Depression Clinical Trials

229 studies are recruiting for depression in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 5

1. Assessing the Effectiveness of Digital Wellness Modules on Perceived Quality of Life

   The study will examine the role of digital wellness modules (brief mindfulness and light to moderate physical exercise) delivered through a smartphone wellness application and their short-term effects on health behavior motivation and change, and longer-term quality of life and non-pathological aff…

   Stage

   Not phased

   Ages

   18 to 65

   Site

   Yale University, New Haven, Connecticut

   Run by

   Yale University

   See if you can join NCT05810259 on ClinicalTrials.gov

2. Inflammation and Depression in People With HIV

   The purpose of this 10-week, double-blind, placebo-controlled study is to determine whether inflammation impacts reward and motor neural circuitry to contribute to depressive symptoms like anhedonia and psychomotor slowing in people with Human Immunodeficiency Virus (HIV) and depression. Sixty male…

   Stage

   Phase 2

   Ages

   18 to 65

   Site

   Grady Memorial Hospital, Atlanta, Georgia

   Locations

   2 in total

   Run by

   Emory University

   See if you can join NCT05849038 on ClinicalTrials.gov

3. Effects of Transcutaneous Vagal Nerve Stimulation on Post-Surgical Return to Consciousness, Delirium, and Depression

   This study will examine whether noninvasive, transcutaneous vagal nerve stimulation (tcVNS) can help restore consciousness in patients in the operating room and the Post Anesthesia Care Unit (PACU). The study will also investigate if tcVNS can expedite discharge from the PACU and examine whether tc…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Northwestern University Feinberg School of Medicine, Chicago, Illinois

   Run by

   Northwestern University

   See if you can join NCT07610655 on ClinicalTrials.gov

4. Well-being Training for Adolescent Depressive Symptoms (TeenWell Study)

   This study is being done to see if the Healthy Minds Program app helps adolescents with elevated depressive symptoms. Up to 200 participants will be on study for 20 weeks.

   Stage

   Not phased

   Ages

   14 to 19

   Site

   Center for Healthy Minds, University of Wisconsin Madison, Madison, Wisconsin

   Run by

   University of Wisconsin, Madison

   See if you can join NCT06626425 on ClinicalTrials.gov

5. Self-Help Cognitive Processing Therapy (CPT)/Women Veterans Network (WoVeN) Study

   Posttraumatic stress disorder (PTSD) can have significant impairment on aspects of mental well-being (MWB) including functioning, loneliness, physical health, and quality of life. There are several evidence-based treatments (EBPs) effective in treating PTSD such as Cognitive Processing Therapy (CPT…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Fully online study, Boston, Massachusetts

   Run by

   Boston University

   See if you can join NCT07250061 on ClinicalTrials.gov

6. Personalized Mobile Cognitive Behavioral Therapy Application

   This study aims to compare the effectiveness of a standard mobile cognitive behavioral therapy program to a personalized mobile cognitive behavioral therapy program that introduces new skills over a shorter period of time. Participants will use the Maya app for two days per week, at least 20 minute…

   Stage

   Not phased

   Ages

   18 to 25

   Site

   Weill Cornell Medical College, New York, New York

   Run by

   Weill Medical College of Cornell University

   See if you can join NCT05699525 on ClinicalTrials.gov

7. Mobile CBT for Middle Aged and Older Adults

   This study aims to assess a mobile app called MAYA for use in middle-aged and older adults with anxiety or mood disorders. The MAYA app is designed to teach coping skills for anxiety and depression that are drawn from cognitive behavioral therapy. Participants will be asked to use the app for at le…

   Stage

   Not phased

   Ages

   40 and older

   Site

   Weill Cornell Medicine, New York, New York

   Run by

   Weill Medical College of Cornell University

   See if you can join NCT05754151 on ClinicalTrials.gov

8. Identifying and Treating Depression in the Orthopaedic Trauma Population

   The goal of this trial is to pilot a way for orthopaedic surgeons to safely screen for depression and provide treatment for depression with medication. The main questions it aims to answer are: 1. What are the outcomes of patients who screen positive for depressive symptoms and are prescribed eithe…

