Heart Failure Clinical Trials

151 studies are recruiting for heart failure in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 6

1. His Bundle Pacing in Bradycardia and Heart Failure

   Participants in this study will either have heart failure (HF) and are scheduled to undergo pace maker (PM) implantation, cardiac resynchronization therapy pacemaker (CRT-P), cardiac resynchronization therapy defibrillator (CRT-D) implantation, His bundle pacing (HIBP) or left bundle area pacing (L…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Mayo Clinic, Rochester, Minnesota

   Run by

   Yong-Mei Cha

   See if you can join NCT03008291 on ClinicalTrials.gov

2. Remote Ischemic Preconditioning for Renal and Cardiac Protection in Congestive Heart Failure (RICH) Trial

   This is a prospective, double-blind, sham-controlled, multicenter, randomized clinical trial is to study the effects of remote ischemic preconditioning on contrast-associated acute kidney injury, functional capacity, and major adverse kidney events in in patients with congestive heart failure under…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA, Pittsburgh, Pennsylvania

   Locations

   3 in total

   Run by

   VA Office of Research and Development

   See if you can join NCT04982419 on ClinicalTrials.gov

3. A SkeleTal Muscle Recovery Intervention With Dietary Protein in Heart Failure

   Severe skeletal wasting and catabolic weight loss are highly common among patients with heart failure with reduced ejection fraction (HFrEF). This prospective randomized controlled trial will compare changes in the muscle mass in the arms and the legs (appendicular lean mass) in patients with HFrEF…

   Stage

   Not phased

   Ages

   18 to 100

   Site

   Tufts Medical Center, Boston, Massachusetts

   Locations

   2 in total

   Run by

   Tufts Medical Center

   See if you can join NCT05627440 on ClinicalTrials.gov

4. Real World Effectiveness of the Cordella Pulmonary Artery Sensor System in Patients With Chronic Heart Heart Failure

   This retrospective, non-randomized cohort study will evaluate how well the Cordella PA Sensor System works compared to standard medication treatment in people with chronic heart failure. The study will track patients for two years to see if those using the Cordella system have fewer deaths and hosp…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Endotronix, Naperville, Illinois

   Run by

   Endotronix, Inc.

   See if you can join NCT06783335 on ClinicalTrials.gov

5. Enhanced Nutritional Optimization in LVAD Trial

   The goal of this clinical trial is to assess whether a peri-operative intervention with nutritional immune modulating intervention (Ensure Surgery Immunonutrition shake) has beneficial effects on the complex interplay between gut microbiome, systemic inflammation and malnutrition that is commonly p…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Columbia University Medical Center, New York, New York

   Run by

   Columbia University

   See if you can join NCT05655910 on ClinicalTrials.gov

6. Pulmonary Artery Catheter in Cardiogenic Shock Trial

   The primary objective of the PACCS trial is to assess if early invasive hemodynamic assessment and ongoing management with a PAC in patients with cardiogenic shock due to acutely decompensated heart failure (AHDF-CS) is associated with lower in-hospital mortality risk compared to the current standa…

   Stage

   Not phased

   Ages

   18 to 90

   Site

   Tufts Medical Center, Boston, Massachusetts

   Run by

   Tufts Medical Center

   See if you can join NCT05485376 on ClinicalTrials.gov

7. Ertugliflozin in Chronic Heart Failure

   The purpose of this study is to determine the effects on heart failure signs and symptoms of the use of either ertugliflozin, metolazone or placebo, in conjunction with intravenous loop diuretic use in acute settings and chronic oral loop diuretic therapy. There are two general purposes for this st…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Yale School of Medicine, New Haven, Connecticut

   Run by

   Yale University

   See if you can join NCT04438213 on ClinicalTrials.gov

8. Left vs Left Randomized Clinical Trial

   The investigators aim to prospectively test the comparative effectiveness of His or Left bundle branch pacing in relation to patient centered outcomes (quality of life, physical activity, heart failure hospitalization, mortality) and comparative safety in relation to device-related complications an…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Mercy Gilbert & Chandler Regional Medical Centers, Gilbert AZ, Gilbert, Arizona

   Locations

   71 in total

   Run by

   Baylor College of Medicine

   See if you can join NCT05650658 on ClinicalTrials.gov

9. A Nurse-Led Weight Monitoring Intervention For Heart Failure Quality of LIfe and Self-Care

   Ongoing self-care for heart failure is essential to avoid complications and hospitalization. Supportive strategies are needed; however, patients with heart failure may find many interventions complicated and overwhelming. The purpose of this pilot study is to implement a simple weight tracking tool…

