Parkinson Disease Clinical Trials

117 studies are recruiting for parkinson disease in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 4

1. Percept Transitions in FOG and PD

   The purpose of this research is to examine the possible causes and signs of freezing of gait (FOG) secondary to Parkinson's disease (PD). To achieve this, the study will use the novel (on-label and FDA-approved) local field potential (LFP) measuring capability of the Medtronic Percept™ deep brain s…

   Stage

   Not phased

   Ages

   21 to 75

   Site

   University of Minnesota, Movement Disorders Lab, Minneapolis, Minnesota

   Run by

   University of Minnesota

   See if you can join NCT06848205 on ClinicalTrials.gov

2. Black and African Americans Connections to Parkinson's Disease (BLAAC PD)

   BLAAC PD is a research study to understand what Parkinson's disease looks like for Black and African American communities. BLAAC PD is happening at research centers around the United States. The study is part of the Global Parkinson's Genetics Program (GP2). GP2 is a research project working to tra…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Alabama at Birmingham, Birmingham, Alabama

   Locations

   12 in total

   Run by

   Michael J. Fox Foundation for Parkinson's Research

   See if you can join NCT06719583 on ClinicalTrials.gov

3. Pyridostigmine for the Treatment of Constipation in Parkinson Disease

   Constipation is a common and debilitating non-motor symptom of Parkinson disease (PD) that often precedes the onset of classic motor symptoms by decades. There is no standardized algorithm for managing constipation in this patient population, nor are there dedicated treatments. Studies suggest that…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   University of Vermont Medical Center, Burlington, Vermont

   Run by

   University of Vermont Medical Center

   See if you can join NCT05603715 on ClinicalTrials.gov

4. Social & QoL Behaviors in Parkinson's Disease

   Adults with Parkinson's Disease experience an array of challenges and changes in daily living, behaviors, and functioning throughout the progression of their condition. The investigators want to learn more about the effects of Parkinson's Disease on individuals' social behavior and quality of life …

   Stage

   Not phased

   Ages

   40 and older

   Site

   The George Washington University, Washington D.C., District of Columbia

   Run by

   Gregory Wallace

   See if you can join NCT06385184 on ClinicalTrials.gov

5. Colonoscopic Detection of Phosphorylated Alpha-synuclein for Parkinson's Diagnosis

   The goal of this observational study is to learn whether tissue samples taken from the colon during routine colonoscopy can detect signs of Parkinson's disease. The main question it aims to answer is: Can doctors find a protein called alpha-synuclein in colon tissue samples from people with Parkins…

   Stage

   Not phased

   Ages

   40 to 99

   Site

   Oregon Health & Science University, Portland, Oregon

   Run by

   CND Life Sciences

   See if you can join NCT07204652 on ClinicalTrials.gov

6. Colonic Tissue Biopsy Detection of Phosphorylated Alpha-synuclein for Parkinson's Diagnosis or REM Sleep Behavior Disorder

   The goal of this observational study is to learn whether tissue samples taken from the colon during routine colonoscopy can detect signs of Parkinson's disease or REM Sleep Behavior Disorder (RBD). The main question it aims to answer is: Can doctors find a protein called alpha-synuclein in colon ti…

   Stage

   Not phased

   Ages

   40 to 99

   Site

   Digestive Disease Associates, Branford, Connecticut

   Run by

   CND Life Sciences

   See if you can join NCT07217054 on ClinicalTrials.gov

7. Facilitating Diagnostics and Prognostics of Parkinsonian Syndromes Using Neuroimaging

   The goals of this study are: 1) to identify biomarkers using neuroimaging that are associated with progression rate using statistical methods, and 2) to identify biomarkers that are associated with the differential diagnosis of Parkinson's disease and atypical parkinsonism.

   Stage

   Not phased

   Ages

   Any age

   Site

   UT Southwestern Medical Center, Dallas, Texas

   Run by

   University of Texas Southwestern Medical Center

   See if you can join NCT03872102 on ClinicalTrials.gov

8. Circuit-Based Deep Brain Stimulation for Parkinson's Disease P1A2&3 Catalyst

   This study will help us better understand how the brain works in people with Parkinson's disease (PD). PD is a brain disease that gets worse over time, and affects over 10 million people world-wide. A common treatment for PD is Deep Brain Stimulation (DBS). To improve DBS therapy for PD, we need a …

   Stage

   Not phased

   Ages

   21 and older

   Site

   University Of Minnesota, Minneapolis, Minnesota

   Run by

   University of Minnesota

   See if you can join NCT05658302 on ClinicalTrials.gov

9. Sensory Filtering in the Human Basal Ganglia as a Mechanism of Parkinson's Disease

   The investigators are investigating the brain activity associated with sensory information in movement disorders in order to improve treatment of these symptoms beyond what is currently available.

