Opioid Use Disorder Clinical Trials

135 studies are recruiting for opioid use disorder in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 4

1. Efficacy of Buprenorphine and XR-Naltrexone Combination for Relapse Prevention in Opioid Use Disorder

   This study will evaluate the effectiveness of a new pharmacological approach to increase efficacy of treatment with extended release naltrexone (XR-naltrexone) for individuals with opioid use disorder by combining it with buprenorphine-naloxone. This is a two arm, double-blind, placebo-controlled s…

   Stage

   Phase 2

   Ages

   18 to 65

   Site

   Avery Road Treatment Center (ARTC), Rockville, Maryland

   Locations

   2 in total

   Run by

   New York State Psychiatric Institute

   See if you can join NCT05011266 on ClinicalTrials.gov

2. Novel Telemedicine-Delivered Prolonged Exposure Therapy for Treating PTSD in Individuals With OUD

   Among individuals with opioid use disorder (OUD), posttraumatic stress disorder (PTSD) presents a significant clinical challenge. The prevalence of PTSD is substantially higher in individuals with OUD than in the general population, with nearly 90% reporting lifetime trauma exposure and 33% meeting…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Vemont, Burlington, Vermont

   Run by

   University of Vermont

   See if you can join NCT06288711 on ClinicalTrials.gov

3. Systems Analysis and Improvement to Optimize Opioid Use Disorder Care Quality and Continuity for Patients Exiting Jail

   This study evaluates the effectiveness of a health systems strategy (the Systems Analysis and Improvement Approach - SAIA) that packages systems engineering tools (including cascade analysis, flow mapping, and continuous quality improvement) to optimize the management of opioid use disorder (MOUD) …

   Stage

   Not phased

   Ages

   18 to 110

   Site

   University of Washington, Seattle, Washington

   Run by

   University of Washington

   See if you can join NCT06593353 on ClinicalTrials.gov

4. Injectable Buprenorphine in Prison: A Preference Trial

   The goal of this pilot trial is to compare two branded extended-release buprenorphine (XR-B) formulations (Sublocade vs. Brixadi) to explore how they improve treatment retention after release from prison among incarcerated individuals with opioid use disorder (OUD) who are transitioning back into t…

   Stage

   Phase 4

   Ages

   18 and older

   Site

   Rhode Island Department of Corrections, Cranston, Rhode Island

   Run by

   Lifespan

   See if you can join NCT06880718 on ClinicalTrials.gov

5. Development of an mHealth Behavioral Sleep Medicine Intervention for Use During Medication Assisted Treatment for MOUD

   This study is to develop and test a medical health application based on cognitive behavioral therapy for insomnia and augmented with other evidence-based sleep interventions that address common sleep-related problems in opioid use disorder. An initial program will be built utilizing input from pers…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Medical University of South Carolina, Charleston, South Carolina

   Run by

   Medical University of South Carolina

   See if you can join NCT06157840 on ClinicalTrials.gov

6. Overdose Recovery and Care Access (ORCA) Qualitative Stakeholder Interviews and County-level Data

   The study is a quasi-experimental investigation of a sub-acute stabilization center (SASC) for people who have had or are at risk for having an opioid overdose and have an encounter with Seattle Fire Department emergency medical services (EMS) in Seattle, WA. Those transported to the SASC are the i…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Downtown Emergency Service Center's Overdose Recovery and Care Access Centers, Seattle, Washington

   Run by

   University of Washington

   See if you can join NCT06768814 on ClinicalTrials.gov

7. Building Retention and Initiation Through Delivery of Peer-Guided Evidence-Based Practices

   This study will provide longitudinal data for 6-months on a target sample of patients with Opioid Use Disorder (OUD) recruited from Prisma Health Mobile Health Clinics in South Carolina. The goal of our study is to increase OUD treatment initiation and retention and maximize prevention of overdose …

   Stage

   Not phased

   Ages

   18 and older

   Site

   Prisma Health Upstate, Greenville, South Carolina

   Run by

   Prisma Health-Upstate

   See if you can join NCT07541417 on ClinicalTrials.gov

8. Imaging Cannabinoid Receptors Using Positron Emission Tomography (PET) Scanning

   The aim of the present study is to assess the availability of cannabinoid receptors (CB1R) in the human brain. CB1R are present in everyone's brain, regardless of whether or not someone has used cannabis. The investigators will image brain cannabinoid receptors using Positron Emission Tomography (P…

   Stage

   Not phased

   Ages

   18 to 55

   Site

   Connecticut Mental Health Center, Clinical Neuroscience Research Unit, New Haven, Connecticut

