Parkinson Disease Clinical Trials

118 studies are recruiting for parkinson disease in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 2

1. Cortical Electrophysiology of Response Inhibition in Parkinson's Disease

   Patients with Parkinson's Disease will be studied before, during, and after a deep brain stimulation implantation procedure to see if the stimulation location and the size of the electrical field produced by subthalamic nucleus (STN) DBS determine the degree to which DBS engages circuits that invol…

   Stage

   Phase 4

   Ages

   45 to 75

   Site

   Emory University Hospital, Atlanta, Georgia

   Locations

   2 in total

   Run by

   Emory University

   See if you can join NCT06234995 on ClinicalTrials.gov

2. Deep Brain Stimulation Neural Recordings of Varied Stimulation During Sleep in Parkinson's Disease

   This study employs an exploratory, prospective, single center, naturalistic clinical trial design with a randomized crossover intervention.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Cleveland Clinic, Cleveland, Ohio

   Run by

   The Cleveland Clinic

   See if you can join NCT07110376 on ClinicalTrials.gov

3. Accelerated rTMS for Apathy in Parkinson's Disease

   This single-site, open-label pilot study will evaluate the feasibility, tolerability, and preliminary efficacy of accelerated intermittent theta-burst stimulation (iTBS) targeting the dorsomedial prefrontal cortex (dmPFC) for apathy in individuals with Parkinson's Disease (PD). Fifteen participants…

   Stage

   Not phased

   Ages

   45 to 85

   Site

   Medical University of South Carolina, Charleston, South Carolina

   Run by

   Medical University of South Carolina

   See if you can join NCT07399496 on ClinicalTrials.gov

4. A Digital Therapeutic Platform for Swallowing and Drooling Problems in Parkinson's

   The purpose of this study is the development and early-stage validation of a wearable sensor for dysphagia in patients with PD.

   Stage

   Phase 3

   Ages

   22 and older

   Site

   Northwestern University, Evanston, Illinois

   Run by

   Northwestern University

   See if you can join NCT04664634 on ClinicalTrials.gov

5. Correlation of STN-DBS Induced Visuospatial Changes and Freezing of Gait

   The purpose of this research is to determine how deep brain stimulation (DBS) for Parkinson's disease affects attention and visuospatial function. Additionally, this study will evaluate how deficits in visual attention are associated with freezing of gait (FOG) in Parkinson's disease. There is curr…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Medical University of South Carolina, Charleston, South Carolina

   Run by

   Medical University of South Carolina

   See if you can join NCT06994728 on ClinicalTrials.gov

6. Cross-System Effects of Acute Intermittent Hypercapnia-Based Interventions in PD

   Parkinsonism impairs upper airway and axial motor control, leading to disordered breathing, reduced speech volume, and ineffective cough. Symptoms are poorly addressed by current therapies. This randomized pilot trial tests whether a single session of acute intermittent hypercapnic hypoxia (AIHH) o…

   Stage

   Not phased

   Ages

   40 to 75

   Site

   University of Florida, Gainesville, Florida

   Locations

   2 in total

   Run by

   University of Florida

   See if you can join NCT07674264 on ClinicalTrials.gov

7. Personalized Real-Time DBS and PD Mechanisms

   A prospective cohort of patients scheduled to undergo deep brain stimulation (DBS) implantation surgery for the treatment of Parkinson's disease as per standard of care will be invited to participate in this study. This mechanistic study is aimed at better understanding the role of basal ganglia be…

   Stage

   Phase 4

   Ages

   18 to 80

   Site

   Cleveland Clinic, Cleveland, Ohio

   Run by

   David Escobar

   See if you can join NCT06013956 on ClinicalTrials.gov

8. Using the EHR to Advance Genomic Medicine Across a Diverse Health System

   Given the expansion of indications for genetic testing and our understanding of conditions for which the results change medical management, it is imperative to consider novel ways to deliver care beyond the traditional genetic counseling visit, which are both amenable to large-scale implementation …

   Stage

   Not phased

   Ages

   18 and older

   Site

   Penn Medicine, Philadelphia, Pennsylvania

   Run by

   University of Pennsylvania

   See if you can join NCT06377033 on ClinicalTrials.gov

9. A Pilot Study of In-lab Dynamic Standing in Parkinson's Disease

   This research is studying the use of a new type of standing desk in a small number of people to learn about the user experience for people with Parkinson's disease. 12 4-hour sessions will be performed to test the primary hypothesis that dynamic standing improves gait function compared to static st…

