Opioid Use Disorder Clinical Trials

135 studies are recruiting for opioid use disorder in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

Search these by distance from you

By city

Studies now recruiting

1. Study to Assess the Use of Tezampanel for Opioid Withdrawal Syndrome in Treatment-Seeking Patients With Opioid Use Disorder

   This study is examining the use of Tezampanel (TZP) for treatment of Opioid Withdrawal Syndrome (OWS) in participants with Opioid Use Disorder (OUD). Participants will receive TZP or placebo (PBO) daily on Days 2 - 7 during a 7-day inpatient stay at the research center to determine safety, pharmaco…

   Stage

   Phase 1

   Ages

   18 to 65

   Site

   Indiana University School of Medicine, Indianapolis, Indiana

   Run by

   Proniras Corporation

   See if you can join NCT06538558 on ClinicalTrials.gov

2. Kentucky Women's Justice Community Overdose Innovation Network - Phase II

   This project continues our work with women in the Kentucky Women's Justice Community Overdose Innovation Network Phase II (WJCOIN-II) with the overall aim of reducing overdose risk during the transition from jail to rural communities. WJCOIN-II has potential for significant impact regarding the eff…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Knox County Detention Center, Barbourville, Kentucky

   Locations

   3 in total

   Run by

   Michele Staton

   See if you can join NCT07179614 on ClinicalTrials.gov

3. Office-based Methadone Versus Buprenorphine to Address Retention in Medication for Opioid Use Disorder Treatment.

   The purpose of this clinical trial is to compare the effectiveness of office-based methadone with pharmacy administration and/or dispensing to office-based buprenorphine for the treatment of opioid use disorder. This study will also examine factors influencing the implementation of office-based met…

   Stage

   Phase 4

   Ages

   18 to 99

   Site

   Highland Hospital Bridge Clinic at Alameda Health System, Oakland, California

   Locations

   6 in total

   Run by

   Yale University

   See if you can join NCT06323824 on ClinicalTrials.gov

4. Opioid and Pain Treatment in Indigenous Communities (OPTIC) Trial

   The present study seeks to examine the implementation process of culturally tailoring screening and brief intervention for both chronic pain and opioid misuse/opioid use disorder in three American Indian and Alaska Native (AI/AN) serving clinics. The investigators also will assess staff perspective…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Clinic Site A (blinded pending tribal approval), Arcata, California

   Locations

   3 in total

   Run by

   University of New Mexico

   See if you can join NCT06565416 on ClinicalTrials.gov

5. A Study Comparing Oral Buprenorphine and Injectable Buprenorphine for the Treatment of Opioid Use Disorder

   VA-BRAVE will determine whether a 28-day long-acting injectable sub-cutaneous formulation of buprenorphine at a target dose of 300 milligrams (mg) is superior in retaining Veterans in opioid treatment and in sustaining opioid abstinence compared to the daily sublingual (under the tongue) buprenorph…

   Stage

   Phase 4

   Ages

   18 and older

   Site

   Phoenix VA Health Care System, Phoenix, AZ, Phoenix, Arizona

   Locations

   25 in total

   Run by

   VA Office of Research and Development

   See if you can join NCT04375033 on ClinicalTrials.gov

6. OMAR Opioid Use Disorder

   The goal of this research study is to examine the endocannabinoid (eCB) function in vivo in individuals with opioid use disorder (OUD) by measuring cannabinoid receptor 1 (CB1R) availability.

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Connecticut Mental Health Center, Clinical Neuroscience Research Unit, New Haven, Connecticut

   Run by

   Yale University

   See if you can join NCT05683184 on ClinicalTrials.gov

7. Building Social and Structural Connections for the Prevention of Opioid Use Disorder Among Youth Experiencing Homelessness

   Homelessness severely affects health and well-being and is particularly negative for youth. Between 70-95% of youth experiencing homelessness (YEH) report problem substance use and 66-89% have a mental health disorder. Youth appear to be at greater risk for living on the streets or being homeless t…

   Stage

   Not phased

   Ages

   14 to 24

   Site

   Star House, Columbus, Ohio

   Locations

   2 in total

   Run by

   Ohio State University

   See if you can join NCT06311838 on ClinicalTrials.gov

8. Pilot Testing of the emPath Platform to Improve Medication for Opioid Use Disorder (MOUD) Linkage and Retention Among Adults With Opioid Use Disorder in Durham, North Carolina

