Parkinson Disease Clinical Trials

118 studies are recruiting for parkinson disease in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. A Phase 2 Study and Open-Label Extension of NEU-411 in Companion Diagnostic-Positive Participants With Early Parkinson's Disease

   The goal of this Phase 2 clinical trial is to investigate the efficacy and safety of NEU-411 in men and women aged 40-80 years with early Parkinson's Disease (PD) who have predicted elevations in the activity of the "leucine-rich repeat kinase 2" ("LRRK2" for short) pathway based on their genetic p…

   Stage

   Phase 2

   Ages

   40 to 80

   Site

   Banner Sun Health Research Institute, Sun City, Arizona

   Locations

   72 in total

   Run by

   Neuron23 Inc.

   See if you can join NCT06680830 on ClinicalTrials.gov

2. A Study to Evaluate the Effectiveness of Two Doses of AP-472 as Adjunctive Therapy to Levodopa in Parkinson's Disease (PD) Participants With Motor Fluctuations

   This is a Phase 2 study in people with Parkinson's disease who experience motor fluctuations while taking levodopa. The study will evaluate how effective two different doses of the study drug AP-472 are when added to levodopa treatment, compared with a placebo. The study will last about 14 weeks. P…

   Stage

   Phase 2

   Ages

   30 to 80

   Site

   University of Arkansas for Medical Sciences (Site #208), Little Rock, Arkansas

   Locations

   30 in total

   Run by

   Appello Pharmaceuticals, Inc.

   See if you can join NCT07432958 on ClinicalTrials.gov

3. Genetics and Aerobic Exercise to Slow Parkinson's Disease Trial

   The proposed multi-site, Genetics and Aerobic Exercise to Slow PD (GEARS) Trial will, for the first time, determine the interplay between genetics and exercise in altering PD progression. In sum, 200 PD patients will be recruited from the Cleveland and Salt Lake City metro areas to participate in t…

   Stage

   Not phased

   Ages

   18 and older

   Site

   The Cleveland Clinic, Cleveland, Ohio

   Run by

   Jay Alberts

   See if you can join NCT06442033 on ClinicalTrials.gov

4. Decoding the Neural Mechanisms Underlying Postural Instability and Gait Dysfunction in Parkinson's Disease

   The purpose of this study is to learn how brain signals are related to freezing of gait (FOG) and balance problems in Parkinson's disease (PD) and to study how different deep brain stimulation (DBS) settings may affect these symptoms.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Cleveland Clinic, Cleveland, Ohio

   Run by

   The Cleveland Clinic

   See if you can join NCT07748962 on ClinicalTrials.gov

5. A Study to Determine if BHV-8000 is Effective, Safe and Tolerable as a Treatment for Adults Living With Early Parkinson's Disease

   A study to determine if BHV-8000 is efficacious, safe and tolerable in adults diagnosed with early Parkinson's disease. The study will consist of a 48-week double-blind treatment phase followed by a 48-week open-label phase.

   Stage

   Phase 2

   Ages

   40 to 80

   Site

   Site-049, Birmingham, Alabama

   Locations

   25 in total

   Run by

   Biohaven Therapeutics Ltd.

   See if you can join NCT06976268 on ClinicalTrials.gov

6. Stimulus-Evoked Directional Field Potentials to Guide Subthalamic and Pallidal DBS for PD

   Our goal is to better understand how DBS modifies local neuronal activity and to pioneer device technologies that can record local DBS-evoked potentials (DLEPs) to guide therapy. Our vision is for a patient's unique electrophysiology to guide both electrode targeting during surgery and programming …

   Stage

   Not phased

   Ages

   18 to 89

   Site

   University of Alabama at Birmingham, Birmingham, Alabama

   Run by

   University of Alabama at Birmingham

   See if you can join NCT06169852 on ClinicalTrials.gov

7. EXercise-induced PhysioLogical Adaptations In Neurological Disorders

   The goal of this study is to investigate how a one-time exercise session influences different parameters of brain function in people with neurological diseases compared to healthy volunteers. The main questions the study aims to answer are: * How do fitness level, exercise performance, and physical…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Brigham and Women's Hospital, Boston, Massachusetts

   Run by

   Brigham and Women's Hospital

   See if you can join NCT07883720 on ClinicalTrials.gov

8. Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cell Exosomes for Parkinson's Disease

   This trial will study the safety and efficacy of intranasal instillation of cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cell exosomes for the treatment of Parkinson's Disease

