Parkinson Disease Clinical Trials

117 studies are recruiting for parkinson disease in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

Search these by distance from you

By city

Studies, page 3

1. Use of CereGate Therapy for Freezing of Gait in PD

   A Multi-Center, Controlled Study to Evaluate Use of CereGate Therapy to Reduce Freezing of Gait in Participants Diagnosed with Parkinson's Disease.

   Stage

   Not phased

   Ages

   21 to 80

   Site

   Kaiser Permanente, KPNC Comprehensive Movement Disorders Program, Redwood City, California

   Locations

   7 in total

   Run by

   CereGate Inc.

   See if you can join NCT05292794 on ClinicalTrials.gov

2. Intestinal Immunity in Neurologic Disease

   The purpose of this study is to ascertain the functional profiles of the immune cells within the gastrointestinal tract and to determine how these cells contribute to autoimmune and neurologic diseases.

   Stage

   Not phased

   Ages

   18 to 99

   Site

   Yale MS Clinic, North Haven, Connecticut

   Run by

   Yale University

   See if you can join NCT06329453 on ClinicalTrials.gov

3. Zesty Exercise System for Therapeutic Engagement

   This study will evaluate exercise delivered through the Zesty Exercise System for Therapeutic Engagement (ZEST-E) for people with Parkinson's disease when sessions are monitored either in person or remotely. Participants will complete robot-guided exercise three times per week for three weeks. The …

   Stage

   Not phased

   Ages

   40 and older

   Site

   Emory University, 57 Executive Park S NE, Ste 200, Atlanta, Georgia

   Run by

   Emory University

   See if you can join NCT07382674 on ClinicalTrials.gov

4. Parkinson's Disease Biomarkers in Nerve Cells in the Gut

   Parkinson's disease affects all the nerve cells in the body, including the ones in the gut. The gut contains its own nervous system, the enteric nervous system, and can be thought of as a "second brain". This second brain can reflect what is going on in the actual brain. This study is being done to…

   Stage

   Not phased

   Ages

   45 to 75

   Site

   Weill Cornell Medicine, New York, New York

   Run by

   Weill Medical College of Cornell University

   See if you can join NCT05347407 on ClinicalTrials.gov

5. Balance Tele-Rehab in Parkinson's Disease

   This project will determine the feasibility and efficacy of remote assessment and treatment of balance disorders in people with Parkinson's disease.

   Stage

   Not phased

   Ages

   55 to 85

   Site

   Oregon Health Science University, Portland, Oregon

   Run by

   Oregon Health and Science University

   See if you can join NCT05680597 on ClinicalTrials.gov

6. Speech Amplification Devices for Parkinson Disease: Talker- and Technology-Driven Enhancements

   The proposed research aims to investigate the use of speech amplification devices as a potential treatment option for people with Parkinson's disease and related disorders who exhibit hypophonia, a voice disorder that affects over half of those with Parkinson's disease. By characterizing the acoust…

   Stage

   Not phased

   Ages

   50 and older

   Site

   Michigan State University, East Lansing, Michigan

   Run by

   Michigan State University

   See if you can join NCT07599696 on ClinicalTrials.gov

7. This Clinical Trial is Designed to Evaluate the Safety, Tolerability, Feasibility and Preliminary Efficacy of NouvNeu001 (Human Dopaminergic Progenitor Cells Injection) in Patients With Parkinson's Disease.

   This is a phase 1/2 clinical study to evaluate the safety, tolerability, feasibility, and preliminary efficacy of NouvNeu001 in patients with advanced Parkinson's Disease.

   Stage

   Phase 1

   Ages

   30 to 75

   Site

   Cornell University Weill Medical College, New York, New York

   Run by

   iRegene Therapeutics Co., Ltd.

   See if you can join NCT07102342 on ClinicalTrials.gov

8. Multiple Objective Particle Swarm Optimization Postural Instability Gait Disorder

   Sixty patients will be enrolled in this study who are treated for Parkinson's disease (PD) with bilateral deep brain stimulation of subthalamic nucleus (STN) or globus pallidus (GP), who have a pre- operative 7 Tesla MRI including diffusion tensor imaging for tractography and a postoperative head C…

   Stage

   EARLY_Phase 1

   Ages

   18 to 89

   Site

   University of Minnesota, Minneapolis, Minnesota

   Run by

   University of Minnesota

   See if you can join NCT05893186 on ClinicalTrials.gov

9. Effects of RAS on Gait in PD Patients With DBS

   Participants will be asked to walk along with the metronome beats (RAS) during the participants' stimulation state (ON or OFF) for four minutes for each state. The researcher will collect the gait parameters (cadence, velocity, and stride length) of patients before, during, and after RAS in both DB…