   Stage

   Phase 4

   Ages

   18 and older

   Site

   Wake Forest University Health Sciences, Winston-Salem, North Carolina

   Run by

   Wake Forest University Health Sciences

   See if you can join NCT05976347 on ClinicalTrials.gov

9. IMPACT (IMproving Proactive Approaches for Cancer Survivors' Mental Health Treatment)

   The purpose of this research study is to evaluate a mobile application (app) for depression treatment called "Moodivate" among cancer survivors. Moodivate was developed by our research team to assist with the treatment of depressed mood. Participants will be randomly assigned to either download the…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Medical University of South Carolina, Charleston, South Carolina

   Run by

   Medical University of South Carolina

   See if you can join NCT06582784 on ClinicalTrials.gov

10. Social Needs Screening and Chronic Diseases Study (WE CARE)

    The goal of this clinical trial is to learn if the implementation of the WE CARE social determinants of health (SDOH) screening and referral intervention with an antiracist lens in primary care settings can lead to a meaningful decrease in chronic disease by monitoring conditions such as hypertensi…

    Stage

    Not phased

    Ages

    Any age

    Site

    UMass Memorial Medical Center - Hahnemann Campus, Worcester, Massachusetts

    Locations

    3 in total

    Run by

    University of Massachusetts, Worcester

    See if you can join NCT06903897 on ClinicalTrials.gov

11. Rapid Antidepressant Dynamics in Acute Neuromodulation Treatments

    The goal of this clinical trial is to learn how different types of non-invasive brain stimulation affect mood and brain function in adults with major depressive disorder (MDD). It will also study how brain stimulation may work together with antidepressant treatments. The main questions this study a…

    Stage

    Not phased

    Ages

    18 to 55

    Site

    Bellefield Towers, Pittsburgh, Pennsylvania

    Run by

    Marta Peciña, MD PhD

    See if you can join NCT06976840 on ClinicalTrials.gov

12. Storytelling and Mindfulness for Graduate Student Wellbeing

    The purpose of this study is to evaluate an intervention for improving Science, Technology, Engineering, and Math (STEM) graduate student wellbeing. Participants will be recruited from the University of Wisconsin-Madison graduate student body. Data will be collected from participants for up to 2 ye…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Wisconsin Institute for Discovery, Madison, Wisconsin

    Run by

    University of Wisconsin, Madison

    See if you can join NCT05826860 on ClinicalTrials.gov

13. Cognitive and Affective Processes Online

    This study will provide data for evaluating the psychometric characteristics of the tests assessing cognitive flexibility, including their (1) internal consistency, (2) feasibility and tolerability, their (3) convergent and discriminant validity of cognitive and affective constructs such as those i…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Minnesota, Minneapolis, Minnesota

    Run by

    University of Minnesota

    See if you can join NCT05736471 on ClinicalTrials.gov

14. Assessing Improvements in Mood and Sleep Trial

    This is a multi-site randomized control trial involving people age 55+ years who have current depression symptoms plus another suicide risk indicator (either current suicidal ideation or a past history of attempt). Our goal is evaluate which of two different approaches works best to improve things …

    Stage

    Not phased

    Ages

    55 and older

    Site

    The Regents of the University of California, Los Angeles, Los Angeles, California

    Locations

    3 in total

    Run by

    University of Pittsburgh

    See if you can join NCT06639477 on ClinicalTrials.gov

15. Pharmacologic Augmentation of TMS for Depression With D-serine

    The goal of this study is to test whether combining D-serine with 30 treatments of a) iTBS and b) 18-Hz protocols will enhance clinical outcomes compared to rTMS with placebo (i.e., sugar pill). The investigators hypothesize that NMDA receptor activation via D-serine combined with repeated sessions…

    Stage

    Phase 1

    Ages

    18 to 80

    Site

    McLean Hospital, Belmont, Massachusetts

    Run by

    Mclean Hospital

    See if you can join NCT06876129 on ClinicalTrials.gov

16. Families With Pride ("Familias Con Orgullo").

    This study will evaluate the effects of a parenting intervention for Hispanic sexual minority youth in preventing/reducing drug use and depressive symptoms. It will also examine whether the intervention improves parent social support for the adolescent, parent acceptance, family functioning, and wh…

    Stage

    Not phased

    Ages

    13 to 19

    Site

    University of Miami, Coral Gables, Florida

    Run by

    University of Miami

    See if you can join NCT06057337 on ClinicalTrials.gov

17. A Precision Medicine Approach to Target Engagement for Emotion Regulation

    The proposed study is designed to first test whether teaching people personalized or standardized emotion regulation skills leads to greater decreases in daily negative emotion intensity. Second, using data from an initial sample, the investigators will prospectively assign an independent sample of…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Ohio State University, Columbus, Ohio

    Run by

    Matthew Southward, PhD

    See if you can join NCT05651295 on ClinicalTrials.gov

18. Safe Mothers, Safe Children Initiative

    The purpose of this study is to assess the efficacy of the combined interventions, Skills Training in Affective and Interpersonal Regulation (STAIR) and Parent-Child Interaction Therapy (PCIT) or P-STAIR, for treating maternal PTSD and reducing maltreatment recidivism.

