Parkinson Disease Clinical Trials

118 studies are recruiting for parkinson disease in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

Search these by distance from you

By city

Studies, page 4

1. Cortical-Basal Ganglia Speech Networks

   In this research study the researchers want to learn more about brain activity related to speech perception and production.

   Stage

   Not phased

   Ages

   18 to 85

   Site

   Massachusetts General Hospital, Boston, Massachusetts

   Run by

   Massachusetts General Hospital

   See if you can join NCT04286308 on ClinicalTrials.gov

2. Treating Parkinson's Disease Through Transplantation of Autologous Stem Cell-Derived Dopaminergic Neurons

   The goal of this clinical trial is to assess the safety and tolerability of the surgical transplantation of dopaminergic progenitor cells into the brains of participants with Parkinson's disease. The transplanted dopaminergic cells will be derived from the participant's own skin cells.

   Stage

   Phase 1

   Ages

   45 to 80

   Site

   Massachusetts General Hospital, Boston, Massachusetts

   Run by

   Jeffrey S. Schweitzer, MD, PhD

   See if you can join NCT06687837 on ClinicalTrials.gov

3. Cerebellar Stimulation and Cognitive Control

   The purpose of this study is to examine whether cerebellar stimulation can be used to improve cognitive deficits and mood in patients with schizophrenia, autism, bipolar disorder, Parkinson's disease, and major depression.

   Stage

   Not phased

   Ages

   18 to 90

   Site

   University of Iowa, Iowa City, Iowa

   Run by

   Krystal Parker, PhD

   See if you can join NCT03217110 on ClinicalTrials.gov

4. Vestibular and Cortical Contributions to Transitions in Freezing of Gait in Parkinson's Disease

   Currently, there is a lack of comprehensive knowledge about the role of vestibulospinal drive and cortical activity during self-initiated movement transitions in older adults and people with PD (both with and without FOG). This set of experiments has two primary purposes: to (1) understand the path…

   Stage

   Not phased

   Ages

   21 to 80

   Site

   University of Minnesota, Movement Disorders Lab, Minneapolis, Minnesota

   Run by

   University of Minnesota

   See if you can join NCT06506058 on ClinicalTrials.gov

5. [18F]F-DOPA Imaging in Patients With Autonomic Failure

   Alpha-synucleinopathies refer to age-related neurodegenerative and dementing disorders, characterized by the accumulation of alpha-synuclein in neurons and/or glia. The anatomical location of alpha-synuclein inclusions (Lewy Bodies) and the pattern of progressive neuronal death (e.g. caudal to rost…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Vanderbilt University Medical Center, Nashville, Tennessee

   Run by

   Daniel Claassen

   See if you can join NCT04246437 on ClinicalTrials.gov

6. Characterizing the Pathophysiological Role of the Pallido-thalamocortical Motor Pathway in Parkinson's Disease.

   When a patient gets DBS surgery, the neurosurgeon makes a hole in the skull through which they can put the DBS lead down in deep parts of the brain that help control movement. For this study, research participants will also have an ECoG strip put through the same hole (no extra holes are being made…

   Stage

   Not phased

   Ages

   21 to 75

   Site

   University of Minnesota, Minneapolis, Minnesota

   Run by

   University of Minnesota

   See if you can join NCT06692920 on ClinicalTrials.gov

7. Spinal Cord Stimulation for Parkinson's Disease Rehabilitation

   This study explores the use of multifunctional, non-invasive spinal cord transcutaneous stimulation (scTS) to address axial motor symptoms, particularly gait dysfunction, in Parkinson's disease (PD). These symptoms, resistant to levodopa and inadequately managed by deep brain stimulation (DBS), ari…

   Stage

   Not phased

   Ages

   18 to 80

   Site

   Frazier Rehab Institute, Louisville, Kentucky

   Run by

   University of Louisville

   See if you can join NCT06804642 on ClinicalTrials.gov

8. Udall Project 2 Aim 2A&C

   This protocol will leverage the novel (on-label, FDA-approved) local field potential measuring capability of the Medtronic Percept™ PC or RC DBS system to study the effects of globus pallidus internus, globus pallidus externus (GPi, GPe), and subthalamic nucleus (STN) DBS on: the wash-out and wash-…

   Stage

   Not phased

   Ages

   Any age

   Site

   University of Minnesota, Minneapolis, Minnesota

   Run by

   University of Minnesota

   See if you can join NCT05656586 on ClinicalTrials.gov

9. Percept Transitions in FOG and PD

   The purpose of this research is to examine the possible causes and signs of freezing of gait (FOG) secondary to Parkinson's disease (PD). To achieve this, the study will use the novel (on-label and FDA-approved) local field potential (LFP) measuring capability of the Medtronic Percept™ deep brain s…

