Depression Clinical Trials

229 studies are recruiting for depression in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 2

1. A Primary Care-Based Psychosocial Intervention To Improve Cognitive & Depression Outcomes in Older Adults With MCI & Early Stage AD

   The purpose of the study is to examine the effect of Problem Adaptation Therapy for Pain (PATH-Pain) on cognitive functioning, depression and pain-related disability in 100 older adults with cognitive impairment, chronic pain, and depression. The study will test if PATH-Pain has better cognitive, a…

   Stage

   Not phased

   Ages

   60 and older

   Site

   Weill Cornell Medicine, White Plains, New York

   Run by

   Weill Medical College of Cornell University

   See if you can join NCT05081596 on ClinicalTrials.gov

2. A Digital Intervention for Post-Stroke Depression and Executive Dysfunction

   Individuals with stroke commonly experience both depression and cognitive difficulties. The goal of this study is to evaluate the efficacy of a treatment that combines a digital therapeutic (an iPad-based cognitive training program) with learning cognitive strategies. The hypotheses are that this t…

   Stage

   Phase 2

   Ages

   50 to 79

   Site

   Weill Cornell Medical Center, New York, New York

   Run by

   Weill Medical College of Cornell University

   See if you can join NCT05507138 on ClinicalTrials.gov

3. Type I Hybrid Effectiveness-Implementation Trial of Primary Care Brief Mindfulness Training for Veterans

   The VA wants to understand what type of integrative and whole health approaches are helpful for Veterans. The study is comparing two primary care based mental health treatments, a mindfulness class that teaches mindfulness meditation and a problem-solving class that teaches problem-solving skills a…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Phoenix VA Health Care System, Phoenix, AZ, Phoenix, Arizona

   Locations

   4 in total

   Run by

   VA Office of Research and Development

   See if you can join NCT06162741 on ClinicalTrials.gov

4. Accelerated Intermittent Theta Burst in Treatment-Naive Adolescents

   This is a single-site open-label clinical trial of fMRI-guided accelerated intermittent theta burst stimulation. The goal of this clinical trial is to learn if a new form of transcranial magnetic stimulation (TMS)-known generally as accelerated intermittent theta burst stimulation (aiTBS)-is effect…

   Stage

   Not phased

   Ages

   13 to 20

   Site

   Dell Medical School at University of Texas at Austin, Austin, Texas

   Run by

   University of Texas at Austin

   See if you can join NCT06523439 on ClinicalTrials.gov

5. Cognitive Training as an Adjunct to Ketamine in Real-world Clinics

   In a sample of patients already receiving ketamine (or esketamine) treatment as part of their clinical care, this project seeks to test whether we can enhance and/or extend (es)ketamine's rapid effects by introducing helpful information delivered by a computer-based cognitive training protocol. Thi…

   Stage

   Not phased

   Ages

   18 to 80

   Site

   University of Illinois at Chicago, Chicago, Illinois

   Locations

   3 in total

   Run by

   University of Pittsburgh

   See if you can join NCT06526078 on ClinicalTrials.gov

6. PET Imaging of Cyclooxygenase in Participants With Major Depressive Disorder (MDD)

   Background: Researchers developed [11C]MC1, a radioligand for cyclooxygenase-2 (COX-2). COX-2 is an enzyme induced in the brain during inflammation. Researchers want to see the levels of COX-1 (measured as distribution volume VT) are elevated in the brain of two groups of mood disorders patients un…

   Stage

   Phase 1

   Ages

   18 to 70

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Mental Health (NIMH)

   See if you can join NCT04582916 on ClinicalTrials.gov

7. Digital InteGrated Behavioral treatmeNt for Comorbid obesITy and deprEssion Among Racial and Ethnic Adults Age 50 and Older

   The goal of this randomized clinical trial is to test the efficacy of a fully digital intervention, combining the Lumen problem-solving therapy virtual coach for depression management with the Diabetes Prevention Program video-based program for weight loss, among racial and ethnic minorities with c…

   Stage

   Not phased

   Ages

   50 to 74

   Site

   Department of Medicine, Vitoux Program on Aging and Prevention, Chicago, Illinois

   Locations

   2 in total

   Run by

   University of Illinois at Chicago

   See if you can join NCT06636058 on ClinicalTrials.gov

8. [18F]PF-06445974 to Image PDE4B in Major Depressive Disorder Using PET

   Background: Major depressive disorder (MDD) is a psychiatric condition. People with MDD have occasional bouts of depressive symptoms; these bouts are called major depressive episodes (MDEs). Researchers want to know if people having MDEs have lower levels of an enzyme called PDE4B in their brains. …

