Heart Failure Clinical Trials

150 studies are recruiting for heart failure in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 2

1. A Research Study Comparing Different Doses of CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Preserved Ejection Fraction and Left Ventricular Hypertrophy

   This study will look into how CDR132L (a potential new medicine) works on the structure and function of the heart in people living with heart failure. Participants will either get CDR132L or placebo (a medicine which has no effect on the body), which treatment the participants get is decided by cha…

   Stage

   Phase 2

   Ages

   40 to 84

   Site

   Univ of Alabama Birmingham, Birmingham, Alabama

   Locations

   118 in total

   Run by

   Novo Nordisk A/S

   See if you can join NCT06979362 on ClinicalTrials.gov

2. Early Feasibility Study - Edwards APTURE Transcatheter Shunt System

   The purpose of this study is to evaluate initial clinical safety, device functionality and effectiveness of the Edwards APTURE transcatheter shunt system.

   Stage

   Not phased

   Ages

   18 and older

   Site

   The Ohio State University Medical Center, Columbus, Ohio

   Locations

   19 in total

   Run by

   Edwards Lifesciences

   See if you can join NCT03523416 on ClinicalTrials.gov

3. Infusing Needed Iron to Target Insufficiency in Adults Treated for Evidence of Heart Failure

   The INITIATE-HF study is a cluster randomized controlled trial that aims to find out if reminding doctors about treatment guidelines for iron deficiency in adults with heart failure who are hospitalized and have evidence of iron deficiency changes the subsequent use of intravenous (IV) iron. Two gr…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Division of Research, Pleasanton, California

   Run by

   Kaiser Permanente

   See if you can join NCT07467668 on ClinicalTrials.gov

4. HeartShare: Combining Omics, Deep Phenotyping, and Electronic Health Records for Heart Failure Subtypes and Treatment Targets

   HeartShare is a comprehensive study of heart failure, a common and serious medical condition which occurs when the heart is unable to keep up with the demands of the body, resulting in shortness of breath, fluid retention, and fatigue. HeartShare aims to better classify heart failure into subtypes …

   Stage

   Not phased

   Ages

   30 and older

   Site

   University of California Davis, Sacramento, California

   Locations

   6 in total

   Run by

   Northwestern University

   See if you can join NCT05873634 on ClinicalTrials.gov

5. Myocardial Mechanisms in Heart Failure With Preserved Ejection Fraction

   The purpose of this study is to identify changes in heart tissue structure and biological function in patients with heart failure by performing an endomyocardial biopsy (EMB or heart biopsy) during a right heart catheterization (RHC). The ultimate goal is to use this information to develop new trea…

   Stage

   Not phased

   Ages

   30 and older

   Site

   Northwestern University, Chicago, Illinois

   Locations

   6 in total

   Run by

   Northwestern University

   See if you can join NCT06517186 on ClinicalTrials.gov

6. NT-ProBNP-based Heart Failure Screening and Prevention Trial in Patients With Type 2 Diabetes: STRONG-DM Study

   A pragmatic, randomized clinical trial to evaluate the effect of a heart failure (HF) risk assessment and prevention strategy incorporating HF clinical risk scores (WATCH-DM) with cardiac biomarker (NT-proBNP) paired with a clinical decision support tool to implement an intensive prevention strateg…

   Stage

   Not phased

   Ages

   Any age

   Site

   University of Texas Southwestern Medical Center, Dallas, Texas

   Locations

   3 in total

   Run by

   University of Texas Southwestern Medical Center

   See if you can join NCT06593327 on ClinicalTrials.gov

7. BiVACOR® Total Artificial Heart Early Feasibility Study

   The purpose of this study is to assess the feasibility of using the BiVACOR Total Artificial Heart (TAH) System to support adult patients with severe biventricular heart failure, or univentricular heart failure in which left ventricular assist device (LVAD) support is not recommended, who require m…

   Stage

   Not phased

   Ages

   18 to 70

   Site

   Banner - University Medical Center Phoenix, Phoenix, Arizona

   Locations

   4 in total

   Run by

   BiVACOR Inc.

