Opioid Use Disorder Clinical Trials

135 studies are recruiting for opioid use disorder in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 4

1. Optimizing Evidence-based HIV Prevention Targeting People Who Inject Drugs on PrEP

   The investigators will conduct an optimization trial among N=256 PWID newly started on medication for opioid use disorder and Pre-Exposure Prophylaxis (PrEP) to assess the performance of four intervention components (Attention, Executive Functioning, Memory, and Information Processing) aimed at enh…

   Stage

   Phase 4

   Ages

   18 and older

   Site

   APT Foundation, New Haven, Connecticut

   Run by

   University of Connecticut

   See if you can join NCT05669534 on ClinicalTrials.gov

2. Coordinating Outpatient bupreNorphiNe for Emergency Care and Continuing Treatment

   The main purpose of this stepped wedge trial will be to test the impact of a bundle of implementation strategies designed to improve ED-outpatient care coordination on long-term buprenorphine retention among adult patients who start buprenorphine for opioid use disorder in a hospital emergency depa…

   Stage

   Not phased

   Ages

   14 and older

   Site

   Marshall Medical Center Emergency Department, Placerville, California

   Locations

   4 in total

   Run by

   University of California, Davis

   See if you can join NCT07024498 on ClinicalTrials.gov

3. Adaptive Decision Support for Addiction Treatment Master

   This study refines and optimizes the EMBED* clinical decision support (CDS; see NCT03658642) to increase number of ED physicians following standard of care for the administration of buprenorphine to appropriate patients with opioid use disorder. This study does not have open enrollment. Investigato…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Yale New Haven Shoreline Medical Center, Guilford, Connecticut

   Locations

   3 in total

   Run by

   Yale University

   See if you can join NCT06799117 on ClinicalTrials.gov

4. Better Experiences in Substance Treatment: A Brief Alcohol-focused Intervention Tailored for Patients in Opioid Agonist Treatment

   This study will help determine the feasibility and acceptability of a brief opioid-informed alcohol intervention in patients receiving prescribed buprenorphine for opioid use who are currently drinking alcohol. It will also provide initial information on whether the intervention improves outcomes r…

   Stage

   Not phased

   Ages

   18 and older

   Site

   The University of Notre Dame, Notre Dame, Indiana

   Run by

   University of Notre Dame

   See if you can join NCT07342504 on ClinicalTrials.gov

5. Postpartum Intervention for Mothers With Opioid Use Disorders (R33)

   Having met the milestones of the R61, this R33 is a 2-site, 2-group, pre/post RCT of mothers with OUD (n=~80/group). We will test whether the beneficial pre-post changes in OUD mothers randomized to vMP exceed those of mothers assigned to Enhanced Usual Care (EUC) and via changes in Maternal Brain …

   Stage

   Not phased

   Ages

   18 to 50

   Site

   University of Michigan, Ann Arbor, Michigan

   Locations

   2 in total

   Run by

   Stony Brook University

   See if you can join NCT07632053 on ClinicalTrials.gov

6. Buprenorphine for Individuals in Jail

   This study is an open label randomized controlled trial of extended-release buprenorphine (BRIXADI, XR-B) vs. sublingual buprenorphine (SL-B) in a large metropolitan jail. An open-label design will randomly assign 240 adults with moderate-to-severe OUDs who are soon-to-be-released from jail to eith…

   Stage

   Phase 3

   Ages

   18 and older

   Site

   Friends Research Institute, Baltimore, Maryland

   Locations

   2 in total

   Run by

   Friends Research Institute, Inc.

   See if you can join NCT06306443 on ClinicalTrials.gov

7. Integrated e-Health (Electronic Health) for HIV and Substance Use Disorders in Justice Involved Women

   The purpose of this 2-site (CT, AL) study is to test innovative interventions to reduce stigma and improve the pre-exposure prophylaxis (PrEP) and opioid use disorder (OUD) care continua in women involved in the criminal justice system (WICJ). This study evaluates a newly validated PrEP decision ai…

   Stage

   Phase 4

   Ages

   18 and older

   Site

   University of Alabama in Birmingham, Birmingham, Alabama

   Locations

   2 in total

   Run by

   Yale University

   See if you can join NCT05547048 on ClinicalTrials.gov

8. A Clinical Trial Comparing Buprenorphine Formulations for High Potency Synthetic Opioid Use

   The goal of this clinical trial is to compare buprenorphine formulations (sublingual buprenorphine versus long-acting injectable buprenorphine) for treating opioid use disorder among individuals who use fentanyl and/or other high potency synthetic opioids. Individuals aged 18-65 will be eligible fo…

