Depression Clinical Trials

229 studies are recruiting for depression in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

Search these by distance from you

By city

Studies now recruiting

1. Confirmatory Efficacy of the Building a Strong Identity and Coping Skills Program

   The goal of this clinical trial is to the efficacy of the Building a Strong Identity and Coping Skills intervention within a sample of low-income and minoritized youth aged 11-14 who are seeking mental health treatment and have been placed on a waitlist to receive services. The aims of this study a…

   Stage

   Not phased

   Ages

   11 and older

   Site

   Penn State Health Medical Group - Psychiatry and Behavioral Health, Hershey, Pennsylvania

   Locations

   5 in total

   Run by

   Penn State University

   See if you can join NCT05789446 on ClinicalTrials.gov

2. Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder

   Background: Most medications that treat depression take weeks or months to work. Researchers want to develop fast-acting treatments. One dose of ketamine has a rapid antidepressant effect. For most people, this lasts a week or less. Repeated doses of ketamine may help maintain this effect. Objectiv…

   Stage

   Phase 1

   Ages

   18 to 65

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Mental Health (NIMH)

   See if you can join NCT03065335 on ClinicalTrials.gov

3. Transdiagnostic Cognitive Biomarkers

   The overall objective of this study is to determine the feasibility of identifying transdiagnostic biomarkers of cognitive function mediated by neuromodulation of the dorsolateral prefrontal cortex that are translatable across disease groups in order to more accurately phenotype clusters of cogniti…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Minnesota, Minneapolis, Minnesota

   Run by

   University of Minnesota

   See if you can join NCT04864080 on ClinicalTrials.gov

4. Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression

   Background: Major depressive disorder (MDD) is a serious mental illness that can put people at risk of self-harm and death. Many drugs are used to treat MDD, but it can take a long time for them to be effective. Researchers want to know if a faster-acting drug, (2R,6R)-hydroxynorketamine (HNK), can…

   Stage

   Phase 2

   Ages

   18 to 70

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Mental Health (NIMH)

   See if you can join NCT06511908 on ClinicalTrials.gov

5. Efficacy of a Multi-level School Intervention for LGBTQ Youth

   Efficacy of a Multi-level School Intervention for LGBTQ Youth

   Stage

   Not phased

   Ages

   12 to 20

   Site

   Washington University in St. Louis, St Louis, Missouri

   Locations

   23 in total

   Run by

   Washington University School of Medicine

   See if you can join NCT05541406 on ClinicalTrials.gov

6. Parenting STAIR: Adapting a Trauma-Focused Parenting Intervention for Military-Connected Mothers and Their Children

   The goal of this study is to assess Parenting STAIR Modular (PSTAIR-M), a promising and innovative intervention for military-connected mothers (MCM) who have experienced trauma and their young children (ages 2-10). PSTAIR-M aims to help mothers manage the strong feelings that sometimes happen after…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Steven A. Cohen Military Family Clinic at Endeavors, El Paso, El Paso, Texas

   Locations

   3 in total

   Run by

   New York University

   See if you can join NCT06262178 on ClinicalTrials.gov

7. Characterization and Treatment of Adolescent Depression

   This research study seeks to find causes and treatments of depression in teenagers. The study goals are to increase our knowledge of treatments for depression and understand how the brain changes when teenagers have depression. The study will also compare teenagers with depression to those without …

   Stage

   Not phased

   Ages

   11 to 25

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Locations

   3 in total

   Run by

   National Institute of Mental Health (NIMH)

   See if you can join NCT03388606 on ClinicalTrials.gov

8. Mechanism of Action Underlying Ketamine's Antidepressant Effects: The AMPA Throughput Theory in Patients With Treatment-Resistant Major Depression

   Background: Most drugs that treat mood disorders take a long time to work. Ketamine works within hours. A dose can last for a week or more. Certain receptors in the brain might help ketamine work. A drug that blocks these receptors might affect how it works. Objective: To see if the antidepressant …

   Stage

   Phase 1

   Ages

   18 to 70

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Mental Health (NIMH)

   See if you can join NCT03973268 on ClinicalTrials.gov

9. A Ketamine-assisted Group Therapy Intervention for Spanish-speaking Adults With Depression

   This is a pilot clinical trial to assess the feasibility, safety, and preliminary efficacy of ketamine-assisted group therapy for Spanish-speaking adults with depression