   See if you can join NCT06174103 on ClinicalTrials.gov

8. : Vascular Function in Health and Disease

   Many control mechanisms exist which successfully match the supply of blood with the metabolic demand of various tissues under wide-ranging conditions. One primary regulator of vasomotion and thus perfusion to the muscle tissue is the host of chemical factors originating from the vascular endotheliu…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   University of Utah, Salt Lake City, Utah

   Run by

   D. Walter Wray

   See if you can join NCT02966665 on ClinicalTrials.gov

9. Evaluation of Liver Stiffness Performance, by FibroScan®, to Detect Elevated Central Venous Pressure (CVP)

   This is a pivotal, global, prospective, cross-sectional, multicentric clinical investigation designed to explore a non-invasive, reliable alternative to invasive, catheter-based hemodynamic assessments, which are associated with procedural risks and limited applicability in certain participant popu…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Minnesota, Minneota, Minnesota

   Locations

   7 in total

   Run by

   Echosens

   See if you can join NCT07222813 on ClinicalTrials.gov

10. A Study of LY3971297 in Participants With Heart Failure

    The main purpose of this study is to assess how well LY3971297 is tolerated and what side effects may occur in participants with heart failure with preserved ejection fraction (HFpEF) and participants with heart failure with reduced ejection fraction (HFrEF). Blood tests will be performed to invest…

    Stage

    Phase 1

    Ages

    18 to 65

    Site

    Republican Clinical Hospital ARENSIA Exploratory Medicine, Chisinau,

    Locations

    11 in total

    Run by

    Eli Lilly and Company

    See if you can join NCT07547540 on ClinicalTrials.gov

11. A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients

    Finerenone will be compared to placebo to determine efficacy and safety of treatment in patients hospitalized with acute decompensated heart failure (HF) and mildly reduced or preserved left ventricular ejection fraction.

    Stage

    Phase 3

    Ages

    18 and older

    Site

    Birmingham, AL Investigative Site 10012, Birmingham, Alabama

    Locations

    356 in total

    Run by

    Colorado Prevention Center

    See if you can join NCT06008197 on ClinicalTrials.gov

12. A Study to Determine the Efficacy and Safety of Finerenone and SGLT2i in Combination in Hospitalized Patients With Heart Failure (CONFIRMATION-HF)

    Combination therapy of finerenone plus empagliflozin will be compared to usual care to determine the efficacy and safety of treatment in patients hospitalized with heart failure.

    Stage

    Phase 3

    Ages

    18 and older

    Site

    CON-10004 Fairhope, AL Investigational Site, Fairhope, Alabama

    Locations

    140 in total

    Run by

    Colorado Prevention Center

    See if you can join NCT06024746 on ClinicalTrials.gov

13. Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failure

    The goal of this study is to evaluate the safety and efficacy of the BrioVAD System by demonstrating non-inferiority to the HeartMate 3 Left Ventricular Assist System when used for the treatment of advanced, refractory, left ventricular heart failure.

    Stage

    Not phased

    Ages

    18 to 100

    Site

    University of Alabama at Birmingham Hospital, Birmingham, Alabama

    Locations

    47 in total

    Run by

    BrioHealth Solutions, Inc.

    See if you can join NCT06310031 on ClinicalTrials.gov

14. Mechanisms of Diuretic Resistance in Heart Failure, Aim 2

    Randomized placebo-controlled, double-blind, double-dummy, crossover design testing combinations placebo/placebo, bendroflumethiazide/placebo, amiloride/placebo, and bendroflumethiazide/amiloride added to bumetanide.

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Yale University, New Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT05753059 on ClinicalTrials.gov

15. Prevalence and Prediction of ATTR in Ambulatory Patients With HFpEF

    Recent studies have shown that transthyretin amyloidosis (ATTR) can sometimes cause a type of heart failure where the pumping function of the heart is normal, also known as Heart Failure with Preserved Ejection Fraction (HFpEF) or diastolic heart failure. In this single center diagnostic study, we …

    Stage

    Not phased

    Ages

    65 and older

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT05577819 on ClinicalTrials.gov

16. Targeted Artificial Intelligence Language mOdel Recommendations for Heart Failure (TAILOR-HF)

    This study is an investigator-initiated, cluster-randomized implementation trial evaluating a large language model (LLM)-based clinical decision support (CDS) tool designed to improve guideline-directed medical therapy (GDMT) for adult patients with heart failure seen in outpatient cardiology clini…

