Opioid Use Disorder Clinical Trials

135 studies are recruiting for opioid use disorder in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 5

1. LIFU for Treatment for Refractory Opioid Use Disorder

   This is a randomized, double-blind, sham-controlled, partial crossover study investigating LIFU targeting the NAc and VC for participants with severe, treatment refractory OUD.

   Stage

   Not phased

   Ages

   22 to 60

   Site

   WVU Rockefeller Neuroscience Institute, Morgantown, West Virginia

   Run by

   Ali Rezai

   See if you can join NCT06218706 on ClinicalTrials.gov

2. Encouraging Abstinence Behavior in a Drug Epidemic: Optimizing Dynamic Incentives

   Combatting the rise of the opioid epidemic is a central challenge of U.S. health care policy. A promising approach for improving welfare and decreasing medical costs of people with substance abuse disorders is offering incentive payments for healthy behaviors. This approach, broadly known as "conti…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Rogers Behavioral Health, Oconomowoc, Wisconsin

   Locations

   2 in total

   Run by

   Wake Forest University Health Sciences

   See if you can join NCT04927143 on ClinicalTrials.gov

3. Divided or Single Exposure (DOSE) Study

   This study will evaluate whether once versus twice daily dosing of methadone will be an effective method for managing comorbid pain and opioid use disorder.

   Stage

   Phase 2

   Ages

   18 to 100

   Site

   Addiction Treatment Services (ATS), Baltimore, Maryland

   Run by

   University of Maryland, Baltimore

   See if you can join NCT05459402 on ClinicalTrials.gov

4. Psilocybin for Opioid Use Disorder (OUD)

   This is a double-blind, adaptive, 2-stage, multi-site, phase 2 randomized controlled clinical trial designed to evaluate effects of moderate and high dose psilocybin, relative to low-dose psilocybin control, in OUD patients who continue to use illicit opioids in spite of adherence to standard-of-ca…

   Stage

   Phase 2

   Ages

   18 to 65

   Site

   Duke City Recovery Toolbox, Albuquerque, New Mexico

   Locations

   5 in total

   Run by

   NYU Langone Health

   See if you can join NCT06796062 on ClinicalTrials.gov

5. OUD (Opioid Use Disorder) Target Trial

   In this research study the investigators will work with 80-participants with opioid use disorder who are starting treatment with the medication buprenorphine and are trying to quit using opioids. The investigators are trying to learn two things: 1. Can an MRI brain marker be used to predict which p…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Duke University, Durham, North Carolina

   Run by

   Duke University

   See if you can join NCT06585709 on ClinicalTrials.gov

6. Opioid Use Disorder in Pregnancy in Long-Term Maternal/Infant Outcomes

   The objective of this study is to better understand the comprehensive integration of both clinical and genetic factors that will help to identify mothers who could be at an increased risk of poor response to opioid substitution and infants at risk of significant neonatal abstinence syndrome (NAS).

   Stage

   Not phased

   Ages

   18 and older

   Site

   UPMC Children's Hospital, Pittsburgh, Pennsylvania

   Run by

   Senthil Sadhasivam

   See if you can join NCT03923374 on ClinicalTrials.gov

7. Intervening on Opioid Use and Loneliness

   This study aims to enroll 300 participants who will be assigned to one of three 3 groups. Each group will receive an intervention lasting 6, weekly sessions of 40-60 minutes. Eligibility include having an opioid use disorder and reporting loneliness or feeling alone or disconnected.

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Rochester, Rochester, New York

   Run by

   University of Rochester

   See if you can join NCT06458335 on ClinicalTrials.gov

8. Integrating Brain, Neurocognitive, and Computational Tools in OUD

   The 5-year K01 Mentored Research Scientist proposal will employ brain, neurocognitive, and computational tools (e.g., machine learning) to understand the impact of opioid-use disorder (OUD) and common co-occurring issues on executive function and clinical outcomes. There have been record numbers of…

   Stage

   Not phased

   Ages

   18 to 60

   Site

   University of Pennsylvania, Philadelphia, Pennsylvania

   Run by

   University of Pennsylvania

   See if you can join NCT06136247 on ClinicalTrials.gov

9. NavSTAR Implementation Effectiveness Trial Across a Health System

   Patient Navigation (PN) interventions following hospitalization can improve outcomes for people with opioid use disorder treatment. Delivering PN interventions on a wide scale requires many resources and coordination across institutions. This will use an evidence-based process to find solutions to …

   Stage

   Not phased

   Ages

   18 and older

   Site

   Jefferson Health, Philadelphia, Pennsylvania

   Run by

   Friends Research Institute, Inc.

