Heart Failure Clinical Trials

148 studies are recruiting for heart failure in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 3

1. Care Transitions App for Patients With Multiple Chronic Conditions

   The objective of this study is to widely implement and evaluate the Care Transitions App in a randomized controlled trial. The app the investigators designed for patients with multiple chronic conditions has four envisioned modules: 1) falls-reduction content, 2) a digital post-discharge transition…

   Stage

   Not phased

   Ages

   55 and older

   Site

   Brigham and Women's Hospital, Boston, Massachusetts

   Run by

   Brigham and Women's Hospital

   See if you can join NCT06051058 on ClinicalTrials.gov

2. Treating Heart Dysfunction Related to Cancer Therapy With Sacubitril/Valsartan

   To determine feasibility of recruitment and tolerability of treatment with sacubitril-valsartan among adult age survivors of cancer diagnosed at or before age 39 who have stage B heart failure.

   Stage

   Phase 1

   Ages

   18 to 120

   Site

   Virginia Commonwealth University, Richmond, Virginia

   Run by

   Virginia Commonwealth University

   See if you can join NCT05194111 on ClinicalTrials.gov

3. Project 4: ACHIEVE PATHFINDER

   ACHIEVE-P4: PATHFINDER is a randomized, blinded clinical trial of portable air cleaners (PAC) provided at the time of hospital discharge to Heart Failure (HF) patients. It will be carried out at Henry Ford Hospitals. This project is part of the ACHIEVE GREATER (Addressing Cardiometabolic Health In …

   Stage

   Not phased

   Ages

   18 and older

   Site

   Henry Ford Health, Detroit, Michigan

   Run by

   Henry Ford Health System

   See if you can join NCT06070428 on ClinicalTrials.gov

4. The STOP-MED CTRCD Trial

   Cancer therapy-related cardiac dysfunction (CTRCD) is when the heart's ability to pump oxygenated blood to the body is compromised. It is a side effect of cancer therapy which can occur as commonly as in 1 in 5 patients. When this occurs, heart failure medications are started to protect the heart f…

   Stage

   Phase 4

   Ages

   18 and older

   Site

   Brigham and Women's Hospital, Boston, Massachusetts

   Locations

   14 in total

   Run by

   Dinesh Thavendiranathan

   See if you can join NCT06183437 on ClinicalTrials.gov

5. UPBEAT: Using Polygenic Scores to Guide BB Therapy in HF With Mildly Reduced EF

   This study will use polygenic scores, a tool which describes differences in genetics, to examine effectiveness of beta blocker medication in heart failure patients with ejection fraction of 41-50 percent. The study will also assess beta blockers' effect on the changes in left ventricular end-systol…

   Stage

   Not phased

   Ages

   18 to 89

   Site

   Henry Ford Health, Detroit, Michigan

   Run by

   David Lanfear

   See if you can join NCT07054489 on ClinicalTrials.gov

6. 18F-mFBG Imaging for Myocardial Sympathetic Innervation

   This is a Phase 2 study evaluating the positron-emitting radiopharmaceutical 18F-mFBG as an imaging agent for quantification of myocardial sympathetic innervation. The study will examine a group of stable patients with heart failure (HF) from ischemic cardiomyopathy. All subjects will have left ven…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   UT Health Houston, Houston, Texas

   Run by

   Innervate Radiopharmaceuticals LLC (Formerly: Illumina Radiopharmaceuticals LLC)

   See if you can join NCT06965621 on ClinicalTrials.gov

7. PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III

   This is a prospective, multi-center, open label, randomized control clinical trial evaluating the safety and efficacy of the Cordella™ Pulmonary Artery Sensor System in NYHA Class II-III Heart Failure Patients (PROACTIVE-HF-2 Trial). The study contains of 5 arms: NYHA II Cohort - To demonstrate saf…

   Stage

   Not phased

   Ages

   18 and older

   Site

   St. Joseph's Hospital and Medical Center, Phoenix, Arizona

   Locations

   48 in total

   Run by

   Endotronix, Inc.

