Heart Failure Clinical Trials

148 studies are recruiting for heart failure in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 2

1. A Randomized Placebo-procedure Controlled Trial of the Enhancor System (PULmonary Artery Denervation) to Evaluate Safety and Efficacy in Patients With Combined Pre- and Post-capillary Pulmonary Hypertension Associated With Left Heart Disease

   The goal of this clinical study is to evaluate the safety and efficacy of percutaneous pulmonary artery denervation with the Multi-Pole Pulmonary Artery Radiofrequency Ablation Enhancor System in patients with combined pre- and post-capillary pulmonary hypertension (CpcPH) associated with left hear…

   Stage

   Not phased

   Ages

   18 to 85

   Site

   Banner - University Medical Center Tucson, Tucson, Arizona

   Locations

   6 in total

   Run by

   Pulnovo Medical, Inc.

   See if you can join NCT07214376 on ClinicalTrials.gov

2. A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity

   This study is being done to look at the safety and effect of NNC0487-0111 in people with Heart Failure with preserved Ejection Fraction (HFpEF) or Heart Failure with mildly reduced Ejection Fraction (HFmrEF) and excess body weight when compared to placebo. The purpose of this clinical study is to f…

   Stage

   Phase 3

   Ages

   18 and older

   Site

   Advanced Cardiovascular, LLC, Alexander City, Alabama

   Locations

   838 in total

   Run by

   Novo Nordisk A/S

   See if you can join NCT07567001 on ClinicalTrials.gov

3. Circulating Markers That Underlie the Transition From Compensated Hypertrophy to Heart Failure

   The purpose of this research is to determine if two proteins in the blood are increased during acute heart failure. These two proteins are produced when the heart becomes dysfunctional and unable to contract normally. They may then be released into the blood and be detected by standard method in th…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Connecticut Health Center, Farmington, Connecticut

   Run by

   UConn Health

   See if you can join NCT00762008 on ClinicalTrials.gov

4. Alleviant ALLAY-HF Study

   Prospective, multicenter, randomized, sham-controlled, double blinded, adaptive study designed to evaluate the safety and efficacy of a percutaneously created interatrial shunt using the Alleviant ALV1 System in patients with HFpEF/HFmrEF.

   Stage

   Not phased

   Ages

   40 and older

   Site

   Pima Heart and Vascular, Tucson, Arizona

   Locations

   93 in total

   Run by

   Alleviant Medical, Inc.

   See if you can join NCT05685303 on ClinicalTrials.gov

5. CSP #2025 - Geriatric OUt-of-hospital Randomized MEal Trial in Heart Failure: Veterans Affairs (GOURMET-VA)

   The purpose of this multi-center clinical trial is to study the efficacy and safety of providing nutritional support added to the study-defined standard of care which consists of standardized dietary education and a single dietary counseling session shortly after discharge, versus study-defined sta…

   Stage

   Not phased

   Ages

   60 and older

   Site

   Birmingham VA Medical Center, Birmingham, AL, Birmingham, Alabama

   Locations

   16 in total

   Run by

   VA Office of Research and Development

   See if you can join NCT05996328 on ClinicalTrials.gov

6. MediBeacon® Transdermal GFR System for the Evaluation of Kidney Function in Adults With Heart Failure

   The goal of this clinical trial is to evaluate the accuracy and feasibility of transdermal glomerular filtration rate (tGFR) assessment using relmapirazin (Lumitrace) and the MediBeacon tGFR system compared to plasma clearance measurement of GFR in adults with heart failure. The main question it ai…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Columbia University, New York, New York

   Run by

   MediBeacon

   See if you can join NCT07349797 on ClinicalTrials.gov

7. LVAD Conditioning for Cardiac Recovery

   The purpose of this study is to investigate the potential recovery of heart function in end-stage heart failure patients supported with a Left Ventricular Assist Device (LVAD) through applying a myocardial conditioning protocol. During myocardial conditioning, LVAD speed is reduced gradually in ord…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Utah, Salt Lake City, Utah

   Run by

   STAVROS G DRAKOS

   See if you can join NCT03238690 on ClinicalTrials.gov

8. Improving Self-Care of Caregivers of Adults in Homecare With Heart Failure and Cognitive Impairment

   This RCT design will enroll 256 informal caregivers (spouse/partner or child) of HHC patients with HF/CI and 60 patients with HF and mild to moderate CI (60 dyads). After collecting baseline data, we will block randomize the caregivers 1:1 to the ViCCY intervention or comparator group, stratifying …

