Opioid Use Disorder Clinical Trials

135 studies are recruiting for opioid use disorder in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 5

1. Adolescent Outcomes of Post-operative Opioid EXposure

   The goal of this observational study is to examine the factors associated with the transition from medical exposure to opioids with "signposts" of future opioid use disorder among adolescent surgical patients. The main question aims to identify factors (moderators, mediators, and covariates) associ…

   Stage

   Not phased

   Ages

   12 to 17

   Site

   Boston Childrens Hopsital - Division of Addiction Medicine, Boston, Massachusetts

   Locations

   5 in total

   Run by

   Sharon Levy

   See if you can join NCT06350409 on ClinicalTrials.gov

2. MDMA for Co-occurring PTSD and OUD After Childbirth

   This is an open-label study of the use of MDMA Assisted Therapy for postpartum people with co-occurring Post Traumatic Stress Disorder (PTSD) and Opioid Use Disorder (OUD). The study protocol has been adapted from the Phase 3 studies sponsored by the Multidisciplinary Association for Psychedelic St…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   University of New Mexico Health Sciences, Albuquerque, New Mexico

   Run by

   University of New Mexico

   See if you can join NCT05219175 on ClinicalTrials.gov

3. E-Cigarettes for Harm Reduction in Smokers With Opioid Use Disorder

   The purpose of this an open-label, randomized controlled trial study is to compare the effectiveness of electronic cigarettes (e-cigarettes/e-cigs) versus telehealth motivational counseling with combination nicotine replacement therapy (NRT) + telehealth counseling on combustible cigarettes smoking…

   Stage

   Phase 2

   Ages

   21 to 75

   Site

   NYU Langone Health, New York, New York

   Locations

   2 in total

   Run by

   NYU Langone Health

   See if you can join NCT05722561 on ClinicalTrials.gov

4. Optimization of NIBS for Treatment of Addiction

   The purpose of this study is to assess the effects of transcranial Direct Current Stimulation (tDCS) applied in conjunction with Transcranial Ultrasound (TUS) for the treatment of addiction in opiate use disorder with chronic pain. The investigators hypothesize that there will be a decrease in drug…

   Stage

   Not phased

   Ages

   18 to 85

   Site

   University of Illinois Health/ University of Illinois at Chicago, Hinsdale, Illinois

   Locations

   3 in total

   Run by

   Case Western Reserve University

   See if you can join NCT04379115 on ClinicalTrials.gov

5. Adaptive Interventions for Emergency Department Patients With Opioid Use Disorder

   The ADAPT-ED study is a two-stage, sequential multiple assignment randomized trial (SMART) to inform the development of an adaptive intervention that is optimally effective in increasing long-term buprenorphine use for adults presenting to the ED with probable opioid use disorder (OUD).

   Stage

   Not phased

   Ages

   18 and older

   Site

   Arrowhead Regional Medical Center, Colton, California

   Run by

   RAND

   See if you can join NCT06827288 on ClinicalTrials.gov

6. HIV, Equity, and Addiction Training (HEAT) Program

   This project is a pilot study to determine the feasibility and acceptability of a telemedicine intervention for substance use disorder service delivery in diverse people living with HIV in Alabama.

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Alabama at Birmingham, Birmingham, Alabama

   Run by

   University of Alabama at Birmingham

   See if you can join NCT06370481 on ClinicalTrials.gov

7. Evaluation of a Peer Recovery Support Program Adapted to Target Retention in Clinic-based Medication for Opioid Use Disorder Treatment

   The goal of this clinical trial is to learn if receiving peer recovery support (support services provided by trained "peers" with lived experience of addiction and recovery) improves retention in medication treatment among people with opioid use disorder. The main question it aims to answer is: doe…

   Stage

   Not phased

   Ages

   18 to 89

   Site

   Geisinger Clinic, Danville, Pennsylvania

   Run by

   Geisinger Clinic

   See if you can join NCT07197801 on ClinicalTrials.gov

8. LIFU for Treatment for Refractory Opioid Use Disorder

   This is a randomized, double-blind, sham-controlled, partial crossover study investigating LIFU targeting the NAc and VC for participants with severe, treatment refractory OUD.

   Stage

   Not phased

   Ages

   22 to 60

   Site

   WVU Rockefeller Neuroscience Institute, Morgantown, West Virginia

   Run by

   Ali Rezai

   See if you can join NCT06218706 on ClinicalTrials.gov

9. Divided or Single Exposure (DOSE) Study

   This study will evaluate whether once versus twice daily dosing of methadone will be an effective method for managing comorbid pain and opioid use disorder.

