Depression Clinical Trials

229 studies are recruiting for depression in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

Search these by distance from you

By city

Studies, page 8

1. Latino Teen Depression Treatment Study

   Despite experiencing higher rates of depressive symptoms (Center for Disease Control and Prevention, 2020) and similar rates of Major Depressive Disorder (MDD; Substance Abuse and Mental Health Services Administration (SAMHSA), 2019), Latino adolescents in the U.S. are significantly less likely tha…

   Stage

   Not phased

   Ages

   13 and older

   Site

   Researchmatch.org, Nashville, Tennessee

   Run by

   Duke University

   See if you can join NCT05499182 on ClinicalTrials.gov

2. Dosing rTMS for Depression Post-SCI

   Depression is a leading cause of disability worldwide and is more commonly seen in individual's post-spinal cord injury (SCI) than in the general population. Depression post-SCI impacts an individuals' quality of life and recovery. It has been reported that among Veterans with an SCI, those without…

   Stage

   Not phased

   Ages

   18 to 60

   Site

   Ralph H. Johnson VA Medical Center, Charleston, SC, Charleston, South Carolina

   Run by

   VA Office of Research and Development

   See if you can join NCT05553353 on ClinicalTrials.gov

3. Suicidal Behavior in Patients Diagnosed With Bipolar Disorder

   The purpose of this study is to learn the environmental and psychological factors that impact suicidality in patients diagnosed with Bipolar Disorder. Additionally, the study aims to identify treatments to reduce the suicidal behavior and improve quality of life through a 6-week group-based interve…

   Stage

   Not phased

   Ages

   18 to 64

   Site

   Grady Health System, Atlanta, Georgia

   Run by

   Emory University

   See if you can join NCT02604277 on ClinicalTrials.gov

4. Optimizing the AYA Survivors' Coping and Emotional Needs Toolkit

   Our team has developed a digital intervention that aims to help adolescent and young adult cancer survivors (AYAs) manage symptoms of depression. This tool includes one psychoeducation component and four components that are based on evidence-based interventions for depression. The goal of this stud…

   Stage

   Not phased

   Ages

   15 to 39

   Site

   East Carolina University, Greenville, North Carolina

   Locations

   2 in total

   Run by

   East Carolina University

   See if you can join NCT07173205 on ClinicalTrials.gov

5. Depression, Aging, Stress and Heart Health Study

   Depression is a known risk factor for cardiovascular disease (CVD), and this comorbidity contributes significantly to the morbidity and mortality of women. The menopausal transition or perimenopause is a period of vulnerability for both depression and CVD, making it a key time to study this critica…

   Stage

   Not phased

   Ages

   44 to 55

   Site

   University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

   Run by

   University of North Carolina, Chapel Hill

   See if you can join NCT05570721 on ClinicalTrials.gov

6. RCT for Latina Mental Health Using Web-Based Apps

   This study compares a choice-driven, interactive, evidence-informed storytelling web-based app intervention with links to resources and treatment (Tx) recommendations (made by a character via her blog) and Tx locator, to a web-based app with links to publicly available informational internet videos…

   Stage

   Not phased

   Ages

   18 and older

   Site

   UCLA, Los Angeles, California

   Run by

   University of California, Los Angeles

   See if you can join NCT06874790 on ClinicalTrials.gov

7. Ketamine-assisted Integrative Treatment for Veterans With Chronic Low Back Pain and Comorbid Depression

   This is a pilot study to evaluate the feasibility, acceptability, and safety of ketamine infusions followed by a brief behavioral intervention in Veterans with chronic low back pain and depression.

   Stage

   Phase 2

   Ages

   18 and older

   Site

   VA Ann Arbor Healthcare System, Ann Arbor, MI, Ann Arbor, Michigan

   Run by

   VA Office of Research and Development

   See if you can join NCT06419439 on ClinicalTrials.gov

8. Validating an Autonomous Interactive Internet-Based Delivery of an Empirically Supported Cognitive Behavioral Therapy for Comorbidity

   This project is designed to determine if a computer-delivered cognitive-behavioral treatment can improve the otherwise poor alcohol use disorder treatment outcomes for individuals with a co-occurring anxiety disorder. In the past, the investigators showed that this treatment does improve outcomes f…

