Sickle Cell Disease Clinical Trials

92 studies are recruiting for sickle cell disease in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 4

1. Virtual Reality Devices as an Adjunct to Usual Care for Patients With Sickle Cell Disease Experiencing Vaso-Occlusive Crises

   This study aims to evaluate the use of virtual reality as an adjunct to standard care for patients with sickle cell disease experiencing vaso-occlusive crises.

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Maryland Medical Systems, Baltimore, Maryland

   Run by

   University of Maryland, Baltimore

   See if you can join NCT06184126 on ClinicalTrials.gov

2. A Pilot Study on Neuroimaging in SCD: Part of The Boston Consortium to Cure Sickle Cell Disease

   Sickle Cell Disease (SCD) impairs oxygen transport to tissue and causes endothelial injury. Thus, therapeutic interventions aim to improve both, but there is an unmet need for biomarkers to determine when intervention is necessary and evaluate the effectiveness of the chosen intervention in individ…

   Stage

   Not phased

   Ages

   8 to 18

   Site

   Boston Children's Hospital, Boston, Massachusetts

   Run by

   Boston Children's Hospital

   See if you can join NCT04166526 on ClinicalTrials.gov

3. SMYLS Multi-site Trial

   The purpose of this study is to find out whether a web-based intervention using a mobile app is helpful for teens and young adults with sickle cell disease (SCD) in learning how to care for and manage their symptoms.

   Stage

   Not phased

   Ages

   14 to 21

   Site

   Medical University of South Carolina, Charleston, South Carolina

   Run by

   Medical University of South Carolina

   See if you can join NCT06035939 on ClinicalTrials.gov

4. Integrative Training Program for Pediatric Sickle Cell Pain

   This research aims to answer the question: does a group training program specifically for teens with chronic sickle cell disease (SCD) pain that teaches skills to strengthen the mind and body help improve everyday functioning and reduce pain symptoms? The program will be tailored to address challen…

   Stage

   Not phased

   Ages

   12 to 18

   Site

   Connecticut Children's Medical Center, Hartford, Connecticut

   Locations

   4 in total

   Run by

   Emory University

   See if you can join NCT06691867 on ClinicalTrials.gov

5. Cutaneous Hydration Assessment in SCD

   This study will validate the diagnostic accuracy of a cutaneous hydration sensor. This sensor will also be evaluated for its feasibility as a point-of-care device for the assessment of hydration status and its potential to guide hydration therapy in patients with sickle cell disease (SCD).

   Stage

   Not phased

   Ages

   12 and older

   Site

   UPMC Sickle Cell Clinic, Pittsburgh, Pennsylvania

   Run by

   Enrico Novelli

   See if you can join NCT05210114 on ClinicalTrials.gov

6. Cannabinoids for the Reduction of Inflammation and Sickle Cell Related Pain

   A randomized, double blind, study of dronabinol as a palliative agent in the treatment of pain, inflammation, and other complications of sickle cell disease (SCD).

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Mount Sinai Hospital, New York, New York

   Run by

   Icahn School of Medicine at Mount Sinai

   See if you can join NCT05519111 on ClinicalTrials.gov

7. Sickle Cell Disease Transplant Using a Nonmyeloablative Approach for Patients With Anti-donor Red Cell Antibody

   This multicenter prospective study seeks to determine if daratumumab given, prior to HLA-identical sibling donor transplantation using alemtuzumab, low dose total-body irradiation, and sirolimus, can prevent pure red blood cell aplasia with an acceptable safety profile in patients with anti-donor r…

   Stage

   Phase 2

   Ages

   2 to 25

   Site

   Children's National Hospital, Washington D.C., District of Columbia

   Run by

   Children's National Research Institute

   See if you can join NCT06358638 on ClinicalTrials.gov

8. Cerebral Oxygen Metabolism in Children

   The purpose of this research study is to better understand how blood flow and metabolism change can influence brain development in the early decades of life. We will examine brain blood flow and metabolism using magnetic resonance imaging (MRI). The brain's blood vessels expand and constrict to reg…

   Stage

   Not phased

   Ages

   3 to 50

   Site

   Washington University of St. Louis, St Louis, Missouri

   Run by

   Washington University School of Medicine

   See if you can join NCT04157179 on ClinicalTrials.gov

9. AlloSCT for Malignant and Non-malignant Hematologic Diseases Utilizing Alpha/Beta T Cell and CD19+ B Cell Depletion

   Children, adolescents, and young adults with malignant and non-malignant conditionsundergoing an allogeneic stem cell transplantation (AlloSCT) will have the stem cells selected utilizing α/β CD3+/CD19+ cell depletion. All other treatment is standard of care.

