Parkinson Disease Clinical Trials

117 studies are recruiting for parkinson disease in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 2

1. Blood Pressure Effects on Cognition and Brain Blood Flow in PD

   Parkinson's disease (PD) is the second most common neurodegenerative disorder worldwide. Besides causing symptoms that impair movement, PD also causes non-motor symptoms, such as problems thinking and orthostatic hypotension (OH), i.e., low blood pressure (BP) when standing. About one-third of peop…

   Stage

   Not phased

   Ages

   50 and older

   Site

   University of California San Diego, San Diego, California

   Run by

   University of California, San Diego

   See if you can join NCT05400174 on ClinicalTrials.gov

2. Psilocybin Therapy for Depression in Parkinson's Disease

   The purpose of this study is to understand whether people with Parkinson's Disease and depression have improvement in their symptoms after psilocybin therapy.

   Stage

   Phase 2

   Ages

   40 to 80

   Site

   University of California, San Francisco, San Francisco, California

   Run by

   Joshua Woolley, MD, PhD

   See if you can join NCT06455293 on ClinicalTrials.gov

3. Autoimmune Features of Neurodegenerative Disorders

   This study is being conducted to better understand the role of inflammation in Parkinson's disease (PD) and Alzheimer's disease (AD). The investigators plan to recruit 30 PD, 30 AD/Amnestic Mild Cognitive Impairment (aMCI), and 60 age matched healthy controls in this study to study the role of immu…

   Stage

   Not phased

   Ages

   55 to 90

   Site

   Columbia University Medical Center, New York, New York

   Run by

   Columbia University

   See if you can join NCT04239079 on ClinicalTrials.gov

4. Effects of Transcranial Focused Ultrasound Stimulation (tFUS) on Neurological and Cognitive Outcomes in Parkinson's Disease

   This is a pilot randomized, sham-controlled, double-blind, multi-center study evaluating the safety and preliminary effectiveness of the Gen0Bh Transcranial Focused Ultrasound System for the treatment of motor symptoms in individuals with idiopathic Parkinson's disease.

   Stage

   Not phased

   Ages

   22 to 80

   Site

   University of Arizona, Tucson, Arizona

   Locations

   4 in total

   Run by

   Sanmai Technologies PBC dba Sanmai

   See if you can join NCT07207122 on ClinicalTrials.gov

5. Moderate Versus High Volume Light-Moderate Intensity Exercise for People With Moderate Parkinson's Disease

   Veterans with mid to later stage Parkinson's disease (PD) may not be able to work out as hard as they need to, to prevent brain cell loss. Maybe they could work out longer and more frequently to make up for this during their good times and good weeks and then rest during the bad weeks. The investig…

   Stage

   Not phased

   Ages

   40 and older

   Site

   Atlanta VA Medical and Rehab Center, Decatur, GA, Decatur, Georgia

   Run by

   VA Office of Research and Development

   See if you can join NCT06088355 on ClinicalTrials.gov

6. PPMI Clinical - Establishing a Deeply Phenotyped PD Cohort

   The Parkinson Progression Marker Initiative (PPMI) is a longitudinal, observational, multi-center natural history study to assess progression of clinical features, digital outcomes, and imaging, biologic and genetic markers of Parkinson's disease (PD) progression in study participants with manifest…

   Stage

   Not phased

   Ages

   30 and older

   Site

   University of Alabama at Birmingham, Birmingham, Alabama

   Locations

   50 in total

   Run by

   Michael J. Fox Foundation for Parkinson's Research

   See if you can join NCT04477785 on ClinicalTrials.gov

7. Motor Network Physiology

   The brain networks controlling movement are complex, involving multiple areas of the brain. Some neurological disorders, like Parkinson's disease (PD) and essential tremor (ET), cause abnormalities in these brain networks. Deep brain stimulation is a treatment that is used to treat these types of n…

   Stage

   Not phased

   Ages

   18 to 89

   Site

   UT Southwestern Medical Center, Dallas, Texas

   Run by

   University of Texas Southwestern Medical Center

   See if you can join NCT04957095 on ClinicalTrials.gov

8. Intranasal Insulin and Glutathione as an Add-On Therapy in Parkinson's Disease

   This study will be evaluating the safety and efficacy of insulin and glutathione in subjects with Parkinson's Disease compared to placebo.