   Stage

   Phase 1

   Ages

   18 to 64

   Site

   Massachusetts General Hospital, Chelsea, Chelsea, Massachusetts

   Run by

   Juliana Zambrano, MD, MPH

   See if you can join NCT06597695 on ClinicalTrials.gov

10. Neurobiology of Suicide

    Background: There are no good treatments for people considering suicide. Researchers want to study suicide with questions, blood tests, brain imaging, and sleep studies. They hope to better understand suicide, so they can help suicidal people. Objective: To understand what happens in the brain when…

    Stage

    Phase 2

    Ages

    18 to 70

    Site

    National Institutes of Health Clinical Center, Bethesda, Maryland

    Run by

    National Institute of Mental Health (NIMH)

    See if you can join NCT02543983 on ClinicalTrials.gov

11. Testing a Scalable Model of Care to Improve Patients Access to Mental Health Services After Traumatic Injury

    The purpose of this study to learn about patients' experience with the Trauma Resilience and Recovery program (TRRP) and/or the enhanced care group.

    Stage

    Not phased

    Ages

    16 and older

    Site

    George Washington University Hospital, Washington, Virginia

    Run by

    Medical University of South Carolina

    See if you can join NCT05497115 on ClinicalTrials.gov

12. PCORI Comparative Effectiveness Study-Esketamine (Spravato) vs. Ketamine-Equivalence Study

    The purpose of this study is to compare the relative effectiveness, acceptability, and side effects of ketamine delivered through an IV (a drip into the arm) which is not currently FDA approved for use in the treatment of treatment-resistant depression (TRD) and Esketamine (Spravato®), taken as a n…

    Stage

    Phase 3

    Ages

    18 and older

    Site

    Mood Institute, Milford, Connecticut

    Locations

    8 in total

    Run by

    Yale University

    See if you can join NCT06713616 on ClinicalTrials.gov

13. Psilocybin for Depression in People With Mild Cognitive Impairment or Early Alzheimer's Disease

    This open-label pilot study examines whether the hallucinogenic drug, psilocybin, given under supportive conditions, is safe and effective for depression in people with Mild Cognitive Impairment (MCI) or early Alzheimer's Disease (AD). This study will also assess whether psilocybin may improve qual…

    Stage

    EARLY_Phase 1

    Ages

    18 to 85

    Site

    Johns Hopkins Center for Psychedelic and Consciousness Research, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT04123314 on ClinicalTrials.gov

14. Psilocybin in Chronic Low Back Pain and Depression

    This study seeks to provide insight on psilocybin's effects on mechanisms of chronic pain among patients with co-morbid chronic low back pain and depression (CLBP+D). Participants will receive either a single high-dose of psilocybin (25mg absolute dose) or methylphenidate (40mg absolute dose). Part…

    Stage

    Phase 1

    Ages

    21 to 80

    Site

    Johns Hopkins University School of Medicine, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT06355414 on ClinicalTrials.gov

15. Teachers Leading the Front Lines - North Carolina (Tealeaf-NC)

    Purpose: The purpose of this research is to pilot test a novel, alternative, potentially sustainable system of teacher-delivered, task-shifted child mental health care. Participants: ~300 estimated Procedures: This is a RE-AIM (Reach, Effectiveness, Adoption, Implementation, Maintenance) guided, mi…

    Stage

    Not phased

    Ages

    5 to 99

    Site

    University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

    Run by

    University of North Carolina, Chapel Hill

    See if you can join NCT06587230 on ClinicalTrials.gov

16. Project neuroARTEMIS

    The purpose of this research is to understand how chronic stress affects the way our brain and immune systems function, and in turn how this affects the way people feel, think, and behave. By learning more about how these processes work, the hope is to be able to develop better treatments to help w…

    Stage

    Not phased

    Ages

    18 to 59

    Site

    Wake Forest University School of Medicine, Winston-Salem, North Carolina

    Run by

    Wake Forest University Health Sciences

    See if you can join NCT06814275 on ClinicalTrials.gov

17. The Oh Happy Day Class - Digital Connections (OHDC-DC): A Pilot Study

    The goal of this clinical trial is to see if a mobile phone app can deliver depression treatment to African Americans who are depressed. The main question it aims to answer is if this treatment is effective in reducing symptoms of depression. Participants will attend six 90-minute weekly classes vi…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Wisconsin, Madison, Wisconsin

