Depression Clinical Trials

229 studies are recruiting for depression in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 4

1. A Randomized Pilot rTMS Trial for Knee Arthritis Pain and Depression

   Osteoarthritis (OA) is a major public health problem, and involvement of the knee is especially disabling. Symptomatic knee OA has an incidence rate between 40 to 1,020 per 100,000 person years1 and is among the most common causes of disability worldwide. Knee arthritis pain and disability are high…

   Stage

   EARLY_Phase 1

   Ages

   50 to 95

   Site

   UCLA Semel Institute - Neuropsychiatric Institute (NPI), Los Angeles, California

   Run by

   University of California, Los Angeles

   See if you can join NCT06906939 on ClinicalTrials.gov

2. Comparing the Efficacy of Heated Yoga and Sauna as a Treatment for Depression

   This project explores whether heated yoga, sauna, and a mindfulness app reduce depressive symptoms

   Stage

   Not phased

   Ages

   18 to 65

   Site

   Massachusetts General Hospital, Boston, Massachusetts

   Run by

   Massachusetts General Hospital

   See if you can join NCT07082998 on ClinicalTrials.gov

3. Health And Response: Digital Markers for Outcomes in Perinatal Depression Treatment Study

   The purpose of this study is to determine if the addition of digital sensing data collected from phones and watches during the early stages of perinatal depression (PND) treatment can better predict treatment outcomes than using self-reported symptoms alone.STAND for PND: The UCLA Depression Grand …

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of California, Los Angeles, Los Angeles, California

   Run by

   University of California, Los Angeles

   See if you can join NCT07577947 on ClinicalTrials.gov

4. Clemastine for Improving White Matter and Boosting Antidepressant Response in Late-life Depression

   The goal of this study is to find out if the antihistamine, clemastine, can make the white matter in the brain better in older adults with depression. The study will also determine whether this improvement can make antidepressant treatment work better, reduce depressive symptoms, and improve memory…

   Stage

   Phase 2

   Ages

   60 and older

   Site

   University of Illinois College of Medicine, Chicago, Illinois

   Run by

   University of Illinois at Chicago

   See if you can join NCT06591091 on ClinicalTrials.gov

5. The Neural Underpinnings of Depression and Cannabis Use in Young People Living With HIV

   To elucidate mechanisms of substance use disorders (SUD) and comorbid mental illnesses in people living with HIV (PLWH), the study team seeks to investigate reward and pain circuitry in cannabis use and depression comorbidity, two highly prevalent conditions in PLWH. The study team proposes a tight…

   Stage

   Not phased

   Ages

   18 to 59

   Site

   University of Miami, Miami, Florida

   Run by

   University of Miami

   See if you can join NCT05453513 on ClinicalTrials.gov

6. Home-Based Transcranial Direct Current Stimulation (tDCS) for Depression in Multiple Sclerosis (MS)

   This project is a double-blind, sham-controlled, parallel-arm, randomized controlled trial. We will recruit n=170 people living with MS, who are experiencing an episode of depression in the context of a major depressive episode (MDE). Using our remotely supervised (RS) tDCS protocol, enrolled parti…

   Stage

   Phase 2

   Ages

   18 to 65

   Site

   NYU Langone Health, New York, New York

   Run by

   NYU Langone Health

   See if you can join NCT06901687 on ClinicalTrials.gov

7. Feasibility of Home-Based Intermittent 60Hz Light Therapy for Major Depressive Disorder (MDD)

   This pilot study evaluates the feasibility, safety, and preliminary efficacy of home-based 60Hz intermittent light therapy in adults with a major depressive episode (MDE). Participants will be randomized in a 2:1 ratio to receive either active or sham 60Hz intermittent light stimulation for 30 minu…

   Stage

   Not phased

   Ages

   24 to 65

   Site

   NYU Langone Health, New York, New York

   Run by

   NYU Langone Health

   See if you can join NCT07111390 on ClinicalTrials.gov

8. Implementing Depression and Adherence Treatment

   The goal of this clinical trial is to compare a core set and enhanced set of implementation strategies in increasing the reach of evidence-based treatments to patients with HIV and depression. The main questions it aims to answer are: What proportion of patients start an evidence-based treatment fo…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Miami, Miami, Florida

   Locations

   3 in total

   Run by

   University of Miami

   See if you can join NCT07032363 on ClinicalTrials.gov

9. Inhibitory Mechanisms of Negative Urgency in Adolescent Suicidal Behavior

   The goal of this study is to understand why some people act more impulsively when feeling negative emotions, which is called negative urgency. The researchers hope to understand how negative urgency relates to the way networks of brain cells communicate with one another. The researchers will measur…