   Stage

   Phase 2

   Ages

   30 and older

   Site

   Institute for Neuroimmune Medicine, Davie, Florida

   Locations

   4 in total

   Run by

   Gateway Institute for Brain Research

   See if you can join NCT05266417 on ClinicalTrials.gov

9. Neurophysiology of Locomotor Adaptation and Freezing of Gait in Parkinson's Disease

   Locomotor adaptation will be studied using an established split-belt treadmill paradigm, consisting of baseline (1:1 speed ratio), split-belt adaptation (2:1) and post-adaptation (1:1) walking. Split-belt walking will be performed under DBS ON and DBS OFF conditions, while off-medication.

   Stage

   Not phased

   Ages

   18 to 80

   Site

   University of Florida, Gainesville, Florida

   Run by

   University of Florida

   See if you can join NCT06911229 on ClinicalTrials.gov

10. Superior Parietal iTBS for PD-MCI

    The goal of this study is to determine the whether a short-term, high-dose form of non-invasive brain stimulation (intermittent theta burst stimulation; iTBS) is a promising and safe treatment for mild cognitive impairment in Parkinson's disease (PD-MCI).

    Stage

    Not phased

    Ages

    50 to 85

    Site

    Medical University of South Carolina, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT07701785 on ClinicalTrials.gov

11. Virtual Cycling Environments for Persons With Parkinson Disease

    This study asks three questions about Persons with Parkinson Disease that use a bicycle for exercise. 1. Does the use of virtual reality increase the intensity and and enjoyment of the experience compared to bicycling without virtual reality? 2. Does the way in which the bicycling (interval compare…

    Stage

    Not phased

    Ages

    45 to 75

    Site

    School of Health Professions, Newark, New Jersey

    Locations

    2 in total

    Run by

    Rutgers, The State University of New Jersey

    See if you can join NCT04804202 on ClinicalTrials.gov

12. Apathy in Parkinson Disease TMS Study

    The goal of this clinical trial is to develop non-invasive brain stimulation targets for the treatment of apathy, or motivation problems, in Parkinson Disease. The main questions the study aims to answer are: 1. Does transcranial magnetic stimulation change effort task performance in Parkinson's Di…

    Stage

    Not phased

    Ages

    55 to 80

    Site

    UNC-Chapel Hill, Cassidy Lab, Chapel Hill, North Carolina

    Run by

    University of North Carolina, Chapel Hill

    See if you can join NCT06087926 on ClinicalTrials.gov

13. Safety and Tolerability of Patterned Stimulation for DBS in the Home Setting

    The primary objective of the proposed pilot study is to assess the safety and tolerability of active patterned Deep Brain Stimulation (pDBS) when administered in a home setting for patients with Parkinson's disease (PD) who have had stable bilateral Subthalamic Nucleus (STN) and Globus Pallidus int…

    Stage

    Not phased

    Ages

    18 to 80

    Site

    University of Florida, Gainesville, Florida

    Run by

    University of Florida

    See if you can join NCT07410598 on ClinicalTrials.gov

14. Pathways Mediating Impaired Postural Control in Parkinson's Disease

    The purpose of this project is to use transcranial magnetic stimulation (TMS) to explore the state of excitability of corticocortical and corticofugal (cortex to spinal cord, cortex to brainstem to spinal cord) pathways that project to muscles that control the legs and trunk in people with Parkinso…

    Stage

    Not phased

    Ages

    45 to 80

    Site

    University of Minnesota, Minneapolis, Minnesota

    Run by

    University of Minnesota

    See if you can join NCT06464029 on ClinicalTrials.gov

15. A Study of AAV2-GDNF in Adults With Moderate Parkinson's Disease (REGENERATE-PD)

    The objective of this randomized, surgically controlled, double-blinded, Phase 2 study is to evaluate the safety and efficacy of AAV2-GDNF delivered to the putamen in subjects with moderate Parkinson's Disease.

    Stage

    Phase 2

    Ages

    45 to 75

    Site

    UCI Alpha Clinic (Neurology), Irvine, California

    Locations

    46 in total

    Run by

    AskBio Inc

    See if you can join NCT06285643 on ClinicalTrials.gov

16. Targeted Motor Learning to Improve Gait for Individuals With Parkinson Disease

    The purpose of this research study is to determine how training to step with a metronome on both a treadmill, as well as overground, will influence the way that people with Parkinson disease walk. Using metronomes is commonly used in clinics, but the investigators will be using a combination of slo…

    Stage

    Not phased

    Ages

    50 to 80

    Site

    University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

    Run by

    University of North Carolina, Chapel Hill

    See if you can join NCT05864157 on ClinicalTrials.gov

17. BOOST-PD A Naturalistic Study on IPX-203 for Parkinson's Disease

    The purpose of this study is to evaluate the effect of IPX203 (Crexont®) - the newest extended-release levodopa formulation - on the duration and quality of good on time, using a wearable device to monitor symptoms. 'Good on time' refers to a period (minutes to hours) when a patient experiences opt…

