Heart Failure Clinical Trials in Boston, Massachusetts

29 studies are recruiting for heart failure in Boston, Massachusetts right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

  1. Alleviant ALLAY-HFrEF Study

    Prospective, multicenter, randomized, sham-controlled, double blind (patient and observer), study designed to evaluate the safety and efficacy of a percutaneously created interatrial shunt using the Alleviant ALV1 System in patients with HFrEF.

    Stage
    Not phased
    Ages
    18 and older
    Site
    Tufts Medical Center, Boston, Massachusetts
    Locations
    68 in total
    Run by
    Alleviant Medical, Inc.

    See if you can join NCT06812533 on ClinicalTrials.gov

  2. Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin

    Participants include men and women ≥ 40 years of age with T2DM, established CV disease, a history of HTN with an SBP of at least 130 mmHg at screening, who meet the predefined serum potassium level, and with at least one additional risk factor for HF. The study will include an optional pre-screenin…

    Stage
    Phase 3
    Ages
    40 and older
    Site
    Research Site, Boston, Massachusetts
    Locations
    957 in total
    Run by
    AstraZeneca

    See if you can join NCT06677060 on ClinicalTrials.gov

  3. A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients

    Finerenone will be compared to placebo to determine efficacy and safety of treatment in patients hospitalized with acute decompensated heart failure (HF) and mildly reduced or preserved left ventricular ejection fraction.

    Stage
    Phase 3
    Ages
    18 and older
    Site
    Boston, MA Investigative Stie 10087, Boston, Massachusetts
    Locations
    356 in total
    Run by
    Colorado Prevention Center

    See if you can join NCT06008197 on ClinicalTrials.gov

  4. Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failure

    The goal of this study is to evaluate the safety and efficacy of the BrioVAD System by demonstrating non-inferiority to the HeartMate 3 Left Ventricular Assist System when used for the treatment of advanced, refractory, left ventricular heart failure.

    Stage
    Not phased
    Ages
    18 to 100
    Site
    Tufts Medical Center, Boston, Massachusetts
    Locations
    47 in total
    Run by
    BrioHealth Solutions, Inc.

    See if you can join NCT06310031 on ClinicalTrials.gov

  5. Prevalence and Prediction of ATTR in Ambulatory Patients With HFpEF

    Recent studies have shown that transthyretin amyloidosis (ATTR) can sometimes cause a type of heart failure where the pumping function of the heart is normal, also known as Heart Failure with Preserved Ejection Fraction (HFpEF) or diastolic heart failure. In this single center diagnostic study, we …

    Stage
    Not phased
    Ages
    65 and older
    Site
    Massachusetts General Hospital, Boston, Massachusetts
    Run by
    Massachusetts General Hospital

    See if you can join NCT05577819 on ClinicalTrials.gov

  6. Targeted Artificial Intelligence Language mOdel Recommendations for Heart Failure (TAILOR-HF)

    This study is an investigator-initiated, cluster-randomized implementation trial evaluating a large language model (LLM)-based clinical decision support (CDS) tool designed to improve guideline-directed medical therapy (GDMT) for adult patients with heart failure seen in outpatient cardiology clini…

    Stage
    Not phased
    Ages
    18 to 85
    Site
    Mass General Brigham, Boston, Massachusetts
    Run by
    Brigham and Women's Hospital

    See if you can join NCT07337577 on ClinicalTrials.gov

  7. Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)

    This study aims to compare the efficacy of vericiguat versus placebo on change in n-terminal pro-brain natriuretic peptide (NTproBNP) from baseline to Week 16 of the Base Period. The primary hypothesis is that vericiguat is superior to placebo in reducing NT-proBNP at Week 16 of the Base Period.

    Stage
    Phase 2
    Ages
    0 to 17
    Site
    Boston Children's Hospital ( Site 0035), Boston, Massachusetts
    Locations
    109 in total
    Run by
    Merck Sharp & Dohme LLC

    See if you can join NCT05714085 on ClinicalTrials.gov

  8. Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction

    The purpose of this study is to find out if the investigational drug called omecamtiv mecarbil can reduce the risk of the effects of heart failure, like hospitalization, transplantation, or death in patients with heart failure and severely reduced ejection fraction.

    Stage
    Phase 3
    Ages
    18 to 85
    Site
    Tufts Medical Center, Boston, Massachusetts
    Locations
    205 in total
    Run by
    Cytokinetics

    See if you can join NCT06736574 on ClinicalTrials.gov

  9. Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)

    The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the most safe and effective dose for children. The primary objective of this study is to evaluate the PK…

    Stage
    Not phased
    Ages
    0 to 20
    Site
    Boston Children's Hospital, Boston, Massachusetts
    Locations
    52 in total
    Run by
    Duke University

    See if you can join NCT04278404 on ClinicalTrials.gov

  10. Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products

    The main purpose of the Product Performance Report (formerly referred to as System Longevity Study) is to evaluate long-term performance of Medtronic market-released cardiac rhythm products by analyzing product survival probabilities.

