Depression Clinical Trials

227 studies are recruiting for depression in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Early Life Stress and Depression: Molecular and Functional Imaging

   Severe childhood adversity accounts for a large portion of psychiatric illness, and an increased risk for major depressive disorder (MDD). For some individuals, childhood adversity has negative psychological and medical consequences; others preserve mental and physical health despite such experienc…

   Stage

   Not phased

   Ages

   20 to 32

   Site

   McLean Hospital, Belmont, Massachusetts

   Run by

   Mclean Hospital

   See if you can join NCT04713722 on ClinicalTrials.gov

2. A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder

   The purpose of this study is to determine the efficacy, safety and tolerability of CYB003 compared to matching placebo as adjunctive treatment in patients with MDD. For more information about the EMBRACE study, including participating study locations, and to register your interest in learning more …

   Stage

   Phase 3

   Ages

   18 to 85

   Site

   UAB Psychiatry and Behavioral Neurology, Birmingham, Alabama

   Locations

   79 in total

   Run by

   Cybin IRL Limited

   See if you can join NCT06793397 on ClinicalTrials.gov

3. Mechanism of Action Underlying Ketamine's Antidepressant Effects: The AMPA Throughput Theory in Patients With Treatment-Resistant Major Depression

   Background: Most drugs that treat mood disorders take a long time to work. Ketamine works within hours. A dose can last for a week or more. Certain receptors in the brain might help ketamine work. A drug that blocks these receptors might affect how it works. Objective: To see if the antidepressant …

   Stage

   Phase 1

   Ages

   18 to 70

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Mental Health (NIMH)

   See if you can join NCT03973268 on ClinicalTrials.gov

4. To Improve Depressive Symptoms Using a Web-App

   This study is being done to answer a question on whether a Web App-based Lifestyle Physical Activity Promotion Program is effective in improving depressive symptom experience of midlife Korean American women (WPAPP-K).

   Stage

   Not phased

   Ages

   40 to 60

   Site

   Vanderbilt University, Nashville, Tennessee

   Run by

   Vanderbilt University

   See if you can join NCT05405803 on ClinicalTrials.gov

5. A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)

   The goal of this clinical trial is to learn if a drug called TNX-102 SL works to treat moderate to severe major depressive disorder in adults. It will also learn about the safety of TNX-102 SL. The main questions it aims to answer are: Does TNX-102 SL improve depression symptoms according to a depr…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Clinical Research Site, Phoenix, Arizona

   Locations

   27 in total

   Run by

   Tonix Pharmaceuticals, Inc.

   See if you can join NCT07621237 on ClinicalTrials.gov

6. The Mindful Smartphone Use Study

   The goal of this clinical trial is to understand the feasibility and acceptability on a mindfulness-based intervention to address co-existing smartphone addiction and psychological distress among adolescents ages 13-19 self-reporting elevated levels of depression and/or anxiety symptoms and problem…

   Stage

   Not phased

   Ages

   13 to 19

   Site

   Brown University, Providence, Rhode Island

   Run by

   Brown University

   See if you can join NCT07892807 on ClinicalTrials.gov

7. Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder

   Background: Most medications that treat depression take weeks or months to work. Researchers want to develop fast-acting treatments. One dose of ketamine has a rapid antidepressant effect. For most people, this lasts a week or less. Repeated doses of ketamine may help maintain this effect. Objectiv…

   Stage

   Phase 1

   Ages

   18 to 65

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Mental Health (NIMH)

   See if you can join NCT03065335 on ClinicalTrials.gov

8. The WeACT Program for Family Caregivers of People Living With Dementia

   The goal of this clinical trial is to learn whether WeACT, a self-paced, web-based program, is feasible and helpful for adult family caregivers of a relative living with dementia. WeACT is based on acceptance and commitment therapy (ACT), which teaches skills to handle difficult thoughts and feelin…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of South Florida, Tampa, Florida

   Run by

   University of South Florida

   See if you can join NCT07342569 on ClinicalTrials.gov

9. Focused Ultrasound for Behavioral Health

   This is a double-blind, within-participant crossover, multi-site dose-finding study evaluating the safety, feasibility, and preliminary efficacy of repeated low-intensity focused ultrasound (LIFU) stimulation using the ATTN201 device across seven candidate deep-brain targets in adults with subsyndr…

