Sickle Cell Disease Clinical Trials in Durham, North Carolina

8 studies are recruiting for sickle cell disease in Durham, North Carolina right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. A Research Study Looking at Long-term Treatment With Etavopivat in People With Sickle Cell Disease or Thalassaemia

   Etavopivat is a new medicine under development for treating blood disorders like sickle cell disease and thalassaemia. Sickle cell disease and thalassaemia are inherited blood disorders that affect haemoglobin. Haemoglobin is the protein that carries oxygen through the body. This study is looking i…

   Stage

   Phase 3

   Ages

   2 and older

   Site

   Duke University_Durham, Durham, North Carolina

   Locations

   107 in total

   Run by

   Novo Nordisk A/S

   See if you can join NCT06609226 on ClinicalTrials.gov

2. A Study to Evaluate How Well Etavopivat Works in People With Sickle Cell Disease

   This study is conducted to confirm whether etavopivat works well at reducing the number of Vaso-occlusive crisis VOCs (sickle cell pain crises) caused by obstructions in blood vessels in adults and adolescents living with sickle cell disease. The study will also evaluate how well etavopivat can red…

   Stage

   Phase 3

   Ages

   12 and older

   Site

   Duke Comprehen Sickle Cell, Durham, North Carolina

   Locations

   175 in total

   Run by

   Novo Nordisk A/S

   See if you can join NCT06612268 on ClinicalTrials.gov

3. A Phase 1b, Open-Label Study of DISC-3405 in Participants With Sickle Cell Disease (SCD)

   This is an open-label, multicenter, within-participant dose-escalation study examining up to 3 dose levels of DISC-3405 and will assess the safety, tolerability, PK, and PD of DISC 3405 in participants with sickle cell disease.

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Duke University Medical Center, Durham, North Carolina

   Locations

   9 in total

   Run by

   Disc Medicine, Inc

   See if you can join NCT07187973 on ClinicalTrials.gov

4. A Phase 2/3 Study of Osivelotor in Adult and Adolescent Participants With SCD

   The purpose of this study is to evaluate the safety, tolerability, efficacy, pharmacokinetics and pharmacodynamics of osivelotor.

   Stage

   Phase 2

   Ages

   12 and older

   Site

   Duke University IDS Pharmacy, Durham, North Carolina

   Locations

   80 in total

   Run by

   Pfizer

   See if you can join NCT05431088 on ClinicalTrials.gov

5. SickleFit Exercise and Nutrition Study

   To goal of this study is to pilot the SickleFit exercise and nutrition intervention in adults with sickle cell disease in a randomized control trial

   Stage

   Not phased

   Ages

   35 and older

   Site

   Duke University, Durham, North Carolina

   Run by

   Duke University

   See if you can join NCT07442851 on ClinicalTrials.gov

6. Predictors of Pain in Sickle Cell Disease

   Sickle cell disease is a painful inherited disorder that affects approximately 100,000 people in the United States, and more than half of these individuals develop chronic or persistent pain that is often severe and disabling. The factors that predict whether an individual with sickle cell disease …

   Stage

   Not phased

   Ages

   15 to 40

   Site

   Duke University Medical Center, Durham, North Carolina

   Run by

   Duke University

   See if you can join NCT06139510 on ClinicalTrials.gov

7. Zinc Supplementation in Sickle Cell Disease: A Precursor to the Think Zinc for Bones Trial

   The goal of this short term prospective Phase II study is to compare the effects of two alternate daily doses of zinc (25 and 40 mg/day) in 34 randomly assigned homozygous Sickle Cell Disease (SCD-SS) patients aged 15-40 years old. The main question it aims to answer is: Which biomarkers are most r…

   Stage

   Phase 2

   Ages

   15 to 40

   Site

   Duke University Medical Center, Durham, North Carolina

   Locations

   6 in total

   Run by

   University of California, San Francisco

   See if you can join NCT06260891 on ClinicalTrials.gov

8. Peer Support for Adolescents and Emerging Adults With Sickle Cell Pain

   The study, known as the Peer suppoRt for adolescents and Emerging adults with Sickle cell pain: promoting ENgagement in Cognitive behavioral thErapy (PRESENCE), aims to determine the effectiveness of digital CBT in reducing pain, opioid use, and healthcare utilization among AYAs with SCD. It also s…

   Stage

   Not phased

   Ages

   16 to 30

   Site

   Wake Forest Baptist Hospital, Durham, North Carolina

   Locations

   14 in total

   Run by

   University of Pittsburgh

   See if you can join NCT06374238 on ClinicalTrials.gov