   Stage

   Not phased

   Ages

   55 and older

   Site

   Cleveland Clinic Avon Hospital, Avon, Ohio

   Run by

   Lee Anne Siegmund

   See if you can join NCT07184541 on ClinicalTrials.gov

10. UIC Multi-Ethnic DCM Registry

    Dilated cardiomyopathy (DCM), a condition where the heart loses its ability to pump blood throughout the body, is a common cause of death in the United States (US). It affects minorities more frequently and appears to causes greater harm than Whites. However, almost all research related to DCM has …

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Illinois Hospital & Health Sciences, Chicago, Illinois

    Run by

    University of Illinois at Chicago

    See if you can join NCT07145138 on ClinicalTrials.gov

11. Lifestyle Medicine: Establishing Clinical Approaches to Chronic Disease for Rural Patients

    Developed nations worldwide are currently enduring a health crisis, as chronic diseases continue to decrease quality of life and promote additional disease states or even death for much of the population. Rural populations are at a particular disadvantage, as they lack access to health clubs, welln…

    Stage

    Not phased

    Ages

    18 to 64

    Site

    West Virginia School of Osteopathic Medicine, Lewisburg, West Virginia

    Run by

    West Virginia School of Osteopathic Medicine

    See if you can join NCT06049420 on ClinicalTrials.gov

12. Integration of Telemedicine and Home-Based Cardiac Rehabilitation: Feasibility, Efficacy, and Adherence

    The aim of this study is to evaluate feasibility, efficacy, and adherence of home-based cardiac rehabilitation with the integration of telemedicine. Several components will be assessed such as quality-of-life, nutritional counseling, maximum metabolic activity (MET's), diabetic management, tobacco …

    Stage

    Not phased

    Ages

    18 and older

    Site

    ROMTech, Brookfield, Connecticut

    Run by

    ROM Technologies, INC

    See if you can join NCT05972070 on ClinicalTrials.gov

13. A Multi-center, National, Open-label, Prospective Study to Evaluate the Performance of the V-Lap™ System

    The objective of this study is to evaluate the safety and performance of the V-LAP System in subjects with New York Heart Association (NYHA) functional class II and III HF, irrespective of left ventricular ejection fraction.

    Stage

    Not phased

    Ages

    22 to 88

    Site

    One Boston Medical Center Place, Boston, Massachusetts

    Run by

    Vectorious Medical Technologies Ltd.

    See if you can join NCT06147336 on ClinicalTrials.gov

14. Studies of Neuregulin/ERBB Signaling in Human Heart

    This study examines the role of the epidermal growth factor (EGF) receptor family and the EGF family of ligands in the regulation of non-myocytes isolated from the human heart.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Maine Medical Center, Portland, Maine

    Run by

    Douglas B. Sawyer

    See if you can join NCT02820233 on ClinicalTrials.gov

15. AN INTERNATIONAL, OBSERVATIONAL, BLINDED STUDY TO ASSESS THE PERFORMANCE OF THE CORDIO HEARO SYSTEM

    Study Design: This is an international, multicenter, observational, non-interventional, prospective, blinded, single-arm, two-period study, to collect patient utterances that will be retrospectively analyzed to determine the sensitivity and UPNR of the HearO system.

    Stage

    Not phased

    Ages

    22 and older

    Site

    Eastern Shore Research Institute, Fairhope, Alabama

    Locations

    45 in total

    Run by

    Cordio Medical

    See if you can join NCT06378632 on ClinicalTrials.gov

16. Dilated Cardiomyopathy Detection Using AI and Screening With Mobile Technology (DCM-DETECT)

    This is a prospective, single-arm clinical trial in which participants with dilated cardiomyopathy will invite their first degree relatives to undergo mobile cardiac, electrocardiogram screening.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Lancaster General Hospital, Lancaster, Pennsylvania

    Run by

    Lancaster General Hospital

    See if you can join NCT06688396 on ClinicalTrials.gov

17. Get With The Guidelines-Heart Failure Registry

    Get With The Guidelines-Heart Failure is designed to improve the quality of care in patients hospitalized with heart failure. The program aims to help ensure that eligible patients are initiated on guideline recommended therapies and receive appropriate counseling prior to hospital discharge.

