Opioid Use Disorder Clinical Trials

135 studies are recruiting for opioid use disorder in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 3

1. Using Clinical Decision Support to Provide Social Risk-Informed Care for Opioid Use Disorder in the Emergency Department

   The overarching goal of this proposal is to integrate patient social risk information into an existing electronic health record (EHR)-based clinical decision support (CDS) tool (CDSv1) to facilitate emergency department (ED)-initiated, social risk-informed opioid use disorder (OUD) medication treat…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of California, San Francisco, San Francisco, California

   Run by

   University of California, San Francisco

   See if you can join NCT06872190 on ClinicalTrials.gov

2. Telehealth vs In-Person Evaluation of Addiction Treatment After Visiting the Emergency Department

   Main study objective: compare long-term buprenorphine treatment outcomes for patients who start buprenorphine for opioid use disorder (OUD) in the emergency department and are then referred to get outpatient buprenorphine treatment either via telehealth or at an in-person clinic. Researchers will: …

   Stage

   Not phased

   Ages

   18 and older

   Site

   El Centro Regional Medical Center Emergency Department, El Centro, California

   Locations

   3 in total

   Run by

   University of California, Davis

   See if you can join NCT06961058 on ClinicalTrials.gov

3. Exablate for LIFU Neuromodulation in Patients With Opioid Use Disorder (OUD) and/or Other Substance Use Disorders (SUDs)

   The purpose of this clinical trial is to investigate Low Intensity Focused Ultrasound (LIFU) using the Exablate® Model 4000 Type 2.0/2.1 as an adjunctive neuromodulatory treatment for OUD (Opioid Use Disorder) and/or other Substance Use Disorders (SUDs) by assessing its safety and tolerability in s…

   Stage

   Not phased

   Ages

   18 to 60

   Site

   University of Maryland, Baltimore, Baltimore, Maryland

   Locations

   4 in total

   Run by

   InSightec

   See if you can join NCT04197921 on ClinicalTrials.gov

4. Smartphones for Opiate Addiction Recovery

   Treatments for opioid addiction exist, but effectiveness is compromised when subjects use illicit opiates during treatment. Reuse rates during treatment can be high, and reducing illicit opiate use during treatment has thus recently become a major NIDA policy goal. The 5-minute battery indicates th…

   Stage

   Phase 3

   Ages

   18 to 85

   Site

   NYU Langone, New York, New York

   Locations

   2 in total

   Run by

   NYU Langone Health

   See if you can join NCT05033028 on ClinicalTrials.gov

5. Measuring Acute Drug Demand in Humans

   This research is being done to evaluate whether suvorexant may reduce the use of, subjective liking, and demand for various drugs.

   Stage

   EARLY_Phase 1

   Ages

   18 to 65

   Site

   General Clinical Research Center, Baltimore, Maryland

   Run by

   University of Maryland, Baltimore

   See if you can join NCT05829655 on ClinicalTrials.gov

6. Resilience Among Individuals With Opioid Use Disorder

   The goal of this clinical trial is to develop a human laboratory model of resilience in people with opioid use disorder (OUD). The investigators aim to learn if objective tasks that measure cognitive, emotional, and control aspects of resilience match up with self-reported resilience during stress …

   Stage

   Not phased

   Ages

   18 and older

   Site

   Johns Hopkins University Bayview Medical Campus, Baltimore, Maryland

   Locations

   2 in total

   Run by

   Johns Hopkins University

   See if you can join NCT06954402 on ClinicalTrials.gov

7. Brief Digitally-Enhanced Intervention for Reducing Alcohol Use During MOUD

   The goal of this clinical trial is to reduce heavy drinking and enhance medication for opioid use disorder (MOUD) outcomes in individuals receiving MOUD. The main questions it aims to answer are: * Does the brief, digitally-enhanced, virtual psychotherapeutic intervention, called Managing Physical …

   Stage

   Not phased

   Ages

   18 and older

   Site

   Ohio State University, Columbus, Ohio

   Run by

   Ohio State University

   See if you can join NCT06718491 on ClinicalTrials.gov

8. Cannabis and Opioid Use Disorder

   This study plans to enroll participants with opioid use disorder who are not currently seeking treatment to assess the effects of cannabis on opioid withdrawal and other related outcomes.

