Heart Failure Clinical Trials

150 studies are recruiting for heart failure in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 3

1. A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity

   This study is being done to look at the safety and effect of NNC0487-0111 in people with Heart Failure with preserved Ejection Fraction (HFpEF) or Heart Failure with mildly reduced Ejection Fraction (HFmrEF) and excess body weight when compared to placebo. The purpose of this clinical study is to f…

   Stage

   Phase 3

   Ages

   18 and older

   Site

   Advanced Cardiovascular, LLC, Alexander City, Alabama

   Locations

   838 in total

   Run by

   Novo Nordisk A/S

   See if you can join NCT07567001 on ClinicalTrials.gov

2. Circulating Markers That Underlie the Transition From Compensated Hypertrophy to Heart Failure

   The purpose of this research is to determine if two proteins in the blood are increased during acute heart failure. These two proteins are produced when the heart becomes dysfunctional and unable to contract normally. They may then be released into the blood and be detected by standard method in th…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Connecticut Health Center, Farmington, Connecticut

   Run by

   UConn Health

   See if you can join NCT00762008 on ClinicalTrials.gov

3. Alleviant ALLAY-HF Study

   Prospective, multicenter, randomized, sham-controlled, double blinded, adaptive study designed to evaluate the safety and efficacy of a percutaneously created interatrial shunt using the Alleviant ALV1 System in patients with HFpEF/HFmrEF.

   Stage

   Not phased

   Ages

   40 and older

   Site

   Pima Heart and Vascular, Tucson, Arizona

   Locations

   93 in total

   Run by

   Alleviant Medical, Inc.

   See if you can join NCT05685303 on ClinicalTrials.gov

4. MediBeacon® Transdermal GFR System for the Evaluation of Kidney Function in Adults With Heart Failure

   The goal of this clinical trial is to evaluate the accuracy and feasibility of transdermal glomerular filtration rate (tGFR) assessment using relmapirazin (Lumitrace) and the MediBeacon tGFR system compared to plasma clearance measurement of GFR in adults with heart failure. The main question it ai…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Columbia University, New York, New York

   Run by

   MediBeacon

   See if you can join NCT07349797 on ClinicalTrials.gov

5. LVAD Conditioning for Cardiac Recovery

   The purpose of this study is to investigate the potential recovery of heart function in end-stage heart failure patients supported with a Left Ventricular Assist Device (LVAD) through applying a myocardial conditioning protocol. During myocardial conditioning, LVAD speed is reduced gradually in ord…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Utah, Salt Lake City, Utah

   Run by

   STAVROS G DRAKOS

   See if you can join NCT03238690 on ClinicalTrials.gov

6. Improving Self-Care of Caregivers of Adults in Homecare With Heart Failure and Cognitive Impairment

   This RCT design will enroll 256 informal caregivers (spouse/partner or child) of HHC patients with HF/CI and 60 patients with HF and mild to moderate CI (60 dyads). After collecting baseline data, we will block randomize the caregivers 1:1 to the ViCCY intervention or comparator group, stratifying …

   Stage

   Not phased

   Ages

   18 to 101

   Site

   VNS Health, New York, New York

   Run by

   Visiting Nurse Service of New York

   See if you can join NCT07220798 on ClinicalTrials.gov

7. Study of the Progression of Chronic Cardiovascular Conditions

   This study will collect physiologic data in patients with cardiovascular conditions and observe the natural history of those conditions for research purposes.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Prolaio, Chicago, Illinois

   Run by

   Prolaio

   See if you can join NCT07420907 on ClinicalTrials.gov

8. Multicenter Trial of ECMO in Children With Severe Cardiac Failure Using the Cardiohelp System

   There are two primary goals of this multicenter clinical trial that combines an FDA device trial and a phase II drug trial in the same study cohort. These two goals are to: 1. To evaluate the safety and effectiveness of the Cardiohelp Device for VA-ECMO (heart-lung support) for up to 30 days of sup…

   Stage

   Phase 2

   Ages

   0 to 16

   Site

   Lucile Packard Children's Hospital, Palo Alto, California

   Locations

   5 in total

   Run by

   Stanford University

   See if you can join NCT06080074 on ClinicalTrials.gov

9. Cardiovascular Multimodality Imaging Study

   Determining the etiology of cardiomyopathy is of high clinical importance for optimal treatment strategy and prediction of prognosis. There is increased risk for cardiovascular disease and higher propensity for cardiovascular related mortality among Black and non-Hispanic White patients. Recently, …