   Stage

   EARLY_Phase 1

   Ages

   18 to 65

   Site

   Substance Treatment and Research Service, New York, New York

   Run by

   Rachel R. Luba

   See if you can join NCT06726200 on ClinicalTrials.gov

9. TMS to Improve Recovery Outcomes Among Patients With Opioid Use Disorder (OUD) and Alcohol Use Disorder (AUD)

   The study aims to explore the potential of Transcranial Magnetic Stimulation (TMS), particularly Theta Burst Stimulation (TBS), as an adjunctive treatment to enhance recovery outcomes (consumption and craving; withdrawal symptoms; mental, physical, sleep, and cognitive health; engagement with thera…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Another Chance Drug & Alcohol Rehab Center of Portland, Portland, Oregon

   Run by

   Washington State University

   See if you can join NCT07171359 on ClinicalTrials.gov

10. Standard Versus High Dose ED-Initiated Buprenorphine Induction

    This study is a multisite double-blind, double-dummy, randomized clinical trial enrolling ED patients with untreated moderate to severe opioid use disorder (OUD) to compare Standard Dose Induction (SDI) and High Dose Induction (HDI) on rates of participation in OUD treatment within 10 days post ran…

    Stage

    Phase 3

    Ages

    18 to 65

    Site

    Highland Hospital, Oakland, California

    Locations

    5 in total

    Run by

    Yale University

    See if you can join NCT06494904 on ClinicalTrials.gov

11. Longitudinal Neural Fingerprinting of Opioid-use Trajectories

    This project aims to collect a densely sampled neuroimaging dataset among individuals receiving medications for opioid use disorder (MOUD). MOUD is multiphasic, comprised of medication induction, stabilization, ongoing treatment, and eventual dis-continuation phases. However, with a few small excep…

    Stage

    Not phased

    Ages

    18 to 50

    Site

    MRRC at The Anlyan Center, New Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT06207162 on ClinicalTrials.gov

12. Addressing Racial Disparities in Opioid Overdose Using Peer Recovery Coach Training and mHealth Platform

    The study aims to adapt an existing Cultural Structural Humility (CSH) training into a video format for peer recovery coaches (PRCs) and refine an AI-driven texting tool to reinforce the training. After refining these tools using user-centered design, a pilot test will be conducted to assess their …

    Stage

    Not phased

    Ages

    18 to 99

    Site

    START Treatment and Recovery, New York, New York

    Run by

    Friends Research Institute, Inc.

    See if you can join NCT06573476 on ClinicalTrials.gov

13. Efficacy of Buprenorphine and XR-Naltrexone Combination for Relapse Prevention in Opioid Use Disorder

    This study will evaluate the effectiveness of a new pharmacological approach to increase efficacy of treatment with extended release naltrexone (XR-naltrexone) for individuals with opioid use disorder by combining it with buprenorphine-naloxone. This is a two arm, double-blind, placebo-controlled s…

    Stage

    Phase 2

    Ages

    18 to 65

    Site

    Avery Road Treatment Center (ARTC), Rockville, Maryland

    Locations

    2 in total

    Run by

    New York State Psychiatric Institute

    See if you can join NCT05011266 on ClinicalTrials.gov

14. Novel Telemedicine-Delivered Prolonged Exposure Therapy for Treating PTSD in Individuals With OUD

    Among individuals with opioid use disorder (OUD), posttraumatic stress disorder (PTSD) presents a significant clinical challenge. The prevalence of PTSD is substantially higher in individuals with OUD than in the general population, with nearly 90% reporting lifetime trauma exposure and 33% meeting…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Vemont, Burlington, Vermont

    Run by

    University of Vermont

    See if you can join NCT06288711 on ClinicalTrials.gov

15. Systems Analysis and Improvement to Optimize Opioid Use Disorder Care Quality and Continuity for Patients Exiting Jail

    This study evaluates the effectiveness of a health systems strategy (the Systems Analysis and Improvement Approach - SAIA) that packages systems engineering tools (including cascade analysis, flow mapping, and continuous quality improvement) to optimize the management of opioid use disorder (MOUD) …

    Stage

    Not phased

    Ages

    18 to 110

    Site

    University of Washington, Seattle, Washington

    Run by

    University of Washington

    See if you can join NCT06593353 on ClinicalTrials.gov

16. Injectable Buprenorphine in Prison: A Preference Trial

    The goal of this pilot trial is to compare two branded extended-release buprenorphine (XR-B) formulations (Sublocade vs. Brixadi) to explore how they improve treatment retention after release from prison among incarcerated individuals with opioid use disorder (OUD) who are transitioning back into t…

    Stage

    Phase 4

    Ages

    18 and older

    Site

    Rhode Island Department of Corrections, Cranston, Rhode Island

    Run by

    Lifespan

    See if you can join NCT06880718 on ClinicalTrials.gov

17. Overdose Recovery and Care Access (ORCA) Qualitative Stakeholder Interviews and County-level Data

    The study is a quasi-experimental investigation of a sub-acute stabilization center (SASC) for people who have had or are at risk for having an opioid overdose and have an encounter with Seattle Fire Department emergency medical services (EMS) in Seattle, WA. Those transported to the SASC are the i…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Downtown Emergency Service Center's Overdose Recovery and Care Access Centers, Seattle, Washington