   Stage

   Not phased

   Ages

   18 to 89

   Site

   Johns Hopkins School of Medicine, Baltimore, Maryland

   Run by

   Johns Hopkins University

   See if you can join NCT05763732 on ClinicalTrials.gov

10. rTMS Over the Dorsolateral Prefrontal Cortex for the Treatment of Impulse Control Disorders in Parkinson's Disease

    This study's objective is to evaluate the effects of repetitive transcranial magnetic stimulation (rTMS) over the dorsolateral prefrontal cortex (dlPFC) of patients with Parkinson's Disease (PD) who experience impulse control disorders (ICDs) on impulse control symptoms and cognitive behaviors link…

    Stage

    Not phased

    Ages

    18 and older

    Site

    West Virginia University Hospitals, Morgantown, West Virginia

    Run by

    West Virginia University

    See if you can join NCT06237868 on ClinicalTrials.gov

11. A Study of LY4006896 in Healthy Participants and Participants With Parkinson's Disease

    The purpose of this study is to generate evidence of the safety, tolerability, and pharmacokinetics/pharmacodynamics of IV LY4006896 compared with placebo in healthy participants and participants with Parkinson's disease.

    Stage

    Phase 1

    Ages

    30 to 85

    Site

    Collaborative Neuroscience Network - CNS, Los Alamitos, California

    Locations

    14 in total

    Run by

    Eli Lilly and Company

    See if you can join NCT06809400 on ClinicalTrials.gov

12. First-in-Human Single and Multiple Dose of HL-400

    This is a randomized, double-blind, placebo-controlled, dose-escalation study in healthy subjects to evaluate the safety, tolerability, pharmacokinetics of HL-400 (a NLRP3 inhibitor) following oral single and multiple ascending dose administration.

    Stage

    Phase 1

    Ages

    18 to 65

    Site

    Pharmaron CPC, Inc., Baltimore, Maryland

    Run by

    Highlightll Pharmaceutical (USA) LLC

    See if you can join NCT06997484 on ClinicalTrials.gov

13. Dance and Energy Expenditure Among Adults With Parkinson's

    The first purpose of the study is to develop and test new methods for quantifying dance among adults with a diagnosis of Parkinson's using various kinds of cameras, wearable activity monitors, and questionnaires. The second reason we are conducting the study is to better understand the relationship…

    Stage

    Not phased

    Ages

    18 to 85

    Site

    Northeastern University, Boston, Massachusetts

    Run by

    Northeastern University

    See if you can join NCT06425731 on ClinicalTrials.gov

14. CPAP for the Treatment of Supine Hypertension

    This study aims to learn about the effects of continuous positive airway pressure (CPAP) on people with autonomic failure and high blood pressure when lying down (supine hypertension) to determine if it can be used to treat their high blood pressure during the night. CPAP (a widely used treatment f…

    Stage

    Not phased

    Ages

    40 to 80

    Site

    Autonomic Dysfunction Center/ Vanderbilt University Medical Center, Nashville, Tennessee

    Run by

    Vanderbilt University Medical Center

    See if you can join NCT05489575 on ClinicalTrials.gov

15. Low Voltage Electrical Stimulation for Depression in Parkinson's Patients

    The goal of this clinical trial is to determine the relative efficacy of fMRI model guided Transcranial Direct Current Stimulation (mgTDCS) in improving the depressive symptoms of patients with Parkinson's Disease (PD). The main questions it aims to answer are: 1) Can the use of mgTDCS significantl…

    Stage

    Not phased

    Ages

    19 to 65

    Site

    University of South Alabama, Mobile, Alabama

    Run by

    University of South Alabama

    See if you can join NCT06467695 on ClinicalTrials.gov

16. High Frequency Light, Sound, and Tactile Stimulation to Improve Motor and Cognitive Deficits in Parkinson's Disease

    Parkinson's disease (PD) impacts different types of neural oscillations in the brain, including beta (13-30Hz) and gamma oscillations (30-80Hz), which contributes to PD's cardinal symptoms of resting tremor, rigidity, bradykinesia (slowness of movement), and gait instability. The investigators' lab…

    Stage

    Not phased

    Ages

    45 to 90

    Site

    Massachusetts Institute of Technology, Cambridge, Massachusetts

    Run by

    Massachusetts Institute of Technology

    See if you can join NCT05268887 on ClinicalTrials.gov

17. Reducing Falls With Varenicline in Hypocholinergic Parkinson Disease

    This trial aims to test whether one year of Varenicline, when compared to placebo, can reduce fall risk and show improvement in the ability to multitask while walking. Participants that are eligible after screening for the study will be randomized to receive Varenicline or placebo. Along with the s…

    Stage

    Phase 2

    Ages

    45 and older

    Site

    University of Michigan, Ann Arbor, Michigan

    Run by

    Vikas Kotagal

    See if you can join NCT06679374 on ClinicalTrials.gov

18. Cortical-Basal Ganglia Speech Networks

    In this research study the researchers want to learn more about brain activity related to speech perception and production.