    Stage

    Phase 4

    Ages

    40 and older

    Site

    Cleveland Clinic, Cleveland, Ohio

    Run by

    The Cleveland Clinic

    See if you can join NCT07138560 on ClinicalTrials.gov

18. Corticostriatal Contributions to Parkinson's Disease Cognitive Impairment

    The goal of this study is to learn more about the brain activity underlying Parkinson's disease cognitive impairment. The investigators will utilize neural recordings from corticostriatal structures performed during deep brain stimulation surgery to measure neural activity underlying nonmotor sympt…

    Stage

    Not phased

    Ages

    40 and older

    Site

    Vanderbilt University Medical Center, Nashville, Tennessee

    Run by

    Vanderbilt University Medical Center

    See if you can join NCT04715984 on ClinicalTrials.gov

19. Neurophysiology of Reward Signaling in Parkinson's Disease

    The goal of this study is to learn more about the brain activity underlying Parkinson's disease risk taking and reward seeking behaviors. The investigators will utilize neural recordings from corticostriatal structures performed during deep brain stimulation surgery to measure neural activity under…

    Stage

    Not phased

    Ages

    40 and older

    Site

    Vanderbilt University Medical Center, Nashville, Tennessee

    Run by

    Vanderbilt University Medical Center

    See if you can join NCT07409207 on ClinicalTrials.gov

20. Striatal and Extra-Striatal Cholinergic Terminal Density in LRRK2-PD Mutation

    This study explores how a specific genetic mutation of leucine-rich repeat kinase 2 (LRRK2) affects individuals with Parkinson's disease (PD), comparing those with the mutation to others with Parkinson's disease and without the mutation (iPD). Participants will complete positron emission tomography…

    Stage

    Not phased

    Ages

    45 and older

    Site

    University of Michigan, Ann Arbor, Michigan

    Run by

    University of Michigan

    See if you can join NCT07642908 on ClinicalTrials.gov

21. Natural History Study of Synucleinopathies

    Synucleinopathies are a group of rare diseases associated with worsening neurological deficits and the abnormal accumulation of the protein α-synuclein in the nervous system. Onset is usually in late adulthood at age 50 or older. Usually, synucleinopathies present clinically with slowness of moveme…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Beth Israel Deaconess Medical Center, Boston, Massachusetts

    Locations

    8 in total

    Run by

    NYU Langone Health

    See if you can join NCT01799915 on ClinicalTrials.gov

22. Evaluation of [¹⁸F]MODAG-009 PET Imaging in Synucleinopathies

    This is a single-center, open-label clinical study designed to evaluate the imaging characteristics and safety of [¹⁸F]MODAG-009 in participants with Parkinson's disease (PD), Multiple system atrophy (MSA), and Healthy controls (HC). Approximately 13 participants will be enrolled in this study. Eac…

    Stage

    EARLY_Phase 1

    Ages

    50 to 80

    Site

    Institute for Neurodegenerative Disorders and XingImaging, LLC, New Haven, Connecticut

    Run by

    MODAG GmbH

    See if you can join NCT07640555 on ClinicalTrials.gov

23. Understanding Motivation in Parkinson's Patients Through Neurophysiology

    The study aims to better understand motivation and value-based decision-making in Parkinson's patients through neurophysiology using Medtronic's Percept DBS device. By combining behavioral tasks with neural recordings, the study seeks to uncover how DBS affects motivation, particularly in relation …

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of California San Francisco, San Francisco, California

    Run by

    University of California, San Francisco

    See if you can join NCT05065151 on ClinicalTrials.gov

24. Cognitive Decline Following Deep Brain Stimulation

    This research study aims to identify MRI-based brain biomarkers that predict an individual's response to Deep Brain Stimulation (DBS). In particular, this study will focus on changes in cognition associated with DBS. A total of 55 participants with Parkinson's Disease planning to undergo DBS will b…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Medical University of South Carolina, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT05822388 on ClinicalTrials.gov

25. Imaging Core Aim 2, and Udall Project 2 Aim 2

    More than one million people in the United States have Parkinson's disease (PD) and the prevalence is expected to double by 2040. Over 60% of these individuals will develop debilitating postural instability and gait disturbances (PIGD), including freezing of gait (FOG). With disease progression, ax…

    Stage

    Not phased

    Ages

    21 and older

    Site

    University of Minnesota, Minneapolis, Minnesota

    Run by

    University of Minnesota

    See if you can join NCT06998303 on ClinicalTrials.gov