   Stage

   Not phased

   Ages

   18 to 65

   Site

   Lodging Plus Program, Fairview Hospital, Minneapolis, Minnesota

   Run by

   University of Minnesota

   See if you can join NCT05117255 on ClinicalTrials.gov

9. Attenuating DEPression With Internet CBT to Slow Cognitive Decline in Older ICU Survivors(ADEPT-ICU)

   Depression affects one-third of intensive care unit (ICU) survivors and represents a potentially modifiable target to slow cognitive decline and reduce the risk of Alzheimer's disease and related dementias (ADRD). Our multi-PI team proposes a two-arm RCT called ADEPT-ICU (Attenuating DEPression wit…

   Stage

   Not phased

   Ages

   50 and older

   Site

   Eskenazi Hospital, Indianapolis, Indiana

   Locations

   2 in total

   Run by

   Indiana University

   See if you can join NCT06627894 on ClinicalTrials.gov

10. Early Life Stress and Depression: Molecular and Functional Imaging

    Severe childhood adversity accounts for a large portion of psychiatric illness, and an increased risk for major depressive disorder (MDD). For some individuals, childhood adversity has negative psychological and medical consequences; others preserve mental and physical health despite such experienc…

    Stage

    Not phased

    Ages

    20 to 32

    Site

    McLean Hospital, Belmont, Massachusetts

    Run by

    Mclean Hospital

    See if you can join NCT04713722 on ClinicalTrials.gov

11. The Student Wellness and Emotional Growth Resiliency (SWAG-R) Program

    The purpose of this research study is to provide a free 6-week, online psychological coaching program to NSU undergraduate students to help with anxiety, depression, and stress, while improving quality of life and healthy coping skills.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Nova Southeastern University, Fort Lauderdale, Florida

    Run by

    Nova Southeastern University

    See if you can join NCT06652503 on ClinicalTrials.gov

12. Brain Stimulation and Decision-making

    Decision-making is an important process that is frequently shown to be impaired in patients with depression. While a number of preclinical and clinical studies have identified key regions involved in this process, it remains unclear exactly how these regions are influencing choice behavior especial…

    Stage

    Not phased

    Ages

    18 to 50

    Site

    Emory University, Atlanta, Georgia

    Run by

    Emory University

    See if you can join NCT04099056 on ClinicalTrials.gov

13. Long-term Observation of Participants With Mood Disorders

    Background: More than 12,000 people have taken part in research at the Experimental Therapeutics \& Pathophysiology Branch at the National Institute of Mental Health Intramural Program. This has led to advances in the treatment of depression, bipolar disorder, and suicide risk. Researchers want to …

    Stage

    Not phased

    Ages

    18 to 99

    Site

    National Institutes of Health Clinical Center, Bethesda, Maryland

    Run by

    National Institute of Mental Health (NIMH)

    See if you can join NCT04877977 on ClinicalTrials.gov

14. Heart Rate Variability (HRV)-Guided Transcranial Direct Current Stimulation (tDCS)

    This technology development project will be informed and guided by initial data collection of human subject data. For this purpose, the investigators will recruit n=100 people with mild to moderate depression in a double-blinded, parallel-arm, sham-controlled data collection period administered at …

    Stage

    Not phased

    Ages

    18 to 65

    Site

    NYU Langone Health, New York, New York

    Run by

    NYU Langone Health

    See if you can join NCT06455527 on ClinicalTrials.gov

15. Psilocybin rTMS for Treatment Resistant Depression

    The purpose of this study is to determine the safety and feasibility of sequencing psilocybin therapy with a short-duration, aiTBS protocol (Stanford Accelerated Intelligent Neuromodulation Therapy, or SAINT) in individuals with treatment-resistant major depressive disorder.

    Stage

    Phase 2

    Ages

    22 to 65

    Site

    Health Discovery Building (HDB), 1601 Trinity St., Bldg B., Z0600, Austin, Texas

    Run by

    University of Texas at Austin

    See if you can join NCT06132178 on ClinicalTrials.gov

16. Antidepressant Adherence for Depressed Adults in Primary Care

    The goal of this study is to test ways to help people improve their health and manage their medication for depression. This study will measure both medication adherence and depression outcomes.

