Sickle Cell Disease Clinical Trials in Atlanta, Georgia

16 studies are recruiting for sickle cell disease in Atlanta, Georgia right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. A Research Study Looking at Long-term Treatment With Etavopivat in People With Sickle Cell Disease or Thalassaemia

   Etavopivat is a new medicine under development for treating blood disorders like sickle cell disease and thalassaemia. Sickle cell disease and thalassaemia are inherited blood disorders that affect haemoglobin. Haemoglobin is the protein that carries oxygen through the body. This study is looking i…

   Stage

   Phase 3

   Ages

   2 and older

   Site

   Children's Healthcare Atlanta, Atlanta, Georgia

   Locations

   107 in total

   Run by

   Novo Nordisk A/S

   See if you can join NCT06609226 on ClinicalTrials.gov

2. A Study to Evaluate How Well Etavopivat Works in People With Sickle Cell Disease

   This study is conducted to confirm whether etavopivat works well at reducing the number of Vaso-occlusive crisis VOCs (sickle cell pain crises) caused by obstructions in blood vessels in adults and adolescents living with sickle cell disease. The study will also evaluate how well etavopivat can red…

   Stage

   Phase 3

   Ages

   12 and older

   Site

   Children's Healthcare Atlanta, Atlanta, Georgia

   Locations

   175 in total

   Run by

   Novo Nordisk A/S

   See if you can join NCT06612268 on ClinicalTrials.gov

3. A Phase 1b, Open-Label Study of DISC-3405 in Participants With Sickle Cell Disease (SCD)

   This is an open-label, multicenter, within-participant dose-escalation study examining up to 3 dose levels of DISC-3405 and will assess the safety, tolerability, PK, and PD of DISC 3405 in participants with sickle cell disease.

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Emory University, Atlanta, Georgia

   Locations

   9 in total

   Run by

   Disc Medicine, Inc

   See if you can join NCT07187973 on ClinicalTrials.gov

4. Assessing Molecular Mechanisms and Effects of Music Therapy in Youth With Sickle Cell Disease Using Single-cell RNA-sequencing

   The goal of this clinical trial is to evaluate whether a 4-week music therapy (MT) intervention can reduce chronic pain and improve psychosocial outcomes in youth with sickle cell disease (SCD). The main questions it aims to answer are: * Does MT reduce pain intensity, frequency of pain episodes, a…

   Stage

   Not phased

   Ages

   8 to 18

   Site

   Children's Healthcare of Atlanta, Atlanta, Georgia

   Run by

   Emory University

   See if you can join NCT07562451 on ClinicalTrials.gov

5. A Phase 2/3 Study of Osivelotor in Adult and Adolescent Participants With SCD

   The purpose of this study is to evaluate the safety, tolerability, efficacy, pharmacokinetics and pharmacodynamics of osivelotor.

   Stage

   Phase 2

   Ages

   12 and older

   Site

   Children's Center for Advanced Pediatrics, Atlanta, Georgia

   Locations

   80 in total

   Run by

   Pfizer

   See if you can join NCT05431088 on ClinicalTrials.gov

6. ATHN Transcends: A Natural History Study of Non-Neoplastic Hematologic Disorders

   In parallel with the growth of ATHN's clinical studies, the number of new therapies for all blood disorders is increasing significantly. Some of the recently FDA-approved therapies for congenital and acquired hematologic conditions have not yet demonstrated long-term safety and effectiveness beyond…

   Stage

   Not phased

   Ages

   Any age

   Site

   Comprehensive Bleeding Disorders Center at Emory University and Children's Healthcare of Atlanta, Atlanta, Georgia

   Locations

   76 in total

   Run by

   American Thrombosis and Hemostasis Network

   See if you can join NCT04398628 on ClinicalTrials.gov

7. Safety of Anumigilimab (CSL324) in Adults With Sickle Cell Disease (SCD)

   This is a phase 2a, global, multicenter, randomized, double-blind, placebo-controlled study investigating the safety of anumigilimab administered subcutaneously (SC) at the maximum tolerated dose (MTD) in adult participants with SCD. The primary aim of the study is to assess the safety of anumigili…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Arthur M. Blank Hospital- Children's Healthcare of Atlanta, Atlanta, Georgia

   Locations

   16 in total

   Run by

   CSL Behring

   See if you can join NCT07224360 on ClinicalTrials.gov

8. Arginine Therapy for the Treatment of Pain in Children With Sickle Cell Disease

   The purpose of this study is to determine whether giving extra arginine to patients with sickle cell disease seeking treatment for vaso-occlusive painful events (VOE) will decrease pain scores, decrease need for pain medications or decrease length of hospital stay or emergency department visit.

