Depression Clinical Trials

229 studies are recruiting for depression in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 3

1. Developing Resilience and Anxiety Management Through the Arts

   The Developing Resilience and Anxiety Management Through the Arts (DRAMA) Study examines the degree to which the arts can help to address stress, anxiety, and sad mood in children and adolescents. The researchers will pair theatrical improvisation exercises with cognitive-behavioral therapy (CBT) t…

   Stage

   Not phased

   Ages

   8 to 17

   Site

   Case Western Reserve University, Cleveland, Ohio

   Run by

   Case Western Reserve University

   See if you can join NCT07033052 on ClinicalTrials.gov

2. Telehealth Music Therapy for Adults With Endocrine Disorder and Depression

   The goal of this clinical trial is to explore if a telehealth music therapy intervention helps with quality of life, depression symptoms, anxiety symptoms. It will also explore the participants' relationship to music. The main questions it aims to answer are: * Refine and tailor the music therapy i…

   Stage

   Not phased

   Ages

   18 to 65

   Site

   Appalachian State University, Boone, North Carolina

   Run by

   Appalachian State University

   See if you can join NCT07413874 on ClinicalTrials.gov

3. Tele-PROTECT Therapy: Effectiveness, Empowerment, and Implementation

   The purpose of this randomized trial is to conduct a fully powered effectiveness trial of video-delivered PROTECT (Tele-PROTECT) compared to a video-delivered depression education (DepEd) control condition to be delivered to 140 English- and Spanish-speaking NYC elder abuse victims. Investigators h…

   Stage

   Not phased

   Ages

   60 and older

   Site

   Weill Cornell Medicine, New York, New York

   Run by

   Weill Medical College of Cornell University

   See if you can join NCT06039930 on ClinicalTrials.gov

4. A Study to Assess Change in Disease Activity and Adverse Events (AEs) With Cariprazine in the Treatment of Depressive Episodes in Pediatric Participants Participants (10 to 17 Years of Age) With Bipolar I Disorder.

   Bipolar disorder is a severe chronic mood disorder that affects up to 4% of the adult population and 1.8% of the pediatric population in the United States. The treatment of the depressive episodes of bipolar disorder in the pediatric population has not been as widely studied as the treatment of dep…

   Stage

   Phase 3

   Ages

   10 to 17

   Site

   Advanced Research Center /ID# 227073, Anaheim, California

   Locations

   81 in total

   Run by

   AbbVie

   See if you can join NCT04777357 on ClinicalTrials.gov

5. Behavioral Activation Delivered Via Home-based Telehealth to Improve Functioning in Cardiovascular Disease Patients Recently Discharged From Inpatient Care

   The purpose of this study is to demonstrate whether Behavioral Activation for depression delivered via home based telehealth (BA-HT) is effective in improving social and role functioning in Veterans recently discharged from Cardiovascular disease (CVD-related) inpatient care. Eligible participants …

   Stage

   Not phased

   Ages

   21 and older

   Site

   Ralph H. Johnson VA Medical Center, Charleston, SC, Charleston, South Carolina

   Run by

   VA Office of Research and Development

   See if you can join NCT04877197 on ClinicalTrials.gov

6. Supporting Mental Health and Reducing Care Stress in Caregivers of Persons With Cardiovascular Disease

   The purpose of this study is to evaluate the preliminary efficacy, feasibility, acceptability, and barriers and facilitators to implementation of the Confident Caregiver intervention among family caregivers of persons with cardiovascular disease participating in cardiac rehabilitation. Caregivers r…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of California Davis Health System, Sacramento, California

   Run by

   University of California, Davis

   See if you can join NCT07717723 on ClinicalTrials.gov

7. Internet Based Psychological Support

   The investigators have developed interactive, multimedia-intensive, computer-based treatment programs that include depression (Problem-Solving Therapy), stress management, and conflict management. Together the three modules are called PATH. The problem-solving module is based on an evidence-based p…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire

   Run by

   Dartmouth-Hitchcock Medical Center

   See if you can join NCT02726061 on ClinicalTrials.gov

8. Adaptive Coping Skills Training to Improve Psychological Distress Among Cardiorespiratory Failure Survivors

   Conditions treated in intensive care units (ICUs) such as the acute respiratory distress syndrome (ARDS), congestive heart failure, COVID pneumonia, and sepsis are common. These can lead to high rates of depression, anxiety, and PTSD that worsen quality of life. Yet there are few effective strategi…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Duke University Medical Center, Durham, North Carolina

