Parkinson Disease Clinical Trials

118 studies are recruiting for parkinson disease in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 3

1. Targeted Motor Learning to Improve Gait for Individuals With Parkinson Disease

   The purpose of this research study is to determine how training to step with a metronome on both a treadmill, as well as overground, will influence the way that people with Parkinson disease walk. Using metronomes is commonly used in clinics, but the investigators will be using a combination of slo…

   Stage

   Not phased

   Ages

   50 to 80

   Site

   University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

   Run by

   University of North Carolina, Chapel Hill

   See if you can join NCT05864157 on ClinicalTrials.gov

2. Corticostriatal Contributions to Parkinson's Disease Cognitive Impairment

   The goal of this study is to learn more about the brain activity underlying Parkinson's disease cognitive impairment. The investigators will utilize neural recordings from corticostriatal structures performed during deep brain stimulation surgery to measure neural activity underlying nonmotor sympt…

   Stage

   Not phased

   Ages

   40 and older

   Site

   Vanderbilt University Medical Center, Nashville, Tennessee

   Run by

   Vanderbilt University Medical Center

   See if you can join NCT04715984 on ClinicalTrials.gov

3. Neurophysiology of Reward Signaling in Parkinson's Disease

   The goal of this study is to learn more about the brain activity underlying Parkinson's disease risk taking and reward seeking behaviors. The investigators will utilize neural recordings from corticostriatal structures performed during deep brain stimulation surgery to measure neural activity under…

   Stage

   Not phased

   Ages

   40 and older

   Site

   Vanderbilt University Medical Center, Nashville, Tennessee

   Run by

   Vanderbilt University Medical Center

   See if you can join NCT07409207 on ClinicalTrials.gov

4. Striatal and Extra-Striatal Cholinergic Terminal Density in LRRK2-PD Mutation

   This study explores how a specific genetic mutation of leucine-rich repeat kinase 2 (LRRK2) affects individuals with Parkinson's disease (PD), comparing those with the mutation to others with Parkinson's disease and without the mutation (iPD). Participants will complete positron emission tomography…

   Stage

   Not phased

   Ages

   45 and older

   Site

   University of Michigan, Ann Arbor, Michigan

   Run by

   University of Michigan

   See if you can join NCT07642908 on ClinicalTrials.gov

5. Natural History Study of Synucleinopathies

   Synucleinopathies are a group of rare diseases associated with worsening neurological deficits and the abnormal accumulation of the protein α-synuclein in the nervous system. Onset is usually in late adulthood at age 50 or older. Usually, synucleinopathies present clinically with slowness of moveme…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Beth Israel Deaconess Medical Center, Boston, Massachusetts

   Locations

   8 in total

   Run by

   NYU Langone Health

   See if you can join NCT01799915 on ClinicalTrials.gov

6. Evaluation of [¹⁸F]MODAG-009 PET Imaging in Synucleinopathies

   This is a single-center, open-label clinical study designed to evaluate the imaging characteristics and safety of [¹⁸F]MODAG-009 in participants with Parkinson's disease (PD), Multiple system atrophy (MSA), and Healthy controls (HC). Approximately 13 participants will be enrolled in this study. Eac…

   Stage

   EARLY_Phase 1

   Ages

   50 to 80

   Site

   Institute for Neurodegenerative Disorders and XingImaging, LLC, New Haven, Connecticut

   Run by

   MODAG GmbH

   See if you can join NCT07640555 on ClinicalTrials.gov

7. Understanding Motivation in Parkinson's Patients Through Neurophysiology

   The study aims to better understand motivation and value-based decision-making in Parkinson's patients through neurophysiology using Medtronic's Percept DBS device. By combining behavioral tasks with neural recordings, the study seeks to uncover how DBS affects motivation, particularly in relation …

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of California San Francisco, San Francisco, California

   Run by

   University of California, San Francisco

   See if you can join NCT05065151 on ClinicalTrials.gov

8. Cognitive Decline Following Deep Brain Stimulation

   This research study aims to identify MRI-based brain biomarkers that predict an individual's response to Deep Brain Stimulation (DBS). In particular, this study will focus on changes in cognition associated with DBS. A total of 55 participants with Parkinson's Disease planning to undergo DBS will b…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Medical University of South Carolina, Charleston, South Carolina

   Run by

   Medical University of South Carolina

   See if you can join NCT05822388 on ClinicalTrials.gov

9. Imaging Core Aim 2, and Udall Project 2 Aim 2

   More than one million people in the United States have Parkinson's disease (PD) and the prevalence is expected to double by 2040. Over 60% of these individuals will develop debilitating postural instability and gait disturbances (PIGD), including freezing of gait (FOG). With disease progression, ax…

   Stage

   Not phased

   Ages

   21 and older

   Site

   University of Minnesota, Minneapolis, Minnesota

   Run by

   University of Minnesota

   See if you can join NCT06998303 on ClinicalTrials.gov

10. Use of CereGate Therapy for Freezing of Gait in PD

    A Multi-Center, Controlled Study to Evaluate Use of CereGate Therapy to Reduce Freezing of Gait in Participants Diagnosed with Parkinson's Disease.