   This pilot study will evaluate the emPath digital platform, a platform designed to improve access to and retention in low-barrier telemedicine for delivery of medication for opioid use disorder (MOUD) among adults with opioid use disorder who engage with community outreach programs in Durham, North…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Project MAPS (Mobile Addiction Treatment and Primary Care Services), Durham, North Carolina

   Run by

   Duke University

   See if you can join NCT07810322 on ClinicalTrials.gov

9. Using Facebook to Support Opioid Recovery Among American Indian Women

   The purpose of this study is to find out whether a Facebook group will help Native women in recovery from opioid use.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Mayo Clinic, Rochester, Minnesota

   Run by

   Mayo Clinic

   See if you can join NCT05995886 on ClinicalTrials.gov

10. A Study of Brenipatide in Participants With Opioid Use Disorder

    The purpose of this study is to see if brenipatide, when compared to placebo, is safe and effective for participants with opioid use disorder, when used with buprenorphine with or without naloxone. The maximum potential duration of study participation for a participant in Part A is approximately 14…

    Stage

    Phase 2

    Ages

    18 to 75

    Site

    NoesisPharma - Phoenix - East Shea Boulevard, Phoenix, Arizona

    Locations

    59 in total

    Run by

    Eli Lilly and Company

    See if you can join NCT07420283 on ClinicalTrials.gov

11. Deep Brain Stimulation Effects In Patients With Opioid Use Disorder

    This is a pilot study to evaluate the safety and efficacy of deep brain stimulation (DBS) of the nucleus accumbens (NAc) as adjunctive treatment for treatment-refractory opioid use disorder. This study will include 3 individuals with opioid use disorder and relapsing opioid use despite active parti…

    Stage

    Not phased

    Ages

    22 to 65

    Site

    AHN Allegheny General Hospital, Pittsburgh, Pennsylvania

    Run by

    Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)

    See if you can join NCT04354077 on ClinicalTrials.gov

12. Ketamine for Opioid Use Disorder

    The goal of this clinical trial is to learn if ketamine works to reduce craving for opioids in adults enrolled in methadone treatment for opioid use disorder. The main questions it aims to answer are: * Does ketamine reduce craving for opioids in patients with opioid use disorder? * Does ketamine r…

    Stage

    Phase 2

    Ages

    18 to 65

    Site

    University of Maryland Addiction Programs and Affiliated Clinics, Baltimore, Maryland

    Run by

    University of Maryland, Baltimore

    See if you can join NCT06943859 on ClinicalTrials.gov

13. GLP-1R Agonist Treatment for Opioid Use Disorder

    The goal of this clinical trial is to learn if semaglutide can reduce illicit opioid use in adults in outpatient treatment for opioid use disorder, and who are receiving either buprenorphine or methadone maintenance treatment. The main question it aims to answer is: • Does semaglutide increase the …

    Stage

    Phase 2

    Ages

    18 to 75

    Site

    Stanley Street Treatment and Resources, Fall River, Massachusetts

    Locations

    4 in total

    Run by

    Milton S. Hershey Medical Center

    See if you can join NCT06548490 on ClinicalTrials.gov

14. PRoducing Outcome Measures for OTP Quality Improvement

    This study tests ways to help opioid treatment programs (OTPs) keep patients in care. Staying on methadone or buprenorphine is linked to better outcomes, yet many people leave treatment early. The project will compare two approaches that provide clinics with retention/outcome quality measures and a…

    Stage

    Not phased

    Ages

    18 and older

    Site

    RTI International, Research Triangle Park, North Carolina

    Run by

    RTI International

    See if you can join NCT07214389 on ClinicalTrials.gov

15. EMS-Initiated Buprenorphine

    This is a multisite EMS study that will first conduct a sequence of pragmatic, prehospital field studies to provide preliminary feasibility, acceptability, and safety data for refinement and enhancement of a subsequent single-arm prospective trial that will provide preliminary effectiveness data, f…

    Stage

    Not phased

    Ages

    Any age

    Site

    Alameda Health System, Oakland, California

    Locations

    3 in total

    Run by

    Yale University

    See if you can join NCT07475728 on ClinicalTrials.gov

16. Personalized Addiction Treatment enHancement

    Many patients stop medication-based treatments for Opioid Use Disorder (OUD) prematurely, placing them at increased risk for overdose and death. Providing targeted interventions for OUD, particularly through an accessible, digital health platform, is a potential way to enhance recovery and keep pat…