    Stage
    Not phased
    Ages
    Any age
    Site
    Research site, Boston, Massachusetts
    Locations
    333 in total
    Run by
    Medtronic

    See if you can join NCT00271180 on ClinicalTrials.gov

  11. Alleviant ALLAY-HF Study

    Prospective, multicenter, randomized, sham-controlled, double blinded, adaptive study designed to evaluate the safety and efficacy of a percutaneously created interatrial shunt using the Alleviant ALV1 System in patients with HFpEF/HFmrEF.

    Stage
    Not phased
    Ages
    40 and older
    Site
    Brigham and Women's Hospital, Boston, Massachusetts
    Locations
    93 in total
    Run by
    Alleviant Medical, Inc.

    See if you can join NCT05685303 on ClinicalTrials.gov

  12. Assessment of CCM in HF With Higher Ejection Fraction

    The AIM HIGHer Clinical Trial will evaluate the safety and efficacy of Cardiac Contractility Modulation (CCM) therapy in patients with heart failure with LVEF ≥40% and ≤70%.

    Stage
    Not phased
    Ages
    18 and older
    Site
    Massachusetts General Hospital, Boston, Massachusetts
    Locations
    105 in total
    Run by
    Impulse Dynamics

    See if you can join NCT05064709 on ClinicalTrials.gov

  13. Care Transitions App for Patients With Multiple Chronic Conditions

    The objective of this study is to widely implement and evaluate the Care Transitions App in a randomized controlled trial. The app the investigators designed for patients with multiple chronic conditions has four envisioned modules: 1) falls-reduction content, 2) a digital post-discharge transition…

    Stage
    Not phased
    Ages
    55 and older
    Site
    Brigham and Women's Hospital, Boston, Massachusetts
    Run by
    Brigham and Women's Hospital

    See if you can join NCT06051058 on ClinicalTrials.gov

  14. The STOP-MED CTRCD Trial

    Cancer therapy-related cardiac dysfunction (CTRCD) is when the heart's ability to pump oxygenated blood to the body is compromised. It is a side effect of cancer therapy which can occur as commonly as in 1 in 5 patients. When this occurs, heart failure medications are started to protect the heart f…

    Stage
    Phase 4
    Ages
    18 and older
    Site
    Brigham and Women's Hospital, Boston, Massachusetts
    Locations
    14 in total
    Run by
    Dinesh Thavendiranathan

    See if you can join NCT06183437 on ClinicalTrials.gov

  15. PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III

    This is a prospective, multi-center, open label, randomized control clinical trial evaluating the safety and efficacy of the Cordella™ Pulmonary Artery Sensor System in NYHA Class II-III Heart Failure Patients (PROACTIVE-HF-2 Trial). The study contains of 5 arms: NYHA II Cohort - To demonstrate saf…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Tufts Medical Center, Boston, Massachusetts
    Locations
    48 in total
    Run by
    Endotronix, Inc.

    See if you can join NCT05934487 on ClinicalTrials.gov

  16. Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure

    The purpose of TEAM-HF IDE clinical trial is to evaluate safety and effectiveness of the HeartMate 3 LVAS compared to guideline directed medical therapy (GDMT) in a population of ambulatory advanced heart failure patients who are not dependent on intravenous inotrope.

    Stage
    Not phased
    Ages
    18 and older
    Site
    Massachusetts General Hospital, Boston, Massachusetts
    Locations
    68 in total
    Run by
    Abbott Medical Devices

    See if you can join NCT06526195 on ClinicalTrials.gov

  17. CCM OPEN HF Registry

    The registry has been designed to evaluate the long-term safety and efficacy of CCM therapy in a real-world setting.

    Stage
    Not phased
    Ages
    18 and older
    Site
    Massachusetts General Hospital, Boston, Massachusetts
    Locations
    28 in total
    Run by
    Impulse Dynamics

    See if you can join NCT07112924 on ClinicalTrials.gov

  18. Promoting Well-being and Health in Heart Failure

    The focus of this study is to test the efficacy of a 12-week, phone-delivered Positive Psychology-Motivational Interviewing (PP-MI) intervention, with additional twice weekly PP and health behavior text messages for a total of 24 weeks (with interactive, algorithm-driven, goal-focused text messages…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Massachusetts General Hospital, Boston, Massachusetts
    Run by
    Massachusetts General Hospital

    See if you can join NCT04829617 on ClinicalTrials.gov

  19. The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR

    The objective of this prospective, randomized, double- blinded (patient and assessors), sham-controlled clinical trial is to assess the safety and efficacy of the CMCS in treating heart failure with functional regurgitation (FMR).

