Sickle Cell Disease Clinical Trials

92 studies are recruiting for sickle cell disease in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 3

1. Predictors of Pain in Sickle Cell Disease

   Sickle cell disease is a painful inherited disorder that affects approximately 100,000 people in the United States, and more than half of these individuals develop chronic or persistent pain that is often severe and disabling. The factors that predict whether an individual with sickle cell disease …

   Stage

   Not phased

   Ages

   15 to 40

   Site

   Duke University Medical Center, Durham, North Carolina

   Run by

   Duke University

   See if you can join NCT06139510 on ClinicalTrials.gov

2. Gene Editing For Sickle Cell Disease

   This study is being done to test the safety of a new treatment called gene editing in Sickle Cell Disease (SCD) patients and to see if a single dose of this genetically modified cellular product will increase the amount of a certain hemoglobin called fetal hemoglobin (HbF) and help reduce the sympt…

   Stage

   Phase 1

   Ages

   18 to 24

   Site

   St. Jude Children's Research Hospital, Memphis, Tennessee

   Run by

   St. Jude Children's Research Hospital

   See if you can join NCT06506461 on ClinicalTrials.gov

3. Promoting Resilience Among Adolescents and Young Adults With Sickle Cell Disease

   Adolescents and young adults with sickle cell disease (SCD) face challenges managing their illness and maintaining their well-being. This study proposes to test the feasibility and acceptability of a resilience-promoting intervention through a Collaborative Care Model. The primary goal is to determ…

   Stage

   Not phased

   Ages

   8 to 25

   Site

   Boston Children's Hospital, Boston, Massachusetts

   Run by

   Boston Children's Hospital

   See if you can join NCT06555939 on ClinicalTrials.gov

4. Sickle Cell Disease and the Genomic and Gene Therapy Needs of Stakeholders

   The primary objectives of this prospective mixed-method interview study are to use semi-structured interviews in parents of sickle cell disease (SCD) patients to describe parental attitudes of research involving genomic sequencing, including concerns about participation and expectations from resear…

   Stage

   Not phased

   Ages

   13 and older

   Site

   St. Jude Children's Research Hospital, Memphis, Tennessee

   Run by

   St. Jude Children's Research Hospital

   See if you can join NCT04416178 on ClinicalTrials.gov

5. School Readiness Intervention for Preschool Children With Sickle Cell Disease

   The study participant is being asked to take part in this clinical trial, a type of research study, because the participant is a young child with sickle cell disease or the caregiver of a child with sickle cell disease. This study is being done to test a school readiness program for children with s…

   Stage

   Not phased

   Ages

   3 to 6

   Site

   St. Jude Children's Research Hospital, Memphis, Tennessee

   Run by

   St. Jude Children's Research Hospital

   See if you can join NCT06367192 on ClinicalTrials.gov

6. ATHNdataset Registry

   The Hemophilia Treatment Center (HTC) where you receive care is working with The American Thrombosis and Hemostasis Network (ATHN) to look at the quality of life of people with blood disorders and problems. Doctors, scientists, policymakers, and other health care providers need a large amount of in…

   Stage

   Not phased

   Ages

   Any age

   Site

   American Thrombosis and Hemostasis Network, Hickory, North Carolina

   Run by

   American Thrombosis and Hemostasis Network

   See if you can join NCT06820515 on ClinicalTrials.gov

7. Transplantation of Clustered Regularly Interspaced Short Palindromic Repeats Modified Hematopoietic Progenitor Stem Cells (CRISPR_SCD001) in Patients With Severe Sickle Cell Disease

   This is an open label, non-randomized, 2-center, phase 1/2 trial of a single infusion of sickle allele modified cluster of differentiation (CD34+) hematopoietic stem progenitor cells (HSPCs) in subjects with in subjects ≥12 years old to 35 years old severe Sickle Cell Disease (SCD). The study will …

   Stage

   Phase 1

   Ages

   12 to 35

   Site

   University of California, Los Angeles, Los Angeles, California

   Locations

   2 in total

   Run by

   Mark Walters, MD

   See if you can join NCT04774536 on ClinicalTrials.gov

8. Study of a Single Dose of a 21-valent Pneumococcal Conjugate Vaccine in Children and Adolescents With Sickle Cell Disease

   The purpose of this study is to measure whether PCV21 vaccine (investigational pneumococcal vaccine) is safe and can help the body to develop germ-fighting agents called "antibodies" (immunogenicity) compared with 20vPCV (licensed pneumococcal vaccine) when given as a single dose to children aged 2…

   Stage

   Phase 3

   Ages

   2 to 17

   Site

   Site # 8400006, Atlanta, Georgia

   Locations

   7 in total

   Run by

   Sanofi

   See if you can join NCT07247188 on ClinicalTrials.gov

9. Intravenous L-Citrulline for Vaso-occlusive Pain Episode in Sickle Cell Disease

   The goal of this clinical trial is to learn if intravenous citrulline works to treat acute pain in hospitalized patients with sickle cell disease. It will also learn about the safety of intravenous citrulline. The main questions it aims to answer are: * Does intravenous citrulline decrease the dura…