   Stage

   Phase 2

   Ages

   0 to 30

   Site

   New York Medical College, Valhalla, New York

   Run by

   Mitchell Cairo

   See if you can join NCT04099966 on ClinicalTrials.gov

10. Bone Loss, Physical Function and Frailty in Older Women With Sickle Cell Trait Sickle Cell Trait

    This is a cross-sectional, clinical research study comparing postmenopausal women of African Descent (AD) with different hemoglobin genotypes: normal and sickle cell trait (SCT). This research study has two purposes. The first purpose is to determine whether having SCT is a risk factor for the deve…

    Stage

    Not phased

    Ages

    50 and older

    Site

    UConn Health, Farmington, Connecticut

    Run by

    UConn Health

    See if you can join NCT07083531 on ClinicalTrials.gov

11. Cannabidiol in Sickle Cell Disease

    Randomized, placebo-controlled, double masked, dose finding study of twice daily cannabidiol given at 3 dose levels, 200mg, 400mg, and 600mg, compared to placebo for 4 weeks.

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Icahn School of Medicine at Mount Sinai, Manhattan, New York

    Run by

    Icahn School of Medicine at Mount Sinai

    See if you can join NCT06930703 on ClinicalTrials.gov

12. Recruitment and Engagement in Care to Impact Practice Enhancement (RECIPE) for Sickle Cell Disease

    The goal of this observational study is to help us understand more about the best ways to help individuals living with Sickle Cell Disease (SCD) get the best care. The main question it aims to answer is: How to find individuals unaffiliated from SCD specialist care use three distinct pathways? Once…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Alabama, Birmingham (UAB), Birmingham, Alabama

    Locations

    9 in total

    Run by

    RTI International

    See if you can join NCT06385886 on ClinicalTrials.gov

13. A Study of Nicotinamide With Oral Tetrahydrouridine and Decitabine to Treat High Risk Sickle Cell Disease

    A randomized control trial in 20 subjects with sickle cell disease comparing oral THU-decitabine to nicotinamide and in combination (THU, decitabine and nicotinamide).

    Stage

    Phase 1

    Ages

    18 and older

    Site

    University of Illinois at Chicago College of Medicine, Chicago, Illinois

    Run by

    EpiDestiny, Inc.

    See if you can join NCT04055818 on ClinicalTrials.gov

14. Advancing Feasibility and Acceptability of Digital Cognitive Rehabilitation in Sickle Cell Disease

    This is a single site nonrandomized pilot clinical trial of the feasibility, acceptability, and efficacy of a combination treatment involving digital Cogmed working memory skills training, social support components, and memory strategy training to improve adherence to Cogmed in youth with sickle ce…

    Stage

    Not phased

    Ages

    7 to 16

    Site

    Children's National Hospital, Washington D.C., District of Columbia

    Run by

    Children's National Research Institute

    See if you can join NCT06770010 on ClinicalTrials.gov

15. Virtual Reality As Adjunct Therapy for Vaso-Occlusive Pain

    The goal of this randomized control clinical trial is to learn if virtual reality can be used to treat sickle cell pain in children. The main questions it aims to answer are: Does virtual reality reduce pain severity during a child's hospital stay for a vaso-occlusive pain crisis? Does virtual real…

    Stage

    Not phased

    Ages

    8 to 21

    Site

    Children's Hospital of New Orleans, New Orleans, Louisiana

    Run by

    Louisiana State University Health Sciences Center in New Orleans

    See if you can join NCT06773715 on ClinicalTrials.gov

16. Feasibility and Efficacy of Attentional-Control Training in Sickle Cell Disease

    Children with sickle cell disease (SCD) exhibit significantly reduced cognitive functioning (often difficulties with attention) compared to peers and siblings without SCD. EndeavorRx (Akili Interactive Labs: Boston, MA) is an FDA-approved home-based, electronic attentional-control training program …

    Stage

    Not phased

    Ages

    8 to 16

    Site

    Children's National Hospital, Washington D.C., District of Columbia

    Run by

    Children's National Research Institute

    See if you can join NCT05099874 on ClinicalTrials.gov

17. Study of the Role of Genetic Modifiers in Hemoglobinopathies

    This study will investigate the role of genetic modifiers in hemoglobinopathies through a large-scale, multi-ethnic genome-wide association study (GWAS).

    Stage

    Not phased

    Ages

    2 and older

    Site

    Boston Children's Hospital, Boston, Massachusetts

    Locations

    26 in total

    Run by

    Cyprus Institute of Neurology and Genetics

    See if you can join NCT05799118 on ClinicalTrials.gov