   Stage

   Phase 1

   Ages

   Any age

   Site

   Prodromos Stem Cell Institute, Naples, Florida

   Locations

   2 in total

   Run by

   The Foundation for Orthopaedics and Regenerative Medicine

   See if you can join NCT05152394 on ClinicalTrials.gov

9. Wearable Biofeedback for Swallowing Disorders Rehabilitation in Stroke and Parkinson Disease

   Dysphagia, or difficulty swallowing, is a common symptom of many neurological diseases but its treatment is not well established or easily accessible. To start addressing this gap, the researchers developed and validated a cost-effective wearable surface electromyography (sEMG) biofeedback sensor t…

   Stage

   Phase 2

   Ages

   50 to 90

   Site

   University of Illinois Urbana-Champaign, Champaign, Illinois

   Locations

   2 in total

   Run by

   University of Illinois at Urbana-Champaign

   See if you can join NCT06638944 on ClinicalTrials.gov

10. Slow-SPEED: Slowing Parkinson's Early Through Exercise Dosage

    The goal of this clinical trial is two-fold. First to investigate the feasibility of whether a remotely administered smartphone app can increase the volume and intensity of physical activity in daily life in individuals with a LRRK2 G2019S or GBA1 N370S genetic mutation over a long period of time (…

    Stage

    Not phased

    Ages

    50 and older

    Site

    University of Rochester Center for Health and Technology (CHeT), Rochester, New York

    Locations

    2 in total

    Run by

    Radboud University Medical Center

    See if you can join NCT06993142 on ClinicalTrials.gov

11. BOOST-PD A Naturalistic Study on IPX-203 for Parkinson's Disease

    The purpose of this study is to evaluate the effect of IPX203 (Crexont®) - the newest extended-release levodopa formulation - on the duration and quality of good on time, using a wearable device to monitor symptoms. 'Good on time' refers to a period (minutes to hours) when a patient experiences opt…

    Stage

    Phase 4

    Ages

    40 and older

    Site

    Cleveland Clinic, Cleveland, Ohio

    Run by

    The Cleveland Clinic

    See if you can join NCT07138560 on ClinicalTrials.gov

12. A Study of LY4006896 in Healthy Participants and Participants With Parkinson's Disease

    The purpose of this study is to generate evidence of the safety, tolerability, and pharmacokinetics/pharmacodynamics of IV LY4006896 compared with placebo in healthy participants and participants with Parkinson's disease.

    Stage

    Phase 1

    Ages

    30 to 85

    Site

    Collaborative Neuroscience Network - CNS, Los Alamitos, California

    Locations

    14 in total

    Run by

    Eli Lilly and Company

    See if you can join NCT06809400 on ClinicalTrials.gov

13. Superior Parietal iTBS for PD-MCI

    The goal of this study is to determine the whether a short-term, high-dose form of non-invasive brain stimulation (intermittent theta burst stimulation; iTBS) is a promising and safe treatment for mild cognitive impairment in Parkinson's disease (PD-MCI).

    Stage

    Not phased

    Ages

    50 to 85

    Site

    Medical University of South Carolina, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT07701785 on ClinicalTrials.gov

14. Parkinson's Disease and Movement Disorders Clinical Database

    The research database contains demographic and family history information, longitudinal information on the clinical symptoms, neuropsychological profile and treatments, stored biological samples, and brain images of patients with Parkinson's disease and related disorders receiving care at the Parki…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Pennsylvania, Philadelphia, Pennsylvania

    Run by

    University of Pennsylvania

    See if you can join NCT04997642 on ClinicalTrials.gov

15. Rehabilitation of Airway Protection in Parkinson's Disease

    Airway protective disorders are a prevalent and progressive consequence of Parkinson's Disease (PD), and often result in aspiration pneumonia which is the leading cause of death in PD. Despite this, a large number of patients with PD do not access specialized services to address these critical defi…

    Stage

    Phase 2

    Ages

    50 to 90

    Site

    Teachers College, Columbia University, New York, New York

    Locations

    2 in total

    Run by

    Teachers College, Columbia University

    See if you can join NCT05700825 on ClinicalTrials.gov

16. Cognitive Decline Following Deep Brain Stimulation: A DBS-fMRI Study

    The objective of this research study is to understand how Deep Brain Stimulation (DBS) targeting the subthalamic nucleus (STN) affects cognitive networks in the brain, potentially leading to cognitive decline in patients with Parkinson's Disease (PD). A total of 55 participants with PD who have und…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Medical University of South Carolina, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT06960096 on ClinicalTrials.gov

17. Deep Brain Stimulation (DBS) Retrospective Outcomes Study

    The primary objective of this study is to characterize real-world clinical outcomes of Deep Brain Stimulation (DBS) using retrospective review of de-identified patient records.