    Stage

    Not phased

    Ages

    18 to 85

    Site

    Mass General Brigham, Boston, Massachusetts

    Run by

    Brigham and Women's Hospital

    See if you can join NCT07337577 on ClinicalTrials.gov

17. Optimizing Heart Failure Therapies Among Patients With Limited Access in Denver

    Numerous pharmacotherapies have been proven to reduce mortality and hospitalization rates for heart failure with reduced ejection fraction (HFrEF) patients. However, these are underutilized clinically, preventing realization of proven benefits. Simplified patient education tools and multidisciplina…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Denver Health and Hospital Authority, Denver, Colorado

    Run by

    Denver Health and Hospital Authority

    See if you can join NCT07435662 on ClinicalTrials.gov

18. Diuretics Alone vs. Aortix Endovascular Device for Acute Heart Failure

    Aortix is a circulatory support device for chronic heart failure patients on medical management who have been hospitalized for acute decompensated heart failure (ADHF) and have persistent congestion despite usual medical therapy. Eligible ADHF patients with diuretic resistance (irrespective of ejec…

    Stage

    Not phased

    Ages

    21 and older

    Site

    Banner--University Medical Center Phoenix, Phoenix, Arizona

    Locations

    50 in total

    Run by

    Procyrion

    See if you can join NCT05677100 on ClinicalTrials.gov

19. Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)

    The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the most safe and effective dose for children. The primary objective of this study is to evaluate the PK…

    Stage

    Not phased

    Ages

    0 to 20

    Site

    Lucile Packard Children's Hospital, Palo Alto, California

    Locations

    52 in total

    Run by

    Duke University

    See if you can join NCT04278404 on ClinicalTrials.gov

20. A Preliminary Study for INFORMED

    Investigators will determine whether N-of-1 trials, as a pragmatic, participant-centered approach to medication optimization that can overcome key barriers of deprescribing, can lead to increased participant confidence regarding their preference to continue or discontinue beta-blockers in older adu…

    Stage

    Phase 4

    Ages

    65 and older

    Site

    Weill Cornell Medicine, New York, New York

    Run by

    Weill Medical College of Cornell University

    See if you can join NCT05585125 on ClinicalTrials.gov

21. Improving TRansitions ANd OutcomeS for Heart FailurE Patients in Home Health CaRe (I-TRANSFER-HF)

    This study is trying to improve the hospital-to-home transition for people with heart failure who receive home care services. The study will test an intervention called I-TRANSFER-HF, which differs from usual care by combining early home health nurse visits and outpatient medical appointments. The …

    Stage

    Not phased

    Ages

    18 and older

    Site

    VNS Health Partners in Care, New York, New York

    Locations

    2 in total

    Run by

    Weill Medical College of Cornell University

    See if you can join NCT06118983 on ClinicalTrials.gov

22. Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products

    The main purpose of the Product Performance Report (formerly referred to as System Longevity Study) is to evaluate long-term performance of Medtronic market-released cardiac rhythm products by analyzing product survival probabilities.

    Stage

    Not phased

    Ages

    Any age

    Site

    Research site, Birmingham, Alabama

    Locations

    333 in total

    Run by

    Medtronic

    See if you can join NCT00271180 on ClinicalTrials.gov

23. Contrast Echocardiography During Exercise to Assess Pulmonary Blood Volume

    The purpose of this study is to evaluate whether pulmonary blood volume (PBV) derived from contrast echocardiography can serve as a non-invasive surrogate for invasive pulmonary artery wedge pressure (PAWP) during exercise. Also, to compare changes in PBV with exercise in patients with and without …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Mayo Clinic in Rochester, Rochester, Minnesota

    Run by

    Mayo Clinic

    See if you can join NCT06195059 on ClinicalTrials.gov

24. Feasibility and Efficacy Study of the CardioPulmonary Management (CPM) System in Patients With Chronic Heart Failure

    The primary purpose for this study is to support the hypothesis (pilot data) that the use of the Sensinel CPM system reduces the rate of HF-related events and the related healthcare cost. The study will also measure the impact on quality of care and patient satisfaction. In order to support the pri…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Baptist Health South Florida, Miami, Florida

    Locations

    7 in total

    Run by

    Analog Device, Inc.

    See if you can join NCT05650541 on ClinicalTrials.gov

25. Impella Reverse Remodeling in End-Stage Heart Failure

    This observational study is being done to learn more about heart attack recovery in patients supported with the Impella 5.5 left ventricular assist device (LVAD) as part of their standard of care. There are three stages in this study: screening, treatment and post treatment. There will be two phase…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Columbia University, New York, New York

    Run by

    Columbia University

    See if you can join NCT06800716 on ClinicalTrials.gov