    Run by

    University of Wisconsin, Madison

    See if you can join NCT06206226 on ClinicalTrials.gov

18. Neurodevelopmental Outcomes in Children: Strengthening the Caregiver-Child Story

    The main goal of this research is to help families who are experiencing food insecurity (FI) and help mothers with depression. The next goal is to provide other resources to help with household needs like rent or utility assistance, health insurance, anxiety, and depression. Our theory is that help…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Texas Children's Hospital, Houston, Texas

    Run by

    Baylor College of Medicine

    See if you can join NCT05809115 on ClinicalTrials.gov

19. Anterior Cruciate Ligament Recovery With Virtual Psychological Intervention

    The goal of this parallel arm prospective randomized control trial study is to compare outcomes in Anterior Cruciate Ligament Reconstruction (ACLR) Surgery patients after exposure to a virtual psychological intervention (VPI) versus standard care. The main question the investigators are asking is i…

    Stage

    Not phased

    Ages

    13 and older

    Site

    Henry Ford Health System, Detroit, Michigan

    Run by

    Henry Ford Health System

    See if you can join NCT05965310 on ClinicalTrials.gov

20. Neuroscience of Psychotherapy for Depression

    The goal of this study is to learn the extent to which client-therapist brain activity may synchronize during a psychosocial intervention for depression symptoms. The study will compare behavioral activation, a client-centered type of cognitive-behavioral therapy, to psychoeducation which delivers …

    Stage

    Not phased

    Ages

    18 to 30

    Site

    Carolina Center for Neurostimulation, Chapel Hill, North Carolina

    Run by

    University of North Carolina, Chapel Hill

    See if you can join NCT06696001 on ClinicalTrials.gov

21. Slow Wave Induction by Propofol to Eliminate Depression (SWIPED) Stage II

    The investigators hypothesize that brief behavioral therapy and targeted propofol infusion in depressed geriatric patients will augment subsequent slow wave sleep and improve clinical and cognitive outcomes. The team will recruit 70 participants for a double-blinded placebo controlled randomized co…

    Stage

    Phase 2

    Ages

    60 and older

    Site

    Washington University School of Medicine/Barnes-Jewish Hospital, St Louis, Missouri

    Run by

    Washington University School of Medicine

    See if you can join NCT06867549 on ClinicalTrials.gov

22. Study on Allopregnanolone and Depression in Women Across the Menopause Transition

    This study aims to identify how enhanced allopregnanolone activity (via pregnenolone) affects behavior and neurobiology that may underlie perimenopausal depression.

    Stage

    Not phased

    Ages

    40 to 60

    Site

    Beth Israel Deaconess Medical Center, Boston, Massachusetts

    Run by

    Beth Israel Deaconess Medical Center

    See if you can join NCT06238700 on ClinicalTrials.gov

23. A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder

    The purpose of this study is to determine the efficacy, safety and tolerability of CYB003 compared to matching placebo as adjunctive treatment in patients with MDD. For more information about the EMBRACE study, including participating study locations, and to register your interest in learning more …

    Stage

    Phase 3

    Ages

    18 to 85

    Site

    UAB Psychiatry and Behavioral Neurology, Birmingham, Alabama

    Locations

    69 in total

    Run by

    Cybin IRL Limited

    See if you can join NCT06793397 on ClinicalTrials.gov

24. Mindfulness-based Cognitive Therapy vs the Health Enhancement Program for Chronic Pain and Depression; The Quiet Focus Study

    The goal of this clinical trial is to pilot a randomized controlled trial comparing an adaptation of mindfulness-based cognitive therapy to the health enhancement program for chronic pain and depression. The main questions it aims to answer in a later fully powered randomized controlled trial are: …

    Stage

    Not phased

    Ages

    50 to 120

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT07118722 on ClinicalTrials.gov

25. Accelerated rTMS for Substance Use Disorder and Depression

    This study is a small open-label feasibility trial of an accelerated course of repetitive transcranial magnetic stimulation (rTMS) for individuals with depression and stimulant use disorder [including methamphetamine or cocaine use disorder (MUD/CUD)].

    Stage

    Not phased

    Ages

    18 to 65

    Site

    UT Southwestern Medical Center, Dallas, Texas

    Run by

    University of Texas Southwestern Medical Center

    See if you can join NCT06424184 on ClinicalTrials.gov