Opioid Use Disorder Clinical Trials in Philadelphia, Pennsylvania

12 studies are recruiting for opioid use disorder in Philadelphia, Pennsylvania right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. A Study Comparing Oral Buprenorphine and Injectable Buprenorphine for the Treatment of Opioid Use Disorder

   VA-BRAVE will determine whether a 28-day long-acting injectable sub-cutaneous formulation of buprenorphine at a target dose of 300 milligrams (mg) is superior in retaining Veterans in opioid treatment and in sustaining opioid abstinence compared to the daily sublingual (under the tongue) buprenorph…

   Stage

   Phase 4

   Ages

   18 and older

   Site

   Philadelphia MultiService Center, Philadelphia, PA, Philadelphia, Pennsylvania

   Locations

   25 in total

   Run by

   VA Office of Research and Development

   See if you can join NCT04375033 on ClinicalTrials.gov

2. A Study of Brenipatide in Participants With Opioid Use Disorder

   The purpose of this study is to see if brenipatide, when compared to placebo, is safe and effective for participants with opioid use disorder, when used with buprenorphine with or without naloxone. The maximum potential duration of study participation for a participant in Part A is approximately 14…

   Stage

   Phase 2

   Ages

   18 to 75

   Site

   Adams Clinical Philadelphia, Philadelphia, Pennsylvania

   Locations

   59 in total

   Run by

   Eli Lilly and Company

   See if you can join NCT07420283 on ClinicalTrials.gov

3. Adapting the Penny Chatbot for Perinatal OUD Patients: COPILOT

   To address both loneliness and engagement in perinatal and OUD care among perinatal women, the investigators plan to adapt an existing texting support chatbot, Penny, to make it appropriate for use by women who are pregnant and postpartum and dealing with OUD. The newly adapted chatbot, Penny COPIL…

   Stage

   Not phased

   Ages

   Any age

   Site

   Hospital of the University of Pennsylvania (HUP), Philadelphia, Pennsylvania

   Locations

   2 in total

   Run by

   University of Pennsylvania

   See if you can join NCT06969261 on ClinicalTrials.gov

4. Rapid Outpatient Low-dose Initiation of Buprenorphine for OUD With Fentanyl Use

   The goal of this clinical trial is to learn if buprenorphine can be started for opioid use disorder with fentanyl use without requiring or precipitating opioid withdrawal. To be eligible, participants must have moderate or severe opioid use disorder and must have fentanyl detected on a urine drug t…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   University of Pennsylvania Center for Studies of Addiction, Philadelphia, Pennsylvania

   Run by

   University of Pennsylvania

   See if you can join NCT06379984 on ClinicalTrials.gov

5. Autobiographical Memory in Opioid Use Disorder

   The research study is being conducted to better understand memory function in people with opioid use disorder (OUD) and whether memory training can improve the symptoms and lives of people with OUD. Further, this study seeks to identify how brain and heart activity contribute to memory function and…

   Stage

   Not phased

   Ages

   18 to 60

   Site

   University of Pennsylvania, Philadelphia, Pennsylvania

   Run by

   University of Pennsylvania

   See if you can join NCT06643988 on ClinicalTrials.gov

6. Psilocybin on Brain Mechanisms of Motivation in OUD

   The goal of this study is to test addiction-related brain circuitry (motivation/reward and inhibition) as well as neurocognitive circuitry prior to and following low or high dose psilocybin (PEX010 from Filament). Using fMRI, brain circuits will be examined that are relevant to drug relapse as well…

   Stage

   Phase 2

   Ages

   18 to 60

   Site

   University of Pennsylvania, Philadelphia, Pennsylvania

   Run by

   University of Pennsylvania

   See if you can join NCT06810310 on ClinicalTrials.gov

7. An Intervention Mapping Approach to Closing the Gap in Maternal OUD and Infant NAS Care (SUPPORT)

   The purpose of this study is to address the gap in maternal OUD treatment and infant neonatal opioid withdrawal syndrome care. The research team will develop a treatment model and a set of strategies to provide evidence-based OUD treatment to postpartum mothers in NICUs. First, the investigators wi…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania

   Locations

   3 in total

   Run by

   University of Pennsylvania

   See if you can join NCT06576323 on ClinicalTrials.gov

8. Adolescent Outcomes of Post-operative Opioid EXposure

   The goal of this observational study is to examine the factors associated with the transition from medical exposure to opioids with "signposts" of future opioid use disorder among adolescent surgical patients. The main question aims to identify factors (moderators, mediators, and covariates) associ…

   Stage

   Not phased

   Ages

   12 to 17

   Site

   Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

   Locations

   5 in total

   Run by

   Sharon Levy

   See if you can join NCT06350409 on ClinicalTrials.gov

9. Integrating Brain, Neurocognitive, and Computational Tools in OUD

   The 5-year K01 Mentored Research Scientist proposal will employ brain, neurocognitive, and computational tools (e.g., machine learning) to understand the impact of opioid-use disorder (OUD) and common co-occurring issues on executive function and clinical outcomes. There have been record numbers of…

   Stage

   Not phased

   Ages

   18 to 60

   Site

   University of Pennsylvania, Philadelphia, Pennsylvania

   Run by

   University of Pennsylvania

   See if you can join NCT06136247 on ClinicalTrials.gov

10. NavSTAR Implementation Effectiveness Trial Across a Health System

    Patient Navigation (PN) interventions following hospitalization can improve outcomes for people with opioid use disorder treatment. Delivering PN interventions on a wide scale requires many resources and coordination across institutions. This will use an evidence-based process to find solutions to …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Jefferson Health, Philadelphia, Pennsylvania

    Run by

    Friends Research Institute, Inc.

    See if you can join NCT07262190 on ClinicalTrials.gov

11. Wellcome Leap Psilocybin for OUD

    Investigators will recruit 36 individuals on MAT for OUD for a double-blind, placebo-controlled design to determine whether PEX010 (25-mg/d) shows preliminary efficacy on neural correlates of neurocognition and on clinical outcomes. Participants will be randomized to either (single dose) 25-mg (PEX…

    Stage

    Phase 2

    Ages

    18 to 60

    Site

    University of Pennsylvania, Philadelphia, Pennsylvania

    Run by

    Anna Rose Childress, Ph.D.

    See if you can join NCT06786325 on ClinicalTrials.gov

12. Opioid Treatment and Peer Recovery Support

    Determine whether a facilitated local change team intervention improves a probation organization's client-level medication for opioid use disorder (MOUD) outcomes and implementation outcomes relative to baseline across multiple sites. Determine whether client-level outcomes are further enhanced by …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Temple University, Philadelphia, Pennsylvania

    Locations

    3 in total

    Run by

    Brown University

    See if you can join NCT04978168 on ClinicalTrials.gov