   Stage

   Phase 1

   Ages

   50 and older

   Site

   Domino's Farms, Ann Arbor, Michigan

   Run by

   University of Michigan

   See if you can join NCT07543861 on ClinicalTrials.gov

10. The University of Alabama at Birmingham (UAB) Neuroinflammation in Parkinson's Disease-TSPO- Positron Emission Tomography (PET) Substudy

    The primary objective of this substudy is to measure the concentration and the regional brain distribution of activated brain microglia/macrophages using the PET ligand [18F]DPA-714 in participants enrolled in the UAB Innate and Adaptive Immunity in Parkinson's Disease (Clinical Research Core) and …

    Stage

    Phase 1

    Ages

    30 and older

    Site

    UAB Advanced Imaging Facility, Birmingham, Alabama

    Run by

    University of Alabama at Birmingham

    See if you can join NCT03457493 on ClinicalTrials.gov

11. Longitudinal TSPO PET Imaging With [18F]DPA-714 in PPMI (PPMI DPA-714 PET Imaging)

    The overall goal of this protocol is to investigate [18F]DPA-714 binding in prodromal and early manifest Parkinson's Disease (PD) and to determine the baseline and change from baseline in [18F]DPA-714 binding in PD participants during a 24-month interval. Primary Objectives * To compare [18F]DPA-71…

    Stage

    EARLY_Phase 1

    Ages

    18 to 99

    Site

    UAB, Birmingham, Alabama

    Run by

    University of Alabama at Birmingham

    See if you can join NCT06289582 on ClinicalTrials.gov

12. Young Onset Parkinson's Disease Subtypes and Pathogenic Mechanisms

    Young Onset Parkinson's disease (YOPD) refers to a group of patients in which the disease starts earlier in life (before the age of 50 years) and has a profound impact on most of patient's life. Current knowledge regarding the mechanisms leading to development of Parkinson's disease in younger indi…

    Stage

    Not phased

    Ages

    18 and older

    Site

    NYU Langone Health, New York, New York

    Run by

    NYU Langone Health

    See if you can join NCT07752355 on ClinicalTrials.gov

13. Characterization of the Serotonin 2A Receptor Selective PET Tracer [18F]MH.MZ in Patients With Neurodegenerative Diseases

    It is hypothesize that patients with clinically diagnosed neurodegenerative diseases will have significantly different receptor occupancy of 5HT2A receptors compared to a healthy age/sex-matched control group. This will be tested by measuring 5HT2A receptor density using the PET radioligand (R)-[18…

    Stage

    Phase 4

    Ages

    50 to 85

    Site

    Vanderbilt University Medical Center, Nashville, Tennessee

    Run by

    Vanderbilt University Medical Center

    See if you can join NCT05357612 on ClinicalTrials.gov

14. Blood Pressure Effects on Cognition and Brain Blood Flow in PD

    Parkinson's disease (PD) is the second most common neurodegenerative disorder worldwide. Besides causing symptoms that impair movement, PD also causes non-motor symptoms, such as problems thinking and orthostatic hypotension (OH), i.e., low blood pressure (BP) when standing. About one-third of peop…

    Stage

    Not phased

    Ages

    50 and older

    Site

    University of California San Diego, San Diego, California

    Run by

    University of California, San Diego

    See if you can join NCT05400174 on ClinicalTrials.gov

15. Psilocybin Therapy for Depression in Parkinson's Disease

    The purpose of this study is to understand whether people with Parkinson's Disease and depression have improvement in their symptoms after psilocybin therapy.

    Stage

    Phase 2

    Ages

    40 to 80

    Site

    University of California, San Francisco, San Francisco, California

    Run by

    Joshua Woolley, MD, PhD

    See if you can join NCT06455293 on ClinicalTrials.gov

16. Autoimmune Features of Neurodegenerative Disorders

    This study is being conducted to better understand the role of inflammation in Parkinson's disease (PD) and Alzheimer's disease (AD). The investigators plan to recruit 30 PD, 30 AD/Amnestic Mild Cognitive Impairment (aMCI), and 60 age matched healthy controls in this study to study the role of immu…

    Stage

    Not phased

    Ages

    55 to 90

    Site

    Columbia University Medical Center, New York, New York

    Run by

    Columbia University

    See if you can join NCT04239079 on ClinicalTrials.gov

17. Effects of Transcranial Focused Ultrasound Stimulation (tFUS) on Neurological and Cognitive Outcomes in Parkinson's Disease

    This is a pilot randomized, sham-controlled, double-blind, multi-center study evaluating the safety and preliminary effectiveness of the Gen0Bh Transcranial Focused Ultrasound System for the treatment of motor symptoms in individuals with idiopathic Parkinson's disease.