    Stage

    Not phased

    Ages

    22 and older

    Site

    Rhode Island Hospital, Providence, Rhode Island

    Run by

    Rhode Island Hospital

    See if you can join NCT07778394 on ClinicalTrials.gov

17. Ketones for Opioid Craving

    The goal of this clinical trial is to learn if ketone supplementation (KS) works to reduce craving for opioids for adults with opioid use disorder (OUD) undergoing in-patient acute withdrawal management. The main questions it aims to answer are: * Does KS reduce craving for opioids in patients with…

    Stage

    Phase 2

    Ages

    18 to 75

    Site

    Caron Pennsylvania Addiction Treatment and Rehab Center, Wernersville, Pennsylvania

    Run by

    University of Maryland, Baltimore

    See if you can join NCT07128524 on ClinicalTrials.gov

18. Evaluating Buspirone to Treat Opioid Withdrawal

    The investigators propose a rigorous, Phase II, three-group, placebo-controlled double-blind randomized controlled trial (RCT) to evaluate the efficacy of buspirone for both withdrawal and craving among individuals with opioid use disorder (OUD) undergoing a standardized stepwise taper. During this…

    Stage

    Phase 2

    Ages

    18 to 75

    Site

    Kahlert Institute for Addictino Medicin, Baltimore, Maryland

    Run by

    University of Maryland, Baltimore

    See if you can join NCT05511909 on ClinicalTrials.gov

19. Evaluation of a Patient Decision Aid for Emergency Department Initiated Buprenorphine

    This study aims to develop and pilot test a patient decision aid (PtDA) for emergency department (ED)-initiated buprenorphine treatment for opioid use disorder (OUD). The PtDA will be evaluated for acceptability, impact on patient knowledge, decisional conflict, and buprenorphine uptake compared to…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Medical University of South Carolina, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT07278518 on ClinicalTrials.gov

20. Buprenorphine Implementation at Syringe Service Programs to Reduce Overdoses

    This study is testing whether offering buprenorphine treatment directly at syringe service programs (SSPs) helps more people start and stay in treatment for opioid use disorder (OUD) than referring them to community buprenorphine treatment providers. Buprenorphine is a medication that helps reduce …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Community Health Project Los Angeles (CHPLA), Los Angeles, California

    Locations

    8 in total

    Run by

    Montefiore Medical Center

    See if you can join NCT07631598 on ClinicalTrials.gov

21. TRTME: Improving Outpatient Initiation of Medication for Opioid Use Disorder Following Hospitalization

    The primary objective of this study is to evaluate the ability of TRTME to increase initiation of MOUD outpatient treatment and MOUD knowledge in hospitalized patients with OUD deemed to be good candidates for MOUD by the UCMC Addiction Consult Team (ACT). The secondary objective is to evaluate the…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Cincinnati Addiction Sciences Division, Cincinnati, Ohio

    Run by

    T. John Winhusen, PhD

    See if you can join NCT07780097 on ClinicalTrials.gov

22. Cerebral Physiology of NOWS

    This study will use a new device to measure blood flow and oxygen levels in the brains of newborn infants who have had exposure to opioid medications in the womb, compared to newborns who have not had any exposure.

    Stage

    Not phased

    Ages

    Up to 0

    Site

    Indiana University - Riley Hospital for Children, Indianapolis, Indiana

    Run by

    Indiana University

    See if you can join NCT07610746 on ClinicalTrials.gov

23. Social Functioning in Opioid Use Disorder

    Problems with social functioning are core to opioid use disorder (OUD), though specific, modifiable social functioning targets and how they relate to OUD treatment outcomes are poorly understood. This study will utilize both data from both patients with OUD and their concerned significant other (CS…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Medical University of South Carolina, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT07044466 on ClinicalTrials.gov

24. Medications for Opioid Use Disorder Photosensitive Retinal Ganglion Cell Function, Sleep, and Circadian Rhythms: Implications for Treatment

    Opioid use disorder (OUD) is a treatable medical illness with three medications FDA approved for treatment. However, persons with OUD report significant sleep disturbance, even when treated with medications for opioid use disorder, leading to high rates of relapse. In this project, we will investig…

    Stage

    Not phased

    Ages

    18 to 80

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Run by

    University of Alabama at Birmingham

    See if you can join NCT06104280 on ClinicalTrials.gov

25. Evaluation of Tirzepatide as an Adjunct to Buprenorphine for the Treatment of Opioid Use Disorder

    The primary objective of this research study is to evaluate the effect of tirzepatide, relative to placebo, as an adjunct to BUP on retention, substance use, and sleep outcomes in individuals with OUD.

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Gateway Community Services, Jacksonville, Florida

    Locations

    9 in total

    Run by

    T. John Winhusen, PhD

    See if you can join NCT06651177 on ClinicalTrials.gov