    Run by

    University of Washington

    See if you can join NCT06768814 on ClinicalTrials.gov

18. Building Retention and Initiation Through Delivery of Peer-Guided Evidence-Based Practices

    This study will provide longitudinal data for 6-months on a target sample of patients with Opioid Use Disorder (OUD) recruited from Prisma Health Mobile Health Clinics in South Carolina. The goal of our study is to increase OUD treatment initiation and retention and maximize prevention of overdose …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Prisma Health Upstate, Greenville, South Carolina

    Run by

    Prisma Health-Upstate

    See if you can join NCT07541417 on ClinicalTrials.gov

19. Imaging Cannabinoid Receptors Using Positron Emission Tomography (PET) Scanning

    The aim of the present study is to assess the availability of cannabinoid receptors (CB1R) in the human brain. CB1R are present in everyone's brain, regardless of whether or not someone has used cannabis. The investigators will image brain cannabinoid receptors using Positron Emission Tomography (P…

    Stage

    Not phased

    Ages

    18 to 55

    Site

    Connecticut Mental Health Center, Clinical Neuroscience Research Unit, New Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT01730781 on ClinicalTrials.gov

20. Clinical Trials of Multivalent Opioid Vaccine Components

    Currently, abuse of prescription opioid analgesics and heroin is a serious problem in the U.S. Although several medications, including methadone, buprenorphine, and naltrexone, are available and effective in treating opioid use disorder (OUD), long-term relapse rates remain high. The current study …

    Stage

    Phase 1

    Ages

    18 to 59

    Site

    Clinilabs Drug Development Corporation, Eatontown, New Jersey

    Locations

    2 in total

    Run by

    New York State Psychiatric Institute

    See if you can join NCT04458545 on ClinicalTrials.gov

21. Technology-Enhanced Therapy vs. Medication Monitoring for Buprenorphine Retention in Pregnant Persons

    This study involves testing how useful a technology-enhanced therapy is for pregnant people prescribed buprenorphine for the treatment of opioid use disorder, compared to medication monitoring. Participants are randomized to one of the conditions. If participants are randomized to receive the thera…

    Stage

    Not phased

    Ages

    18 to 45

    Site

    Medical University of South Carolina, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT06999811 on ClinicalTrials.gov

22. PrEP and MOUD Rapid Access for Persons Who Inject Drugs: The CHORUS+ Study

    The US opioid overdose epidemic has been accompanied by an increase in human immunodeficiency (HIV) among persons who inject drugs. HIV pre-exposure prophylaxis (PrEP) is an FDA approved medication taken daily orally by individuals who are HIV negative, but who are at increased risk for HIV. In ord…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Boston Medical Center Faster Paths Bridge Clinic, Boston, Massachusetts

    Locations

    2 in total

    Run by

    Boston Medical Center

    See if you can join NCT05769218 on ClinicalTrials.gov

23. Buprenorphine as a Post-operative Analgesic in Opioid-Naive Patients After Ankle Fracture Surgery

    Addictive full-agonist opioids, like oxycodone and hydrocodone, are often used to treat pain after surgery. However, these full-agonist opioids can be very addictive. After ankle fracture surgery, about 1 in 5 patients that did not take opioids before surgery become addicted to opioids after surger…

    Stage

    Phase 4

    Ages

    18 and older

    Site

    Washington University in St. Louis/Barnes Jewish Hospital, St Louis, Missouri

    Run by

    Jenna-Leigh Wilson

    See if you can join NCT06949826 on ClinicalTrials.gov

24. Non-invasive Vagal Nerve Stimulation in Opioid Use Disorders UH3

    This study is being done to answer the question: what is the effect of Vagal Nerve Stimulation (VNS) dosing on opioid withdrawal responses in individuals with a history of Opioid Use Disorders (OUDs)? Eligible participants will be in the study for one week in an inpatient research hospital stay, ha…

    Stage

    Phase 3

    Ages

    18 to 75

    Site

    Emory University Clinical Research Network, Atlanta, Georgia

    Locations

    6 in total

    Run by

    Emory University

    See if you can join NCT05834478 on ClinicalTrials.gov

25. Remotely Observed Methadone Evaluation II

    Methadone is an effective treatment for severe opioid use disorder (OUD), but access is limited due to the requirement of daily observed dosing by most opioid treatment programs (OTPs). Sonara Health designed a HIPAA-compliant web-application called Sonara that features integrated video dosing reco…

    Stage

    Phase 2

    Ages

    18 to 64

    Site

    FGC Wabash, Chicago, Illinois

    Run by

    Sonara Health

    See if you can join NCT06338280 on ClinicalTrials.gov