   Stage

   Phase 2

   Ages

   4 to 21

   Site

   Children's National Hospital, Washington D.C., District of Columbia

   Run by

   Suvankar Majumdar

   See if you can join NCT06635902 on ClinicalTrials.gov

10. Exercise in Child Health

    This study is a cooperative investigation funded by the NIH. The project is a collaboration among three major NIH Clinical Translational Science Awardees: 1) UCI (lead site with its affiliate CHOC), 2) Northwestern University (with its affiliate Lurie Children's Hospital), and 3) USC (with its affi…

    Stage

    Not phased

    Ages

    10 to 17

    Site

    University of California, Irvine, Irvine, California

    Run by

    University of California, Irvine

    See if you can join NCT05359991 on ClinicalTrials.gov

11. Evaluation of Efficacy and Safety of a Single Dose of CTX001 in Participants With Transfusion-Dependent β-Thalassemia and Severe Sickle Cell Disease

    This is a single-dose, open-label study in participants with transfusion-dependent β-thalassemia (TDT) or severe sickle cell disease (SCD). The study will evaluate the safety and efficacy of autologous CRISPR-Cas9 modified CD34+ human hematopoietic stem and progenitor cells (hHSPCs) using CTX001.

    Stage

    Phase 3

    Ages

    12 to 35

    Site

    New York Presbyterian Hospital - Morgan Stanley Children's Hospital, New York, New York

    Locations

    6 in total

    Run by

    Vertex Pharmaceuticals Incorporated

    See if you can join NCT05477563 on ClinicalTrials.gov

12. Delivering Patient-Facing Evidence-Based Guidelines Through mHealth to Adults With Sickle Cell Disease

    In a hybrid type I effectiveness-implementation trial, our three-center research teams aim to examine whether empowering adults with sickle cell disease (SCD) with patient-facing SCD-specific guidelines through an mHealth application with booklets will decrease acute healthcare utilization and be c…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Illinois at Chicago, Chicago, Illinois

    Locations

    4 in total

    Run by

    Ohio State University

    See if you can join NCT06919224 on ClinicalTrials.gov

13. Zinc Supplementation in Sickle Cell Disease: A Precursor to the Think Zinc for Bones Trial

    The goal of this short term prospective Phase II study is to compare the effects of two alternate daily doses of zinc (25 and 40 mg/day) in 34 randomly assigned homozygous Sickle Cell Disease (SCD-SS) patients aged 15-40 years old. The main question it aims to answer is: Which biomarkers are most r…

    Stage

    Phase 2

    Ages

    15 to 40

    Site

    UCSF Benioff Children's Hospital Oakland, Oakland, California

    Locations

    6 in total

    Run by

    University of California, San Francisco

    See if you can join NCT06260891 on ClinicalTrials.gov

14. Minimizing Toxicity in HLA-identical Sibling Donor Transplantation for Children With Sickle Cell Disease

    This multisite prospective study seeks to determine if HLA-identical sibling donor transplantation using alemtuzumab, low dose total-body irradiation, and sirolimus (Sickle transplant Using a Nonmyeloablative approach, "SUN") can decrease the toxicity of transplant while achieving a high cure rate …

    Stage

    Phase 2

    Ages

    2 to 25

    Site

    Children's National Health System, Washington D.C., District of Columbia

    Locations

    7 in total

    Run by

    Robert Nickel

    See if you can join NCT03587272 on ClinicalTrials.gov

15. Cognitive Remediation Intervention to Prepare for Transition of Care

    Randomized Controlled Trial (RTC) testing the efficacy of a telehealth adaptation of the Cognitive-Remediation of Executive and Adaptive Deficits in Youth (C-READY) intervention to prepare adolescents with sickle cell disease for transition of care.

    Stage

    Phase 2

    Ages

    10 to 18

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Run by

    University of Alabama at Birmingham

    See if you can join NCT05336201 on ClinicalTrials.gov

16. Stress Management and Mindfulness Intervention for Patients With Sickle Cell Disease

    The purpose of this research is to determine whether a new stress management and mindfulness program can improve quality of life in individuals with sickle cell disease. The program is based on a number of empirically supported treatments including techniques from cognitive-behavioral therapy like …

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Pennsylvania, Philadelphia, Pennsylvania

    Run by

    University of Pennsylvania

    See if you can join NCT07316478 on ClinicalTrials.gov

17. Writing Relaxing Beats in Adolescents Who Have Sickle Cell Disease

    This research aims to see if songwriting can help reduce anxiety in adolescents with Sickle Cell Disease. The purpose of the study is to discover if participants find songwriting and playing their songs to be practical and acceptable, and helpful for managing anxiety.