   Stage

   Not phased

   Ages

   18 to 101

   Site

   VNS Health, New York, New York

   Run by

   Visiting Nurse Service of New York

   See if you can join NCT07220798 on ClinicalTrials.gov

9. Study of the Progression of Chronic Cardiovascular Conditions

   This study will collect physiologic data in patients with cardiovascular conditions and observe the natural history of those conditions for research purposes.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Prolaio, Chicago, Illinois

   Run by

   Prolaio

   See if you can join NCT07420907 on ClinicalTrials.gov

10. Multicenter Trial of ECMO in Children With Severe Cardiac Failure Using the Cardiohelp System

    There are two primary goals of this multicenter clinical trial that combines an FDA device trial and a phase II drug trial in the same study cohort. These two goals are to: 1. To evaluate the safety and effectiveness of the Cardiohelp Device for VA-ECMO (heart-lung support) for up to 30 days of sup…

    Stage

    Phase 2

    Ages

    0 to 16

    Site

    Lucile Packard Children's Hospital, Palo Alto, California

    Locations

    5 in total

    Run by

    Stanford University

    See if you can join NCT06080074 on ClinicalTrials.gov

11. Cardiovascular Multimodality Imaging Study

    Determining the etiology of cardiomyopathy is of high clinical importance for optimal treatment strategy and prediction of prognosis. There is increased risk for cardiovascular disease and higher propensity for cardiovascular related mortality among Black and non-Hispanic White patients. Recently, …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Montefiore Health System, The Bronx, New York

    Run by

    Montefiore Medical Center

    See if you can join NCT06610019 on ClinicalTrials.gov

12. Inspiratory Muscle Training in HFpEF

    This study is being done to determine how inspiratory muscle training impacts inspiratory muscle function during exercise in heart failure patients.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Mayo Clinic in Rochester, Rochester, Minnesota

    Run by

    Mayo Clinic

    See if you can join NCT06510231 on ClinicalTrials.gov

13. Assessment of CCM in HF With Higher Ejection Fraction

    The AIM HIGHer Clinical Trial will evaluate the safety and efficacy of Cardiac Contractility Modulation (CCM) therapy in patients with heart failure with LVEF ≥40% and ≤70%.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Grandview Medical Group Research, LLC, Birmingham, Alabama

    Locations

    105 in total

    Run by

    Impulse Dynamics

    See if you can join NCT05064709 on ClinicalTrials.gov

14. Cardiac Power Output in Cardiogenic Shock Patients

    The main purpose of this study is to determine whether differences in myocardial reserve predict clinical outcomes for heart failure patients.

    Stage

    EARLY_Phase 1

    Ages

    18 and older

    Site

    The University of Chicago, Chicago, Illinois

    Run by

    University of Chicago

    See if you can join NCT05700617 on ClinicalTrials.gov

15. A Research Study Comparing Different Doses of CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Preserved Ejection Fraction and Left Ventricular Hypertrophy

    This study will look into how CDR132L (a potential new medicine) works on the structure and function of the heart in people living with heart failure. Participants will either get CDR132L or placebo (a medicine which has no effect on the body), which treatment the participants get is decided by cha…

    Stage

    Phase 2

    Ages

    40 to 84

    Site

    Univ of Alabama Birmingham, Birmingham, Alabama

    Locations

    117 in total

    Run by

    Novo Nordisk A/S

    See if you can join NCT06979362 on ClinicalTrials.gov

16. Infusing Needed Iron to Target Insufficiency in Adults Treated for Evidence of Heart Failure

    The INITIATE-HF study is a cluster randomized controlled trial that aims to find out if reminding doctors about treatment guidelines for iron deficiency in adults with heart failure who are hospitalized and have evidence of iron deficiency changes the subsequent use of intravenous (IV) iron. Two gr…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Division of Research, Pleasanton, California

    Run by

    Kaiser Permanente

    See if you can join NCT07467668 on ClinicalTrials.gov

17. Longitudinal Validation of CIRC Technologies

    Cardiovascular disease is the leading cause of death worldwide. Advanced cardiovascular imaging using Magnetic Resonance Imaging (MRI) has proven to be effective in providing gold standard myocardial tissue characterization. Moreover, the intrinsic advantage of MRI's lack of exposure to ionizing ra…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Cleveland Clinic, Cleveland, Ohio