   Stage

   Not phased

   Ages

   18 to 89

   Site

   The University of Alabama at Birmingham Hospital, Birmingham, Alabama

   Run by

   University of Alabama at Birmingham

   See if you can join NCT05482126 on ClinicalTrials.gov

10. Abbott DBS Post-Market Study of Outcomes for Indications Over Time

    The purpose of this international study is to evaluate long-term safety and effectiveness of Abbott deep brain stimulation (DBS) systems for all indications, including Parkinson's disease, essential tremor or other disabling tremor and dystonia.

    Stage

    Not phased

    Ages

    Any age

    Site

    University of South Florida - Department of Neurology, Tampa, Florida

    Locations

    48 in total

    Run by

    Abbott Medical Devices

    See if you can join NCT04071847 on ClinicalTrials.gov

11. Cortical Correlates of Gait in Parkinson's Disease: Impact of Medication and Cueing

    The purpose of the study is to determine the effects of a novel, personalized, tactile cueing system on gait automaticity. The researchers hypothesized that step-synchronized tactile cueing will reduce prefrontal cortex activity (improve automaticity) and improve gait variability (as well as gait s…

    Stage

    Not phased

    Ages

    45 to 85

    Site

    Oregon Health and Science University, Portland, Oregon

    Run by

    Oregon Health and Science University

    See if you can join NCT05818189 on ClinicalTrials.gov

12. Action Regulation Behavioral

    Parkinson's disease (PD) is a neurodegenerative disorder involving a part of the brain that is responsible for motor control, which not only results in changes or disruptions in movement, but also cognitive dysfunctions. Given that the decline of muscle control such as tremors, with difficulty walk…

    Stage

    Not phased

    Ages

    18 to 80

    Site

    University of Texas Southwestern Medical Center, Dallas, Texas

    Run by

    University of Texas Southwestern Medical Center

    See if you can join NCT06489483 on ClinicalTrials.gov

13. Investigating Inhibitory Control Networks in Parkinson's Disease

    The purpose of this study is to investigate the brain activity associated with non-motor symptoms of movement disorders, including Parkinson's disease and essential tremor. These movement disorders commonly have significant non-motor features also, including depression, cognitive impairment, decrea…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Run by

    University of Alabama at Birmingham

    See if you can join NCT04735458 on ClinicalTrials.gov

14. Clinical Validation of DystoniaNet Deep Learning Platform for Diagnosis of Isolated Dystonia

    This research involves retrospective and prospective studies for clinical validation of a DystoniaNet deep learning platform for the diagnosis of isolated dystonia.

    Stage

    Not phased

    Ages

    Any age

    Site

    Massachusetts Eye and Ear Infirmary, Boston, Massachusetts

    Run by

    Massachusetts Eye and Ear Infirmary

    See if you can join NCT05317390 on ClinicalTrials.gov

15. Globus Pallidus Stimulation to Treat Insomnia

    Researchers are to determine if turning on an additional unilateral DBS (deep brain stimulation) electrode with stimulation to the globus pallidus externa (GPe) region of the brain will improve insomnia (sleep).

    Stage

    Not phased

    Ages

    40 to 80

    Site

    Mayo Clinic in Florida, Jacksonville, Florida

    Run by

    Mayo Clinic

    See if you can join NCT04116996 on ClinicalTrials.gov

16. Phase 2 Trial of Tributyrin in People With Parkinson's Disease and Cognitive Impairments

    The goal of this clinical trial is to learn if taking a tributyrin supplement works to improve memory and thinking and walking and balance in adults with Parkinson disease Parkinson disease dementia. It will also learn about the safety of tributyrin supplementation. The main questions it aims to an…

    Stage

    Phase 1

    Ages

    45 and older

    Site

    Domino's Farms, Ann Arbor, Michigan

    Run by

    Prabesh Kanel

    See if you can join NCT07154511 on ClinicalTrials.gov

17. Real-World Patient Experiences Using Continuous Subcutaneous Apomorphine Infusion (ONAPGOTM) in the United States:

    Real-World Participants Experiences Using Continuous Subcutaneous Apomorphine Infusion (ONAPGOTM) in the United States: A Prospective, Phase 4, Multicenter, Observational Study in Parkinson's Disease

    Stage

    Not phased

    Ages

    18 and older

    Site

    Parkinson's Disease and Movement Disorders Center - Orange County (South), Aliso Viejo, California

    Locations

    5 in total

    Run by

    Supernus Pharmaceuticals, Inc.