   Stage

   Not phased

   Ages

   13 to 21

   Site

   University of Minnesota, Minneapolis, Minnesota

   Run by

   University of Minnesota

   See if you can join NCT05652153 on ClinicalTrials.gov

10. ACT Together: Implementing a Web-Based Program With Brief Coaching for Parents of Children With Disabilities in Pediatric Outpatient Clinics

    The goal of this clinical trial is to evaluate the feasibility, usability, and preliminary benefits of implementing ACT Together for parents of children with disabilities in pediatric outpatient clinics. ACT Together includes six self-paced, web-based modules and brief weekly one-on-one coaching se…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of South Florida, Tampa, Florida

    Run by

    University of South Florida

    See if you can join NCT07360600 on ClinicalTrials.gov

11. Mindfulness Training During Accelerated TMS for Depression

    This NIH-funded single-arm pilot tests the feasibility, acceptability, and preliminary effects of embedding brief guided mindfulness practice (via the Waking Up smartphone app) into the inter-session intervals of clinically administered accelerated intermittent theta-burst stimulation (aiTBS) for m…

    Stage

    Not phased

    Ages

    18 to 80

    Site

    IOP, Charleston, South Carolina

    Locations

    2 in total

    Run by

    Medical University of South Carolina

    See if you can join NCT07369557 on ClinicalTrials.gov

12. Pilot Study of a Behavioral Program for Resident Depression in Skilled Nursing Facilities

    The goal of this clinical trial is to test a behavioral health program (Interventions for Stressful Transitions in Later Life, InSTILL, for Individuals) for skilled nursing facility residents. The main questions it aims to answer is whether the program is program is feasible, satisfactory, and help…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT07655232 on ClinicalTrials.gov

13. Study of the Safety, Tolerability, Electrophysiological Effects and Efficacy of DMT in Humans

    The goal of this phase 1 study is to investigate the safety and efficacy of dimethyltryptamine (DMT) in individuals with depression and healthy controls. We hypothesize that administration of DMT will result in decreases in depression, associated symptoms, and neuroplastic changes in depressed subj…

    Stage

    Phase 1

    Ages

    21 to 65

    Site

    Biological Studies Unit at the VA Connecticut Healthcare System, Yale School of Medicine,, West Haven, Connecticut

    Run by

    Deepak C. D'Souza

    See if you can join NCT06671977 on ClinicalTrials.gov

14. Therapy Dog Visits for Patients Hospitalized With Traumatic Injuries

    Animal assisted therapy (AAT) with dogs has been shown to be beneficial for a wide range of patients with both acute and chronic illnesses, including spinal cord injuries, heart failure, myocardial infarctions, strokes, cancer, post-traumatic stress disorder, and depression. Studies have also demon…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Boston Medical Center, Trauma Inpatient Service, Boston, Massachusetts

    Run by

    Boston Medical Center

    See if you can join NCT06812247 on ClinicalTrials.gov

15. Michigan Men's Diabetes Project III(MenDIII): Mind and Motion

    The Michigan Men's Diabetes Project III: Mind \& Motion is an 7-month pilot randomized clinical trial. The investigators are looking to recruit 80 Black men with type 2 diabetes (T2D) (need to have diagnosis for at least one year) that are over the age of 18. Participants also must be under the car…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Michigan, Ann Arbor, Michigan

    Run by

    University of Michigan

    See if you can join NCT06574035 on ClinicalTrials.gov

16. Cannabidiol and Older Adult Cannabis Users

    Cannabis use increased 10 fold among adults over the age of 65 between 2014 and 2016 but very little data exists on the extent of their harmful effects on health and behavior. The overarching goal of this project is to test a novel harm reduction strategy in which older individuals who seek to use …

    Stage

    Phase 2

    Ages

    60 and older

    Site

    University of Colorado at Boulder, Boulder, Colorado

    Run by

    University of Colorado, Boulder

    See if you can join NCT06290063 on ClinicalTrials.gov

17. Equipping Patients Using Interventions for Pain and Depression

    This project is part of the NIH Helping to End Addiction Long-term (HEAL) initiative (https://heal.nih.gov/). This randomized controlled trial (RCT) is phase 2 of a two-phase, 5-year project with the overarching goal of testing a decision aid (DA)/coaching intervention, tailored to Black patients w…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Eskenazi Health Primary Care, Indianapolis, Indiana

    Run by

    Indiana University

    See if you can join NCT06500780 on ClinicalTrials.gov

18. Depression and Driving

    This project will assess how depression, preclinical AD, and antidepressants affect driving behavior in cognitively normal older adults (65 years).