    Stage

    Not phased

    Ages

    21 to 80

    Site

    Kaiser Permanente, KPNC Comprehensive Movement Disorders Program, Redwood City, California

    Locations

    7 in total

    Run by

    CereGate Inc.

    See if you can join NCT05292794 on ClinicalTrials.gov

11. Intestinal Immunity in Neurologic Disease

    The purpose of this study is to ascertain the functional profiles of the immune cells within the gastrointestinal tract and to determine how these cells contribute to autoimmune and neurologic diseases.

    Stage

    Not phased

    Ages

    18 to 99

    Site

    Yale MS Clinic, North Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT06329453 on ClinicalTrials.gov

12. Zesty Exercise System for Therapeutic Engagement

    This study will evaluate exercise delivered through the Zesty Exercise System for Therapeutic Engagement (ZEST-E) for people with Parkinson's disease when sessions are monitored either in person or remotely. Participants will complete robot-guided exercise three times per week for three weeks. The …

    Stage

    Not phased

    Ages

    40 and older

    Site

    Emory University, 57 Executive Park S NE, Ste 200, Atlanta, Georgia

    Run by

    Emory University

    See if you can join NCT07382674 on ClinicalTrials.gov

13. Parkinson's Disease Biomarkers in Nerve Cells in the Gut

    Parkinson's disease affects all the nerve cells in the body, including the ones in the gut. The gut contains its own nervous system, the enteric nervous system, and can be thought of as a "second brain". This second brain can reflect what is going on in the actual brain. This study is being done to…

    Stage

    Not phased

    Ages

    45 to 75

    Site

    Weill Cornell Medicine, New York, New York

    Run by

    Weill Medical College of Cornell University

    See if you can join NCT05347407 on ClinicalTrials.gov

14. Balance Tele-Rehab in Parkinson's Disease

    This project will determine the feasibility and efficacy of remote assessment and treatment of balance disorders in people with Parkinson's disease.

    Stage

    Not phased

    Ages

    55 to 85

    Site

    Oregon Health Science University, Portland, Oregon

    Run by

    Oregon Health and Science University

    See if you can join NCT05680597 on ClinicalTrials.gov

15. Speech Amplification Devices for Parkinson Disease: Talker- and Technology-Driven Enhancements

    The proposed research aims to investigate the use of speech amplification devices as a potential treatment option for people with Parkinson's disease and related disorders who exhibit hypophonia, a voice disorder that affects over half of those with Parkinson's disease. By characterizing the acoust…

    Stage

    Not phased

    Ages

    50 and older

    Site

    Michigan State University, East Lansing, Michigan

    Run by

    Michigan State University

    See if you can join NCT07599696 on ClinicalTrials.gov

16. This Clinical Trial is Designed to Evaluate the Safety, Tolerability, Feasibility and Preliminary Efficacy of NouvNeu001 (Human Dopaminergic Progenitor Cells Injection) in Patients With Parkinson's Disease.

    This is a phase 1/2 clinical study to evaluate the safety, tolerability, feasibility, and preliminary efficacy of NouvNeu001 in patients with advanced Parkinson's Disease.

    Stage

    Phase 1

    Ages

    30 to 75

    Site

    Cornell University Weill Medical College, New York, New York

    Run by

    iRegene Therapeutics Co., Ltd.