   Stage

   Phase 1

   Ages

   7 to 21

   Site

   Children's Healthcare fo Atlanta at Hughes Spalding, Atlanta, Georgia

   Locations

   2 in total

   Run by

   Emory University

   See if you can join NCT02447874 on ClinicalTrials.gov

9. Cooperative Assessment of Late Effects for SCD Curative Therapies

   Sickle Cell Disease is one of the most common genetic diseases in the United States, occurring in approximately 1 in 400 births. Approximately 100,000 individuals are diagnosed with SCD in the United States. Mortality for children with SCD has decreased substantially over the past 4 decades, with >…

   Stage

   Not phased

   Ages

   4 to 65

   Site

   Emory University School of Medicine, Atlanta, Georgia

   Locations

   5 in total

   Run by

   Vanderbilt University Medical Center

   See if you can join NCT05153967 on ClinicalTrials.gov

10. Ruxolitinib-Enhanced Haplo HCT for Children and Young Adults With Sickle Cell Disease

    This trial will determine whether adding ruxolitinib to a reduced intensity conditioning (RIC) regimen reduces the rate of graft failure following haploidentical (haplo) hematopoietic cell transplant (HCT) for children and young adults with sickle cell disease (SCD). This study will enroll and trea…

    Stage

    Phase 1

    Ages

    12 to 45

    Site

    Children's Healthcare of Atlanta, Atlanta, Georgia

    Locations

    4 in total

    Run by

    Arkansas Children's Hospital Research Institute

    See if you can join NCT07252050 on ClinicalTrials.gov

11. Study of a Single Dose of a 21-valent Pneumococcal Conjugate Vaccine in Children and Adolescents With Sickle Cell Disease

    The purpose of this study is to measure whether PCV21 vaccine (investigational pneumococcal vaccine) is safe and can help the body to develop germ-fighting agents called "antibodies" (immunogenicity) compared with 20vPCV (licensed pneumococcal vaccine) when given as a single dose to children aged 2…

    Stage

    Phase 3

    Ages

    2 to 17

    Site

    Site # 8400006, Atlanta, Georgia

    Locations

    7 in total

    Run by

    Sanofi

    See if you can join NCT07247188 on ClinicalTrials.gov

12. Prophylactic Transfusion In Pregnant in Women With Sickle Cell Disease

    The goal of this study is to determine if there is a positive effect of prophylactic red blood cell (RBC) transfusion of leukoreduced, ABO, Rh (D/Cc/Ee) and Kell matched blood compared to standard of care on the number of episodes of acute sickle cell disease (SCD) manifestations or pregnancy-relat…

    Stage

    Phase 4

    Ages

    18 and older

    Site

    Grady Health System, Atlanta, Georgia

    Run by

    Emory University

    See if you can join NCT06979492 on ClinicalTrials.gov

13. A Long-term Follow-up Study in Patients Who Received BEAM-101

    This is a Long-term Follow-up (LTFU) study in patients who received BEAM-101 in the parent study (Study BTX-AUT-001). Eligible patients who received BEAM-101 will be asked to participate in this LTFU study prior to completing Study BTX-AUT-001. Patients who enter into this study will be followed fo…

    Stage

    Not phased

    Ages

    14 to 37

    Site

    Children's Healthcare of Atlanta - Aflac Cancer and Blood Disorders Center- Egleston, Atlanta, Georgia

    Locations

    17 in total

    Run by

    Beam Therapeutics Inc.

    See if you can join NCT07373639 on ClinicalTrials.gov

14. Trans-auricular Nerve Stimulation as an Innovative Approach to the Treatment of Pain in Pediatric Patients Suffering From Sickle Cell Disease

    The goal of this study is to evaluate the effects of transauricular vagus and trigeminal nerve stimulation on the treatment of pain in children with Sickle Cell Disease. * The primary objective is to determine the feasibility of using a tAN device to treat pain in pediatric participants with SCD by…

    Stage

    Not phased

    Ages

    7 to 18

    Site

    Children's Hospital of Atlanta: Eagelston, Atlanta, Georgia

    Run by

    Emory University

    See if you can join NCT07090668 on ClinicalTrials.gov

15. Peer Support for Adolescents and Emerging Adults With Sickle Cell Pain

    The study, known as the Peer suppoRt for adolescents and Emerging adults with Sickle cell pain: promoting ENgagement in Cognitive behavioral thErapy (PRESENCE), aims to determine the effectiveness of digital CBT in reducing pain, opioid use, and healthcare utilization among AYAs with SCD. It also s…

    Stage

    Not phased

    Ages

    16 to 30

    Site

    Children's Healthcare of Atlanta, Atlanta, Georgia

    Locations

    14 in total

    Run by

    University of Pittsburgh

    See if you can join NCT06374238 on ClinicalTrials.gov

16. Integrative Training Program for Pediatric Sickle Cell Pain

    This research aims to answer the question: does a group training program specifically for teens with chronic sickle cell disease (SCD) pain that teaches skills to strengthen the mind and body help improve everyday functioning and reduce pain symptoms? The program will be tailored to address challen…

    Stage

    Not phased

    Ages

    12 to 18

    Site

    Children's Healthcare of Atlanta, Atlanta, Georgia

    Locations

    4 in total

    Run by

    Emory University

    See if you can join NCT06691867 on ClinicalTrials.gov