   See if you can join NCT05934487 on ClinicalTrials.gov

8. Dietary Tracking in Heart Failure

   Emerging evidence links ultra processed foods (UPFs) to adverse cardiovascular outcomes. UPFs are often high in sodium, unhealthy fats and added sugars, while being low in essential nutrients and fiber. UPFs contribute to systemic inflammation, fluid retention, and metabolic dysfunction-key drivers…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Cleveland Clinic Main Campus, Cleveland, Ohio

   Run by

   The Cleveland Clinic

   See if you can join NCT07649148 on ClinicalTrials.gov

9. Wearable Technology in Heart Failure Patients

   The primary objective is to establish a Cleveland Clinic-led registry designed to integrate continuous physiological data from consumer wearables, captured by the HeartBit app and a Case Western Reserve University (CWRU)-based platform, with clinical data from patients' individual Electronic Health…

   Stage

   Not phased

   Ages

   18 to 85

   Site

   Cleveland Clinic, Cleveland, Ohio

   Run by

   The Cleveland Clinic

   See if you can join NCT07650669 on ClinicalTrials.gov

10. Quantifying New Heart Muscle Cells

    Regenerative therapies could provide new ways of treating heart failure. Unlike many organs in the human body, such as the skin and the GI tract, the ability to regenerate heart muscle decreases after birth, but the precise timing of this decrease and how this decrease is altered in heart disease a…

    Stage

    Not phased

    Ages

    0 to 1

    Site

    Weill Cornell Medicine, New York, New York

    Locations

    4 in total

    Run by

    Weill Medical College of Cornell University

    See if you can join NCT06587165 on ClinicalTrials.gov

11. Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure

    The purpose of TEAM-HF IDE clinical trial is to evaluate safety and effectiveness of the HeartMate 3 LVAS compared to guideline directed medical therapy (GDMT) in a population of ambulatory advanced heart failure patients who are not dependent on intravenous inotrope.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Banner-University Medical Center Phoenix, Phoenix, Arizona

    Locations

    68 in total

    Run by

    Abbott Medical Devices

    See if you can join NCT06526195 on ClinicalTrials.gov

12. Gator SCALES-WHF: SubCutaneous Administration of Lasix to Eliminate Symptoms of Worsening Heart Failure

    The primary objective of the study is to develop, implement, and evaluate a site-specific clinical pathway for at-home treatment of eligible patients presenting to the clinic with worsening heart failure. The secondary objectives are: 1. To evaluate patient factors related to parenteral decongestio…

    Stage

    Phase 4

    Ages

    18 to 80

    Site

    University of Florida, Gainesville, Florida

    Run by

    University of Florida

    See if you can join NCT06979726 on ClinicalTrials.gov

13. CALM Study: Cardiomems Assisted Lvad Management

    This prospective, open label, randomized, single-center pilot clinical trial will determine if the rate of heart failure related (HFR) hospitalizations is less in LVAD patients whose PAP is monitored with the CardioMEMS device vs the control patients receiving standard of care treatment.

    Stage

    Not phased

    Ages

    21 to 85

    Site

    Baylor Scott & White The Heart Hospital - Plano, Plano, Texas

    Run by

    Baylor Research Institute

    See if you can join NCT07096544 on ClinicalTrials.gov

14. Home-based Cardiac Rehabilitation in Heart Failure

    This study evaluates a mobile health (mHealth) home-based cardiac rehabilitation program for patients with heart failure. We will stratify randomization between rural and urban populations, with the goal to assess implementation of cardiac rehabilitation across these two geographic areas. . The stu…

    Stage

    Phase 3

    Ages

    18 and older

    Site

    University of Texas Southwestern Medical Center, Dallas, Texas

    Locations

    2 in total

    Run by

    University of Texas Southwestern Medical Center

    See if you can join NCT06349941 on ClinicalTrials.gov

15. AI-Enabled Direct-from-ECG Ejection Fraction (EF) Severity Assessment Using COR ECG Wearable Monitor

    This prospective, multicenter, cluster-randomized controlled study aims to evaluate the accuracy of an investigational artificial intelligence (AI) Software as a Medical Device (SaMD) designed to compute ejection fraction (EF) severity categories based on the American Society of Echocardiography's …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Orange County Heart Institute, Orange, California

    Locations

    8 in total

    Run by

    Peerbridge Health, Inc

    See if you can join NCT06699056 on ClinicalTrials.gov

16. A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF)

    The purpose of this study is to learn about the safety and effects of the study medicine (PF-07328948) for the possible treatment of heart failure (HF).

