Depression Clinical Trials

227 studies are recruiting for depression in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 2

1. Adapting and Pilot Testing a Skills-based Smoking Cessation Intervention to Address Developmental and Health-related Stress Among Adults Who Smoke

   Smoking remains the leading preventable cause of death in the United States, and there are persistent and significant disparities in tobacco use among transgender and gender diverse (TGD) individuals. Stigma, discrimination, gender dysphoria, and other gender minority stressors likely contribute to…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Fenway Health, Boston, Massachusetts

   Locations

   3 in total

   Run by

   Massachusetts General Hospital

   See if you can join NCT06654414 on ClinicalTrials.gov

2. Mind-body Resilience Program for Cardiac Arrest Survivors and Their Caregivers: Recovering Together After Cardiac Arrest

   The purpose of this study is to pilot two resilience interventions for cardiac arrest survivors and their informal caregivers, Recovering Together after Cardiac Arrest 1 and Recovering Together after Cardiac Arrest 2 . The data the investigators gather in this study will be used to further refine t…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Mount Sinai Health System, New York, New York

   Locations

   2 in total

   Run by

   Icahn School of Medicine at Mount Sinai

   See if you can join NCT07143357 on ClinicalTrials.gov

3. Mindfulness Training During Accelerated TMS for Depression

   This NIH-funded single-arm pilot tests the feasibility, acceptability, and preliminary effects of embedding brief guided mindfulness practice (via the Waking Up smartphone app) into the inter-session intervals of clinically administered accelerated intermittent theta-burst stimulation (aiTBS) for m…

   Stage

   Not phased

   Ages

   18 to 80

   Site

   IOP, Charleston, South Carolina

   Locations

   2 in total

   Run by

   Medical University of South Carolina

   See if you can join NCT07369557 on ClinicalTrials.gov

4. The Effect of Remotely Delivered Pilates on Physical , and Psychological Outcomes in Individuals With Multiple Sclerosis

   Objectives Objective 1: To determine the effects of a 16-week remotely delivered Pilates intervention on walking endurance, walking speed, balance, fatigue, and pain compared to a waitlist control group in individuals with MS. Objective 2: To examine the impact of a 16-week remotely delivered Pilat…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Illinois Chicago, Chicago, Illinois

   Run by

   University of Illinois at Chicago

   See if you can join NCT07504120 on ClinicalTrials.gov

5. Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression

   Background: Major depressive disorder (MDD) is a serious mental illness that can put people at risk of self-harm and death. Many drugs are used to treat MDD, but it can take a long time for them to be effective. Researchers want to know if a faster-acting drug, (2R,6R)-hydroxynorketamine (HNK), can…

   Stage

   Phase 2

   Ages

   18 to 70

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Mental Health (NIMH)

   See if you can join NCT06511908 on ClinicalTrials.gov

6. Evaluation of Patients With Mood and Anxiety Disorders and Healthy Volunteers

   The purpose of this protocol is to allow for the careful screening of patients and healthy volunteers for participation in research protocols in the Experimental Therapeutics and Pathophysiology Lab (ETPB) at the National Institute of Mental Health (NIMH) and for the collection of natural history d…

   Stage

   Not phased

   Ages

   3 to 99

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Mental Health (NIMH)

   See if you can join NCT00024635 on ClinicalTrials.gov

7. Effect of Vagal Nerve Stimulation on Gastric Motor Functions

   The specific aim of this study is to compare simultaneous assessment of gastric emptying and gastric accommodation in response to a caloric meal In patients who have previously undergone activation of left cervical VNS for the treatment of medication-resistant depression. Our hypothesis is that cer…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Minnesota, Minneapolis, Minnesota

   Locations

   2 in total

   Run by

   Mayo Clinic

   See if you can join NCT06038929 on ClinicalTrials.gov

8. Long-term Observation of Participants With Mood Disorders

   Background: More than 12,000 people have taken part in research at the Experimental Therapeutics \& Pathophysiology Branch at the National Institute of Mental Health Intramural Program. This has led to advances in the treatment of depression, bipolar disorder, and suicide risk. Researchers want to …

   Stage

   Not phased

   Ages

   18 to 99

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Mental Health (NIMH)

   See if you can join NCT04877977 on ClinicalTrials.gov

9. [18F]PF-06445974 to Image PDE4B in Major Depressive Disorder Using PET

   Background: Major depressive disorder (MDD) is a psychiatric condition. People with MDD have occasional bouts of depressive symptoms; these bouts are called major depressive episodes (MDEs). Researchers want to know if people having MDEs have lower levels of an enzyme called PDE4B in their brains. …

