Opioid Use Disorder Clinical Trials in Baltimore, Maryland

15 studies are recruiting for opioid use disorder in Baltimore, Maryland right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. A Study of Brenipatide in Participants With Opioid Use Disorder

   The purpose of this study is to see if brenipatide, when compared to placebo, is safe and effective for participants with opioid use disorder, when used with buprenorphine with or without naloxone. The maximum potential duration of study participation for a participant in Part A is approximately 14…

   Stage

   Phase 2

   Ages

   18 to 75

   Site

   Maryland Treatment Centers - Mountain Manor Treatment Center, Baltimore, Maryland

   Locations

   59 in total

   Run by

   Eli Lilly and Company

   See if you can join NCT07420283 on ClinicalTrials.gov

2. Ketamine for Opioid Use Disorder

   The goal of this clinical trial is to learn if ketamine works to reduce craving for opioids in adults enrolled in methadone treatment for opioid use disorder. The main questions it aims to answer are: * Does ketamine reduce craving for opioids in patients with opioid use disorder? * Does ketamine r…

   Stage

   Phase 2

   Ages

   18 to 65

   Site

   University of Maryland Addiction Programs and Affiliated Clinics, Baltimore, Maryland

   Run by

   University of Maryland, Baltimore

   See if you can join NCT06943859 on ClinicalTrials.gov

3. GLP-1R Agonist Treatment for Opioid Use Disorder

   The goal of this clinical trial is to learn if semaglutide can reduce illicit opioid use in adults in outpatient treatment for opioid use disorder, and who are receiving either buprenorphine or methadone maintenance treatment. The main question it aims to answer is: • Does semaglutide increase the …

   Stage

   Phase 2

   Ages

   18 to 75

   Site

   University of Maryland Baltimore, Baltimore, Maryland

   Locations

   4 in total

   Run by

   Milton S. Hershey Medical Center

   See if you can join NCT06548490 on ClinicalTrials.gov

4. Evaluating Buspirone to Treat Opioid Withdrawal

   The investigators propose a rigorous, Phase II, three-group, placebo-controlled double-blind randomized controlled trial (RCT) to evaluate the efficacy of buspirone for both withdrawal and craving among individuals with opioid use disorder (OUD) undergoing a standardized stepwise taper. During this…

   Stage

   Phase 2

   Ages

   18 to 75

   Site

   Kahlert Institute for Addictino Medicin, Baltimore, Maryland

   Run by

   University of Maryland, Baltimore

   See if you can join NCT05511909 on ClinicalTrials.gov

5. Outpatient Buprenorphine Induction With Psilocybin for Opioid Use Disorder

   This study will examine the effect of a single high dose of psilocybin therapy (30 mg) versus a very low dose (1 mg) as an adjunctive therapy to individuals undergoing standard-of-care outpatient buprenorphine treatment for Opioid use disorder (OUD). The participants will have previously undergone …

   Stage

   Phase 2

   Ages

   21 to 70

   Site

   Johns Hopkins Center for Psychedelic and Consciousness Research, Baltimore, Maryland

   Run by

   Johns Hopkins University

   See if you can join NCT06067737 on ClinicalTrials.gov

6. Exablate for LIFU Neuromodulation in Patients With Opioid Use Disorder (OUD) and/or Other Substance Use Disorders (SUDs)

   The purpose of this clinical trial is to investigate Low Intensity Focused Ultrasound (LIFU) using the Exablate® Model 4000 Type 2.0/2.1 as an adjunctive neuromodulatory treatment for OUD (Opioid Use Disorder) and/or other Substance Use Disorders (SUDs) by assessing its safety and tolerability in s…

   Stage

   Not phased

   Ages

   18 to 60

   Site

   University of Maryland, Baltimore, Baltimore, Maryland

   Locations

   4 in total

   Run by

   InSightec

   See if you can join NCT04197921 on ClinicalTrials.gov

7. Measuring Acute Drug Demand in Humans

   This research is being done to evaluate whether suvorexant may reduce the use of, subjective liking, and demand for various drugs.