    Stage

    Not phased

    Ages

    Any age

    Site

    St. Joseph's Hospital & Medical Center, Phoenix, Arizona

    Locations

    20 in total

    Run by

    Boston Scientific Corporation

    See if you can join NCT03664609 on ClinicalTrials.gov

18. Tributyrin for Progressive Supranuclear Palsy (PSP): Virtual Trial

    This research is studying a supplement called tributyrin in people with Progressive Supranuclear Palsy (PSP) to learn about its safety and tolerability as a potential treatment. The goal of this research study is to see if a similar supplementation regimen and virtual testing is feasible for people…

    Stage

    Phase 1

    Ages

    45 and older

    Site

    Domino's Farms, Ann Arbor, Michigan

    Run by

    Prabesh Kanel

    See if you can join NCT07863180 on ClinicalTrials.gov

19. Motor Network Physiology

    The brain networks controlling movement are complex, involving multiple areas of the brain. Some neurological disorders, like Parkinson's disease (PD) and essential tremor (ET), cause abnormalities in these brain networks. Deep brain stimulation is a treatment that is used to treat these types of n…

    Stage

    Not phased

    Ages

    18 to 89

    Site

    UT Southwestern Medical Center, Dallas, Texas

    Run by

    University of Texas Southwestern Medical Center

    See if you can join NCT04957095 on ClinicalTrials.gov

20. Visual Hallucinations in Lewy Body Diseases

    The goal of this basic experimental study involving humans (BESH) protocol is to improve the understanding of neural mechanisms underlying visual hallucinations in Lewy Body diseases to inform future treatment developments.

    Stage

    Not phased

    Ages

    18 to 90

    Site

    NYU Langone Health, New York, New York

    Run by

    NYU Langone Health

    See if you can join NCT07849413 on ClinicalTrials.gov

21. Low-dose Carbon Monoxide (HBI-002) Trial to Evaluate Safety, Tolerability, PK, and Biomarkers in Parkinson's Disease

    A phase 2a multicenter, randomized, double-blind, placebo-controlled multiple dose study to evaluate the safety, tolerability, pharmacokinetics, of HBI-002, an oral low-dose carbon monoxide (CO) liquid drug product, administered daily over 14 days in subjects with Parkinson's disease (PD).

    Stage

    Phase 2

    Ages

    40 to 80

    Site

    The Parkinson's & Movement Disorder Institute, Fountain Valley, California

    Locations

    8 in total

    Run by

    Hillhurst Biopharmaceuticals, Inc.

    See if you can join NCT07005180 on ClinicalTrials.gov

22. Stimulating Specific Brain Areas (VOP/VIM) With Electricity to Improve Movement and Muscle Control

    In this study the investigators aim to enroll patients scheduled to undergo deep brain stimulation (DBS) implantation for movement disorders for intra-operative testing. In addition to standard-of-care surgical procedure to implant deep brain stimulation electrode leads, participants will also be s…

    Stage

    Not phased

    Ages

    18 to 75

    Site

    University of Pittsburgh, Pittsburgh, Pennsylvania

    Run by

    Jorge Gonzalez-Martinez

    See if you can join NCT07056361 on ClinicalTrials.gov

23. Stereotactic Radiosurgery for Essential Tremor and Parkinsonian Tremor

    The purpose of this study is to determine the changes in quality of life and degree of tremor for patients with essential tremor or Parkinsonian tremor who are treated by stereotactic radiosurgery (SRS). This is a questionnaire-based study. Please see Detailed Description below for more information.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Vanderbilt University Medical Center, Nashville, Tennessee

    Run by

    Vanderbilt University Medical Center

    See if you can join NCT01734122 on ClinicalTrials.gov

24. Dual Frequency Stimulation in Parkinson's Disease

    Deep brain stimulation (DBS) in the dorsal region of the subthalamic nucleus (STN) is very effective for reducing motor symptoms of Parkinson's disease (PD). Modeling studies suggest that this therapy may result in current spread into the ventral STN, causing altered cognitive processes. As a resul…

    Stage

    Not phased

    Ages

    18 and older

    Site

    UC Davis Health, Sacramento, California

    Run by

    University of California, Davis

    See if you can join NCT04650932 on ClinicalTrials.gov

25. Parkinson Progression Marker Initiative Online (PPMI Online)

    Parkinson Progression Marker Initiative Online (PPMI Online) is an observational study collecting participant reported information from people with and without Parkinson's disease (PD), for the goal of better understanding risk and predictive factors for PD. PPMI Online is part of the broader Parki…

    Stage

    Not phased

    Ages

    18 and older

    Site

    UCSF Movement Disorders and Neuromodulation Center (MDNC), San Francisco, California

    Run by

    Michael J. Fox Foundation for Parkinson's Research

    See if you can join NCT05065060 on ClinicalTrials.gov