   Stage

   Phase 2

   Ages

   18 to 100

   Site

   Addiction Treatment Services (ATS), Baltimore, Maryland

   Run by

   University of Maryland, Baltimore

   See if you can join NCT05459402 on ClinicalTrials.gov

10. Psilocybin for Opioid Use Disorder (OUD)

    This is a double-blind, adaptive, 2-stage, multi-site, phase 2 randomized controlled clinical trial designed to evaluate effects of moderate and high dose psilocybin, relative to low-dose psilocybin control, in OUD patients who continue to use illicit opioids in spite of adherence to standard-of-ca…

    Stage

    Phase 2

    Ages

    18 to 65

    Site

    Duke City Recovery Toolbox, Albuquerque, New Mexico

    Locations

    5 in total

    Run by

    NYU Langone Health

    See if you can join NCT06796062 on ClinicalTrials.gov

11. OUD (Opioid Use Disorder) Target Trial

    In this research study the investigators will work with 80-participants with opioid use disorder who are starting treatment with the medication buprenorphine and are trying to quit using opioids. The investigators are trying to learn two things: 1. Can an MRI brain marker be used to predict which p…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Duke University, Durham, North Carolina

    Run by

    Duke University

    See if you can join NCT06585709 on ClinicalTrials.gov

12. Opioid Use Disorder in Pregnancy in Long-Term Maternal/Infant Outcomes

    The objective of this study is to better understand the comprehensive integration of both clinical and genetic factors that will help to identify mothers who could be at an increased risk of poor response to opioid substitution and infants at risk of significant neonatal abstinence syndrome (NAS).

    Stage

    Not phased

    Ages

    18 and older

    Site

    UPMC Children's Hospital, Pittsburgh, Pennsylvania

    Run by

    Senthil Sadhasivam

    See if you can join NCT03923374 on ClinicalTrials.gov

13. Intervening on Opioid Use and Loneliness

    This study aims to enroll 300 participants who will be assigned to one of three 3 groups. Each group will receive an intervention lasting 6, weekly sessions of 40-60 minutes. Eligibility include having an opioid use disorder and reporting loneliness or feeling alone or disconnected.

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Rochester, Rochester, New York

    Run by

    University of Rochester

    See if you can join NCT06458335 on ClinicalTrials.gov

14. Integrating Brain, Neurocognitive, and Computational Tools in OUD

    The 5-year K01 Mentored Research Scientist proposal will employ brain, neurocognitive, and computational tools (e.g., machine learning) to understand the impact of opioid-use disorder (OUD) and common co-occurring issues on executive function and clinical outcomes. There have been record numbers of…

    Stage

    Not phased

    Ages

    18 to 60

    Site

    University of Pennsylvania, Philadelphia, Pennsylvania

    Run by

    University of Pennsylvania

    See if you can join NCT06136247 on ClinicalTrials.gov

15. NavSTAR Implementation Effectiveness Trial Across a Health System

    Patient Navigation (PN) interventions following hospitalization can improve outcomes for people with opioid use disorder treatment. Delivering PN interventions on a wide scale requires many resources and coordination across institutions. This will use an evidence-based process to find solutions to …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Jefferson Health, Philadelphia, Pennsylvania

    Run by

    Friends Research Institute, Inc.

    See if you can join NCT07262190 on ClinicalTrials.gov

16. Integrated Treatment for Opioid Use Disorder and PTSD

    This study will test a therapy intervention, HOPE, for individuals with opioid use disorder and posttraumatic stress disorder. Interested individuals will need to be taking medications for opioid use disorder (e.g., suboxone, naltrexone, methadone). Interested participants will complete a 10-12 wee…

    Stage

    Not phased

    Ages

    18 to 70

    Site

    Medical University of South Carolina, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT06641115 on ClinicalTrials.gov

17. Expanding the Youth Opioid Recovery Support (YORS) Intervention for MOUD Adherence to Adolescents With OUD

    Despite rising rates of fatal opioid overdoses in the United States, adolescents with OUD are far less likely than adults to receive and be retained on medication for opioid use disorder (MOUD). The multicomponent Youth Opioid Recovery Support (YORS) intervention for young adults seeks to increase …

    Stage

    Not phased

    Ages

    13 to 21

    Site

    Maryland Treatment Centers, Baltimore, Maryland

    Run by

    Potomac Health Foundations

    See if you can join NCT06774248 on ClinicalTrials.gov

18. Low-Intensity Focused Ultrasound and the Complex Patient

    Studying the effects of Low Intensity Focused Ultrasound (LIFU) on measures of pain, craving, and anxiety in a complex patient population.

