Sickle Cell Disease Clinical Trials in Memphis, Tennessee

18 studies are recruiting for sickle cell disease in Memphis, Tennessee right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. A Research Study Looking at Long-term Treatment With Etavopivat in People With Sickle Cell Disease or Thalassaemia

   Etavopivat is a new medicine under development for treating blood disorders like sickle cell disease and thalassaemia. Sickle cell disease and thalassaemia are inherited blood disorders that affect haemoglobin. Haemoglobin is the protein that carries oxygen through the body. This study is looking i…

   Stage

   Phase 3

   Ages

   2 and older

   Site

   Methodist University Hospital, Memphis, Tennessee

   Locations

   107 in total

   Run by

   Novo Nordisk A/S

   See if you can join NCT06609226 on ClinicalTrials.gov

2. A Study to Evaluate How Well Etavopivat Works in People With Sickle Cell Disease

   This study is conducted to confirm whether etavopivat works well at reducing the number of Vaso-occlusive crisis VOCs (sickle cell pain crises) caused by obstructions in blood vessels in adults and adolescents living with sickle cell disease. The study will also evaluate how well etavopivat can red…

   Stage

   Phase 3

   Ages

   12 and older

   Site

   University of Tennessee Health Science Center, Memphis, Tennessee

   Locations

   175 in total

   Run by

   Novo Nordisk A/S

   See if you can join NCT06612268 on ClinicalTrials.gov

3. Methylphenidate to Address Attention and Executive Deficits Among Children With Sickle Cell Disease

   The purpose of this study is to determine if patients with sickle cell disease (SCD) can consistently take a drug called Methylphenidate (MPH) daily, once a day for 4 weeks to help with any thinking, attention or schoolwork problems and if they have any side effects. The study will assess any think…

   Stage

   Phase 1

   Ages

   8 to 17

   Site

   St. Jude Children's Research Hospital, Memphis, Tennessee

   Run by

   St. Jude Children's Research Hospital

   See if you can join NCT07226219 on ClinicalTrials.gov

4. SCD Stem Cell Mobilization and Apheresis Using Motixafortide

   This study is being done to see if the study drug, motixafortide, is safe in participants with sickle cell disease (SCD). Investigators also want to see if the drug will help the body increase the number of stem cells that can be collected for possible future transplant use. PRIMARY OBJECTIVE * To …

   Stage

   Phase 1

   Ages

   18 and older

   Site

   St. Jude Children's Research Hospital, Memphis, Tennessee

   Locations

   3 in total

   Run by

   St. Jude Children's Research Hospital

   See if you can join NCT06442761 on ClinicalTrials.gov

5. ATHN Transcends: A Natural History Study of Non-Neoplastic Hematologic Disorders

   In parallel with the growth of ATHN's clinical studies, the number of new therapies for all blood disorders is increasing significantly. Some of the recently FDA-approved therapies for congenital and acquired hematologic conditions have not yet demonstrated long-term safety and effectiveness beyond…

   Stage

   Not phased

   Ages

   Any age

   Site

   St. Jude Children's Research Hospital, Memphis, Tennessee

   Locations

   76 in total

   Run by

   American Thrombosis and Hemostasis Network

   See if you can join NCT04398628 on ClinicalTrials.gov

6. Gene Therapy Communication: Use of a Needs Assessment to Drive Decision-AIDS for Gene Therapy for Rare Diseases (GENETX)

   This prospective mixed-method interview study aims to qualitatively describe the beliefs, attitudes, and informational needs around gene therapy for rare pediatric diseases among patients and parents of children with a rare disease targeted for treatment using gene therapy techniques. Using learned…

   Stage

   Not phased

   Ages

   8 and older

   Site

   St. Jude Children's Research Hospital, Memphis, Tennessee

   Run by

   St. Jude Children's Research Hospital

   See if you can join NCT05810181 on ClinicalTrials.gov

7. Haploidentical Donor Hematopoietic Cell Transplant for Sickle Cell Disease

   The purpose of this study it to evaluate a reduced toxicity conditioning regimen for haploidentical donor HCT followed by a GVHD prophylaxis regimen comprising of post-transplant cyclophosphamide, sirolimus and abatacept with the goal to improve the GVHD-free rejection-free survival (GRFS) to great…

   Stage

   Phase 2

   Ages

   Up to 22

   Site

   St Jude Children's Research Hospital, Memphis, Tennessee

   Run by

   St. Jude Children's Research Hospital

   See if you can join NCT07616154 on ClinicalTrials.gov

8. Peripheral Arterial Tonometry and Neurocognition in Sickle Cell Disease

   This study will examine sleep disordered breathing and sleep quality in participants (ages 12-25) diagnosed with sickle cell disease of any genotype. We will utilize remote peripheral arterial tonometry (PAT) and questionnaires to evaluate difficulties with sleep. PAT assessments will occur remotel…

   Stage

   Not phased

   Ages

   12 to 25

   Site

   St. Jude Children's Research Hospital, Memphis, Tennessee

   Run by

   St. Jude Children's Research Hospital

   See if you can join NCT06477289 on ClinicalTrials.gov

9. Investigation of the Genetics of Hematologic Diseases

   The purpose of this study is to collect and store samples and health information for current and future research to learn more about the causes and treatment of blood diseases. This is not a therapeutic or diagnostic protocol for clinical purposes. Blood, bone marrow, hair follicles, nail clippings…

