Opioid Use Disorder Clinical Trials

135 studies are recruiting for opioid use disorder in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 2

1. Project I Test: Implementing HIV Testing in Opioid Treatment Programs

   This study will test two active evidence-based "practice coaching" (PC) interventions to improve opioid treatment programs' (OTPs') provision and sustained implementation of on-site 1) HIV testing and linkage to care and 2) HIV/Hepatitis C virus (HCV) testing and linkage to care among patients seek…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Columbia University Medical Center, New York, New York

   Run by

   Columbia University

   See if you can join NCT03135886 on ClinicalTrials.gov

2. Assessing Optimal XRB Initiation Points in Jail

   This application describes a 3-year, randomized controlled trial. Eligible, consenting adults (N=200) with existing sublingual buprenorphine (SLB) prescriptions who enter Middlesex County House of Corrections (MCHOC) as pre-trial detainees will be randomized at admission on a 1:1 basis to be induct…

   Stage

   Phase 4

   Ages

   Any age

   Site

   Tufts University Health Sciences, Boston, Massachusetts

   Locations

   4 in total

   Run by

   NYU Langone Health

   See if you can join NCT06051890 on ClinicalTrials.gov

3. Predicting and Preventing Adverse Maternal and Child Outcomes of Opioid Use Disorder in Pregnancy

   This study will be a 12-month prospective, genotype-blinded longitudinal observational study with current standard of clinical care. This study will enroll 100 pregnant women with OUD at UPMC Hospitals with its high volumes. Because of the observational nature of the study, the anticipated dropout …

   Stage

   Not phased

   Ages

   18 and older

   Site

   UPMC Magee-Womens Hospital, Pittsburgh, Pennsylvania

   Run by

   Ilana Hull

   See if you can join NCT05942313 on ClinicalTrials.gov

4. Mobile Platform for Optimizing Wellness and Engagement in Recovery

   This pilot study addresses the urgent public health crisis of co-occurring opioid and alcohol use disorders (OUD-AUD), leading causes of mortality in the United States, by testing a scalable digital contingency management (CM) treatment among Medicaid beneficiaries. The study aims to evaluate the f…

   Stage

   Not phased

   Ages

   19 to 63

   Site

   University of Michigan, Ann Arbor, Michigan

   Run by

   University of Michigan

   See if you can join NCT07178990 on ClinicalTrials.gov

5. High Dose Buprenorphine (BUP) Induction in the Emergency Department (ED)

   This project, involving two distinct clinical trials, tests whether induction to a higher than currently recommended buprenorphine (BUP) induction dose is safe and can improve the proportion of patients who engage in comprehensive addiction services within 7-day of induction. Trial 1 is a head-to-h…

   Stage

   Phase 3

   Ages

   18 and older

   Site

   Rutgers University Hospital, Newark, New Jersey

   Run by

   Rutgers, The State University of New Jersey

   See if you can join NCT05589181 on ClinicalTrials.gov

6. iSTEP-N 101b: Pharmacokinetics and Safety Study of Low- and High-Dose Naltrexone Implants vs Monthly Vivitrol in Healthy Volunteers

   This Phase 1b clinical study is evaluating iSTEP-N, an investigational extended-release implant containing naltrexone, a medication used to block the effects of opioids. The implant is placed under the skin of the thigh and is designed to release medication continuously over many months. The main p…

   Stage

   Phase 1

   Ages

   18 to 65

   Site

   JBR Cenexel, Millcreek, Utah

   Run by

   Akyso Therapeutics, LLC

   See if you can join NCT07064564 on ClinicalTrials.gov

7. Pilot of Mailing Buprenorphine

   This pilot study evaluates the feasibility, acceptability, and preliminary effectiveness of mailing buprenorphine to individuals with opioid use disorder (OUD) following medical hospitalization. The intervention aims to improve retention in treatment by overcoming barriers such as transportation an…

   Stage

   EARLY_Phase 1

   Ages

   18 and older

   Site

   Medical University of South Carolina, Charleston, South Carolina

   Locations

   2 in total

   Run by

   Medical University of South Carolina

   See if you can join NCT07421102 on ClinicalTrials.gov

8. Adapting the Penny Chatbot for Perinatal OUD Patients: COPILOT

   To address both loneliness and engagement in perinatal and OUD care among perinatal women, the investigators plan to adapt an existing texting support chatbot, Penny, to make it appropriate for use by women who are pregnant and postpartum and dealing with OUD. The newly adapted chatbot, Penny COPIL…

   Stage

   Not phased

   Ages

   Any age

   Site

   Hospital of the University of Pennsylvania (HUP), Philadelphia, Pennsylvania

   Locations

   2 in total

   Run by

   University of Pennsylvania

   See if you can join NCT06969261 on ClinicalTrials.gov

9. Low-dose Buprenorphine Initiation for Opioid Use Disorder

   The purpose of this study is to test whether low-dose buprenorphine initiation for treatment of opioid use disorder is safe and effective.