   Stage

   Phase 1

   Ages

   18 to 55

   Site

   Center on Drug and Alcohol Research, Lexington, Kentucky

   Run by

   Shanna Babalonis, PhD

   See if you can join NCT05729932 on ClinicalTrials.gov

9. Machine-Learning Prediction and Reducing Overdoses With EHR Nudges

   The goal of this cluster randomized clinical trial is to test a clinician-targeted behavioral nudge intervention in the Electronic Health Record (EHR) for patients who are identified by a machine-learning based risk prediction model as having an elevated risk for an opioid overdose. The clinical tr…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Pittsburgh, Pittsburgh, Pennsylvania

   Run by

   University of Pittsburgh

   See if you can join NCT06806163 on ClinicalTrials.gov

10. Opioid Use Disorder and Pain

    The goal of this observational study is to characterize the brain processes of pain avoidance learning dysfunctions in individuals with opioid use disorder (OUD). The main questions it aims to answer are: Compared with healthy controls, do those with OUD exhibit impaired avoidance learning in respo…

    Stage

    Not phased

    Ages

    21 to 60

    Site

    Connecticut Mental Health Center, S105, New Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT06800703 on ClinicalTrials.gov

11. Optimizing Evidence-based HIV Prevention Targeting People Who Inject Drugs on PrEP

    The investigators will conduct an optimization trial among N=256 PWID newly started on medication for opioid use disorder and Pre-Exposure Prophylaxis (PrEP) to assess the performance of four intervention components (Attention, Executive Functioning, Memory, and Information Processing) aimed at enh…

    Stage

    Phase 4

    Ages

    18 and older

    Site

    APT Foundation, New Haven, Connecticut

    Run by

    University of Connecticut

    See if you can join NCT05669534 on ClinicalTrials.gov

12. Coordinating Outpatient bupreNorphiNe for Emergency Care and Continuing Treatment

    The main purpose of this stepped wedge trial will be to test the impact of a bundle of implementation strategies designed to improve ED-outpatient care coordination on long-term buprenorphine retention among adult patients who start buprenorphine for opioid use disorder in a hospital emergency depa…

    Stage

    Not phased

    Ages

    14 and older

    Site

    Marshall Medical Center Emergency Department, Placerville, California

    Locations

    4 in total

    Run by

    University of California, Davis

    See if you can join NCT07024498 on ClinicalTrials.gov

13. Adaptive Decision Support for Addiction Treatment Master

    This study refines and optimizes the EMBED* clinical decision support (CDS; see NCT03658642) to increase number of ED physicians following standard of care for the administration of buprenorphine to appropriate patients with opioid use disorder. This study does not have open enrollment. Investigato…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Yale New Haven Shoreline Medical Center, Guilford, Connecticut

    Locations

    3 in total

    Run by

    Yale University

    See if you can join NCT06799117 on ClinicalTrials.gov

14. Better Experiences in Substance Treatment: A Brief Alcohol-focused Intervention Tailored for Patients in Opioid Agonist Treatment

    This study will help determine the feasibility and acceptability of a brief opioid-informed alcohol intervention in patients receiving prescribed buprenorphine for opioid use who are currently drinking alcohol. It will also provide initial information on whether the intervention improves outcomes r…

    Stage

    Not phased

    Ages

    18 and older

    Site

    The University of Notre Dame, Notre Dame, Indiana

    Run by

    University of Notre Dame

    See if you can join NCT07342504 on ClinicalTrials.gov

15. Postpartum Intervention for Mothers With Opioid Use Disorders (R33)

    Having met the milestones of the R61, this R33 is a 2-site, 2-group, pre/post RCT of mothers with OUD (n=~80/group). We will test whether the beneficial pre-post changes in OUD mothers randomized to vMP exceed those of mothers assigned to Enhanced Usual Care (EUC) and via changes in Maternal Brain …

    Stage

    Not phased

    Ages

    18 to 50

    Site

    University of Michigan, Ann Arbor, Michigan

    Locations

    2 in total

    Run by

    Stony Brook University

    See if you can join NCT07632053 on ClinicalTrials.gov

16. Supporting Treatment Access and Recovery in COD

    This 4-year study will randomize 1,000 people with co-occurring opioid use and mental health disorders (COD) at medication for opioid use disorder (MOUD) clinics to evaluate the effectiveness of MISSION, a multi-component team approach, or its components with MOUD versus MOUD alone, as well as the …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Behavioral Health Network, Holyoke, Massachusetts

    Locations

    5 in total

    Run by

    University of Massachusetts, Worcester

    See if you can join NCT05138614 on ClinicalTrials.gov

17. Buprenorphine for Individuals in Jail

    This study is an open label randomized controlled trial of extended-release buprenorphine (BRIXADI, XR-B) vs. sublingual buprenorphine (SL-B) in a large metropolitan jail. An open-label design will randomly assign 240 adults with moderate-to-severe OUDs who are soon-to-be-released from jail to eith…

    Stage

    Phase 3

    Ages

    18 and older

    Site

    Friends Research Institute, Baltimore, Maryland

    Locations

    2 in total

    Run by

    Friends Research Institute, Inc.

