Parkinson Disease Clinical Trials in Gainesville, Florida

9 studies are recruiting for parkinson disease in Gainesville, Florida right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. A Phase 2 Study and Open-Label Extension of NEU-411 in Companion Diagnostic-Positive Participants With Early Parkinson's Disease

   The goal of this Phase 2 clinical trial is to investigate the efficacy and safety of NEU-411 in men and women aged 40-80 years with early Parkinson's Disease (PD) who have predicted elevations in the activity of the "leucine-rich repeat kinase 2" ("LRRK2" for short) pathway based on their genetic p…

   Stage

   Phase 2

   Ages

   40 to 80

   Site

   University of Florida, Gainesville, Florida

   Locations

   72 in total

   Run by

   Neuron23 Inc.

   See if you can join NCT06680830 on ClinicalTrials.gov

2. Cross-System Effects of Acute Intermittent Hypercapnia-Based Interventions in PD

   Parkinsonism impairs upper airway and axial motor control, leading to disordered breathing, reduced speech volume, and ineffective cough. Symptoms are poorly addressed by current therapies. This randomized pilot trial tests whether a single session of acute intermittent hypercapnic hypoxia (AIHH) o…

   Stage

   Not phased

   Ages

   40 to 75

   Site

   University of Florida, Gainesville, Florida

   Locations

   2 in total

   Run by

   University of Florida

   See if you can join NCT07674264 on ClinicalTrials.gov

3. Low-dose Carbon Monoxide (HBI-002) Trial to Evaluate Safety, Tolerability, PK, and Biomarkers in Parkinson's Disease

   A phase 2a multicenter, randomized, double-blind, placebo-controlled multiple dose study to evaluate the safety, tolerability, pharmacokinetics, of HBI-002, an oral low-dose carbon monoxide (CO) liquid drug product, administered daily over 14 days in subjects with Parkinson's disease (PD).

   Stage

   Phase 2

   Ages

   40 to 80

   Site

   University of Florida, Gainesville, Florida

   Locations

   5 in total

   Run by

   Hillhurst Biopharmaceuticals, Inc.

   See if you can join NCT07005180 on ClinicalTrials.gov

4. Effects of Transcranial Focused Ultrasound Stimulation (tFUS) on Neurological and Cognitive Outcomes in Parkinson's Disease

   This is a pilot randomized, sham-controlled, double-blind, multi-center study evaluating the safety and preliminary effectiveness of the Gen0Bh Transcranial Focused Ultrasound System for the treatment of motor symptoms in individuals with idiopathic Parkinson's disease.

   Stage

   Not phased

   Ages

   22 to 80

   Site

   UF - McKnight Brain Institute, Gainesville, Florida

   Locations

   4 in total

   Run by

   Sanmai Technologies PBC dba Sanmai

   See if you can join NCT07207122 on ClinicalTrials.gov

5. PPMI Clinical - Establishing a Deeply Phenotyped PD Cohort

   The Parkinson Progression Marker Initiative (PPMI) is a longitudinal, observational, multi-center natural history study to assess progression of clinical features, digital outcomes, and imaging, biologic and genetic markers of Parkinson's disease (PD) progression in study participants with manifest…

   Stage

   Not phased

   Ages

   30 and older

   Site

   University of Florida, Gainesville, Florida

   Locations

   50 in total

   Run by

   Michael J. Fox Foundation for Parkinson's Research

   See if you can join NCT04477785 on ClinicalTrials.gov

6. Neurophysiology of Locomotor Adaptation and Freezing of Gait in Parkinson's Disease

   Locomotor adaptation will be studied using an established split-belt treadmill paradigm, consisting of baseline (1:1 speed ratio), split-belt adaptation (2:1) and post-adaptation (1:1) walking. Split-belt walking will be performed under DBS ON and DBS OFF conditions, while off-medication.

   Stage

   Not phased

   Ages

   18 to 80

   Site

   University of Florida, Gainesville, Florida

   Run by

   University of Florida

   See if you can join NCT06911229 on ClinicalTrials.gov

7. Safety and Tolerability of Patterned Stimulation for DBS in the Home Setting

   The primary objective of the proposed pilot study is to assess the safety and tolerability of active patterned Deep Brain Stimulation (pDBS) when administered in a home setting for patients with Parkinson's disease (PD) who have had stable bilateral Subthalamic Nucleus (STN) and Globus Pallidus int…

   Stage

   Not phased

   Ages

   18 to 80

   Site

   University of Florida, Gainesville, Florida

   Run by

   University of Florida

   See if you can join NCT07410598 on ClinicalTrials.gov

8. A Study of AAV2-GDNF in Adults With Moderate Parkinson's Disease (REGENERATE-PD)

   The objective of this randomized, surgically controlled, double-blinded, Phase 2 study is to evaluate the safety and efficacy of AAV2-GDNF delivered to the putamen in subjects with moderate Parkinson's Disease.

   Stage

   Phase 2

   Ages

   45 to 75

   Site

   University of Florida, Gainesville, Florida

   Locations

   46 in total

   Run by

   AskBio Inc

   See if you can join NCT06285643 on ClinicalTrials.gov

9. Black and African Americans Connections to Parkinson's Disease (BLAAC PD)

   BLAAC PD is a research study to understand what Parkinson's disease looks like for Black and African American communities. BLAAC PD is happening at research centers around the United States. The study is part of the Global Parkinson's Genetics Program (GP2). GP2 is a research project working to tra…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Florida, Gainesville, Florida

   Locations

   12 in total

   Run by

   Michael J. Fox Foundation for Parkinson's Research

   See if you can join NCT06719583 on ClinicalTrials.gov