    Stage

    Not phased

    Ages

    22 to 80

    Site

    University of Arizona, Tucson, Arizona

    Locations

    4 in total

    Run by

    Sanmai Technologies PBC dba Sanmai

    See if you can join NCT07207122 on ClinicalTrials.gov

18. Moderate Versus High Volume Light-Moderate Intensity Exercise for People With Moderate Parkinson's Disease

    Veterans with mid to later stage Parkinson's disease (PD) may not be able to work out as hard as they need to, to prevent brain cell loss. Maybe they could work out longer and more frequently to make up for this during their good times and good weeks and then rest during the bad weeks. The investig…

    Stage

    Not phased

    Ages

    40 and older

    Site

    Atlanta VA Medical and Rehab Center, Decatur, GA, Decatur, Georgia

    Run by

    VA Office of Research and Development

    See if you can join NCT06088355 on ClinicalTrials.gov

19. PPMI Clinical - Establishing a Deeply Phenotyped PD Cohort

    The Parkinson Progression Marker Initiative (PPMI) is a longitudinal, observational, multi-center natural history study to assess progression of clinical features, digital outcomes, and imaging, biologic and genetic markers of Parkinson's disease (PD) progression in study participants with manifest…

    Stage

    Not phased

    Ages

    30 and older

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Locations

    50 in total

    Run by

    Michael J. Fox Foundation for Parkinson's Research

    See if you can join NCT04477785 on ClinicalTrials.gov

20. Intranasal Insulin and Glutathione as an Add-On Therapy in Parkinson's Disease

    This study will be evaluating the safety and efficacy of insulin and glutathione in subjects with Parkinson's Disease compared to placebo.

    Stage

    Phase 2

    Ages

    30 and older

    Site

    Institute for Neuroimmune Medicine, Davie, Florida

    Locations

    4 in total

    Run by

    Gateway Institute for Brain Research

    See if you can join NCT05266417 on ClinicalTrials.gov

21. Neurophysiology of Locomotor Adaptation and Freezing of Gait in Parkinson's Disease

    Locomotor adaptation will be studied using an established split-belt treadmill paradigm, consisting of baseline (1:1 speed ratio), split-belt adaptation (2:1) and post-adaptation (1:1) walking. Split-belt walking will be performed under DBS ON and DBS OFF conditions, while off-medication.

    Stage

    Not phased

    Ages

    18 to 80

    Site

    University of Florida, Gainesville, Florida

    Run by

    University of Florida

    See if you can join NCT06911229 on ClinicalTrials.gov

22. Virtual Cycling Environments for Persons With Parkinson Disease

    This study asks three questions about Persons with Parkinson Disease that use a bicycle for exercise. 1. Does the use of virtual reality increase the intensity and and enjoyment of the experience compared to bicycling without virtual reality? 2. Does the way in which the bicycling (interval compare…

    Stage

    Not phased

    Ages

    45 to 75

    Site

    School of Health Professions, Newark, New Jersey

    Locations

    2 in total

    Run by

    Rutgers, The State University of New Jersey

    See if you can join NCT04804202 on ClinicalTrials.gov

23. Apathy in Parkinson Disease TMS Study

    The goal of this clinical trial is to develop non-invasive brain stimulation targets for the treatment of apathy, or motivation problems, in Parkinson Disease. The main questions the study aims to answer are: 1. Does transcranial magnetic stimulation change effort task performance in Parkinson's Di…

    Stage

    Not phased

    Ages

    55 to 80

    Site

    UNC-Chapel Hill, Cassidy Lab, Chapel Hill, North Carolina

    Run by

    University of North Carolina, Chapel Hill

    See if you can join NCT06087926 on ClinicalTrials.gov

24. Safety and Tolerability of Patterned Stimulation for DBS in the Home Setting

    The primary objective of the proposed pilot study is to assess the safety and tolerability of active patterned Deep Brain Stimulation (pDBS) when administered in a home setting for patients with Parkinson's disease (PD) who have had stable bilateral Subthalamic Nucleus (STN) and Globus Pallidus int…

    Stage

    Not phased

    Ages

    18 to 80

    Site

    University of Florida, Gainesville, Florida

    Run by

    University of Florida

    See if you can join NCT07410598 on ClinicalTrials.gov

25. Pathways Mediating Impaired Postural Control in Parkinson's Disease

    The purpose of this project is to use transcranial magnetic stimulation (TMS) to explore the state of excitability of corticocortical and corticofugal (cortex to spinal cord, cortex to brainstem to spinal cord) pathways that project to muscles that control the legs and trunk in people with Parkinso…

    Stage

    Not phased

    Ages

    45 to 80

    Site

    University of Minnesota, Minneapolis, Minnesota

    Run by

    University of Minnesota

    See if you can join NCT06464029 on ClinicalTrials.gov