   Run by

   Yale University

   See if you can join NCT01730781 on ClinicalTrials.gov

9. Mindfulness-Based Ecological Momentary Intervention for Opioid Use Disorder and Chronic Pain

   The goal of this clinical trial is to evaluate whether a smartphone app-based ecological momentary intervention called Mindful Journey, which teaches mindfulness skills, can support adults in recovery from both opioid use disorder and chronic pain. The primary objective of this pilot study is to as…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Arizona State University, Phoenix, Arizona

   Locations

   2 in total

   Run by

   Arizona State University

   See if you can join NCT06947122 on ClinicalTrials.gov

10. Clinical Trials of Multivalent Opioid Vaccine Components

    Currently, abuse of prescription opioid analgesics and heroin is a serious problem in the U.S. Although several medications, including methadone, buprenorphine, and naltrexone, are available and effective in treating opioid use disorder (OUD), long-term relapse rates remain high. The current study …

    Stage

    Phase 1

    Ages

    18 to 59

    Site

    Clinilabs Drug Development Corporation, Eatontown, New Jersey

    Locations

    2 in total

    Run by

    New York State Psychiatric Institute

    See if you can join NCT04458545 on ClinicalTrials.gov

11. Cannabidiol in Opioid Use Disorder and Chronic Pain

    This is a randomized, placebo-controlled, crossover human laboratory study investigating the dose-dependent safety and acute effects of Cannabidiol (CBD) on measures of pain and opioid craving in outpatients with opioid use disorder (OUD) receiving medication-assisted treatment with methadone or bu…

    Stage

    EARLY_Phase 1

    Ages

    18 to 70

    Site

    Department of Veterans Affairs Hospital, West Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT04587791 on ClinicalTrials.gov

12. Technology-Enhanced Therapy vs. Medication Monitoring for Buprenorphine Retention in Pregnant Persons

    This study involves testing how useful a technology-enhanced therapy is for pregnant people prescribed buprenorphine for the treatment of opioid use disorder, compared to medication monitoring. Participants are randomized to one of the conditions. If participants are randomized to receive the thera…

    Stage

    Not phased

    Ages

    18 to 45

    Site

    Medical University of South Carolina, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT06999811 on ClinicalTrials.gov

13. PrEP and MOUD Rapid Access for Persons Who Inject Drugs: The CHORUS+ Study

    The US opioid overdose epidemic has been accompanied by an increase in human immunodeficiency (HIV) among persons who inject drugs. HIV pre-exposure prophylaxis (PrEP) is an FDA approved medication taken daily orally by individuals who are HIV negative, but who are at increased risk for HIV. In ord…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Boston Medical Center Faster Paths Bridge Clinic, Boston, Massachusetts

    Locations

    2 in total

    Run by

    Boston Medical Center

    See if you can join NCT05769218 on ClinicalTrials.gov

14. Buprenorphine as a Post-operative Analgesic in Opioid-Naive Patients After Ankle Fracture Surgery

    Addictive full-agonist opioids, like oxycodone and hydrocodone, are often used to treat pain after surgery. However, these full-agonist opioids can be very addictive. After ankle fracture surgery, about 1 in 5 patients that did not take opioids before surgery become addicted to opioids after surger…

    Stage

    Phase 4

    Ages

    18 and older

    Site

    Washington University in St. Louis/Barnes Jewish Hospital, St Louis, Missouri

    Run by

    Jenna-Leigh Wilson

    See if you can join NCT06949826 on ClinicalTrials.gov

15. Non-invasive Vagal Nerve Stimulation in Opioid Use Disorders UH3

    This study is being done to answer the question: what is the effect of Vagal Nerve Stimulation (VNS) dosing on opioid withdrawal responses in individuals with a history of Opioid Use Disorders (OUDs)? Eligible participants will be in the study for one week in an inpatient research hospital stay, ha…

    Stage

    Phase 3

    Ages

    18 to 75

    Site

    Emory University Clinical Research Network, Atlanta, Georgia

    Locations

    6 in total

    Run by

    Emory University

    See if you can join NCT05834478 on ClinicalTrials.gov

16. Remotely Observed Methadone Evaluation II

    Methadone is an effective treatment for severe opioid use disorder (OUD), but access is limited due to the requirement of daily observed dosing by most opioid treatment programs (OTPs). Sonara Health designed a HIPAA-compliant web-application called Sonara that features integrated video dosing reco…

    Stage

    Phase 2

    Ages

    18 to 64

    Site

    FGC Wabash, Chicago, Illinois

    Run by

    Sonara Health

    See if you can join NCT06338280 on ClinicalTrials.gov

17. Adolescent Outcomes of Post-operative Opioid EXposure

    The goal of this observational study is to examine the factors associated with the transition from medical exposure to opioids with "signposts" of future opioid use disorder among adolescent surgical patients. The main question aims to identify factors (moderators, mediators, and covariates) associ…