   Stage

   Phase 1

   Ages

   18 to 70

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Mental Health (NIMH)

   See if you can join NCT05703685 on ClinicalTrials.gov

10. HBOT Effects on First Responders' Cognition and Well-Being

    The goal of this study is to examine changes in cognitive functioning and post-concussive symptoms following hyperbaric oxygen therapy (HBOT) in current and former first responders with a history of traumatic brain injury. The main questions it aims to answer are: 1. Do cognitive functioning and po…

    Stage

    Phase 2

    Ages

    18 to 75

    Site

    Summit Hyperbarics and Wellness, Boise, Idaho

    Run by

    Summit Hyperbarics and Wellness

    See if you can join NCT07852728 on ClinicalTrials.gov

11. Geolocation Positional System (GPS) Experience

    The purpose of this study is to use smartphone technology to capture individual location emotional and cognitive data, to examine how real-world behaviors thoughts, emotions, and brain activity are related to one another.

    Stage

    Not phased

    Ages

    18 to 50

    Site

    University of Miami, Coral Gables, Florida

    Run by

    University of Miami

    See if you can join NCT05991713 on ClinicalTrials.gov

12. The Oh Happy Day Class - Digital Connections (OHDC-DC): A Pilot Study

    The goal of this clinical trial is to see if a mobile phone app can deliver depression treatment to African Americans who are depressed. The main question it aims to answer is if this treatment is effective in reducing symptoms of depression. Participants will attend six 90-minute weekly classes vi…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Wisconsin, Madison, Wisconsin

    Run by

    University of Wisconsin, Madison

    See if you can join NCT06206226 on ClinicalTrials.gov

13. The Efficacy of Psilocybin Therapy for Depression in Parkinson's Disease

    The purpose of this study is to understand whether people with Parkinson's Disease and depression have improvement in their symptoms after psilocybin therapy.

    Stage

    Phase 2

    Ages

    40 to 80

    Site

    Yale University, New Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT07610369 on ClinicalTrials.gov

14. Heart Rate Variability (HRV)-Guided Transcranial Direct Current Stimulation (tDCS)

    This technology development project will be informed and guided by initial data collection of human subject data. For this purpose, the investigators will recruit n=100 people with mild to moderate depression in a double-blinded, parallel-arm, sham-controlled data collection period administered at …

    Stage

    Not phased

    Ages

    18 to 65

    Site

    NYU Langone Health, New York, New York

    Run by

    NYU Langone Health

    See if you can join NCT06455527 on ClinicalTrials.gov

15. WellPATH-PREVENT: A Mobile Intervention for Middle-Aged and Older Adults Hospitalized for Suicidal Ideation or Attempt

    The goal of this project is to test whether WellPATH-PREVENT (a novel, mobile psychosocial intervention) improves a specific aspect of emotion regulation, i.e., cognitive reappraisal ability, and reduces suicide risk in middle-aged and older adults (50-90 years old) who have been discharged after a…

    Stage

    Not phased

    Ages

    50 to 90

    Site

    Weill Cornell Institute of Geriatric Psychiatry, Weill Cornell Medicine, White Plains, New York

    Locations

    2 in total

    Run by

    Weill Medical College of Cornell University

    See if you can join NCT05183230 on ClinicalTrials.gov

16. Parent-Adolescent Relationships, Emotional Regulation, and HRV in Adolescents With Depression

    This cross-sectional study examines associations among heart rate variability (HRV), emotional dysregulation, and parent-adolescent relationship quality in adolescents with Major Depressive Disorder (MDD). We hypothesize that lower HRV will be linked to greater emotional dysregulation and that more…

    Stage

    Not phased

    Ages

    12 to 18

    Site

    Child and adolescent psychiatrist at the Children's Health Psychiatry Clinic., Dallas, Texas

    Run by

    University of Texas Southwestern Medical Center

    See if you can join NCT07430774 on ClinicalTrials.gov

17. Confirmatory Efficacy of the Building a Strong Identity and Coping Skills Program

    The goal of this clinical trial is to the efficacy of the Building a Strong Identity and Coping Skills intervention within a sample of low-income and minoritized youth aged 11-14 who are seeking mental health treatment and have been placed on a waitlist to receive services. The aims of this study a…