   Stage

   Not phased

   Ages

   22 to 80

   Site

   Attune, San Francisco Clinical Research Center, San Francisco, California

   Locations

   2 in total

   Run by

   Attune Neurosciences Inc

   See if you can join NCT07851038 on ClinicalTrials.gov

10. Characterization and Treatment of Adolescent Depression

    This research study seeks to find causes and treatments of depression in teenagers. The study goals are to increase our knowledge of treatments for depression and understand how the brain changes when teenagers have depression. The study will also compare teenagers with depression to those without …

    Stage

    Not phased

    Ages

    11 to 25

    Site

    National Institutes of Health Clinical Center, Bethesda, Maryland

    Locations

    3 in total

    Run by

    National Institute of Mental Health (NIMH)

    See if you can join NCT03388606 on ClinicalTrials.gov

11. Virtual Reality Intervention to Improve Psychological Symptom Burden for Cancer Patients Undergoing Treatment

    This clinical trial tests the safety, tolerability, and effectiveness of a virtual reality intervention to improve psychological symptom burden for cancer patients undergoing treatment. Virtual reality (VR) is a technology that allows users to experience and interact with three-dimensional, compute…

    Stage

    Not phased

    Ages

    18 to 90

    Site

    Mayo Clinic in Florida, Jacksonville, Florida

    Run by

    Mayo Clinic

    See if you can join NCT07221409 on ClinicalTrials.gov

12. CBT Enhanced With Social Cognitive Training vs. CBT Only With Depressed Youth

    Depression in youth is a serious public health concern for which more personalized treatments are needed. This randomized controlled trial will test the effect of an intervention aimed at enhancing social cognitive capacities (e.g., ability to take another's perspective), thereby making treatment o…

    Stage

    Not phased

    Ages

    13 to 17

    Site

    Judy Garber, Nashville, Tennessee

    Run by

    Vanderbilt University

    See if you can join NCT05456035 on ClinicalTrials.gov

13. Evaluation of the PACE/PACENET BHL Clinical Program

    The SUpporting Seniors Receiving Treatment And INtervention (SUSTAIN) program is a telephone-based clinical service designed to help identify and manage behavioral health issues among PACE/PACENET enrollees. The purpose of the current project is to a) explore moderators of treatment response among …

    Stage

    Not phased

    Ages

    65 and older

    Site

    Department of Psychiatry (Center for Psychotherapy Research), University of Pennsylvania, Philadelphia, Pennsylvania

    Run by

    University of Pennsylvania

    See if you can join NCT02463266 on ClinicalTrials.gov

14. Be Well at Work-Plus: A Depression and Physical Activity Intervention for Hospital Service Workers (Aim 2)

    This study develops and tests a dynamic workplace-based depression intervention that is tailored to the specific social and behavioral needs of low-wage hospital service workers. The intervention involves assessment of depression-related work impairment, work-focused cognitive behavioral therapy, w…

    Stage

    Not phased

    Ages

    18 and older

    Site

    San Diego State University, San Diego, California

    Run by

    San Diego State University

    See if you can join NCT06753123 on ClinicalTrials.gov

15. A Mechanistic Study to Assess a Single Dose of CYB003 in Participants With Depression and Anxiety

    The goal of this study is to learn how psychedelics may help symptoms of depression and anxiety. Participants with major depressive disorder experiencing symptoms of depression and anxiety will receive one dose of either a drug related to psilocybin or a placebo. Assessments include interviews, sel…

    Stage

    Phase 2

    Ages

    21 to 65

    Site

    The Ohio State University Department of Psychiatry, Columbus, Ohio

    Run by

    Ohio State University

    See if you can join NCT06820723 on ClinicalTrials.gov

16. Development of a College Student-Delivered Cognitive-Behavioral Therapy (CBT) Intervention for Rural High School Students

    This research is being done to find out the effectiveness, feasibility, and acceptability of a college student-delivered cognitive-behavioral therapy (CBT) intervention in high schools in rural Schuylkill County, Pennsylvania to treat mental health problems (i.e. depression and anxiety) in adolesce…

    Stage

    Not phased

    Ages

    13 to 18

    Site

    Penn State College of Medicine, Hershey, Pennsylvania

    Run by

    Milton S. Hershey Medical Center

    See if you can join NCT07240792 on ClinicalTrials.gov

17. Readiness and Progress in Emotion Regulation Therapy

    This study is an open trial designed to examine individual changes that occur before, during, and after 6 modules of Emotion Regulation Therapy (ERT) delivered via telehealth for individuals in New York State who are experiencing elevated worry, rumination, or self-criticism.