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Fralin Biomedical Research Institute at VTC, Roanoke, Virginia

    Run by

    Virginia Polytechnic Institute and State University

    See if you can join NCT06297200 on ClinicalTrials.gov

19. Continuum of Care in Hospitalized Patients With Opioid/Stimulant Use Disorder and Infectious Complications From Drug Use

    This is a two-group randomized controlled trial conducted at five hospitals across the U.S. designed to test the effectiveness of an Integrated infectious diseases/Substance Use Disorder outpatient clinic (IC) compared to treatment as usual aimed at reducing infection related readmissions and impro…

    Stage

    Not phased

    Ages

    18 and older

    Site

    George Washington University, Washington D.C., District of Columbia

    Locations

    4 in total

    Run by

    Elana Rosenthal

    See if you can join NCT06513156 on ClinicalTrials.gov

20. Wellcome Leap Psilocybin for OUD

    Investigators will recruit 36 individuals on MAT for OUD for a double-blind, placebo-controlled design to determine whether PEX010 (25-mg/d) shows preliminary efficacy on neural correlates of neurocognition and on clinical outcomes. Participants will be randomized to either (single dose) 25-mg (PEX…

    Stage

    Phase 2

    Ages

    18 to 60

    Site

    University of Pennsylvania, Philadelphia, Pennsylvania

    Run by

    Anna Rose Childress, Ph.D.

    See if you can join NCT06786325 on ClinicalTrials.gov

21. Identifying Optimal Buprenorphine Dosing for Opioid Use Disorder Treatment and Prevention of Overdose

    The investigators aim to test the effectiveness of a high maintenance daily dose of buprenorphine (24 mg) for improving outcomes among patients who used fentanyl compared to the standard daily dose (16 mg). The main question it aims to answer is: will patients who are randomly assigned to the high …

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Brown University, Providence, Rhode Island

    Run by

    Rhode Island Hospital

    See if you can join NCT06316830 on ClinicalTrials.gov

22. Emergency Medicine Peer Outreach Worker Engagement for Recovery

    This is an observational, prospective case-control study evaluating the effects of an emergency department community health worker-peer recovery specialist program (PCHW), the Substance Misuse Assistance Response Team (SMART). Aims of this study are to 1) understand participant experiences working …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Rhode Island Hospital, Providence, Rhode Island

    Run by

    University of California, Los Angeles

    See if you can join NCT06320015 on ClinicalTrials.gov

23. Young Houston Emergency Opioid Engagement System

    The Houston Emergency Response Opioid Engagement System for Youths and Adolescents (Young HEROES) is a community-based research program integrating assertive outreach, medication for opioid use disorder (MOUD), behavioral counseling, and peer recovery support. The objective is to compare difference…

    Stage

    Phase 4

    Ages

    13 to 17

    Site

    The University of Texas Health Science Center at Houston, Houston, Texas

    Run by

    The University of Texas Health Science Center, Houston

    See if you can join NCT04811014 on ClinicalTrials.gov

24. The Youth Opioid Recovery Support (YORS) Intervention

    Youth are disproportionately affected by the current opioid crisis with catastrophic consequences, and young adults with opioid use disorder (OUD) often struggle with adherence to relapse prevention medications. The Youth Opioid Recovery Support (YORS) model is a promising, innovative, wrap-around …

    Stage

    Not phased

    Ages

    18 to 28

    Site

    Mountain Manor Treatment Center, Baltimore, Maryland

    Run by

    Potomac Health Foundations

    See if you can join NCT04173416 on ClinicalTrials.gov

25. Assessing a Clinically-meaningful Opioid Withdrawal Phenotype

    Evaluate individual differences in the expression of opioid withdrawal symptoms in persons with opioid use disorder (OUD) while completing a clinically-indicated medication taper.

    Stage

    Phase 2

    Ages

    18 to 65

    Site

    University of Maryland, Baltimore, Maryland

    Run by

    University of Maryland, Baltimore

    See if you can join NCT05027919 on ClinicalTrials.gov