    Stage

    Not phased

    Ages

    18 to 85

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT04286308 on ClinicalTrials.gov

19. Treating Parkinson's Disease Through Transplantation of Autologous Stem Cell-Derived Dopaminergic Neurons

    The goal of this clinical trial is to assess the safety and tolerability of the surgical transplantation of dopaminergic progenitor cells into the brains of participants with Parkinson's disease. The transplanted dopaminergic cells will be derived from the participant's own skin cells.

    Stage

    Phase 1

    Ages

    45 to 80

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Jeffrey S. Schweitzer, MD, PhD

    See if you can join NCT06687837 on ClinicalTrials.gov

20. Cerebellar Stimulation and Cognitive Control

    The purpose of this study is to examine whether cerebellar stimulation can be used to improve cognitive deficits and mood in patients with schizophrenia, autism, bipolar disorder, Parkinson's disease, and major depression.

    Stage

    Not phased

    Ages

    18 to 90

    Site

    University of Iowa, Iowa City, Iowa

    Run by

    Krystal Parker, PhD

    See if you can join NCT03217110 on ClinicalTrials.gov

21. Vestibular and Cortical Contributions to Transitions in Freezing of Gait in Parkinson's Disease

    Currently, there is a lack of comprehensive knowledge about the role of vestibulospinal drive and cortical activity during self-initiated movement transitions in older adults and people with PD (both with and without FOG). This set of experiments has two primary purposes: to (1) understand the path…

    Stage

    Not phased

    Ages

    21 to 80

    Site

    University of Minnesota, Movement Disorders Lab, Minneapolis, Minnesota

    Run by

    University of Minnesota

    See if you can join NCT06506058 on ClinicalTrials.gov

22. [18F]F-DOPA Imaging in Patients With Autonomic Failure

    Alpha-synucleinopathies refer to age-related neurodegenerative and dementing disorders, characterized by the accumulation of alpha-synuclein in neurons and/or glia. The anatomical location of alpha-synuclein inclusions (Lewy Bodies) and the pattern of progressive neuronal death (e.g. caudal to rost…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Vanderbilt University Medical Center, Nashville, Tennessee

    Run by

    Daniel Claassen

    See if you can join NCT04246437 on ClinicalTrials.gov

23. Characterizing the Pathophysiological Role of the Pallido-thalamocortical Motor Pathway in Parkinson's Disease.

    When a patient gets DBS surgery, the neurosurgeon makes a hole in the skull through which they can put the DBS lead down in deep parts of the brain that help control movement. For this study, research participants will also have an ECoG strip put through the same hole (no extra holes are being made…

    Stage

    Not phased

    Ages

    21 to 75

    Site

    University of Minnesota, Minneapolis, Minnesota

    Run by

    University of Minnesota

    See if you can join NCT06692920 on ClinicalTrials.gov

24. Spinal Cord Stimulation for Parkinson's Disease Rehabilitation

    This study explores the use of multifunctional, non-invasive spinal cord transcutaneous stimulation (scTS) to address axial motor symptoms, particularly gait dysfunction, in Parkinson's disease (PD). These symptoms, resistant to levodopa and inadequately managed by deep brain stimulation (DBS), ari…

    Stage

    Not phased

    Ages

    18 to 80

    Site

    Frazier Rehab Institute, Louisville, Kentucky

    Run by

    University of Louisville

    See if you can join NCT06804642 on ClinicalTrials.gov

25. Udall Project 2 Aim 2A&C

    This protocol will leverage the novel (on-label, FDA-approved) local field potential measuring capability of the Medtronic Percept™ PC or RC DBS system to study the effects of globus pallidus internus, globus pallidus externus (GPi, GPe), and subthalamic nucleus (STN) DBS on: the wash-out and wash-…

    Stage

    Not phased

    Ages

    Any age

    Site

    University of Minnesota, Minneapolis, Minnesota

    Run by

    University of Minnesota

    See if you can join NCT05656586 on ClinicalTrials.gov