    Stage
    Not phased
    Ages
    18 and older
    Site
    St Elizabeth's Medical Center, Boston, Massachusetts
    Locations
    92 in total
    Run by
    Cardiac Dimensions, Inc.

    See if you can join NCT03142152 on ClinicalTrials.gov

  20. HeartShare: Combining Omics, Deep Phenotyping, and Electronic Health Records for Heart Failure Subtypes and Treatment Targets

    HeartShare is a comprehensive study of heart failure, a common and serious medical condition which occurs when the heart is unable to keep up with the demands of the body, resulting in shortness of breath, fluid retention, and fatigue. HeartShare aims to better classify heart failure into subtypes …

    Stage
    Not phased
    Ages
    30 and older
    Site
    Mass General Brigham, Boston, Massachusetts
    Locations
    6 in total
    Run by
    Northwestern University

    See if you can join NCT05873634 on ClinicalTrials.gov

  21. Myocardial Mechanisms in Heart Failure With Preserved Ejection Fraction

    The purpose of this study is to identify changes in heart tissue structure and biological function in patients with heart failure by performing an endomyocardial biopsy (EMB or heart biopsy) during a right heart catheterization (RHC). The ultimate goal is to use this information to develop new trea…

    Stage
    Not phased
    Ages
    30 and older
    Site
    Mass General Brigham, Boston, Massachusetts
    Locations
    6 in total
    Run by
    Northwestern University

    See if you can join NCT06517186 on ClinicalTrials.gov

  22. Sotagliflozin to Slow Kidney Function Decline in Persons With Type 1 Diabetes and Diabetic Kidney Disease

    Powerful new drugs that can prevent or delay end stage kidney disease (ESKD) - so called sodium-glucose cotransporter-2 inhibitors (SGLT2i) - are now available for patients with type 2 diabetes. Whether these drugs have similar effects in patients with type 1 diabetes (T1D) remains unknown because …

    Stage
    Phase 3
    Ages
    18 to 75
    Site
    Joslin Diabetes Center, Boston, Massachusetts
    Locations
    19 in total
    Run by
    Alessandro Doria

    See if you can join NCT06217302 on ClinicalTrials.gov

  23. Home Hospital for Suddenly Ill Adults

    The investigators propose a home hospital model of care that substitutes for treatment in an acute care hospital. Limited studies of the home hospital model have demonstrated that a sizeable proportion of acute care can be delivered in the home with equal quality and safety, reduced cost, and impro…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Brigham and Women's Hospital, Boston, Massachusetts
    Locations
    2 in total
    Run by
    Brigham and Women's Hospital

    See if you can join NCT03524222 on ClinicalTrials.gov

  24. A SkeleTal Muscle Recovery Intervention With Dietary Protein in Heart Failure

    Severe skeletal wasting and catabolic weight loss are highly common among patients with heart failure with reduced ejection fraction (HFrEF). This prospective randomized controlled trial will compare changes in the muscle mass in the arms and the legs (appendicular lean mass) in patients with HFrEF…

    Stage
    Not phased
    Ages
    18 to 100
    Site
    Tufts Medical Center, Boston, Massachusetts
    Locations
    2 in total
    Run by
    Tufts Medical Center

    See if you can join NCT05627440 on ClinicalTrials.gov

  25. Pulmonary Artery Catheter in Cardiogenic Shock Trial

    The primary objective of the PACCS trial is to assess if early invasive hemodynamic assessment and ongoing management with a PAC in patients with cardiogenic shock due to acutely decompensated heart failure (AHDF-CS) is associated with lower in-hospital mortality risk compared to the current standa…

    Stage
    Not phased
    Ages
    18 to 90
    Site
    Tufts Medical Center, Boston, Massachusetts
    Run by
    Tufts Medical Center

    See if you can join NCT05485376 on ClinicalTrials.gov

How to read this page. Every study here comes from ClinicalTrials.gov, the public registry that research teams are required to file with. We have summarised each one in plain language and shown where it is running. We have not changed what any study says it is doing.

What TrialBoost is. We help people find research that might suit them, and, if they ask us to, we pass their details to the research team running it. We are not a doctor, a research site, or a study sponsor, and we do not decide who takes part in anything. Joining costs nothing and you can change your mind at any point.

Paid placement. Some studies pay us when someone asks to be connected to them. Those are labelled Sponsored wherever they appear, and they only appear when they match what you were actually looking for.