    Stage

    Phase 2

    Ages

    18 to 79

    Site

    National Heart Institute, Beverly Hills, California

    Locations

    142 in total

    Run by

    Pfizer

    See if you can join NCT06991257 on ClinicalTrials.gov

17. IEEM-Heat and Heart Failure

    We will test the hypothesis that increasing skin wetness, and thus evaporative cooling, will attenuate the increase in core body temperature and accompanying cardiac stress during heat wave conditions in individuals with congestive heart failure. Secondly, we propose that wearing a water-saturated …

    Stage

    Not phased

    Ages

    45 and older

    Site

    Institute for Exercise and Environmental Medicine - Texas Health Presbyterian Hospital Dallas, Dallas, Texas

    Run by

    University of Texas Southwestern Medical Center

    See if you can join NCT06961929 on ClinicalTrials.gov

18. Mechanisms of Diuretic Resistance in Heart Failure, Aim 1

    This study will employ a randomized order, double-blind, repeated measures dose ranging design. This design was chosen in order to generate multiple within-subject serial loop diuretic dose response exposures. The overall study schema will include 75 heart failure (HF) patients.

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Yale University, New Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT05323487 on ClinicalTrials.gov

19. Mechanisms of Diuretic Resistance in Heart Failure, Aim 3

    Randomized double-blind placebo-controlled crossover study design

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Yale University, New Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT06209359 on ClinicalTrials.gov

20. CV Imaging of Metabolic Interventions

    Cardiovascular disease is the leading cause of death worldwide. It is becoming clearer that heart failure (HF) is closely associated with body's metabolism. Even before the heart becomes weaker, it responds to the stresses by changing the fuels it burns, which results in a reduction in the heart's …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Cardiovascular Innovation Research Center, Cleveland, Ohio

    Run by

    The Cleveland Clinic

    See if you can join NCT05650307 on ClinicalTrials.gov

21. Development of CIRC Technologies

    Cardiovascular disease is the leading cause of death worldwide. Advanced cardiovascular imaging using Magnetic Resonance Imaging (MRI) has proven to be effective in providing gold standard myocardial tissue characterization. Moreover, the intrinsic advantage of MRI's lack of exposure to ionizing ra…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Cardiovascular Innovation Research Center, Cleveland, Ohio

    Run by

    The Cleveland Clinic

    See if you can join NCT05654272 on ClinicalTrials.gov

22. Early Assessment and Initiation of GuideLine-Directed Evidence-Based Management-HF

    EAGLE-HF (Early Assessment and initiation of GuideLine-directed Evidence-based management-HF) is a prospective single site study of a multinational, unblinded, randomized-controlled, longitudinal trial called SYMPHONY. Primary, secondary and exploratory outcomes that are part of SYMPHONY are not de…

    Stage

    Not phased

    Ages

    40 and older

    Site

    Cleveland Clinic, Cleveland, Ohio

    Run by

    The Cleveland Clinic

    See if you can join NCT06849752 on ClinicalTrials.gov

23. Using Ultromics EchoGo HFpEF Algorithm to Identify and Treat High Heart Failure Risk in Patients With Type 2 Diabetes

    A pragmatic electronic health record (EHR) based randomized controlled trial to evaluate the utility of providing Ultromics EchoGo analysis results and recommendations for HF risk prevention therapies using an EHR embedded clinical decision support tool.

    Stage

    Not phased

    Ages

    Any age

    Site

    UT Southwestern Medical Center, Dallas, Texas

    Run by

    University of Texas Southwestern Medical Center

    See if you can join NCT06593314 on ClinicalTrials.gov

24. Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiometabolic, and Musculoskeletal Disorder Research (VALD)

    The purpose of this research study is to validate (check the accuracy of) laboratory assays, intravenous catheter insertion, and equipment or devices and their reproducibility, which is necessary to perform high quality research on chronic diseases, nutrition, and metabolism (the process by which a…

    Stage

    Not phased

    Ages

    18 to 100

    Site

    University of Missouri-Columbia, Columbia, Missouri

    Run by

    Bettina Mittendorfer

    See if you can join NCT07083557 on ClinicalTrials.gov

25. The Inorganic Nitrate and eXercise Performance in Heart Failure (iNIX-HF)

    The goals of this project are to determine the effectiveness of acute (2 hours after a single dose) and chronic (after 6 weeks of once-a-day dosing) KNO3 treatment (10mmol) vs. placebo on quadriceps muscle power and on aerobic exercise performance (V̇O2peak) in patients with HFrEF (left ventricular…

    Stage

    Phase 2

    Ages

    19 to 79

    Site

    Washington University School of Medicine, St Louis, Missouri

    Run by

    Washington University School of Medicine

    See if you can join NCT05562167 on ClinicalTrials.gov