    Stage

    Not phased

    Ages

    18 to 125

    Site

    Amy Bennett, Dallas, Texas

    Run by

    American Heart Association

    See if you can join NCT02693509 on ClinicalTrials.gov

18. Cardiotoxicity Assessment Through Comprehensive Heart Imaging to Predict Heart Failure

    Anthracycline chemotherapies (e.g. doxorubicin, daunorubicin) are commonly given to treat pediatric cancer, and carry a risk of cardiotoxicity. Over the long term, children who receive these therapies have an increased risk of heart failure and early cardiovascular death. However, current strategie…

    Stage

    Not phased

    Ages

    13 to 39

    Site

    Rady Children's Hospital, San Diego, California

    Run by

    Hari Narayan

    See if you can join NCT04262830 on ClinicalTrials.gov

19. Identification of Genomic Predictors of Adverse Events After Cardiac Surgery

    This study aims to identify genetic causes of adverse events after cardiac surgery, such as atrial fibrillation, myocardial infarction, renal dysfunction and heart failure. Patients undergoing heart surgery at Brigham and Women's Hospital and Texas Heart Institute are eligible to participate.

    Stage

    Not phased

    Ages

    20 to 90

    Site

    UT Southwestern Medical Center, Dallas, Texas

    Locations

    3 in total

    Run by

    Brigham and Women's Hospital

    See if you can join NCT01258231 on ClinicalTrials.gov

20. HF2 Registry - Hemodynamic Frontiers in Heart Failure Registry

    The purpose of the HF2 (Hemodynamic Frontiers in Heart Failure) registry is to collect relevant patient-level demographic, clinical, laboratory, and hemodynamic data from patients implanted with pulmonary artery pressure sensor at participating centers to advance scientific knowledge about ambulato…

    Stage

    Not phased

    Ages

    18 to 100

    Site

    Scripps Health, La Jolla, California

    Locations

    12 in total

    Run by

    University of Kansas Medical Center

    See if you can join NCT06425848 on ClinicalTrials.gov

21. Colchicine in Acutely Decompensated HFREF

    This is a double blind, placebo-controlled pilot trial randomizing patients admitted to the hospital with acutely decompensated heart failure (ADHF) and inflammation to receive either colchicine or matching placebo. Upon enrollment, patients will be randomized 1:1 to receive either the experimental…

    Stage

    Phase 4

    Ages

    18 and older

    Site

    UVA Health, Charlottesville, Virginia

    Run by

    University of Virginia

    See if you can join NCT06286423 on ClinicalTrials.gov

22. Implantable Cardioverter Defibrillator (ICD Registry)

    The ICD Registry™ is a nationwide quality program that helps participating hospitals measure and improve care for patients receiving implantable cardioverter defibrillators (ICDs) and cardiac resynchronization therapy devices with defibrillator (CRT-Ds). The ICD Registry captures the characteristic…

    Stage

    Not phased

    Ages

    Any age

    Site

    American College of Cardiology/National Cardiovascular Data Registry (NCDR), Washington D.C., District of Columbia

    Run by

    American College of Cardiology

    See if you can join NCT01999140 on ClinicalTrials.gov

23. Modulation of SERCA2a of Intra-myocytic Calcium Trafficking in Heart Failure With Reduced Ejection Fraction

    It is believed that targeted SERCA2a enzyme replacement in HFrEF patients will correct defective intracellular Ca2+ hemostasis, resulting in improved cardiac contractile function and energetics which will, in turn, translate to improved clinical outcomes. Additionally, it is hypothesized that corre…

    Stage

    Phase 1

    Ages

    18 to 80

    Site

    San Diego Cardiac Center, San Diego, California

    Locations

    5 in total

    Run by

    Sardocor Corp.

    See if you can join NCT04703842 on ClinicalTrials.gov

24. Care Coordination to Assess Improvement in Outcomes in Hospital Readmissions

    Heart failure is a syndrome that is defined by distinctive clinical, hemodynamic, and neurohormonal findings. HF represents a final common pathway for many different cardiovascular diseases, including coronary disease, hypertension, Valvular disease, and many primary heart muscle diseases. Clinical…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Multiple Locations, Phoenix, Arizona

    Run by

    Aventyn, Inc.

    See if you can join NCT04905160 on ClinicalTrials.gov

25. Screening for earlY Heart Failure Diagnosis and Management in Primary Care or at HOme Using Natriuretic Peptides and echocardiographY "SYMPHONY-HF"

    This is an international prospective, multicentre, unblinded, randomised-controlled trial. The primary aim is to assess a targeted screening strategy to detect undiagnosed heart failure in high-risk patients.

    Stage

    Not phased

    Ages

    40 and older

    Site

    University of Glasgow, Glasgow, Scotland

    Locations

    7 in total

    Run by

    NHS Greater Glasgow and Clyde

    See if you can join NCT05919342 on ClinicalTrials.gov