    See if you can join NCT06306443 on ClinicalTrials.gov

18. Integrated e-Health (Electronic Health) for HIV and Substance Use Disorders in Justice Involved Women

    The purpose of this 2-site (CT, AL) study is to test innovative interventions to reduce stigma and improve the pre-exposure prophylaxis (PrEP) and opioid use disorder (OUD) care continua in women involved in the criminal justice system (WICJ). This study evaluates a newly validated PrEP decision ai…

    Stage

    Phase 4

    Ages

    18 and older

    Site

    University of Alabama in Birmingham, Birmingham, Alabama

    Locations

    2 in total

    Run by

    Yale University

    See if you can join NCT05547048 on ClinicalTrials.gov

19. Sensing Physiological Symptoms of Opioid Withdrawal and Cravings in Patients With Opioid Use Disorder

    The primary objective of this trial is to measure changes in physiologic signals to quantify the status of the autonomic nervous system during opioid withdrawal and cravings.

    Stage

    Not phased

    Ages

    18 to 50

    Site

    Hazelden Betty Ford Foundation, Center City, Minnesota

    Locations

    2 in total

    Run by

    Spark Biomedical, Inc.

    See if you can join NCT06487533 on ClinicalTrials.gov

20. A Clinical Trial Comparing Buprenorphine Formulations for High Potency Synthetic Opioid Use

    The goal of this clinical trial is to compare buprenorphine formulations (sublingual buprenorphine versus long-acting injectable buprenorphine) for treating opioid use disorder among individuals who use fentanyl and/or other high potency synthetic opioids. Individuals aged 18-65 will be eligible fo…

    Stage

    EARLY_Phase 1

    Ages

    18 to 65

    Site

    Substance Treatment and Research Service, New York, New York

    Run by

    Rachel R. Luba

    See if you can join NCT06726200 on ClinicalTrials.gov

21. Contingency Management to Improve Medication for Opioid Use Disorder Continuation After the Emergency Department

    Project Summary The goal of this pilot clinical trial is to assess contingency management (CM) for increasing attendance at outpatient clinics after Medication for Opioid Use Disorder (MOUD) prescription and clinic referral occurred in the hospital Emergency Department (ED). * The researchers will …

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Vermont Medical Center, Burlington, Vermont

    Run by

    University of Vermont

    See if you can join NCT07129902 on ClinicalTrials.gov

22. TMS to Improve Recovery Outcomes Among Patients With Opioid Use Disorder (OUD) and Alcohol Use Disorder (AUD)

    The study aims to explore the potential of Transcranial Magnetic Stimulation (TMS), particularly Theta Burst Stimulation (TBS), as an adjunctive treatment to enhance recovery outcomes (consumption and craving; withdrawal symptoms; mental, physical, sleep, and cognitive health; engagement with thera…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Another Chance Drug & Alcohol Rehab Center of Portland, Portland, Oregon

    Run by

    Washington State University

    See if you can join NCT07171359 on ClinicalTrials.gov

23. Standard Versus High Dose ED-Initiated Buprenorphine Induction

    This study is a multisite double-blind, double-dummy, randomized clinical trial enrolling ED patients with untreated moderate to severe opioid use disorder (OUD) to compare Standard Dose Induction (SDI) and High Dose Induction (HDI) on rates of participation in OUD treatment within 10 days post ran…

    Stage

    Phase 3

    Ages

    18 to 65

    Site

    Highland Hospital, Oakland, California

    Locations

    5 in total

    Run by

    Yale University

    See if you can join NCT06494904 on ClinicalTrials.gov

24. Longitudinal Neural Fingerprinting of Opioid-use Trajectories

    This project aims to collect a densely sampled neuroimaging dataset among individuals receiving medications for opioid use disorder (MOUD). MOUD is multiphasic, comprised of medication induction, stabilization, ongoing treatment, and eventual dis-continuation phases. However, with a few small excep…

    Stage

    Not phased

    Ages

    18 to 50

    Site

    MRRC at The Anlyan Center, New Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT06207162 on ClinicalTrials.gov

25. Addressing Racial Disparities in Opioid Overdose Using Peer Recovery Coach Training and mHealth Platform

    The study aims to adapt an existing Cultural Structural Humility (CSH) training into a video format for peer recovery coaches (PRCs) and refine an AI-driven texting tool to reinforce the training. After refining these tools using user-centered design, a pilot test will be conducted to assess their …

    Stage

    Not phased

    Ages

    18 to 99

    Site

    START Treatment and Recovery, New York, New York

    Run by

    Friends Research Institute, Inc.

    See if you can join NCT06573476 on ClinicalTrials.gov