    Run by

    The Cleveland Clinic

    See if you can join NCT07081711 on ClinicalTrials.gov

18. The HEARTFELT Study

    This pragmatic randomized crossover trial looks at the effect(s) of using a remote patient monitoring device (Heartfelt device) with health alerts to monitor the development of peripheral edema in patients with heart failure (HF). The hypothesis is that this passive measurement method will lead to …

    Stage

    Not phased

    Ages

    22 and older

    Site

    HealthArc, Hackensack, New Jersey

    Locations

    3 in total

    Run by

    Heartfelt Technologies

    See if you can join NCT06222099 on ClinicalTrials.gov

19. Community-Informed Interventions for Equitable Congestive Heart Failure Management in Primary Care

    The purpose of this study is to expand subject matter expertise and sustained capacity for equity-oriented care within the Advanced Care Ecosystem (ACE) by engaging patients, caregivers, community health workers (CHW), and care-team stakeholders in development work focused on adults living with con…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Mayo Clinic, Rochester, Minnesota

    Run by

    Mayo Clinic

    See if you can join NCT07730827 on ClinicalTrials.gov

20. Staged Kidney Transplantation During Combined Heart/Kidney Transplantation

    The primary purpose of this study is to evaluate the safety and efficacy of ex vivo machine perfusion with staged implantation of kidney allografts during combined heart/kidney transplantation.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Cedars-Sinai Medical Center, Los Angeles, California

    Run by

    Cedars-Sinai Medical Center

    See if you can join NCT06877169 on ClinicalTrials.gov

21. A Study to Evaluate Breathing Muscle Training in Cardiac Rehab

    The purpose of this study is to understand if breathing muscle training combined with cardiac rehabilitation influences the blood flow and blood pressure response during exercise.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Mayo Clinic in Rochester, Rochester, Minnesota

    Run by

    Mayo Clinic

    See if you can join NCT04984473 on ClinicalTrials.gov

22. Promoting Palliative Care for People With Heart Failure

    This project will develop and test a novel clinical decision support tool (CDS) that encourages timely referral to palliative care for people hospitalized with heart failure. This intervention will incorporate an existing, validated 1-year mortality risk model into a CDS to deliver prognostic infor…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Yale New Haven Hospital Saint Raphael, New Haven, Connecticut

    Locations

    2 in total

    Run by

    Yale University

    See if you can join NCT06933875 on ClinicalTrials.gov

23. Understanding and Addressing Risks of Low Socioeconomic Status and Diabetes for Heart Failure

    This study aims to determine whether a 6-month multilevel intervention involving problem-solving training, exercise training and support from community health workers is more effective in improving outcomes for individuals with low socioeconomic status, type 2 diabetes, obesity, and early cardiac d…

    Stage

    Not phased

    Ages

    30 to 70

    Site

    Johns Hopkins Center for Health Equity, Baltimore, Maryland

    Locations

    2 in total

    Run by

    Johns Hopkins University

    See if you can join NCT06364644 on ClinicalTrials.gov

24. PRagmatic Trial Of Messaging to Providers About Treatment of Heart Failure at Inova

    A randomized, single-blind intervention trial to test the comparative effectiveness of an electronic health record best practice advisory system that informs clinicians of guideline-indicated and FDA-approved heart failure medications currently not prescribed to their patients with heart failure ve…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Inova Health System, Falls Church, Virginia

    Run by

    Inova Health Care Services

    See if you can join NCT05433220 on ClinicalTrials.gov

25. A Study to Evaluate Finerenone on Clinical Efficacy and Safety in Patients With Heart Failure Who Are Intolerant or Not Eligible for Treatment With Steroidal Mineralocorticoid Receptor Antagonists

    Finerenone will be compared to placebo to determine efficacy and safety of treatment in patients with heart failure and reduced ejection fraction (HFrEF) who are intolerant or ineligible to receive treatment with steroidal mineralocorticoid receptor antagonists (sMRA).

    Stage

    Phase 3

    Ages

    18 and older

    Site

    FIN-10004 Fairhope, AL Investigational Site, Fairhope, Alabama

    Locations

    176 in total

    Run by

    Colorado Prevention Center

    See if you can join NCT06033950 on ClinicalTrials.gov