   Stage

   Phase 4

   Ages

   18 and older

   Site

   Montefiore Medical Center, The Bronx, New York

   Run by

   Montefiore Medical Center

   See if you can join NCT05450718 on ClinicalTrials.gov

10. Outpatient Buprenorphine Induction With Psilocybin for Opioid Use Disorder

    This study will examine the effect of a single high dose of psilocybin therapy (30 mg) versus a very low dose (1 mg) as an adjunctive therapy to individuals undergoing standard-of-care outpatient buprenorphine treatment for Opioid use disorder (OUD). The participants will have previously undergone …

    Stage

    Phase 2

    Ages

    21 to 70

    Site

    Johns Hopkins Center for Psychedelic and Consciousness Research, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT06067737 on ClinicalTrials.gov

11. Adversity, Brain and Opioid Use Study

    The way people process and remember information may be related to adverse childhood experiences and Opioid Use Disorder symptoms. The purpose of this project is to examine brain function and performance during learning and memory tasks in adults. The study will compare measures of learning and memo…

    Stage

    Not phased

    Ages

    18 to 55

    Site

    University of Michigan, Ann Arbor, Michigan

    Run by

    University of Michigan

    See if you can join NCT06355778 on ClinicalTrials.gov

12. Identifying Biomarkers Related to Opioid Use and Pain Response Following Traumatic Injury and Surgery

    The mechanisms leading to opioid tolerance or dependence are not well understood and there are currently no biomarkers for predicting who is at risk for development of OUD. The purpose of this project is to support the feasibility of detecting a miRNA bio-behavioral signature of opioid misuse risk …

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of California, San Diego, La Jolla, California

    Run by

    University of California, San Diego

    See if you can join NCT07693270 on ClinicalTrials.gov

13. Combined THC and CBD for OUD and Chronic Pain

    The primary objective of this phase 2 study is to investigate the therapeutic potential of orally administered combined delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) in relieving both pain and cue-induced opioid craving in people with co-occurring opioid use disorder (OUD) and chronic pa…

    Stage

    Phase 2

    Ages

    18 to 65

    Site

    Connecticut Mental Health Center, New Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT06544291 on ClinicalTrials.gov

14. Methadone Patient Access to Collaborative Treatment

    The trial of Methadone Patient Access to Collaborative Treatment (MPACT) will establish the impact of the intervention on patient outcomes of methadone treatment retention and in treatment overdose. It will also establish the impact of patient and staff trauma symptoms and clinic practice change on…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Arizona College of Nursing, Tucson, Arizona

    Run by

    University of Arizona

    See if you can join NCT06556602 on ClinicalTrials.gov

15. Project STRONGER: Stepped Care for Opioid Use Disorder Treatment Engagement and Recovery

    Using a hybrid type 1 effectiveness-implementation approach, this study aims to evaluate the impact of a novel stepped care model ("PCT+2HOPE") versus treatment as usual (TAU) on increasing retention in community-based medication for opioid use disorder (MOUD) treatment among women who have experie…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Liberation Programs, Bridgeport, Connecticut

    Locations

    3 in total

    Run by

    Yale University

    See if you can join NCT07115030 on ClinicalTrials.gov

16. Rapid Outpatient Low-dose Initiation of Buprenorphine for OUD With Fentanyl Use

    The goal of this clinical trial is to learn if buprenorphine can be started for opioid use disorder with fentanyl use without requiring or precipitating opioid withdrawal. To be eligible, participants must have moderate or severe opioid use disorder and must have fentanyl detected on a urine drug t…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    University of Pennsylvania Center for Studies of Addiction, Philadelphia, Pennsylvania

    Run by

    University of Pennsylvania

    See if you can join NCT06379984 on ClinicalTrials.gov

17. Autobiographical Memory in Opioid Use Disorder

    The research study is being conducted to better understand memory function in people with opioid use disorder (OUD) and whether memory training can improve the symptoms and lives of people with OUD. Further, this study seeks to identify how brain and heart activity contribute to memory function and…

