Opioid Use Disorder Clinical Trials in Boston, Massachusetts

10 studies are recruiting for opioid use disorder in Boston, Massachusetts right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Office-based Methadone Versus Buprenorphine to Address Retention in Medication for Opioid Use Disorder Treatment.

   The purpose of this clinical trial is to compare the effectiveness of office-based methadone with pharmacy administration and/or dispensing to office-based buprenorphine for the treatment of opioid use disorder. This study will also examine factors influencing the implementation of office-based met…

   Stage

   Phase 4

   Ages

   18 to 99

   Site

   Officed Based Addiction Treatment Program, Boston Medical Center, Boston, Massachusetts

   Locations

   6 in total

   Run by

   Yale University

   See if you can join NCT06323824 on ClinicalTrials.gov

2. A Study Comparing Oral Buprenorphine and Injectable Buprenorphine for the Treatment of Opioid Use Disorder

   VA-BRAVE will determine whether a 28-day long-acting injectable sub-cutaneous formulation of buprenorphine at a target dose of 300 milligrams (mg) is superior in retaining Veterans in opioid treatment and in sustaining opioid abstinence compared to the daily sublingual (under the tongue) buprenorph…

   Stage

   Phase 4

   Ages

   18 and older

   Site

   VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA, Boston, Massachusetts

   Locations

   25 in total

   Run by

   VA Office of Research and Development

   See if you can join NCT04375033 on ClinicalTrials.gov

3. A Study of Brenipatide in Participants With Opioid Use Disorder

   The purpose of this study is to see if brenipatide, when compared to placebo, is safe and effective for participants with opioid use disorder, when used with buprenorphine with or without naloxone. The maximum potential duration of study participation for a participant in Part A is approximately 14…

   Stage

   Phase 2

   Ages

   18 to 75

   Site

   Brigham and Women's Hospital, Boston, Massachusetts

   Locations

   59 in total

   Run by

   Eli Lilly and Company

   See if you can join NCT07420283 on ClinicalTrials.gov

4. Assessing Optimal XRB Initiation Points in Jail

   This application describes a 3-year, randomized controlled trial. Eligible, consenting adults (N=200) with existing sublingual buprenorphine (SLB) prescriptions who enter Middlesex County House of Corrections (MCHOC) as pre-trial detainees will be randomized at admission on a 1:1 basis to be induct…

   Stage

   Phase 4

   Ages

   Any age

   Site

   Tufts University Health Sciences, Boston, Massachusetts

   Locations

   4 in total

   Run by

   NYU Langone Health

   See if you can join NCT06051890 on ClinicalTrials.gov

5. Impact of Federal and State Medications for Opioid Use Disorder (MOUD) Policy Changes During the Pandemic

   "Gold-standard" medications for opioid use disorder (MOUD) treatment combines FDA-approved medications, primarily methadone and buprenorphine, with behavioral therapies to provide "whole-patient" treatment. Prior to the pandemic, methadone and buprenorphine were subject to greater federal regulatio…

   Stage

   Not phased

   Ages

   18 and older

   Site

   VA Medical Center, Boston, Massachusetts

   Run by

   Boston University

   See if you can join NCT07232641 on ClinicalTrials.gov

6. PrEP and MOUD Rapid Access for Persons Who Inject Drugs: The CHORUS+ Study

   The US opioid overdose epidemic has been accompanied by an increase in human immunodeficiency (HIV) among persons who inject drugs. HIV pre-exposure prophylaxis (PrEP) is an FDA approved medication taken daily orally by individuals who are HIV negative, but who are at increased risk for HIV. In ord…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Boston Medical Center Faster Paths Bridge Clinic, Boston, Massachusetts

   Locations

   2 in total

   Run by

   Boston Medical Center

   See if you can join NCT05769218 on ClinicalTrials.gov

7. Adolescent Outcomes of Post-operative Opioid EXposure

   The goal of this observational study is to examine the factors associated with the transition from medical exposure to opioids with "signposts" of future opioid use disorder among adolescent surgical patients. The main question aims to identify factors (moderators, mediators, and covariates) associ…

   Stage

   Not phased

   Ages

   12 to 17

   Site

   Boston Childrens Hopsital - Division of Addiction Medicine, Boston, Massachusetts

   Locations

   5 in total

   Run by

   Sharon Levy

   See if you can join NCT06350409 on ClinicalTrials.gov

8. Sustaining Recovery for People on Opioid Agonist Treatment With Conversational Agents

   This study aims to improve retention in buprenorphine treatment, a medication used for opioid use disorder, through the use of a smartphone-delivered recovery support intervention. The intervention involves an Embodied Conversational Agent (ECA), a virtual, animated computer agent designed to simul…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Office-Based Addiction Treatment (OBAT) Clinic, BMC, Boston, Massachusetts

   Run by

   Boston Medical Center

   See if you can join NCT06732596 on ClinicalTrials.gov

9. Semaglutide for Helping Opioid Recovery

   The is a pilot, 12-week, double-blind, placebo-controlled, randomized trial of individuals with opioid use disorder (OUD) newly initiating buprenorphine to receive either weekly injections of semaglutide (n=23) or matching placebo (n=23). The primary aim is to determine the effects of semaglutide o…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Brigham and Women's Hospital, Boston, Massachusetts

   Run by

   Brigham and Women's Hospital

   See if you can join NCT06639464 on ClinicalTrials.gov

10. Towards Testing the Effectiveness of Recovery Community Centers (RCCs)

    The goal of this pilot randomized clinical trial is to prepare for a larger randomized clinical trial (RCT) and collect some early data to learn if the intervention can help people who use medications for opioid use disorder (MOUD). The main questions it aims to answer are: 1. Is it feasible to rec…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT07010978 on ClinicalTrials.gov