    See if you can join NCT07219927 on ClinicalTrials.gov

18. Stimulus-Evoked Directional Field Potentials to Guide Subthalamic and Pallidal DBS for PD

    Our goal is to better understand how DBS modifies local neuronal activity and to pioneer device technologies that can record local DBS-evoked potentials (DLEPs) to guide therapy. Our vision is for a patient's unique electrophysiology to guide both electrode targeting during surgery and programming …

    Stage

    Not phased

    Ages

    18 to 89

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Run by

    University of Alabama at Birmingham

    See if you can join NCT06169852 on ClinicalTrials.gov

19. Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic Failure

    The purpose of this study is to learn more about the effects of midodrine and droxidopa, two medications used for the treatment of orthostatic hypotension (low blood pressure on standing), on the veins of the abdomen of patients with autonomic failure. The study will be conducted at Vanderbilt Univ…

    Stage

    Phase 1

    Ages

    40 to 80

    Site

    Autonomic Dysfunction Center/ Vanderbilt University Medical Center, Nashville, Tennessee

    Run by

    Vanderbilt University Medical Center

    See if you can join NCT02897063 on ClinicalTrials.gov

20. Cognitive Decline Following Deep Brain Stimulation: A DBS-fMRI Study

    The objective of this research study is to understand how Deep Brain Stimulation (DBS) targeting the subthalamic nucleus (STN) affects cognitive networks in the brain, potentially leading to cognitive decline in patients with Parkinson's Disease (PD). A total of 55 participants with PD who have und…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Medical University of South Carolina, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT06960096 on ClinicalTrials.gov

21. Parkinson's Disease and Movement Disorders Clinical Database

    The research database contains demographic and family history information, longitudinal information on the clinical symptoms, neuropsychological profile and treatments, stored biological samples, and brain images of patients with Parkinson's disease and related disorders receiving care at the Parki…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Pennsylvania, Philadelphia, Pennsylvania

    Run by

    University of Pennsylvania

    See if you can join NCT04997642 on ClinicalTrials.gov

22. Rehabilitation of Airway Protection in Parkinson's Disease

    Airway protective disorders are a prevalent and progressive consequence of Parkinson's Disease (PD), and often result in aspiration pneumonia which is the leading cause of death in PD. Despite this, a large number of patients with PD do not access specialized services to address these critical defi…

    Stage

    Phase 2

    Ages

    50 to 90

    Site

    Purdue University, West Lafayette, Indiana

    Locations

    2 in total

    Run by

    Teachers College, Columbia University

    See if you can join NCT05700825 on ClinicalTrials.gov

23. Neocortical Microarchitecture of Executive Function

    This study is being done to the determine the ability and utility of using the Neuropixels probes in the human brain. A Neuropixels probe will be inserted into and removed from the brain of awake human patients who are undergoing awake Deep Brain Stimulation (DBS) surgery.

    Stage

    Not phased

    Ages

    45 to 85

    Site

    University of Colorado, Aurora, Colorado

    Run by

    University of Colorado, Denver

    See if you can join NCT06778135 on ClinicalTrials.gov

24. A Study of CREXONT (Carbidopa and Levodopa) Extended-Release Capsules in Participants With Parkinson's Disease

    The primary purpose of this study is to evaluate efficacy and safety of CREXONT under real world conditions in participants with Parkinson disease (PD).

    Stage

    Phase 4

    Ages

    18 and older

    Site

    University of Arkansas for Medical Sciences, Little Rock, Arkansas

    Locations

    27 in total

    Run by

    Impax Laboratories, LLC

    See if you can join NCT06765668 on ClinicalTrials.gov

25. SegwayPD: The Effect of Sensory-augmented Postural Training Using Segway on Motor and Cognitive Function in Individuals With Parkinson's Disease

    The purpose of this study is to examine the safety and efficacy of postural training emphasized on the integration of multiple sensory information into motor control in individuals with PD. This project is a proof-of-concept study to assess the effectiveness of postural training using Segway, which…

    Stage

    Not phased

    Ages

    50 to 85

    Site

    University of Texas Southwestern Medical Center, Dallas, Texas

    Run by

    University of Texas Southwestern Medical Center

    See if you can join NCT05982730 on ClinicalTrials.gov