   Run by

   Duke University

   See if you can join NCT06538246 on ClinicalTrials.gov

9. A Mechanistic Study to Assess a Single Dose of CYB003 in Participants With Depression and Anxiety

   The goal of this study is to learn how psychedelics may help symptoms of depression and anxiety. Participants with major depressive disorder experiencing symptoms of depression and anxiety will receive one dose of either a drug related to psilocybin or a placebo. Assessments include interviews, sel…

   Stage

   Phase 2

   Ages

   21 to 65

   Site

   The Ohio State University Department of Psychiatry, Columbus, Ohio

   Run by

   Ohio State University

   See if you can join NCT06820723 on ClinicalTrials.gov

10. RECOVERS - Realigning Emotion and COgnition Via prEcision Regulation networkS

    In this research study, investigators examine how brain activity changes during tests of emotional processing, attention, and memory using multimodal neuroimaging methods including electroencephalography (EEG), functional magnetic resonance imaging (fMRI), and functional near-infrared spectroscopy …

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Medical Univeristy of South Carolina, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT05977439 on ClinicalTrials.gov

11. Virtual Poetry Workshops to Enhance Patient Well Being and Reduce Anxiety

    This study examines whether participating in poetry workshops can improve emotional well-being among patients with chronic digestive symptoms. Many individuals with long-standing digestive conditions experience distress, anxiety, isolation, and difficulty expressing their emotions in clinical setti…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Ohio State University Wexner Medical Center, Columbus, Ohio

    Run by

    Ohio State University

    See if you can join NCT07717541 on ClinicalTrials.gov

12. CAPABLE Transplant

    The purpose of this mixed methods study is to adapt CAPABLE as CAPABLE Transplant to accomplish two things: 1) To resolve barriers to being classified as active on the Kidney Transplant (KT) waitlist, 2) as a surgical prehabilitation intervention targeting the pre-frail/ frail KT waitlist populatio…

    Stage

    Not phased

    Ages

    18 to 99

    Site

    Johns Hopkins School of Nursing, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT06326905 on ClinicalTrials.gov

13. The Efficacy of Psilocybin Therapy for Depression in Parkinson's Disease

    The purpose of this study is to understand whether people with Parkinson's Disease and depression have improvement in their symptoms after psilocybin therapy.

    Stage

    Phase 2

    Ages

    40 to 80

    Site

    Yale University, New Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT07610369 on ClinicalTrials.gov

14. Reducing Psychological Barriers to PrEP Persistence Among Pregnant and Postpartum Women in Cape Town, South Africa

    Pregnant women in South Africa (SA) are at high risk of HIV acquisition. Pre-exposure prophylaxis (PrEP) use during pregnancy is both safe and effective in preventing HIV. However, posttraumatic stress (associated with intimate partner violence and/or other traumas) and depression negatively impact…

    Stage

    Not phased

    Ages

    15 and older

    Site

    Gugulethu Midwife Obstetric Unit (MOU), Cape Town, Western Cape

    Locations

    2 in total

    Run by

    Boston University Charles River Campus

    See if you can join NCT05624931 on ClinicalTrials.gov

15. Assessment of Music Experiences in Navigating Depression Part 2

    This study is again looking at the use of music and music therapy experiences in navigating depression. The researchers will provide 11 sessions of music therapy and half will be followed by recitals at the Third Street School Music Settlement where the kids enrolled in our study will observe and i…

    Stage

    Not phased

    Ages

    7 to 15

    Site

    Mount Sinai Union Square, New York, New York

    Run by

    Icahn School of Medicine at Mount Sinai

    See if you can join NCT07218055 on ClinicalTrials.gov

16. Cognition and Behavior With Sham Accelerated TMS

    The goal of this clinical study is to understand how a person's expectations about treatment can influence their mood, motivation, and reactions to everyday rewards. The study includes young people ages 15-25 who will complete a sham (placebo) version of an accelerated transcranial magnetic stimula…

    Stage

    Not phased

    Ages

    15 to 25

    Site

    UC Davis Medical Center, Sacramento, California

    Run by

    University of California, Davis

    See if you can join NCT07397858 on ClinicalTrials.gov

17. Probiotic Administration for Adolescent Depression

    This double-blind, placebo-controlled clinical trial will examine the effect of probiotic Visbiome on the brain and gut microbiome of individuals 15 to 24 years of age.

