

How to read this page. Every study here comes from ClinicalTrials.gov, the public registry that research teams are required to file with. We have summarised each one in plain language and shown where it is running. We have not changed what any study says it is doing.

What TrialBoost is. We help people find research that might suit them, and, if they ask us to, we pass their details to the research team running it. We are not a doctor, a research site, or a study sponsor, and we do not decide who takes part in anything. Joining costs nothing and you can change your mind at any point.

Paid placement. Some studies pay us when someone asks to be connected to them. Those are labelled Sponsored wherever they appear, and they only appear when they match what you were actually looking for.