    Stage

    Not phased

    Ages

    18 and older

    Site

    McSilver Institute for Poverty Policy and Research, New York, New York

    Run by

    New York University

    See if you can join NCT04752618 on ClinicalTrials.gov

19. Training Reward Responsiveness Through Virtual Reality

    The purpose of this study is to compare the effects of Virtual Reality-Reward Training (VR-RT) with an active control condition, Virtual Reality-Memory Training (VR-MT), on positive affect and other clinical symptoms. VR-Reward Training is a novel intervention aimed at enhancing savoring of positiv…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    University of California, Los Angeles, Los Angeles, California

    Run by

    University of California, Los Angeles

    See if you can join NCT07219875 on ClinicalTrials.gov

20. Buspirone and Melatonin for Depression Following Traumatic Brain Injury

    Traumatic brain injuries (TBIs) are common. Post-TBI depression is associated with anxiety, aggression, fatigue, distractibility, anger, irritability, and rumination. The current research group conducted a pilot clinical trial, which investigated the novel treatment combination of buspirone and mel…

    Stage

    Phase 4

    Ages

    18 to 64

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Locations

    2 in total

    Run by

    Massachusetts General Hospital

    See if you can join NCT04400266 on ClinicalTrials.gov

21. Positive Affect Treatment for Adolescents With Early Life Adversity

    Youth exposed to early life adversity (ELA) are known to be at greater risk for depression and suicidality and account for almost half of the youth suffering from psychiatric diseases today. Youth exposed to ELA consistently report symptoms of anhedonia as well as dysregulated positive affect. The …

    Stage

    Not phased

    Ages

    12 to 16

    Site

    University of California Irvine, Irvine, California

    Run by

    University of California, Irvine

    See if you can join NCT06273137 on ClinicalTrials.gov

22. Teen Brain Online II: Understanding How Social Media Affects the Teen Brain

    There has been much interest in the potential role of social media (SM) use in driving a current mental health crisis among teens, with a dire need for evidence that goes beyond self-report. One important avenue is to understand the role of the brain in driving the effects of SM use on emotional he…

    Stage

    Not phased

    Ages

    13 to 17

    Site

    University of Pittsburgh, Pittsburgh, Pennsylvania

    Run by

    University of Pittsburgh

    See if you can join NCT06817993 on ClinicalTrials.gov

23. Being Safe, Healthy, And Positively Empowered (BSHAPE) Intervention Study

    The purpose of the study is to evaluate a trauma informed digital multicomponent intervention design to improve health and safety outcomes for women with lifetime exposures to violence and co-occurring PTSD and/or depression symptoms

    Stage

    Not phased

    Ages

    18 and older

    Site

    Johns Hopkins University, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT07227337 on ClinicalTrials.gov

24. Mindfulness Engaged Neurostimulation for Depression (MEND II)

    Repetitive Transcranial Magnetic stimulation (rTMS) is an FDA-approved therapy for treatment resistant depression (TRD) that involves brief magnetic stimulation pulses on the dorsolateral prefrontal cortex (DLPFC) brain region. But studies of rTMS alone show remission rates of ~30%. Additionally, r…

    Stage

    Phase 2

    Ages

    18 to 65

    Site

    UC San Diego Health Psychiatry, San Diego, California

    Run by

    University of California, San Diego

    See if you can join NCT07512284 on ClinicalTrials.gov

25. Geolocation Positional System (GPS) Experience

    The purpose of this study is to use smartphone technology to capture individual location emotional and cognitive data, to examine how real-world behaviors thoughts, emotions, and brain activity are related to one another.

    Stage

    Not phased

    Ages

    18 to 50

    Site

    University of Miami, Coral Gables, Florida

    Run by

    University of Miami

    See if you can join NCT05991713 on ClinicalTrials.gov