   Stage

   Phase 1

   Ages

   18 to 70

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Mental Health (NIMH)

   See if you can join NCT05703685 on ClinicalTrials.gov

9. Understanding the Role of Doulas in Supporting People With PMADs

   Detailed Description The doula-led intervention developed during the first phase of this project will be pilot tested for feasibility. Following the recruitment procedures described in the recruitment and retention plan, approximately 75 participants will be enrolled into the study. Twenty-five of …

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Montana, Missoula, Montana

   Run by

   University of Montana

   See if you can join NCT05763537 on ClinicalTrials.gov

10. Psilocybin-Assisted Therapy for Intergenerational Trauma

    This is an open-label psilocybin-assisted therapy study that will examine the safety and tolerability of psilocybin-assisted therapy in the offspring of genocide survivors with mood and anxiety disorders. The study will also investigate the efficacy of psilocybin-assisted therapy in reducing sympto…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    The Parsons Research Center for Psychedelic Healing, New York, New York

    Run by

    Rachel Yehuda

    See if you can join NCT06899165 on ClinicalTrials.gov

11. ICBT (Internet Based Cognitive Behavioral Therapy) for Maternal Depression: Community Implementation in Head Start

    Low income women of childbearing age are at increased risk for depression and often do not receive needed treatment. Investigators developed Mom-Net, an on-line cognitive behavioral treatment (CBT) for depression to address the needs of low income women of childbearing age. The intervention program…

    Stage

    Not phased

    Ages

    2 and older

    Site

    Oregon Research Institute, Springfield, Oregon

    Run by

    Oregon Research Institute

    See if you can join NCT05142384 on ClinicalTrials.gov

12. taVNS or TMS or Both for Depression

    The purpose of the research is to test out a combined treatment for depression where the investigators stimulate a nerve in the ear while at the same time stimulate the brain with magnets. These treatments are called transcutaneous (through the skin) auricular (ear) vagus nerve stimulation (taVNS) …

    Stage

    Not phased

    Ages

    18 to 75

    Site

    Medical University of South Carolina Institute of Psychiatry, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT05725239 on ClinicalTrials.gov

13. TRIPS - Treatment to Improve Depression and/or Anxiety Using Psilocybin-assisted Psychotherapy in Cancer Survivors

    This clinical research study is to learn about the feasibility, safety, and effects of psilocybin-assisted psychotherapy for cancer survivors with depression and/or anxiety.

    Stage

    Phase 2

    Ages

    18 and older

    Site

    The University of Texas M. D. Anderson Cancer Center, Houston, Texas

    Run by

    M.D. Anderson Cancer Center

    See if you can join NCT06801041 on ClinicalTrials.gov

14. Changing Lives and Changing Outcomes-9 at Worcester Recovery Center and Hospital

    People with serious mental illness (depression, bipolar, and schizophrenia spectrum disorders) have high rates of repeated criminal legal involvement and psychiatric hospitalizations. Longstanding research shows that in addition to treating clients' symptoms of mental illness, targeting risk factor…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Worcester Recovery Center and Hospital, Worcester, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT07359157 on ClinicalTrials.gov

15. Evaluation of Patients With Mood and Anxiety Disorders and Healthy Volunteers

    The purpose of this protocol is to allow for the careful screening of patients and healthy volunteers for participation in research protocols in the Experimental Therapeutics and Pathophysiology Lab (ETPB) at the National Institute of Mental Health (NIMH) and for the collection of natural history d…

    Stage

    Not phased

    Ages

    3 to 99

    Site

    National Institutes of Health Clinical Center, Bethesda, Maryland

    Run by

    National Institute of Mental Health (NIMH)

    See if you can join NCT00024635 on ClinicalTrials.gov

16. Remote Evaluation and Alerting for Collaborative Health (REACH) in Depression

    Researchers hope to see if the data smartphones collect continuously can be used to predict if patient's depression symptoms will return. They will do this by collecting data from patient's smartphones and comparing it to their depression symptoms. If this method is successful, researchers could de…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Dartmouth College, Hanover, New Hampshire

    Locations

    2 in total

    Run by

    Dartmouth-Hitchcock Medical Center

    See if you can join NCT07174557 on ClinicalTrials.gov

17. A Computerized Depression Intervention in Veterans

    Depressive symptoms are common among Veterans and associated with significant impairment. Timely intervention has the potential to improve mental health outcomes and restore functioning. Interventions delivered through the internet can be completed remotely at any time, and thus minimize burden on …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Central Texas Veterans Health Care System Waco VA Medical Center, Waco, TX, Waco, Texas