    See if you can join NCT07102342 on ClinicalTrials.gov

17. Multiple Objective Particle Swarm Optimization Postural Instability Gait Disorder

    Sixty patients will be enrolled in this study who are treated for Parkinson's disease (PD) with bilateral deep brain stimulation of subthalamic nucleus (STN) or globus pallidus (GP), who have a pre- operative 7 Tesla MRI including diffusion tensor imaging for tractography and a postoperative head C…

    Stage

    EARLY_Phase 1

    Ages

    18 to 89

    Site

    University of Minnesota, Minneapolis, Minnesota

    Run by

    University of Minnesota

    See if you can join NCT05893186 on ClinicalTrials.gov

18. Effects of RAS on Gait in PD Patients With DBS

    Participants will be asked to walk along with the metronome beats (RAS) during the participants' stimulation state (ON or OFF) for four minutes for each state. The researcher will collect the gait parameters (cadence, velocity, and stride length) of patients before, during, and after RAS in both DB…

    Stage

    Not phased

    Ages

    18 to 89

    Site

    Johns Hopkins School of Medicine, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT05763732 on ClinicalTrials.gov

19. rTMS Over the Dorsolateral Prefrontal Cortex for the Treatment of Impulse Control Disorders in Parkinson's Disease

    This study's objective is to evaluate the effects of repetitive transcranial magnetic stimulation (rTMS) over the dorsolateral prefrontal cortex (dlPFC) of patients with Parkinson's Disease (PD) who experience impulse control disorders (ICDs) on impulse control symptoms and cognitive behaviors link…

    Stage

    Not phased

    Ages

    18 and older

    Site

    West Virginia University Hospitals, Morgantown, West Virginia

    Run by

    West Virginia University

    See if you can join NCT06237868 on ClinicalTrials.gov

20. First-in-Human Single and Multiple Dose of HL-400

    This is a randomized, double-blind, placebo-controlled, dose-escalation study in healthy subjects to evaluate the safety, tolerability, pharmacokinetics of HL-400 (a NLRP3 inhibitor) following oral single and multiple ascending dose administration.

    Stage

    Phase 1

    Ages

    18 to 65

    Site

    Pharmaron CPC, Inc., Baltimore, Maryland

    Run by

    Highlightll Pharmaceutical (USA) LLC

    See if you can join NCT06997484 on ClinicalTrials.gov

21. Dance and Energy Expenditure Among Adults With Parkinson's

    The first purpose of the study is to develop and test new methods for quantifying dance among adults with a diagnosis of Parkinson's using various kinds of cameras, wearable activity monitors, and questionnaires. The second reason we are conducting the study is to better understand the relationship…

    Stage

    Not phased

    Ages

    18 to 85

    Site

    Northeastern University, Boston, Massachusetts

    Run by

    Northeastern University

    See if you can join NCT06425731 on ClinicalTrials.gov

22. CPAP for the Treatment of Supine Hypertension

    This study aims to learn about the effects of continuous positive airway pressure (CPAP) on people with autonomic failure and high blood pressure when lying down (supine hypertension) to determine if it can be used to treat their high blood pressure during the night. CPAP (a widely used treatment f…

    Stage

    Not phased

    Ages

    40 to 80

    Site

    Autonomic Dysfunction Center/ Vanderbilt University Medical Center, Nashville, Tennessee

    Run by

    Vanderbilt University Medical Center

    See if you can join NCT05489575 on ClinicalTrials.gov

23. Low Voltage Electrical Stimulation for Depression in Parkinson's Patients

    The goal of this clinical trial is to determine the relative efficacy of fMRI model guided Transcranial Direct Current Stimulation (mgTDCS) in improving the depressive symptoms of patients with Parkinson's Disease (PD). The main questions it aims to answer are: 1) Can the use of mgTDCS significantl…

    Stage

    Not phased

    Ages

    19 to 65

    Site

    University of South Alabama, Mobile, Alabama

    Run by

    University of South Alabama

    See if you can join NCT06467695 on ClinicalTrials.gov

24. High Frequency Light, Sound, and Tactile Stimulation to Improve Motor and Cognitive Deficits in Parkinson's Disease

    Parkinson's disease (PD) impacts different types of neural oscillations in the brain, including beta (13-30Hz) and gamma oscillations (30-80Hz), which contributes to PD's cardinal symptoms of resting tremor, rigidity, bradykinesia (slowness of movement), and gait instability. The investigators' lab…

    Stage

    Not phased

    Ages

    45 to 90

    Site

    Massachusetts Institute of Technology, Cambridge, Massachusetts

    Run by

    Massachusetts Institute of Technology

    See if you can join NCT05268887 on ClinicalTrials.gov

25. Reducing Falls With Varenicline in Hypocholinergic Parkinson Disease

    This trial aims to test whether one year of Varenicline, when compared to placebo, can reduce fall risk and show improvement in the ability to multitask while walking. Participants that are eligible after screening for the study will be randomized to receive Varenicline or placebo. Along with the s…

    Stage

    Phase 2

    Ages

    45 and older

    Site

    University of Michigan, Ann Arbor, Michigan

    Run by

    Vikas Kotagal

    See if you can join NCT06679374 on ClinicalTrials.gov