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Teachers College, Columbia University, New York, New York

    Run by

    Teachers College, Columbia University

    See if you can join NCT07478393 on ClinicalTrials.gov

18. Pilot Study of a Behavioral Program for Resident Depression in Skilled Nursing Facilities

    The goal of this clinical trial is to test a behavioral health program (Interventions for Stressful Transitions in Later Life, InSTILL, for Individuals) for skilled nursing facility residents. The main questions it aims to answer is whether the program is program is feasible, satisfactory, and help…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT07655232 on ClinicalTrials.gov

19. Neurobiology of Suicide

    Background: There are no good treatments for people considering suicide. Researchers want to study suicide with questions, blood tests, brain imaging, and sleep studies. They hope to better understand suicide, so they can help suicidal people. Objective: To understand what happens in the brain when…

    Stage

    Phase 2

    Ages

    18 to 70

    Site

    National Institutes of Health Clinical Center, Bethesda, Maryland

    Run by

    National Institute of Mental Health (NIMH)

    See if you can join NCT02543983 on ClinicalTrials.gov

20. SER Familia: A Family-Based Intervention Addressing Syndemic Conditions Among Latino Families

    This study aims to prevent syndemic health conditions by decreasing acculturative stress and promoting resilience via SER Familia (Salud, Estrés y Resilencia en Familias/ Health, Stress, and Resilience in Families), a family-based intervention. SER Familia is a six-session intervention co-developed…

    Stage

    Not phased

    Ages

    12 to 100

    Site

    Duke School of Nursing, Durham, North Carolina

    Run by

    Duke University

    See if you can join NCT06627764 on ClinicalTrials.gov

21. Training Reward Responsiveness Through Virtual Reality

    The purpose of this study is to compare the effects of Virtual Reality-Reward Training (VR-RT) with an active control condition, Virtual Reality-Memory Training (VR-MT), on positive affect and other clinical symptoms. VR-RT is a novel intervention aimed at enhancing savoring of positive experiences…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    University of California, Los Angeles, Los Angeles, California

    Run by

    University of California, Los Angeles

    See if you can join NCT07219875 on ClinicalTrials.gov

22. Rapid Antidepressant Dynamics in Acute Neuromodulation Treatments

    The goal of this clinical trial is to learn how different types of non-invasive brain stimulation affect mood and brain function in adults with major depressive disorder (MDD). It will also study how brain stimulation may work together with antidepressant treatments. The main questions this study a…

    Stage

    Not phased

    Ages

    18 to 55

    Site

    Bellefield Towers, Pittsburgh, Pennsylvania

    Run by

    Marta Peciña, MD PhD

    See if you can join NCT06976840 on ClinicalTrials.gov

23. CommunityRx-Dementia + Peer Navigation (CRxDpeer)

    The CRxDpeer intervention, delivered by a trained peer navigator, in practice called a "peer mentor", includes three evidence-based components: (a) focused education about common social (e.g., food and housing insecurity) and caregiving (e.g., respite and end of life care) needs, (b) activation of …

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Chicago, Chicago, Illinois

    Run by

    University of Chicago

    See if you can join NCT07346183 on ClinicalTrials.gov

24. Longitudinal Deep Phenotyping of Central Mechanisms in Dysosmia: A Pilot Study Using Electrobulbogram (EBG), Functional MRI (fMRI), and Diffusion-Weighted Imaging (DWI)

    Background: Loss of the sense of smell can seriously affect a person's quality of life. The ability to smell can be damaged by many factors, including illnesses, injuries, and exposure to toxic chemicals. The effects can vary, including complete loss of smell, partial loss, and parosomia, which is …

    Stage

    Not phased

    Ages

    18 to 99

    Site

    National Institutes of Health Clinical Center, Bethesda, Maryland

    Run by

    National Institute on Deafness and Other Communication Disorders (NIDCD)

    See if you can join NCT07149428 on ClinicalTrials.gov

25. Adapting and Pilot Testing a Skills-based Smoking Cessation Intervention to Address Developmental and Health-related Stress Among Adults Who Smoke

    Smoking remains the leading preventable cause of death in the United States, and there are persistent and significant disparities in tobacco use among transgender and gender diverse (TGD) individuals. Stigma, discrimination, gender dysphoria, and other gender minority stressors likely contribute to…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Fenway Health, Boston, Massachusetts

    Locations

    3 in total

    Run by

    Massachusetts General Hospital

    See if you can join NCT06654414 on ClinicalTrials.gov