   Stage

   Not phased

   Ages

   18 and older

   Site

   Montefiore Health System, The Bronx, New York

   Run by

   Montefiore Medical Center

   See if you can join NCT06610019 on ClinicalTrials.gov

10. Inspiratory Muscle Training in HFpEF

    This study is being done to determine how inspiratory muscle training impacts inspiratory muscle function during exercise in heart failure patients.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Mayo Clinic in Rochester, Rochester, Minnesota

    Run by

    Mayo Clinic

    See if you can join NCT06510231 on ClinicalTrials.gov

11. Cardiac Power Output in Cardiogenic Shock Patients

    The main purpose of this study is to determine whether differences in myocardial reserve predict clinical outcomes for heart failure patients.

    Stage

    EARLY_Phase 1

    Ages

    18 and older

    Site

    The University of Chicago, Chicago, Illinois

    Run by

    University of Chicago

    See if you can join NCT05700617 on ClinicalTrials.gov

12. Longitudinal Validation of CIRC Technologies

    Cardiovascular disease is the leading cause of death worldwide. Advanced cardiovascular imaging using Magnetic Resonance Imaging (MRI) has proven to be effective in providing gold standard myocardial tissue characterization. Moreover, the intrinsic advantage of MRI's lack of exposure to ionizing ra…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Cleveland Clinic, Cleveland, Ohio

    Run by

    The Cleveland Clinic

    See if you can join NCT07081711 on ClinicalTrials.gov

13. Community-Informed Interventions for Equitable Congestive Heart Failure Management in Primary Care

    The purpose of this study is to expand subject matter expertise and sustained capacity for equity-oriented care within the Advanced Care Ecosystem (ACE) by engaging patients, caregivers, community health workers (CHW), and care-team stakeholders in development work focused on adults living with con…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Mayo Clinic, Rochester, Minnesota

    Run by

    Mayo Clinic

    See if you can join NCT07730827 on ClinicalTrials.gov

14. Staged Kidney Transplantation During Combined Heart/Kidney Transplantation

    The primary purpose of this study is to evaluate the safety and efficacy of ex vivo machine perfusion with staged implantation of kidney allografts during combined heart/kidney transplantation.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Cedars-Sinai Medical Center, Los Angeles, California

    Run by

    Cedars-Sinai Medical Center

    See if you can join NCT06877169 on ClinicalTrials.gov

15. A Study to Evaluate Breathing Muscle Training in Cardiac Rehab

    The purpose of this study is to understand if breathing muscle training combined with cardiac rehabilitation influences the blood flow and blood pressure response during exercise.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Mayo Clinic in Rochester, Rochester, Minnesota

    Run by

    Mayo Clinic

    See if you can join NCT04984473 on ClinicalTrials.gov

16. Promoting Palliative Care for People With Heart Failure

    This project will develop and test a novel clinical decision support tool (CDS) that encourages timely referral to palliative care for people hospitalized with heart failure. This intervention will incorporate an existing, validated 1-year mortality risk model into a CDS to deliver prognostic infor…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Yale New Haven Hospital Saint Raphael, New Haven, Connecticut

    Locations

    2 in total

    Run by

    Yale University

    See if you can join NCT06933875 on ClinicalTrials.gov

17. PRagmatic Trial Of Messaging to Providers About Treatment of Heart Failure at Inova

    A randomized, single-blind intervention trial to test the comparative effectiveness of an electronic health record best practice advisory system that informs clinicians of guideline-indicated and FDA-approved heart failure medications currently not prescribed to their patients with heart failure ve…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Inova Health System, Falls Church, Virginia

    Run by

    Inova Health Care Services

    See if you can join NCT05433220 on ClinicalTrials.gov

18. A Study to Evaluate Finerenone on Clinical Efficacy and Safety in Patients With Heart Failure Who Are Intolerant or Not Eligible for Treatment With Steroidal Mineralocorticoid Receptor Antagonists

    Finerenone will be compared to placebo to determine efficacy and safety of treatment in patients with heart failure and reduced ejection fraction (HFrEF) who are intolerant or ineligible to receive treatment with steroidal mineralocorticoid receptor antagonists (sMRA).

