Heart Failure Clinical Trials in Chicago, Illinois

25 studies are recruiting for heart failure in Chicago, Illinois right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

  1. Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin

    Participants include men and women ≥ 40 years of age with T2DM, established CV disease, a history of HTN with an SBP of at least 130 mmHg at screening, who meet the predefined serum potassium level, and with at least one additional risk factor for HF. The study will include an optional pre-screenin…

    Stage
    Phase 3
    Ages
    40 and older
    Site
    Research Site, Chicago, Illinois
    Locations
    957 in total
    Run by
    AstraZeneca

    See if you can join NCT06677060 on ClinicalTrials.gov

  2. A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients

    Finerenone will be compared to placebo to determine efficacy and safety of treatment in patients hospitalized with acute decompensated heart failure (HF) and mildly reduced or preserved left ventricular ejection fraction.

    Stage
    Phase 3
    Ages
    18 and older
    Site
    Chicago, IL Investigative Site 10062, Chicago, Illinois
    Locations
    356 in total
    Run by
    Colorado Prevention Center

    See if you can join NCT06008197 on ClinicalTrials.gov

  3. Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failure

    The goal of this study is to evaluate the safety and efficacy of the BrioVAD System by demonstrating non-inferiority to the HeartMate 3 Left Ventricular Assist System when used for the treatment of advanced, refractory, left ventricular heart failure.

    Stage
    Not phased
    Ages
    18 to 100
    Site
    Advocate Christ Medical Center, Chicago, Illinois
    Locations
    47 in total
    Run by
    BrioHealth Solutions, Inc.

    See if you can join NCT06310031 on ClinicalTrials.gov

  4. A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart

    This study is open to adults with chronic heart failure (HF) who have a reduced left ventricular ejection fraction (LVEF) of less than 40%. People can join the study if they have been diagnosed with chronic HF at least 3 months before they start on the study. The purpose of this study is to find ou…

    Stage
    Phase 3
    Ages
    18 and older
    Site
    Illinois Masonic Hospital, Chicago, Illinois
    Locations
    588 in total
    Run by
    Boehringer Ingelheim

    See if you can join NCT06935370 on ClinicalTrials.gov

  5. Diuretics Alone vs. Aortix Endovascular Device for Acute Heart Failure

    Aortix is a circulatory support device for chronic heart failure patients on medical management who have been hospitalized for acute decompensated heart failure (ADHF) and have persistent congestion despite usual medical therapy. Eligible ADHF patients with diuretic resistance (irrespective of ejec…

    Stage
    Not phased
    Ages
    21 and older
    Site
    University of Chicago, Chicago, Illinois
    Locations
    50 in total
    Run by
    Procyrion

    See if you can join NCT05677100 on ClinicalTrials.gov

  6. Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)

    The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the most safe and effective dose for children. The primary objective of this study is to evaluate the PK…

    Stage
    Not phased
    Ages
    0 to 20
    Site
    Ann and Robert H. Lurie Childrens Hospital of Chicago, Chicago, Illinois
    Locations
    52 in total
    Run by
    Duke University

    See if you can join NCT04278404 on ClinicalTrials.gov

  7. A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure

    This study is open to adults aged 18 or above legal age with heart failure. People can join the study if they have heart failure symptoms and a left ventricular ejection fraction (LVEF) of 40% or more. The purpose of this study is to find out whether vicadrostat (BI 690517) in combination with empa…

    Stage
    Phase 3
    Ages
    18 and older
    Site
    Illinois Masonic Hospital, Chicago, Illinois
    Locations
    652 in total
    Run by
    Boehringer Ingelheim

    See if you can join NCT06424288 on ClinicalTrials.gov

  8. A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity

    This study is being done to look at the safety and effect of NNC0487-0111 in people with Heart Failure with preserved Ejection Fraction (HFpEF) or Heart Failure with mildly reduced Ejection Fraction (HFmrEF) and excess body weight when compared to placebo. The purpose of this clinical study is to f…

    Stage
    Phase 3
    Ages
    18 and older
    Site
    Chicago Clinical Research Institute INC, Chicago, Illinois
    Locations
    838 in total
    Run by
    Novo Nordisk A/S

    See if you can join NCT07567001 on ClinicalTrials.gov

  9. Alleviant ALLAY-HF Study

    Prospective, multicenter, randomized, sham-controlled, double blinded, adaptive study designed to evaluate the safety and efficacy of a percutaneously created interatrial shunt using the Alleviant ALV1 System in patients with HFpEF/HFmrEF.

    Stage
    Not phased
    Ages
    40 and older
    Site
    Advocate Illinois Masonic Medical Center, Chicago, Illinois
    Locations
    93 in total
    Run by
    Alleviant Medical, Inc.