    Stage

    Not phased

    Ages

    11 and older

    Site

    Penn State Health Medical Group - Psychiatry and Behavioral Health, Hershey, Pennsylvania

    Locations

    5 in total

    Run by

    Penn State University

    See if you can join NCT05789446 on ClinicalTrials.gov

18. Transdiagnostic Cognitive Biomarkers

    The overall objective of this study is to determine the feasibility of identifying transdiagnostic biomarkers of cognitive function mediated by neuromodulation of the dorsolateral prefrontal cortex that are translatable across disease groups in order to more accurately phenotype clusters of cogniti…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Minnesota, Minneapolis, Minnesota

    Run by

    University of Minnesota

    See if you can join NCT04864080 on ClinicalTrials.gov

19. Efficacy of a Multi-level School Intervention for LGBTQ Youth

    Efficacy of a Multi-level School Intervention for LGBTQ Youth

    Stage

    Not phased

    Ages

    12 to 20

    Site

    Washington University in St. Louis, St Louis, Missouri

    Locations

    23 in total

    Run by

    Washington University School of Medicine

    See if you can join NCT05541406 on ClinicalTrials.gov

20. Parenting STAIR: Adapting a Trauma-Focused Parenting Intervention for Military-Connected Mothers and Their Children

    The goal of this study is to assess Parenting STAIR Modular (PSTAIR-M), a promising and innovative intervention for military-connected mothers (MCM) who have experienced trauma and their young children (ages 2-10). PSTAIR-M aims to help mothers manage the strong feelings that sometimes happen after…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Steven A. Cohen Military Family Clinic at Endeavors, El Paso, El Paso, Texas

    Locations

    3 in total

    Run by

    New York University

    See if you can join NCT06262178 on ClinicalTrials.gov

21. A Ketamine-assisted Group Therapy Intervention for Spanish-speaking Adults With Depression

    This is a pilot clinical trial to assess the feasibility, safety, and preliminary efficacy of ketamine-assisted group therapy for Spanish-speaking adults with depression

    Stage

    Phase 1

    Ages

    18 to 64

    Site

    Massachusetts General Hospital, Chelsea, Chelsea, Massachusetts

    Run by

    Juliana Zambrano, MD, MPH

    See if you can join NCT06597695 on ClinicalTrials.gov

22. Testing a Scalable Model of Care to Improve Patients Access to Mental Health Services After Traumatic Injury

    The purpose of this study to learn about patients' experience with the Trauma Resilience and Recovery program (TRRP) and/or the enhanced care group.

    Stage

    Not phased

    Ages

    16 and older

    Site

    George Washington University Hospital, Washington, Virginia

    Run by

    Medical University of South Carolina

    See if you can join NCT05497115 on ClinicalTrials.gov

23. PCORI Comparative Effectiveness Study-Esketamine (Spravato) vs. Ketamine-Equivalence Study

    The purpose of this study is to compare the relative effectiveness, acceptability, and side effects of ketamine delivered through an IV (a drip into the arm) which is not currently FDA approved for use in the treatment of treatment-resistant depression (TRD) and Esketamine (Spravato®), taken as a n…

    Stage

    Phase 3

    Ages

    18 and older

    Site

    Mood Institute, Milford, Connecticut

    Locations

    8 in total

    Run by

    Yale University

    See if you can join NCT06713616 on ClinicalTrials.gov

24. Psilocybin for Depression in People With Mild Cognitive Impairment or Early Alzheimer's Disease

    This open-label pilot study examines whether the hallucinogenic drug, psilocybin, given under supportive conditions, is safe and effective for depression in people with Mild Cognitive Impairment (MCI) or early Alzheimer's Disease (AD). This study will also assess whether psilocybin may improve qual…

    Stage

    EARLY_Phase 1

    Ages

    18 to 85

    Site

    Johns Hopkins Center for Psychedelic and Consciousness Research, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT04123314 on ClinicalTrials.gov

25. Psilocybin in Chronic Low Back Pain and Depression

    This study seeks to provide insight on psilocybin's effects on mechanisms of chronic pain among patients with co-morbid chronic low back pain and depression (CLBP+D). Participants will receive either a single high-dose of psilocybin (25mg absolute dose) or methylphenidate (40mg absolute dose). Part…

    Stage

    Phase 1

    Ages

    21 to 80

    Site

    Johns Hopkins University School of Medicine, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT06355414 on ClinicalTrials.gov