    Stage

    Not phased

    Ages

    18 to 60

    Site

    University of Pennsylvania, Philadelphia, Pennsylvania

    Run by

    University of Pennsylvania

    See if you can join NCT06643988 on ClinicalTrials.gov

18. Psilocybin on Brain Mechanisms of Motivation in OUD

    The goal of this study is to test addiction-related brain circuitry (motivation/reward and inhibition) as well as neurocognitive circuitry prior to and following low or high dose psilocybin (PEX010 from Filament). Using fMRI, brain circuits will be examined that are relevant to drug relapse as well…

    Stage

    Phase 2

    Ages

    18 to 60

    Site

    University of Pennsylvania, Philadelphia, Pennsylvania

    Run by

    University of Pennsylvania

    See if you can join NCT06810310 on ClinicalTrials.gov

19. Effects of Lemborexant on Insomnia and Its Relationship to Mood and Behavior on Opioid Use Disorder Subjects

    The goal of this clinical trial is to learn about how certain medications used to treat insomnia (e.g., Lemborexant) impact sleep, mood, and behavior in men and women with Opioid Use Disorder who are taking prescribed buprenorphine. The main questions it aims to answer are: 1. What is the effect of…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    VCU Institute for Drug and Alcohol Studies, Richmond, Virginia

    Run by

    Virginia Commonwealth University

    See if you can join NCT06981195 on ClinicalTrials.gov

20. Adjunctive Effects of Psilocybin and a Formulation of Buprenorphine

    Primary Aim: In participants with OUD, to characterize adverse events associated with adding two psilocybin doses to a stable buprenorphine-naloxone formulation. Secondary Aim: To evaluate the effect of psilocybin treatment on the effectiveness of a buprenorphine-naloxone maintenance therapy. Secon…

    Stage

    Phase 1

    Ages

    21 to 65

    Site

    University of Wisconsin, Madison, Wisconsin

    Run by

    University of Wisconsin, Madison

    See if you can join NCT04161066 on ClinicalTrials.gov

21. Exploration of Synaptotrophic Effects of Psilocybin in Opioid Use Disorder (OUD)

    This study will examine the synaptotrophic effects of psilocybin among medically healthy, detoxified OUD subjects. Eligible OUD participants will undergo pre- and post- psilocybin administration PET scans with the [11C]-UCB-J radiotracer while inpatient.

    Stage

    Phase 1

    Ages

    25 to 55

    Site

    Yale University, New Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT06160284 on ClinicalTrials.gov

22. An Intervention Mapping Approach to Closing the Gap in Maternal OUD and Infant NAS Care (SUPPORT)

    The purpose of this study is to address the gap in maternal OUD treatment and infant neonatal opioid withdrawal syndrome care. The research team will develop a treatment model and a set of strategies to provide evidence-based OUD treatment to postpartum mothers in NICUs. First, the investigators wi…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania

    Locations

    3 in total

    Run by

    University of Pennsylvania

    See if you can join NCT06576323 on ClinicalTrials.gov

23. Combined tDCS and Cognitive Training as an Adjunctive Treatment in Opioid Use Disorder

    The overall goal of this study is to investigate the added benefit of a neuromodulation intervention in individuals taking medication for treatment for Opioid Use Disorder(OUD).

    Stage

    Phase 1

    Ages

    18 and older

    Site

    University of Minnesota, Minneapolis, Minnesota

    Run by

    University of Minnesota

    See if you can join NCT07158853 on ClinicalTrials.gov

24. Impact of Federal and State Medications for Opioid Use Disorder (MOUD) Policy Changes During the Pandemic

    "Gold-standard" medications for opioid use disorder (MOUD) treatment combines FDA-approved medications, primarily methadone and buprenorphine, with behavioral therapies to provide "whole-patient" treatment. Prior to the pandemic, methadone and buprenorphine were subject to greater federal regulatio…

    Stage

    Not phased

    Ages

    18 and older

    Site

    VA Medical Center, Boston, Massachusetts

    Run by

    Boston University

    See if you can join NCT07232641 on ClinicalTrials.gov

25. tDCS to Decrease Opioid Relapse (UH3)

    Investigators will measure behavioral and brain responses following transcranial direct current stimulation (tDCS) to the dorsolateral prefrontal cortex (DLPFC) (anode on right DLPFC, cathode on the left DLPFC) delivered during cognitive control network (CCN) priming. In Phase I, the EEG provided v…

    Stage

    Not phased

    Ages

    21 to 60

    Site

    Butler Hospital, Providence, Rhode Island

    Run by

    Butler Hospital

    See if you can join NCT06432465 on ClinicalTrials.gov