    See if you can join NCT05685303 on ClinicalTrials.gov

  10. Study of the Progression of Chronic Cardiovascular Conditions

    This study will collect physiologic data in patients with cardiovascular conditions and observe the natural history of those conditions for research purposes.

    Stage
    Not phased
    Ages
    18 and older
    Site
    Prolaio, Chicago, Illinois
    Run by
    Prolaio

    See if you can join NCT07420907 on ClinicalTrials.gov

  11. Cardiac Power Output in Cardiogenic Shock Patients

    The main purpose of this study is to determine whether differences in myocardial reserve predict clinical outcomes for heart failure patients.

    Stage
    EARLY_Phase 1
    Ages
    18 and older
    Site
    The University of Chicago, Chicago, Illinois
    Run by
    University of Chicago

    See if you can join NCT05700617 on ClinicalTrials.gov

  12. Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure

    The purpose of TEAM-HF IDE clinical trial is to evaluate safety and effectiveness of the HeartMate 3 LVAS compared to guideline directed medical therapy (GDMT) in a population of ambulatory advanced heart failure patients who are not dependent on intravenous inotrope.

    Stage
    Not phased
    Ages
    18 and older
    Site
    University of Chicago, Chicago, Illinois
    Locations
    68 in total
    Run by
    Abbott Medical Devices

    See if you can join NCT06526195 on ClinicalTrials.gov

  13. A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF)

    The purpose of this study is to learn about the safety and effects of the study medicine (PF-07328948) for the possible treatment of heart failure (HF).

    Stage
    Phase 2
    Ages
    18 to 79
    Site
    NMH Clinical Research Unit, Chicago, Illinois
    Locations
    142 in total
    Run by
    Pfizer

    See if you can join NCT06991257 on ClinicalTrials.gov

  14. Ultra-High Frequency - Electrocardiogram (UHF-ECG) for the Diagnosis of Ventricular Electrical Dyssynchrony (VED)

    The purpose of this study is to demonstrate the safety and effectiveness of the VDI UHF-ECG System in the diagnosis of ventricular dyssynchrony when compared to the 12-lead ECG in patients with bradycardia and heart failure indicated for pacemaker implantation.

    Stage
    Not phased
    Ages
    18 and older
    Site
    University of Chicago, Chicago, Illinois
    Locations
    12 in total
    Run by
    VDI Technologies

    See if you can join NCT06641362 on ClinicalTrials.gov

  15. The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR

    The objective of this prospective, randomized, double- blinded (patient and assessors), sham-controlled clinical trial is to assess the safety and efficacy of the CMCS in treating heart failure with functional regurgitation (FMR).

    Stage
    Not phased
    Ages
    18 and older
    Site
    Rush University Medical Center, Chicago, Illinois
    Locations
    92 in total
    Run by
    Cardiac Dimensions, Inc.

    See if you can join NCT03142152 on ClinicalTrials.gov

  16. HeartShare: Combining Omics, Deep Phenotyping, and Electronic Health Records for Heart Failure Subtypes and Treatment Targets

    HeartShare is a comprehensive study of heart failure, a common and serious medical condition which occurs when the heart is unable to keep up with the demands of the body, resulting in shortness of breath, fluid retention, and fatigue. HeartShare aims to better classify heart failure into subtypes …

    Stage
    Not phased
    Ages
    30 and older
    Site
    Northwestern University, Chicago, Illinois
    Locations
    6 in total
    Run by
    Northwestern University

    See if you can join NCT05873634 on ClinicalTrials.gov

  17. Myocardial Mechanisms in Heart Failure With Preserved Ejection Fraction

    The purpose of this study is to identify changes in heart tissue structure and biological function in patients with heart failure by performing an endomyocardial biopsy (EMB or heart biopsy) during a right heart catheterization (RHC). The ultimate goal is to use this information to develop new trea…

    Stage
    Not phased
    Ages
    30 and older
    Site
    Northwestern University, Chicago, Illinois
    Locations
    6 in total
    Run by
    Northwestern University

    See if you can join NCT06517186 on ClinicalTrials.gov

  18. Sotagliflozin to Slow Kidney Function Decline in Persons With Type 1 Diabetes and Diabetic Kidney Disease

    Powerful new drugs that can prevent or delay end stage kidney disease (ESKD) - so called sodium-glucose cotransporter-2 inhibitors (SGLT2i) - are now available for patients with type 2 diabetes. Whether these drugs have similar effects in patients with type 1 diabetes (T1D) remains unknown because …

    Stage
    Phase 3
    Ages
    18 to 75
    Site
    Northwestern University Feinberg School of Medicine, Chicago, Illinois
    Locations
    19 in total
    Run by
    Alessandro Doria

    See if you can join NCT06217302 on ClinicalTrials.gov

  19. XVIVO Heart Box (XHB) With Supplemented XVIVO Heart Solution (SXHS) Continued Access Protocol (CAP)

    The purpose of this study is to evaluate if Non-Ischemic Heart Preservation (NIHP) of extended criteria donor hearts using the XVIVO Heart Preservation System (XHPS) is a safe and effective way to preserve and transport hearts for transplantation.