    Run by

    VA Office of Research and Development

    See if you can join NCT06217198 on ClinicalTrials.gov

18. Apimostinel + Automated Neurocognitive Training for Depression

    Apimostinel shows initial promise as a novel rapid-acting antidepressant medication with minimal side effects or safety concerns. Cognitive Training (CT) is a digital intervention that has shown promise in extending the durability of another similar drug (ketamine). This randomized controlled trial…

    Stage

    Phase 2

    Ages

    18 to 60

    Site

    Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania

    Run by

    Rebecca Price

    See if you can join NCT06400121 on ClinicalTrials.gov

19. Investigation to Understand and Optimize Psilocybin

    This study will examine the effects of a single dose of psilocybin, administered with psychological support, on symptoms of depression. It will also assess whether different post-dosing interventions, including a non-invasive technique called transcutaneous auricular Vagus Nerve Stimulation (taVNS)…

    Stage

    Phase 2

    Ages

    18 to 70

    Site

    Vail Health Behavioral Health, Edwards, Colorado

    Run by

    Charles Raison

    See if you can join NCT06512194 on ClinicalTrials.gov

20. Psilocybin Therapy for Depression in Parkinson's Disease

    The purpose of this study is to understand whether people with Parkinson's Disease and depression have improvement in their symptoms after psilocybin therapy.

    Stage

    Phase 2

    Ages

    40 to 80

    Site

    University of California, San Francisco, San Francisco, California

    Run by

    Joshua Woolley, MD, PhD

    See if you can join NCT06455293 on ClinicalTrials.gov

21. Sleep and Light Intervention (SALI) for Menopausal Mood Dysfunction

    **Participants must live in San Diego County** The purpose of this study is to learn more about an experimental Sleep \& Light Intervention (SALI) for menopausal mood changes or depression. Researchers want to find out whether adjusting the body's internal clock-which helps regulate sleep, hormones…

    Stage

    Not phased

    Ages

    45 to 75

    Site

    University of California San Diego Hillcrest Medical Center, San Diego, California

    Run by

    University of California, San Diego

    See if you can join NCT06678880 on ClinicalTrials.gov

22. Postpartum Education Via Artificial Intelligence for Recovery and Loneliness: A Randomized Controlled Trial

    The goal of this clinical trial is to learn whether a postpartum chatbot powered by generative artificial intelligence (genAI) can help new mothers get better pelvic floor health information and feel less lonely after childbirth. The main questions this study aims to answer are: * Does using the ch…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of California San Diego, La Jolla, California

    Run by

    University of California, San Diego

    See if you can join NCT07223736 on ClinicalTrials.gov

23. Telehealth Behavioral Activation for Teens

    Behavioral activation is one such empirically supported intervention. Derived from cognitive-behavioral therapy, a well-established treatment for depression, behavioral activation uses psychoeducation and skill-building to increase an individual's engagement in valued and enjoyable activities (e.g.…

    Stage

    Not phased

    Ages

    12 to 18

    Site

    Baylor College of Medicine, Houston, Texas

    Run by

    Baylor College of Medicine

    See if you can join NCT06273995 on ClinicalTrials.gov

24. Mobile Cognitive Behavioral Therapy for Stroke

    This study aims to assess the feasibility and acceptability of "MAYA", a mobile cognitive behavioral therapy app for anxiety and mood disorders, in adults who have had a stroke.

    Stage

    Not phased

    Ages

    40 to 79

    Site

    Weill Cornell Medicine, New York, New York

    Run by

    Weill Medical College of Cornell University

    See if you can join NCT06689878 on ClinicalTrials.gov

25. E-Mindfulness Approaches for Living After Breast Cancer

    NRG-CC015 is a prospective, randomized phase III clinical trial to evaluate the efficacy of two distinct digital approaches for delivering a mindfulness-based intervention: a live, instructor-led version delivered over Zoom (MAPs LO), and an app-based, self-paced version (MAPs App). Participants wi…

    Stage

    Phase 3

    Ages

    18 to 50

    Site

    Mayo Clinic Hospital in Arizona, Phoenix, Arizona

    Locations

    383 in total

    Run by

    NRG Oncology

    See if you can join NCT06748222 on ClinicalTrials.gov