    Stage

    Not phased

    Ages

    11 to 18

    Site

    Mayo Clinic Division of Nursing, Rochester, Minnesota

    Run by

    Mayo Clinic

    See if you can join NCT07222475 on ClinicalTrials.gov

18. Prophylactic Transfusion In Pregnant in Women With Sickle Cell Disease

    The goal of this study is to determine if there is a positive effect of prophylactic red blood cell (RBC) transfusion of leukoreduced, ABO, Rh (D/Cc/Ee) and Kell matched blood compared to standard of care on the number of episodes of acute sickle cell disease (SCD) manifestations or pregnancy-relat…

    Stage

    Phase 4

    Ages

    18 and older

    Site

    Grady Health System, Atlanta, Georgia

    Run by

    Emory University

    See if you can join NCT06979492 on ClinicalTrials.gov

19. Hematopoietic Stem Cell BCL11A Enhancer Gene Editing for Severe β-Hemoglobinopathies

    A promising approach for the treatment of genetic diseases is called gene therapy. Gene therapy is a relatively new field of medicine that uses genetic material (mostly DNA) from the patient to treat his or her own disease. In gene therapy, the investigators introduce new genetic material in order …

    Stage

    Phase 1

    Ages

    13 to 40

    Site

    Boston Children's Hospital, Boston, Massachusetts

    Run by

    Daniel Bauer

    See if you can join NCT06647979 on ClinicalTrials.gov

20. MULTIsite Feasibility of MUSIc Therapy to Address Quality Of Life in Sickle Cell Disease

    This is a multi-site, multi-visit feasibility RCT of music therapy (MT) among adolescent and adult patients (aged 14 and older) with sickle cell disease (SCD). Subjects will be randomized into one of three groups, either (1) 6 visits of in- person MT (InMT:); (2) 1 visit of in-person MT and 5 visit…

    Stage

    Not phased

    Ages

    14 and older

    Site

    UH Seidman Cancer Center Adult SCD Clinic or UH Rainbow Babies and Children's Hospital Sickle Cell Anemia Center, Cleveland, Ohio

    Locations

    2 in total

    Run by

    University of California, Irvine

    See if you can join NCT06853158 on ClinicalTrials.gov

21. A Long-term Follow-up Study in Patients Who Received BEAM-101

    This is a Long-term Follow-up (LTFU) study in patients who received BEAM-101 in the parent study (Study BTX-AUT-001). Eligible patients who received BEAM-101 will be asked to participate in this LTFU study prior to completing Study BTX-AUT-001. Patients who enter into this study will be followed fo…

    Stage

    Not phased

    Ages

    14 to 37

    Site

    Boston Children's Hospital, Boston, Massachusetts

    Locations

    17 in total

    Run by

    Beam Therapeutics Inc.

    See if you can join NCT07373639 on ClinicalTrials.gov

22. Trans-auricular Nerve Stimulation as an Innovative Approach to the Treatment of Pain in Pediatric Patients Suffering From Sickle Cell Disease

    The goal of this study is to evaluate the effects of transauricular vagus and trigeminal nerve stimulation on the treatment of pain in children with Sickle Cell Disease. * The primary objective is to determine the feasibility of using a tAN device to treat pain in pediatric participants with SCD by…

    Stage

    Not phased

    Ages

    7 to 18

    Site

    Children's Hospital of Atlanta: Eagelston, Atlanta, Georgia

    Run by

    Emory University

    See if you can join NCT07090668 on ClinicalTrials.gov

23. Verifying Antibodies After Live Immunization Delivery (VALID): A Study of Measles Vaccine Immunogenicity in Children With Sickle Cell Disease

    The goal of this study is to learn if infants with sickle cell disease (SCD) develop adequate protection after measles vaccines. (not looking at any prolonged duration)

    Stage

    Not phased

    Ages

    0 to 6

    Site

    Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio

    Locations

    3 in total

    Run by

    Children's Hospital Medical Center, Cincinnati

    See if you can join NCT07356050 on ClinicalTrials.gov

24. Study of Panobinostat (LBH589) in Patients With Sickle Cell Disease

    The goal of this clinical research study is to find out about the safety and effects of a drug called panobinostat when given to adults with sickle cell disease. Panobinostat is a pan histone deacetylase (HDAC) inhibitor. HDAC inhibitors have been shown to significantly increase hemoglobin F induct…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Augusta University, Augusta, Georgia

    Run by

    Abdullah Kutlar

    See if you can join NCT01245179 on ClinicalTrials.gov

25. Peer Support for Adolescents and Emerging Adults With Sickle Cell Pain

    The study, known as the Peer suppoRt for adolescents and Emerging adults with Sickle cell pain: promoting ENgagement in Cognitive behavioral thErapy (PRESENCE), aims to determine the effectiveness of digital CBT in reducing pain, opioid use, and healthcare utilization among AYAs with SCD. It also s…

    Stage

    Not phased

    Ages

    16 to 30

    Site

    University of South Alabama Medical Center, Mobile, Alabama

    Locations

    14 in total

    Run by

    University of Pittsburgh

    See if you can join NCT06374238 on ClinicalTrials.gov