    Stage
    Not phased
    Ages
    18 and older
    Site
    Northwestern Memorial Hospital, Chicago, Illinois
    Locations
    14 in total
    Run by
    XVIVO Perfusion

    See if you can join NCT06895070 on ClinicalTrials.gov

  20. His-Bundle Corrective Pacing in Heart Failure

    The investigators aim to prospectively evaluate the efficacy and mechanism of benefit of His-bundle pacing enhanced cardiac resynchronization therapy (His-CRT) vs. cardiac resynchronization therapy (BIV-CRT) in patients with heart failure and right bundle branch block (RBBB).

    Stage
    Not phased
    Ages
    18 and older
    Site
    Northwestern Memorial Hospital, Chicago, Illinois
    Locations
    14 in total
    Run by
    University of Rochester

    See if you can join NCT05265520 on ClinicalTrials.gov

  21. iCardia4HF: Multi-component mHealth Intervention for Patients With Heart Failure

    The goal of this factorial randomized trial is to examine the independent and synergistic efficacies of two mobile health technology interventions in people with chronic heart failure. The first intervention involves the use of multiple consumer mHealth apps and sensor devices (MyApps) for heart fa…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Rush University Medical Center, Chicago, Illinois
    Locations
    2 in total
    Run by
    University of Illinois at Chicago

    See if you can join NCT06205225 on ClinicalTrials.gov

  22. Left vs Left Randomized Clinical Trial

    The investigators aim to prospectively test the comparative effectiveness of His or Left bundle branch pacing in relation to patient centered outcomes (quality of life, physical activity, heart failure hospitalization, mortality) and comparative safety in relation to device-related complications an…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Rush University, Chicago, Illinois
    Locations
    71 in total
    Run by
    Baylor College of Medicine

    See if you can join NCT05650658 on ClinicalTrials.gov

  23. TEXT4HF: A Randomized Controlled Trial of a Tailored Text Messaging Intervention to Improve Self-Care in Older Adult Patients With Heart Failure

    The goal of this study is to determine whether an individually tailored text messaging intervention can improve self-care in older adult patients with heart failure. The main question it aims to answer are: * Is a tailored text messaging intervention feasible and acceptable among older adult patien…

    Stage
    Not phased
    Ages
    50 and older
    Site
    University of Illinois, Chicago, Chicago, Illinois
    Run by
    University of Illinois at Chicago

    See if you can join NCT06473532 on ClinicalTrials.gov

  24. UIC Multi-Ethnic DCM Registry

    Dilated cardiomyopathy (DCM), a condition where the heart loses its ability to pump blood throughout the body, is a common cause of death in the United States (US). It affects minorities more frequently and appears to causes greater harm than Whites. However, almost all research related to DCM has …

    Stage
    Not phased
    Ages
    18 and older
    Site
    University of Illinois Hospital & Health Sciences, Chicago, Illinois
    Run by
    University of Illinois at Chicago

    See if you can join NCT07145138 on ClinicalTrials.gov

  25. AN INTERNATIONAL, OBSERVATIONAL, BLINDED STUDY TO ASSESS THE PERFORMANCE OF THE CORDIO HEARO SYSTEM

    Study Design: This is an international, multicenter, observational, non-interventional, prospective, blinded, single-arm, two-period study, to collect patient utterances that will be retrospectively analyzed to determine the sensitivity and UPNR of the HearO system.

    Stage
    Not phased
    Ages
    22 and older
    Site
    University of Chicago, Chicago, Illinois
    Locations
    45 in total
    Run by
    Cordio Medical

    See if you can join NCT06378632 on ClinicalTrials.gov

How to read this page. Every study here comes from ClinicalTrials.gov, the public registry that research teams are required to file with. We have summarised each one in plain language and shown where it is running. We have not changed what any study says it is doing.

What TrialBoost is. We help people find research that might suit them, and, if they ask us to, we pass their details to the research team running it. We are not a doctor, a research site, or a study sponsor, and we do not decide who takes part in anything. Joining costs nothing and you can change your mind at any point.

Paid placement. Some studies pay us when someone asks to be connected to them. Those are labelled Sponsored wherever they appear, and they only appear when they match what you were actually looking for.