    Stage

    Not phased

    Ages

    12 to 17

    Site

    Boston Childrens Hopsital - Division of Addiction Medicine, Boston, Massachusetts

    Locations

    5 in total

    Run by

    Sharon Levy

    See if you can join NCT06350409 on ClinicalTrials.gov

18. MDMA for Co-occurring PTSD and OUD After Childbirth

    This is an open-label study of the use of MDMA Assisted Therapy for postpartum people with co-occurring Post Traumatic Stress Disorder (PTSD) and Opioid Use Disorder (OUD). The study protocol has been adapted from the Phase 3 studies sponsored by the Multidisciplinary Association for Psychedelic St…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    University of New Mexico Health Sciences, Albuquerque, New Mexico

    Run by

    University of New Mexico

    See if you can join NCT05219175 on ClinicalTrials.gov

19. E-Cigarettes for Harm Reduction in Smokers With Opioid Use Disorder

    The purpose of this an open-label, randomized controlled trial study is to compare the effectiveness of electronic cigarettes (e-cigarettes/e-cigs) versus telehealth motivational counseling with combination nicotine replacement therapy (NRT) + telehealth counseling on combustible cigarettes smoking…

    Stage

    Phase 2

    Ages

    21 to 75

    Site

    NYU Langone Health, New York, New York

    Locations

    2 in total

    Run by

    NYU Langone Health

    See if you can join NCT05722561 on ClinicalTrials.gov

20. Optimization of NIBS for Treatment of Addiction

    The purpose of this study is to assess the effects of transcranial Direct Current Stimulation (tDCS) applied in conjunction with Transcranial Ultrasound (TUS) for the treatment of addiction in opiate use disorder with chronic pain. The investigators hypothesize that there will be a decrease in drug…

    Stage

    Not phased

    Ages

    18 to 85

    Site

    University of Illinois Health/ University of Illinois at Chicago, Hinsdale, Illinois

    Locations

    3 in total

    Run by

    Case Western Reserve University

    See if you can join NCT04379115 on ClinicalTrials.gov

21. Teaching Health Resilience in a Hospital Setting: A Peer-led Intervention

    The purpose of the study is to develop an acceptable, feasible, and effective peer-led bundle of health resilience and promotion services to be delivered in the hospital setting, called the THRIVE intervention. The main question it aims to answer is: Will participants receiving the THRIVE intervent…

    Stage

    Not phased

    Ages

    18 and older

    Site

    UPMC Presbyterian-Montefiore Hospital, Pittsburgh, Pennsylvania

    Locations

    3 in total

    Run by

    University of Pennsylvania

    See if you can join NCT06843213 on ClinicalTrials.gov

22. A Bundled Intervention

    Opioid overdose deaths have reached historically high records in the United States and are particularly concentrated among patients after emergency department (ED) discharge. Evidence-based treatment modules to reduce repeat opioid overdose and mortality are lacking in this patient population. A bu…

    Stage

    Phase 1

    Ages

    19 and older

    Site

    UAB, Birmingham, Alabama

    Run by

    University of Alabama at Birmingham

    See if you can join NCT06593093 on ClinicalTrials.gov

23. Adaptive Interventions for Emergency Department Patients With Opioid Use Disorder

    The ADAPT-ED study is a two-stage, sequential multiple assignment randomized trial (SMART) to inform the development of an adaptive intervention that is optimally effective in increasing long-term buprenorphine use for adults presenting to the ED with probable opioid use disorder (OUD).

    Stage

    Not phased

    Ages

    18 and older

    Site

    Arrowhead Regional Medical Center, Colton, California

    Run by

    RAND

    See if you can join NCT06827288 on ClinicalTrials.gov

24. HIV, Equity, and Addiction Training (HEAT) Program

    This project is a pilot study to determine the feasibility and acceptability of a telemedicine intervention for substance use disorder service delivery in diverse people living with HIV in Alabama.

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Run by

    University of Alabama at Birmingham

    See if you can join NCT06370481 on ClinicalTrials.gov

25. Evaluation of a Peer Recovery Support Program Adapted to Target Retention in Clinic-based Medication for Opioid Use Disorder Treatment

    The goal of this clinical trial is to learn if receiving peer recovery support (support services provided by trained "peers" with lived experience of addiction and recovery) improves retention in medication treatment among people with opioid use disorder. The main question it aims to answer is: doe…

    Stage

    Not phased

    Ages

    18 to 89

    Site

    Geisinger Clinic, Danville, Pennsylvania

    Run by

    Geisinger Clinic

    See if you can join NCT07197801 on ClinicalTrials.gov