    Stage

    Phase 3

    Ages

    18 and older

    Site

    FIN-10004 Fairhope, AL Investigational Site, Fairhope, Alabama

    Locations

    176 in total

    Run by

    Colorado Prevention Center

    See if you can join NCT06033950 on ClinicalTrials.gov

19. Care Transitions App for Patients With Multiple Chronic Conditions

    The objective of this study is to widely implement and evaluate the Care Transitions App in a randomized controlled trial. The app the investigators designed for patients with multiple chronic conditions has four envisioned modules: 1) falls-reduction content, 2) a digital post-discharge transition…

    Stage

    Not phased

    Ages

    55 and older

    Site

    Brigham and Women's Hospital, Boston, Massachusetts

    Run by

    Brigham and Women's Hospital

    See if you can join NCT06051058 on ClinicalTrials.gov

20. Treating Heart Dysfunction Related to Cancer Therapy With Sacubitril/Valsartan

    To determine feasibility of recruitment and tolerability of treatment with sacubitril-valsartan among adult age survivors of cancer diagnosed at or before age 39 who have stage B heart failure.

    Stage

    Phase 1

    Ages

    18 to 120

    Site

    Virginia Commonwealth University, Richmond, Virginia

    Run by

    Virginia Commonwealth University

    See if you can join NCT05194111 on ClinicalTrials.gov

21. Project 4: ACHIEVE PATHFINDER

    ACHIEVE-P4: PATHFINDER is a randomized, blinded clinical trial of portable air cleaners (PAC) provided at the time of hospital discharge to Heart Failure (HF) patients. It will be carried out at Henry Ford Hospitals. This project is part of the ACHIEVE GREATER (Addressing Cardiometabolic Health In …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Henry Ford Health, Detroit, Michigan

    Run by

    Henry Ford Health System

    See if you can join NCT06070428 on ClinicalTrials.gov

22. The STOP-MED CTRCD Trial

    Cancer therapy-related cardiac dysfunction (CTRCD) is when the heart's ability to pump oxygenated blood to the body is compromised. It is a side effect of cancer therapy which can occur as commonly as in 1 in 5 patients. When this occurs, heart failure medications are started to protect the heart f…

    Stage

    Phase 4

    Ages

    18 and older

    Site

    Brigham and Women's Hospital, Boston, Massachusetts

    Locations

    14 in total

    Run by

    Dinesh Thavendiranathan

    See if you can join NCT06183437 on ClinicalTrials.gov

23. UPBEAT: Using Polygenic Scores to Guide BB Therapy in HF With Mildly Reduced EF

    This study will use polygenic scores, a tool which describes differences in genetics, to examine effectiveness of beta blocker medication in heart failure patients with ejection fraction of 41-50 percent. The study will also assess beta blockers' effect on the changes in left ventricular end-systol…

    Stage

    Not phased

    Ages

    18 to 89

    Site

    Henry Ford Health, Detroit, Michigan

    Run by

    David Lanfear

    See if you can join NCT07054489 on ClinicalTrials.gov

24. 18F-mFBG Imaging for Myocardial Sympathetic Innervation

    This is a Phase 2 study evaluating the positron-emitting radiopharmaceutical 18F-mFBG as an imaging agent for quantification of myocardial sympathetic innervation. The study will examine a group of stable patients with heart failure (HF) from ischemic cardiomyopathy. All subjects will have left ven…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    UT Health Houston, Houston, Texas

    Run by

    Innervate Radiopharmaceuticals LLC (Formerly: Illumina Radiopharmaceuticals LLC)

    See if you can join NCT06965621 on ClinicalTrials.gov

25. PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III

    This is a prospective, multi-center, open label, randomized control clinical trial evaluating the safety and efficacy of the Cordella™ Pulmonary Artery Sensor System in NYHA Class II-III Heart Failure Patients (PROACTIVE-HF-2 Trial). The study contains of 5 arms: NYHA II Cohort - To demonstrate saf…

    Stage

    Not phased

    Ages

    18 and older

    Site

    St. Joseph's Hospital and Medical Center, Phoenix, Arizona

    Locations

    48 in total

    Run by

    Endotronix, Inc.

    See if you can join NCT05934487 on ClinicalTrials.gov