   Stage

   EARLY_Phase 1

   Ages

   18 to 65

   Site

   General Clinical Research Center, Baltimore, Maryland

   Run by

   University of Maryland, Baltimore

   See if you can join NCT05829655 on ClinicalTrials.gov

8. Resilience Among Individuals With Opioid Use Disorder

   The goal of this clinical trial is to develop a human laboratory model of resilience in people with opioid use disorder (OUD). The investigators aim to learn if objective tasks that measure cognitive, emotional, and control aspects of resilience match up with self-reported resilience during stress …

   Stage

   Not phased

   Ages

   18 and older

   Site

   Johns Hopkins University Bayview Medical Campus, Baltimore, Maryland

   Locations

   2 in total

   Run by

   Johns Hopkins University

   See if you can join NCT06954402 on ClinicalTrials.gov

9. Buprenorphine for Individuals in Jail

   This study is an open label randomized controlled trial of extended-release buprenorphine (BRIXADI, XR-B) vs. sublingual buprenorphine (SL-B) in a large metropolitan jail. An open-label design will randomly assign 240 adults with moderate-to-severe OUDs who are soon-to-be-released from jail to eith…

   Stage

   Phase 3

   Ages

   18 and older

   Site

   Friends Research Institute, Baltimore, Maryland

   Locations

   2 in total

   Run by

   Friends Research Institute, Inc.

   See if you can join NCT06306443 on ClinicalTrials.gov

10. Divided or Single Exposure (DOSE) Study

    This study will evaluate whether once versus twice daily dosing of methadone will be an effective method for managing comorbid pain and opioid use disorder.

    Stage

    Phase 2

    Ages

    18 to 100

    Site

    Addiction Treatment Services (ATS), Baltimore, Maryland

    Run by

    University of Maryland, Baltimore

    See if you can join NCT05459402 on ClinicalTrials.gov

11. Expanding the Youth Opioid Recovery Support (YORS) Intervention for MOUD Adherence to Adolescents With OUD

    Despite rising rates of fatal opioid overdoses in the United States, adolescents with OUD are far less likely than adults to receive and be retained on medication for opioid use disorder (MOUD). The multicomponent Youth Opioid Recovery Support (YORS) intervention for young adults seeks to increase …

    Stage

    Not phased

    Ages

    13 to 21

    Site

    Maryland Treatment Centers, Baltimore, Maryland

    Run by

    Potomac Health Foundations

    See if you can join NCT06774248 on ClinicalTrials.gov

12. Continuum of Care in Hospitalized Patients With Opioid/Stimulant Use Disorder and Infectious Complications From Drug Use

    This is a two-group randomized controlled trial conducted at five hospitals across the U.S. designed to test the effectiveness of an Integrated infectious diseases/Substance Use Disorder outpatient clinic (IC) compared to treatment as usual aimed at reducing infection related readmissions and impro…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Maryland Baltimore, Baltimore, Maryland

    Locations

    4 in total

    Run by

    Elana Rosenthal

    See if you can join NCT06513156 on ClinicalTrials.gov

13. The Youth Opioid Recovery Support (YORS) Intervention

    Youth are disproportionately affected by the current opioid crisis with catastrophic consequences, and young adults with opioid use disorder (OUD) often struggle with adherence to relapse prevention medications. The Youth Opioid Recovery Support (YORS) model is a promising, innovative, wrap-around …

    Stage

    Not phased

    Ages

    18 to 28

    Site

    Mountain Manor Treatment Center, Baltimore, Maryland

    Run by

    Potomac Health Foundations

    See if you can join NCT04173416 on ClinicalTrials.gov

14. Assessing a Clinically-meaningful Opioid Withdrawal Phenotype

    Evaluate individual differences in the expression of opioid withdrawal symptoms in persons with opioid use disorder (OUD) while completing a clinically-indicated medication taper.

    Stage

    Phase 2

    Ages

    18 to 65

    Site

    University of Maryland, Baltimore, Maryland

    Run by

    University of Maryland, Baltimore

    See if you can join NCT05027919 on ClinicalTrials.gov

15. EXPANDED SCOPE for Parent Grant Entitled, "Peer Recovery Support Services for Individuals in Recovery Residences on MOUD"

    The United States is experiencing an unprecedented opioid epidemic. Medications for opioid use disorder (MOUD), such as methadone, buprenorphine, and extended-release naltrexone, are the recommended standard of care. There are, however, many barriers to MOUD initiation so that only a minority of in…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Maryland Treatment Centers, Baltimore, Maryland

    Run by

    Potomac Health Foundations

    See if you can join NCT06696157 on ClinicalTrials.gov