    Stage

    Not phased

    Ages

    21 to 64

    Site

    University of Pennsylvania Health System, Philadelphia, Pennsylvania

    Run by

    University of Pennsylvania

    See if you can join NCT06496646 on ClinicalTrials.gov

17. Empower@Home: Hybrid Effectiveness-Implementation Randomized Controlled Trial (RCT)

    This study is a randomized Type I hybrid effectiveness-implementation trial aimed at evaluating the effectiveness of Empower@Home, an internet-delivered cognitive-behavioral therapy (CBT) program supported by aging service providers, in comparison to enhanced usual care for homebound older adults w…

    Stage

    Not phased

    Ages

    50 and older

    Site

    University of Michigan, Ann Arbor, Michigan

    Run by

    University of Michigan

    See if you can join NCT06584422 on ClinicalTrials.gov

18. Empower@Home: Community Implementation for Older Adults With Ambulatory Disabilities

    This study is a randomized Type I hybrid effectiveness-implementation trial aimed at evaluating the effectiveness of Empower@Home, an internet-delivered cognitive-behavioral therapy (CBT) program supported by social service providers, in comparison to enhanced usual care for depression in older adu…

    Stage

    Not phased

    Ages

    50 and older

    Site

    University of Michigan, Ann Arbor, Michigan

    Run by

    University of Michigan

    See if you can join NCT06721559 on ClinicalTrials.gov

19. Cold and Heat Investigation to Lower Levels of Depression

    This study will recruit 112 medically healthy adults (aged 18-65) currently experiencing depressive symptoms to be randomized to receive either a single Whole Body Hyperthermia (heat therapy) treatment or a Whole Body Hyperthermia treatment followed by a cold water plunge. Participants will complet…

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Vail Health Behavioral Health Innovation Center, Edwards, Colorado

    Run by

    Barry Sandler

    See if you can join NCT06263738 on ClinicalTrials.gov

20. Behavioral Health Program for Short-Stay Nursing Facility Residents & Care Partners

    The goal of this clinical trial is to test a behavioral health program (Interventions for Stressful Transitions in Later Life, InSTILL) for skilled nursing facility residents and their primary support person. The main questions it aims to answer is whether the program is program is feasible, satisf…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT07220486 on ClinicalTrials.gov

21. Combination Therapy for Treatment of Sleep Disturbance in Patients With Advanced Cancer

    To learn if Cognitive Behavior Therapy (called CBT), combined with either Bright Light Therapy (called BLT), methylphenidate, and/or melatonin, can help improve sleep and other related symptoms such as fatigue, anxiety, and depression in cancer patients. This is an investigational study. In this st…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    MD Anderson Cancer Center, Houston, Texas

    Run by

    M.D. Anderson Cancer Center

    See if you can join NCT05474846 on ClinicalTrials.gov

22. Processes and Circuitry Underlying Threat Sensitivity as a Treatment Target for Co-morbid Anxiety and Depression

    This mechanistic study uses an anti anxiety drug and brain imaging to study the threat processing system and associated brain circuits in people with depression, anxiety disorders and comorbid depression and anxiety disorders. In a double blind, placebo controlled crossover design, up to 65 individ…

    Stage

    Phase 4

    Ages

    18 to 65

    Site

    Laureate Institute for Brain Research, Tulsa, Oklahoma

    Run by

    Laureate Institute for Brain Research, Inc.

    See if you can join NCT06004115 on ClinicalTrials.gov

23. WellPATH-PREVENT: A Mobile Intervention for Middle-Aged and Older Adults Hospitalized for Suicidal Ideation or Attempt

    The goal of this project is to test whether WellPATH-PREVENT (a novel, mobile psychosocial intervention) improves a specific aspect of emotion regulation, i.e., cognitive reappraisal ability, and reduces suicide risk in middle-aged and older adults (50-90 years old) who have been discharged after a…

    Stage

    Not phased

    Ages

    50 to 90

    Site

    Weill Cornell Institute of Geriatric Psychiatry, Weill Cornell Medicine, White Plains, New York

    Locations

    2 in total

    Run by

    Weill Medical College of Cornell University

    See if you can join NCT05183230 on ClinicalTrials.gov

24. Enhancing Transdiagnostic Mechanisms of Cognitive Dyscontrol (R33)

    The proposed project aims to test the cognitive and neural effects of a cognitive training in a sample of individuals seeking treatment for anxiety, depression, or traumatic stress symptoms. Participants will be randomly assigned to one of two groups. Group 1 will receive a computer-based program t…

    Stage

    Phase 2

    Ages

    21 to 55

    Site

    UC San Diego, San Diego, California

    Run by

    University of California, San Diego

    See if you can join NCT06273527 on ClinicalTrials.gov

25. Mind-body Resilience Program for Cardiac Arrest Survivors and Their Caregivers: Recovering Together After Cardiac Arrest

    The purpose of this study is to pilot two resilience interventions for cardiac arrest survivors and their informal caregivers, Recovering Together after Cardiac Arrest 1 and Recovering Together after Cardiac Arrest 2 . The data the investigators gather in this study will be used to further refine t…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT07143357 on ClinicalTrials.gov