    Stage

    Not phased

    Ages

    65 and older

    Site

    Washington University School of Medicine, St Louis, Missouri

    Run by

    Washington University School of Medicine

    See if you can join NCT05446805 on ClinicalTrials.gov

19. tDCS: Sleep to Mood in Depression (S2M-D)

    The purpose of this study is to determine whether changes in sleep consolidation occur during home-based transcranial direct current stimulation (tDCS) in adults with moderate depression and whether these changes are temporally associated with improvements in depressive symptoms.

    Stage

    Not phased

    Ages

    18 to 65

    Site

    NYU Langone Health, New York, New York

    Run by

    NYU Langone Health

    See if you can join NCT07572526 on ClinicalTrials.gov

20. Transdiagnostic Sleep and Circadian Intervention + Bright Light in Adolescents With Elevated Depression (TranS-C+BL)

    The goal of this clinical trial is to adapt a sleep intervention for individuals representative of all demographic groups, including those who are at the highest risk for suicidal behavior. Sleep difficulties are a promising target for youth with suicidal thoughts and behavior to focus on as a prev…

    Stage

    Not phased

    Ages

    12 to 18

    Site

    Childrens Hospital of Philadelphia, Philadelphia, Pennsylvania

    Locations

    2 in total

    Run by

    University of Pittsburgh

    See if you can join NCT06963463 on ClinicalTrials.gov

21. RXWell to Decrease Post-Operative Opioid Use in Total Knee or Hip Arthroplasty

    It is envisioned that multipronged benefits from this pilot work for the UPMC ISD and its members. It is expected the RxWell platform to provide the following benefits: expansion of the use of RxWell to all UPMC ISD members providing peri-operative mood management with advantage of improved peri-op…

    Stage

    Not phased

    Ages

    18 to 100

    Site

    UPMC East, Monroeville, Pennsylvania

    Locations

    3 in total

    Run by

    University of Pittsburgh

    See if you can join NCT05658796 on ClinicalTrials.gov

22. A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)

    The goal of this clinical trial is to learn if a drug called TNX-102 SL works to treat moderate to severe major depressive disorder in adults. It will also learn about the safety of TNX-102 SL. The main questions it aims to answer are: Does TNX-102 SL improve depression symptoms according to a depr…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Clinical Neuroscience Solutions Inc. - Orlando, Orlando, Florida

    Locations

    25 in total

    Run by

    Tonix Pharmaceuticals, Inc.

    See if you can join NCT07621237 on ClinicalTrials.gov

23. Mechanisms of Behavioral Activation (BA)

    The investigators will be comparing brain (neural) activation of depressed adolescent patients before, during and after a course of Behavioral Activation (BA) therapy using functional magnetic resonance imaging (fMRI). In particular, the project seeks to determine whether BA targets different neura…

    Stage

    Not phased

    Ages

    15 to 17

    Site

    Emory University, Atlanta, Georgia

    Locations

    3 in total

    Run by

    Emory University

    See if you can join NCT05548244 on ClinicalTrials.gov

24. Exploring Virtual Reality Adventure Training Exergaming

    The current project aims to design and implement an 8-week Virtual Reality Adventure Therapy Exergaming (V-RATE) intervention focused on women veterans. A randomized controlled trial using a repeated measure design with a 1-month follow-up assessment will be employed to examine effects on physical …

    Stage

    Not phased

    Ages

    18 to 45

    Site

    University of Texas at Arlington, Arlington, Texas

    Run by

    The University of Texas at Arlington

    See if you can join NCT05563805 on ClinicalTrials.gov

25. Be Well at Work-Plus: A Depression and Physical Activity Intervention for Hospital Service Workers (Aim 2)

    This study develops and tests a dynamic workplace-based depression intervention that is tailored to the specific social and behavioral needs of low-wage hospital service workers. The intervention involves assessment of depression-related work impairment, work-focused cognitive behavioral therapy, w…

    Stage

    Not phased

    Ages

    18 and older

    Site

    San Diego State University, San Diego, California

    Run by

    San Diego State University

    See if you can join NCT06753123 on ClinicalTrials.gov