Depression Clinical Trials in Chicago, Illinois

13 studies are recruiting for depression in Chicago, Illinois right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

Search these by distance from you

Studies now recruiting

1. A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder

   The purpose of this study is to determine the efficacy, safety and tolerability of CYB003 compared to matching placebo as adjunctive treatment in patients with MDD. For more information about the EMBRACE study, including participating study locations, and to register your interest in learning more …

   Stage

   Phase 3

   Ages

   18 to 85

   Site

   Rush University, Chicago, Illinois

   Locations

   69 in total

   Run by

   Cybin IRL Limited

   See if you can join NCT06793397 on ClinicalTrials.gov

2. Cognitive Training as an Adjunct to Ketamine in Real-world Clinics

   In a sample of patients already receiving ketamine (or esketamine) treatment as part of their clinical care, this project seeks to test whether we can enhance and/or extend (es)ketamine's rapid effects by introducing helpful information delivered by a computer-based cognitive training protocol. Thi…

   Stage

   Not phased

   Ages

   18 to 80

   Site

   University of Illinois at Chicago, Chicago, Illinois

   Locations

   3 in total

   Run by

   University of Pittsburgh

   See if you can join NCT06526078 on ClinicalTrials.gov

3. Digital InteGrated Behavioral treatmeNt for Comorbid obesITy and deprEssion Among Racial and Ethnic Adults Age 50 and Older

   The goal of this randomized clinical trial is to test the efficacy of a fully digital intervention, combining the Lumen problem-solving therapy virtual coach for depression management with the Diabetes Prevention Program video-based program for weight loss, among racial and ethnic minorities with c…

   Stage

   Not phased

   Ages

   50 to 74

   Site

   Department of Medicine, Vitoux Program on Aging and Prevention, Chicago, Illinois

   Locations

   2 in total

   Run by

   University of Illinois at Chicago

   See if you can join NCT06636058 on ClinicalTrials.gov

4. E-Mindfulness Approaches for Living After Breast Cancer

   NRG-CC015 is a prospective, randomized phase III clinical trial to evaluate the efficacy of two distinct digital approaches for delivering a mindfulness-based intervention: a live, instructor-led version delivered over Zoom (MAPs LO), and an app-based, self-paced version (MAPs App). Participants wi…

   Stage

   Phase 3

   Ages

   18 to 50

   Site

   Northwestern University, Chicago, Illinois

   Locations

   383 in total

   Run by

   NRG Oncology

   See if you can join NCT06748222 on ClinicalTrials.gov

5. A Study to Assess Change in Disease Activity and Adverse Events (AEs) With Cariprazine in the Treatment of Depressive Episodes in Pediatric Participants Participants (10 to 17 Years of Age) With Bipolar I Disorder.

   Bipolar disorder is a severe chronic mood disorder that affects up to 4% of the adult population and 1.8% of the pediatric population in the United States. The treatment of the depressive episodes of bipolar disorder in the pediatric population has not been as widely studied as the treatment of dep…

   Stage

   Phase 3

   Ages

   10 to 17

   Site

   Duplicate_Ascension St. Elizabeth /ID# 240772, Chicago, Illinois

   Locations

   81 in total

   Run by

   AbbVie

   See if you can join NCT04777357 on ClinicalTrials.gov

6. Developing a Digital Intervention for Adolescent Nonsuicidal Self-injury

   This is a feasibility trial of a digital mental health intervention aimed at adolescents (ages 14-18) with nonsuicidal self-injury and who are not currently engaged in mental health treatment. The study has two arms: a self-guided DMHI and an active control which will involve the delivery of non-in…

   Stage

   Not phased

   Ages

   14 to 18

   Site

   Northwestern University, Chicago, Illinois

   Run by

   Northwestern University

   See if you can join NCT07224165 on ClinicalTrials.gov

7. Clemastine for Improving White Matter and Boosting Antidepressant Response in Late-life Depression

   The goal of this study is to find out if the antihistamine, clemastine, can make the white matter in the brain better in older adults with depression. The study will also determine whether this improvement can make antidepressant treatment work better, reduce depressive symptoms, and improve memory…

   Stage

   Phase 2

   Ages

   60 and older

   Site

   University of Illinois College of Medicine, Chicago, Illinois

   Run by

   University of Illinois at Chicago

   See if you can join NCT06591091 on ClinicalTrials.gov

8. A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)

   The goal of this clinical trial is to learn if a drug called TNX-102 SL works to treat moderate to severe major depressive disorder in adults. It will also learn about the safety of TNX-102 SL. The main questions it aims to answer are: Does TNX-102 SL improve depression symptoms according to a depr…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Chicago Research Center, Chicago, Illinois

   Locations

   25 in total

   Run by

   Tonix Pharmaceuticals, Inc.

   See if you can join NCT07621237 on ClinicalTrials.gov

9. Effects of Transcutaneous Vagal Nerve Stimulation on Post-Surgical Return to Consciousness, Delirium, and Depression

   This study will examine whether noninvasive, transcutaneous vagal nerve stimulation (tcVNS) can help restore consciousness in patients in the operating room and the Post Anesthesia Care Unit (PACU). The study will also investigate if tcVNS can expedite discharge from the PACU and examine whether tc…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Northwestern University Feinberg School of Medicine, Chicago, Illinois

   Run by

   Northwestern University

   See if you can join NCT07610655 on ClinicalTrials.gov

10. Community-based Approach to Lowering Stress Through Mindfulness

    The goal of this clinical trial is to test a culturally adapted mindfulness-based stress reduction intervention in a community setting for African American adults with high blood pressure (hypertension) and depression. The main questions it aims to answer are: * Does participation in a culturally a…

    Stage

    Not phased

    Ages

    18 and older

    Site

    The Salvation Army Ray and Joan Kroc Corps Community Center Chicago, Chicago, Illinois

    Run by

    Northwestern University

    See if you can join NCT06987799 on ClinicalTrials.gov

11. ACE-D Aim 3 Clinical Cognitive Trial to Enhance Translation in Depression

    The purpose of this study is to understand how a psychotropic medication called guanfacine affects brain network functioning in humans, and how this function interacts with cognitive impairments in people experiencing depressive symptoms.

    Stage

    Phase 2

    Ages

    18 to 60

    Site

    University of Illinois at Chicago, Chicago, Illinois

    Locations

    2 in total

    Run by

    Stanford University

    See if you can join NCT06408246 on ClinicalTrials.gov

12. Hybrid Type 1 Randomized Pilot Trial of a Peer-led Family and Social Strengthening Group Intervention for Refugee Families

    The proposed study draws on prior research to evaluate the feasibility, acceptability and explore preliminary effectiveness of Coffee and Family Education and Support, Version (CAFES2) using a pilot randomized type 1 hybrid effectiveness-implementation design. CAFES2 is a peer-led family and social…

    Stage

    Not phased

    Ages

    12 to 55

    Site

    University of Illinios Chicago, Chicago, Illinois

    Run by

    University of Illinois at Chicago

    See if you can join NCT06261463 on ClinicalTrials.gov

13. Evaluating the Impact of Focused Muscle Contraction Therapy in U.S. Veterans

    This research study is being done to investigate if the GH Method exercise program positively affects body composition, improves physical abilities and can improve the overall sense of wellbeing (e.g. depression, PTSD, etc.) in U.S. Veterans. Subjects will be asked to complete 94 total visits (four…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Illinois at Chicago, Chicago, Illinois

    Run by

    University of Illinois at Chicago

    See if you can join NCT05094297 on ClinicalTrials.gov