    Stage

    EARLY_Phase 1

    Ages

    15 to 24

    Site

    UCSF, San Francisco, California

    Run by

    University of California, San Francisco

    See if you can join NCT06898788 on ClinicalTrials.gov

18. Optimizing Care for Cancer Survivors With Depression: Project 3

    The purpose of this research study is to evaluate different depression treatment approaches among cancer survivors. A cancer survivor is defined as anyone who is living and has been diagnosed with cancer. Participants will be randomly assigned to either receive a mobile app for depression treatment…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Medical University of South Carolina, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT06930729 on ClinicalTrials.gov

19. Neural-Derived Plasma Exosomal MicroRNAs As Promising Novel Biomarkers for Suicidality and Treatment Outcome in Adolescents

    This study is dedicated to help identify biomarkers for depression and suicide. The purpose of the study is to better understand these links to improve medical and psychiatric care in the future. This research is also to test the effects of standard treatment of depression on improvement in depress…

    Stage

    Not phased

    Ages

    10 to 24

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Locations

    2 in total

    Run by

    University of Alabama at Birmingham

    See if you can join NCT05437588 on ClinicalTrials.gov

20. CBT-I vs. MBTI for Traumatic Brain Injury (TBI)-Related Insomnia and Post-Traumatic Stress Symptoms

    This study is a prospective two-arm, single blind randomized controlled trial design to compare the clinical effectiveness of telemedicine-delivered, 6-session, standardized cognitive behavioral therapy for insomnia (CBT-I) and mindfulness-based treatment for insomnia (MBTI) in treating insomnia sy…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Intrepid Spirit Center - Eglin Air Force Base, Eglin Air Force Base, Florida

    Locations

    5 in total

    Run by

    Johns Hopkins University

    See if you can join NCT05663034 on ClinicalTrials.gov

21. Facilitated Transitions From Postpartum to Primary Care Coordination for People With Chronic Conditions

    The lack of postpartum primary care coordination is a missed opportunity to increase primary care engagement and manage chronic conditions early in life, especially for the >30% of pregnant people who have or are at risk for these conditions. This study aims to increase postpartum primary care enga…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT06557005 on ClinicalTrials.gov

22. Digitally Enhanced Stepped-Care for Depression in Primary Care

    This pilot, three-arm randomized clinical trial (N=40; 2:1:1) will evaluate the feasibility and preliminary efficacy of a digitally enhanced stepped-care approach for depression treatment in primary care. Participants will be randomized to: (1) stepped-care beginning with a self-guided Behavioral A…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Medical University of South Carolina, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT07634705 on ClinicalTrials.gov

23. Developing a Digital Intervention for Adolescent Nonsuicidal Self-injury

    This is a feasibility trial of a digital mental health intervention aimed at adolescents (ages 14-18) with nonsuicidal self-injury and who are not currently engaged in mental health treatment. The study has two arms: a self-guided DMHI and an active control which will involve the delivery of non-in…

    Stage

    Not phased

    Ages

    14 to 18

    Site

    Northwestern University, Chicago, Illinois

    Run by

    Northwestern University

    See if you can join NCT07224165 on ClinicalTrials.gov

24. Sleep and Circadian Interventions for College Students at High Risk of Suicide

    The purpose of this study is to examine the extent to which delivering sleep and circadian focused interventions in addition to evidenced based psychiatric care for depression and suicide risk may contribute to decreasing suicide risk among high risk young adults. Investigators will evaluate three …

    Stage

    Not phased

    Ages

    18 to 25

    Site

    Western Psychiatric Hospital/University of Pittsburgh, Pittsburgh, Pennsylvania

    Run by

    University of Pittsburgh

    See if you can join NCT07346014 on ClinicalTrials.gov

25. fMRI Neurofeedback With Matter Neuroscience App

    Study will utilize an app, Matter Neuroscience, designed to help users with depression understand positive emotions and the neurotransmitters that create them. We hope to learn the safety and efficacy of neurofeedback for treating depression and lay the groundwork for a pivotal clinical trial.

    Stage

    Not phased

    Ages

    18 to 80

    Site

    Stanford University Brain Stimulation Lab, Stanford, California

    Run by

    Stanford University

    See if you can join NCT06735885 on ClinicalTrials.gov