   See if you can join NCT07262190 on ClinicalTrials.gov

10. Integrated Treatment for Opioid Use Disorder and PTSD

    This study will test a therapy intervention, HOPE, for individuals with opioid use disorder and posttraumatic stress disorder. Interested individuals will need to be taking medications for opioid use disorder (e.g., suboxone, naltrexone, methadone). Interested participants will complete a 10-12 wee…

    Stage

    Not phased

    Ages

    18 to 70

    Site

    Medical University of South Carolina, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT06641115 on ClinicalTrials.gov

11. Expanding the Youth Opioid Recovery Support (YORS) Intervention for MOUD Adherence to Adolescents With OUD

    Despite rising rates of fatal opioid overdoses in the United States, adolescents with OUD are far less likely than adults to receive and be retained on medication for opioid use disorder (MOUD). The multicomponent Youth Opioid Recovery Support (YORS) intervention for young adults seeks to increase …

    Stage

    Not phased

    Ages

    13 to 21

    Site

    Maryland Treatment Centers, Baltimore, Maryland

    Run by

    Potomac Health Foundations

    See if you can join NCT06774248 on ClinicalTrials.gov

12. Low-Intensity Focused Ultrasound and the Complex Patient

    Studying the effects of Low Intensity Focused Ultrasound (LIFU) on measures of pain, craving, and anxiety in a complex patient population.

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Fralin Biomedical Research Institute at VTC, Roanoke, Virginia

    Run by

    Virginia Polytechnic Institute and State University

    See if you can join NCT06297200 on ClinicalTrials.gov

13. Sustaining Recovery for People on Opioid Agonist Treatment With Conversational Agents

    This study aims to improve retention in buprenorphine treatment, a medication used for opioid use disorder, through the use of a smartphone-delivered recovery support intervention. The intervention involves an Embodied Conversational Agent (ECA), a virtual, animated computer agent designed to simul…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Office-Based Addiction Treatment (OBAT) Clinic, BMC, Boston, Massachusetts

    Run by

    Boston Medical Center

    See if you can join NCT06732596 on ClinicalTrials.gov

14. Continuum of Care in Hospitalized Patients With Opioid/Stimulant Use Disorder and Infectious Complications From Drug Use

    This is a two-group randomized controlled trial conducted at five hospitals across the U.S. designed to test the effectiveness of an Integrated infectious diseases/Substance Use Disorder outpatient clinic (IC) compared to treatment as usual aimed at reducing infection related readmissions and impro…

    Stage

    Not phased

    Ages

    18 and older

    Site

    George Washington University, Washington D.C., District of Columbia

    Locations

    4 in total

    Run by

    Elana Rosenthal

    See if you can join NCT06513156 on ClinicalTrials.gov

15. Wellcome Leap Psilocybin for OUD

    Investigators will recruit 36 individuals on MAT for OUD for a double-blind, placebo-controlled design to determine whether PEX010 (25-mg/d) shows preliminary efficacy on neural correlates of neurocognition and on clinical outcomes. Participants will be randomized to either (single dose) 25-mg (PEX…

    Stage

    Phase 2

    Ages

    18 to 60

    Site

    University of Pennsylvania, Philadelphia, Pennsylvania

    Run by

    Anna Rose Childress, Ph.D.

    See if you can join NCT06786325 on ClinicalTrials.gov

16. Identifying Optimal Buprenorphine Dosing for Opioid Use Disorder Treatment and Prevention of Overdose

    The investigators aim to test the effectiveness of a high maintenance daily dose of buprenorphine (24 mg) for improving outcomes among patients who used fentanyl compared to the standard daily dose (16 mg). The main question it aims to answer is: will patients who are randomly assigned to the high …

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Brown University, Providence, Rhode Island

    Run by

    Rhode Island Hospital

    See if you can join NCT06316830 on ClinicalTrials.gov

17. The Effect of Light Intervention on Recovery in Individuals With Opioid Use Disorder (OUD)

    Opioid use disorder (OUD) is a chronic relapsing disorder and is well-known for its high-risk rate of overdoses and death. In OUD, sleep and circadian disruptions are highly prevalent, interfere with opioid maintenance treatment outcomes and increase the risk of relapse. So far, commonly used pharm…