   Stage

   Not phased

   Ages

   Any age

   Site

   St. Jude Children's Research Hospital, Memphis, Tennessee

   Run by

   St. Jude Children's Research Hospital

   See if you can join NCT02720679 on ClinicalTrials.gov

10. Sickle Cell Clinical Research and Intervention Program

    Despite the important work of previous sickle cell disease (SCD) cohort studies, there remain many understudied areas that require investigation. An important knowledge deficit is the slow but progressive process of chronic end-organ dysfunction. The majority of organ dysfunction becomes apparent i…

    Stage

    Not phased

    Ages

    Any age

    Site

    Regional One Health, Diggs-Kraus Sickle Cell Center, Memphis, Tennessee

    Locations

    6 in total

    Run by

    St. Jude Children's Research Hospital

    See if you can join NCT02098863 on ClinicalTrials.gov

11. Functional Ovarian Reserve in Sickle Cell Disease

    This study aims to look at AMH levels in female children with SCD as they go through puberty to see if they are at the same level as other children without SCD at the same age and/or pubertal stage and will also look at how treatment exposures and pain crises affect the AMH levels in children with …

    Stage

    Not phased

    Ages

    10 to 18

    Site

    St. Jude Children's Research Hospital, Memphis, Tennessee

    Run by

    St. Jude Children's Research Hospital

    See if you can join NCT07392216 on ClinicalTrials.gov

12. Effect of Virtual Reality Technology for Pain Management of Vaso-Occlusive Crisis in Patients With Sickle Cell Disease

    Acute vaso-occlusive crisis (VOC) is the most common complication in patients with sickle cell disease (SCD) and pain related to VOC is often inadequately treated. This is a phase II randomized controlled clinical trial evaluating the efficacy of virtual reality technology when added to standard pa…

    Stage

    Not phased

    Ages

    6 to 25

    Site

    St. Jude Children's Research Hospital, Memphis, Tennessee

    Locations

    2 in total

    Run by

    St. Jude Children's Research Hospital

    See if you can join NCT03353584 on ClinicalTrials.gov

13. Relationship Between Abnormal Myocardial Perfusion and Diastolic Dysfunction in Sickle Cell Disease Using PET

    There is limited information on what causes injury to the heart in individuals with Sickle Cell Disease (SCD). Researchers in this study want to see if decreased blood flow to the heart during stress could be causing the heart damage seen in SCD patients. They also want to test people who don't hav…

    Stage

    Phase 2

    Ages

    18 to 21

    Site

    St. Jude Children's Research Hospital, Memphis, Tennessee

    Run by

    St. Jude Children's Research Hospital

    See if you can join NCT05583721 on ClinicalTrials.gov

14. Gene Editing For Sickle Cell Disease

    This study is being done to test the safety of a new treatment called gene editing in Sickle Cell Disease (SCD) patients and to see if a single dose of this genetically modified cellular product will increase the amount of a certain hemoglobin called fetal hemoglobin (HbF) and help reduce the sympt…

    Stage

    Phase 1

    Ages

    18 to 24

    Site

    St. Jude Children's Research Hospital, Memphis, Tennessee

    Run by

    St. Jude Children's Research Hospital

    See if you can join NCT06506461 on ClinicalTrials.gov

15. Sickle Cell Disease and the Genomic and Gene Therapy Needs of Stakeholders

    The primary objectives of this prospective mixed-method interview study are to use semi-structured interviews in parents of sickle cell disease (SCD) patients to describe parental attitudes of research involving genomic sequencing, including concerns about participation and expectations from resear…

    Stage

    Not phased

    Ages

    13 and older

    Site

    St. Jude Children's Research Hospital, Memphis, Tennessee

    Run by

    St. Jude Children's Research Hospital

    See if you can join NCT04416178 on ClinicalTrials.gov

16. School Readiness Intervention for Preschool Children With Sickle Cell Disease

    The study participant is being asked to take part in this clinical trial, a type of research study, because the participant is a young child with sickle cell disease or the caregiver of a child with sickle cell disease. This study is being done to test a school readiness program for children with s…

    Stage

    Not phased

    Ages

    3 to 6

    Site

    St. Jude Children's Research Hospital, Memphis, Tennessee

    Run by

    St. Jude Children's Research Hospital

    See if you can join NCT06367192 on ClinicalTrials.gov

17. A Long-term Follow-up Study in Patients Who Received BEAM-101

    This is a Long-term Follow-up (LTFU) study in patients who received BEAM-101 in the parent study (Study BTX-AUT-001). Eligible patients who received BEAM-101 will be asked to participate in this LTFU study prior to completing Study BTX-AUT-001. Patients who enter into this study will be followed fo…

    Stage

    Not phased

    Ages

    14 to 37

    Site

    St. Jude Children's Research Hospital, Memphis, Tennessee

    Locations

    17 in total

    Run by

    Beam Therapeutics Inc.

    See if you can join NCT07373639 on ClinicalTrials.gov

18. Recruitment and Engagement in Care to Impact Practice Enhancement (RECIPE) for Sickle Cell Disease

    The goal of this observational study is to help us understand more about the best ways to help individuals living with Sickle Cell Disease (SCD) get the best care. The main question it aims to answer is: How to find individuals unaffiliated from SCD specialist care use three distinct pathways? Once…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Tennessee at Memphis, Memphis, Tennessee

    Locations

    9 in total

    Run by

    RTI International

    See if you can join NCT06385886 on ClinicalTrials.gov