   Stage

   Not phased

   Ages

   21 to 75

   Site

   University of Minnesota, Movement Disorders Lab, Minneapolis, Minnesota

   Run by

   University of Minnesota

   See if you can join NCT06848205 on ClinicalTrials.gov

10. Black and African Americans Connections to Parkinson's Disease (BLAAC PD)

    BLAAC PD is a research study to understand what Parkinson's disease looks like for Black and African American communities. BLAAC PD is happening at research centers around the United States. The study is part of the Global Parkinson's Genetics Program (GP2). GP2 is a research project working to tra…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Locations

    12 in total

    Run by

    Michael J. Fox Foundation for Parkinson's Research

    See if you can join NCT06719583 on ClinicalTrials.gov

11. Pyridostigmine for the Treatment of Constipation in Parkinson Disease

    Constipation is a common and debilitating non-motor symptom of Parkinson disease (PD) that often precedes the onset of classic motor symptoms by decades. There is no standardized algorithm for managing constipation in this patient population, nor are there dedicated treatments. Studies suggest that…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    University of Vermont Medical Center, Burlington, Vermont

    Run by

    University of Vermont Medical Center

    See if you can join NCT05603715 on ClinicalTrials.gov

12. Social & QoL Behaviors in Parkinson's Disease

    Adults with Parkinson's Disease experience an array of challenges and changes in daily living, behaviors, and functioning throughout the progression of their condition. The investigators want to learn more about the effects of Parkinson's Disease on individuals' social behavior and quality of life …

    Stage

    Not phased

    Ages

    40 and older

    Site

    The George Washington University, Washington D.C., District of Columbia

    Run by

    Gregory Wallace

    See if you can join NCT06385184 on ClinicalTrials.gov

13. Colonoscopic Detection of Phosphorylated Alpha-synuclein for Parkinson's Diagnosis

    The goal of this observational study is to learn whether tissue samples taken from the colon during routine colonoscopy can detect signs of Parkinson's disease. The main question it aims to answer is: Can doctors find a protein called alpha-synuclein in colon tissue samples from people with Parkins…

    Stage

    Not phased

    Ages

    40 to 99

    Site

    Oregon Health & Science University, Portland, Oregon

    Run by

    CND Life Sciences

    See if you can join NCT07204652 on ClinicalTrials.gov

14. Colonic Tissue Biopsy Detection of Phosphorylated Alpha-synuclein for Parkinson's Diagnosis or REM Sleep Behavior Disorder

    The goal of this observational study is to learn whether tissue samples taken from the colon during routine colonoscopy can detect signs of Parkinson's disease or REM Sleep Behavior Disorder (RBD). The main question it aims to answer is: Can doctors find a protein called alpha-synuclein in colon ti…

    Stage

    Not phased

    Ages

    40 to 99

    Site

    Digestive Disease Associates, Branford, Connecticut

    Run by

    CND Life Sciences

    See if you can join NCT07217054 on ClinicalTrials.gov

15. Facilitating Diagnostics and Prognostics of Parkinsonian Syndromes Using Neuroimaging

    The goals of this study are: 1) to identify biomarkers using neuroimaging that are associated with progression rate using statistical methods, and 2) to identify biomarkers that are associated with the differential diagnosis of Parkinson's disease and atypical parkinsonism.

    Stage

    Not phased

    Ages

    Any age

    Site

    UT Southwestern Medical Center, Dallas, Texas

    Run by

    University of Texas Southwestern Medical Center

    See if you can join NCT03872102 on ClinicalTrials.gov

16. Circuit-Based Deep Brain Stimulation for Parkinson's Disease P1A2&3 Catalyst

    This study will help us better understand how the brain works in people with Parkinson's disease (PD). PD is a brain disease that gets worse over time, and affects over 10 million people world-wide. A common treatment for PD is Deep Brain Stimulation (DBS). To improve DBS therapy for PD, we need a …

    Stage

    Not phased

    Ages

    21 and older

    Site

    University Of Minnesota, Minneapolis, Minnesota

    Run by

    University of Minnesota

    See if you can join NCT05658302 on ClinicalTrials.gov

17. Abbott DBS Post-Market Study of Outcomes for Indications Over Time

    The purpose of this international study is to evaluate long-term safety and effectiveness of Abbott deep brain stimulation (DBS) systems for all indications, including Parkinson's disease, essential tremor or other disabling tremor and dystonia.