    Stage

    Not phased

    Ages

    18 to 60

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Run by

    University of Alabama at Birmingham

    See if you can join NCT06832007 on ClinicalTrials.gov

18. Emergency Medicine Peer Outreach Worker Engagement for Recovery

    This is an observational, prospective case-control study evaluating the effects of an emergency department community health worker-peer recovery specialist program (PCHW), the Substance Misuse Assistance Response Team (SMART). Aims of this study are to 1) understand participant experiences working …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Rhode Island Hospital, Providence, Rhode Island

    Run by

    University of California, Los Angeles

    See if you can join NCT06320015 on ClinicalTrials.gov

19. Young Houston Emergency Opioid Engagement System

    The Houston Emergency Response Opioid Engagement System for Youths and Adolescents (Young HEROES) is a community-based research program integrating assertive outreach, medication for opioid use disorder (MOUD), behavioral counseling, and peer recovery support. The objective is to compare difference…

    Stage

    Phase 4

    Ages

    13 to 17

    Site

    The University of Texas Health Science Center at Houston, Houston, Texas

    Run by

    The University of Texas Health Science Center, Houston

    See if you can join NCT04811014 on ClinicalTrials.gov

20. Semaglutide for Helping Opioid Recovery

    The is a pilot, 12-week, double-blind, placebo-controlled, randomized trial of individuals with opioid use disorder (OUD) newly initiating buprenorphine to receive either weekly injections of semaglutide (n=23) or matching placebo (n=23). The primary aim is to determine the effects of semaglutide o…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Brigham and Women's Hospital, Boston, Massachusetts

    Run by

    Brigham and Women's Hospital

    See if you can join NCT06639464 on ClinicalTrials.gov

21. Towards Testing the Effectiveness of Recovery Community Centers (RCCs)

    The goal of this pilot randomized clinical trial is to prepare for a larger randomized clinical trial (RCT) and collect some early data to learn if the intervention can help people who use medications for opioid use disorder (MOUD). The main questions it aims to answer are: 1. Is it feasible to rec…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT07010978 on ClinicalTrials.gov

22. The Youth Opioid Recovery Support (YORS) Intervention

    Youth are disproportionately affected by the current opioid crisis with catastrophic consequences, and young adults with opioid use disorder (OUD) often struggle with adherence to relapse prevention medications. The Youth Opioid Recovery Support (YORS) model is a promising, innovative, wrap-around …

    Stage

    Not phased

    Ages

    18 to 28

    Site

    Mountain Manor Treatment Center, Baltimore, Maryland

    Run by

    Potomac Health Foundations

    See if you can join NCT04173416 on ClinicalTrials.gov

23. Expanding Medication-Assisted Therapies in Central Asia

    Central Asia (CA) represents the most rapidly growing HIV epidemic region worldwide, concentrated in people who inject drugs (PWID) and their sexual partners, and scaling up opioid agonist therapies (OAT) in this region is the most cost-effective strategy to prevent new HIV infections, and more eff…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Columbia University Global Health Research Center of Central Asia, Almaty,

    Locations

    4 in total

    Run by

    Yale University

    See if you can join NCT05579470 on ClinicalTrials.gov

24. Assessing a Clinically-meaningful Opioid Withdrawal Phenotype

    Evaluate individual differences in the expression of opioid withdrawal symptoms in persons with opioid use disorder (OUD) while completing a clinically-indicated medication taper.

    Stage

    Phase 2

    Ages

    18 to 65

    Site

    University of Maryland, Baltimore, Maryland

    Run by

    University of Maryland, Baltimore

    See if you can join NCT05027919 on ClinicalTrials.gov

25. Right Tools, Right Time, Right Place: Telehealth for Opioid Use Disorder in Vulnerable Settings

    Our primary objective is to evaluate the ability of Boulder Care's telehealth-platform to create the necessary paradigmatic shift in Opioid Use Disorder (OUD) treatment to reach vulnerable populations, with targets that support both equitable and culturally-specific OUD treatment as well as busines…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Boulder Care, Portland, Oregon

    Run by

    Boulder Care

    See if you can join NCT07169409 on ClinicalTrials.gov