    Stage

    Not phased

    Ages

    Any age

    Site

    University of South Florida - Department of Neurology, Tampa, Florida

    Locations

    48 in total

    Run by

    Abbott Medical Devices

    See if you can join NCT04071847 on ClinicalTrials.gov

18. Cortical Correlates of Gait in Parkinson's Disease: Impact of Medication and Cueing

    The purpose of the study is to determine the effects of a novel, personalized, tactile cueing system on gait automaticity. The researchers hypothesized that step-synchronized tactile cueing will reduce prefrontal cortex activity (improve automaticity) and improve gait variability (as well as gait s…

    Stage

    Not phased

    Ages

    45 to 85

    Site

    Oregon Health and Science University, Portland, Oregon

    Run by

    Oregon Health and Science University

    See if you can join NCT05818189 on ClinicalTrials.gov

19. Action Regulation Behavioral

    Parkinson's disease (PD) is a neurodegenerative disorder involving a part of the brain that is responsible for motor control, which not only results in changes or disruptions in movement, but also cognitive dysfunctions. Given that the decline of muscle control such as tremors, with difficulty walk…

    Stage

    Not phased

    Ages

    18 to 80

    Site

    University of Texas Southwestern Medical Center, Dallas, Texas

    Run by

    University of Texas Southwestern Medical Center

    See if you can join NCT06489483 on ClinicalTrials.gov

20. Investigating Inhibitory Control Networks in Parkinson's Disease

    The purpose of this study is to investigate the brain activity associated with non-motor symptoms of movement disorders, including Parkinson's disease and essential tremor. These movement disorders commonly have significant non-motor features also, including depression, cognitive impairment, decrea…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Run by

    University of Alabama at Birmingham

    See if you can join NCT04735458 on ClinicalTrials.gov

21. Clinical Validation of DystoniaNet Deep Learning Platform for Diagnosis of Isolated Dystonia

    This research involves retrospective and prospective studies for clinical validation of a DystoniaNet deep learning platform for the diagnosis of isolated dystonia.

    Stage

    Not phased

    Ages

    Any age

    Site

    Massachusetts Eye and Ear Infirmary, Boston, Massachusetts

    Run by

    Massachusetts Eye and Ear Infirmary

    See if you can join NCT05317390 on ClinicalTrials.gov

22. Globus Pallidus Stimulation to Treat Insomnia

    Researchers are to determine if turning on an additional unilateral DBS (deep brain stimulation) electrode with stimulation to the globus pallidus externa (GPe) region of the brain will improve insomnia (sleep).

    Stage

    Not phased

    Ages

    40 to 80

    Site

    Mayo Clinic in Florida, Jacksonville, Florida

    Run by

    Mayo Clinic

    See if you can join NCT04116996 on ClinicalTrials.gov

23. Phase 2 Trial of Tributyrin in People With Parkinson's Disease and Cognitive Impairments

    The goal of this clinical trial is to learn if taking a tributyrin supplement works to improve memory and thinking and walking and balance in adults with Parkinson disease Parkinson disease dementia. It will also learn about the safety of tributyrin supplementation. The main questions it aims to an…

    Stage

    Phase 1

    Ages

    45 and older

    Site

    Domino's Farms, Ann Arbor, Michigan

    Run by

    Prabesh Kanel

    See if you can join NCT07154511 on ClinicalTrials.gov

24. Real-World Patient Experiences Using Continuous Subcutaneous Apomorphine Infusion (ONAPGOTM) in the United States:

    Real-World Participants Experiences Using Continuous Subcutaneous Apomorphine Infusion (ONAPGOTM) in the United States: A Prospective, Phase 4, Multicenter, Observational Study in Parkinson's Disease

    Stage

    Not phased

    Ages

    18 and older

    Site

    Parkinson's Disease and Movement Disorders Center - Orange County (South), Aliso Viejo, California

    Locations

    5 in total

    Run by

    Supernus Pharmaceuticals, Inc.

    See if you can join NCT07219927 on ClinicalTrials.gov

25. Neocortical Microarchitecture of Executive Function

    This study is being done to the determine the ability and utility of using the Neuropixels probes in the human brain. A Neuropixels probe will be inserted into and removed from the brain of awake human patients who are undergoing awake Deep Brain Stimulation (DBS) surgery.

    Stage

    Not phased

    Ages

    45 to 85

    Site

    University of Colorado, Aurora, Colorado

    Run by

    University of Colorado, Denver

    See if you can join NCT06778135 on ClinicalTrials.gov