Depression Clinical Trials

229 studies are recruiting for depression in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 6

1. Pilot Effectiveness Trial of an ACT Self-help Workbook Tailored Specifically for Prisons

   The goal of this research study is to adapt an ACT-self-help workbook to the prison setting and determine the feasibility acceptability, and effectiveness of this workbook. Participants can expect to be in the study for 13 weeks.

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Wisconsin, Madison, Wisconsin

   Run by

   University of Wisconsin, Madison

   See if you can join NCT06162624 on ClinicalTrials.gov

2. Combined Neuromodulation and Cognitive Training for Post-mTBI Depression

   The primary goal of this clinical trial is to evaluate whether Personalized Augmented Cognitive Training (PACT) plus intermittent theta burst stimulation (iTBS) is effective for treating depression in Service Members, Veterans, and civilians who have sustained a mild TBI. Participants will receive …

   Stage

   Not phased

   Ages

   18 to 65

   Site

   UCSD, La Jolla, California

   Run by

   University of California, San Diego

   See if you can join NCT05682677 on ClinicalTrials.gov

3. Examining the Effects of Estradiol on Neural and Molecular Response to Reward

   This proposal will examine the effects of estradiol administration on perimenopausal-onset (PO) anhedonia and psychosis symptoms as well as on brain function using simultaneous positron emission tomography and functional magnetic resonance imaging (PET-MR).

   Stage

   Phase 4

   Ages

   45 to 55

   Site

   University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

   Run by

   University of North Carolina, Chapel Hill

   See if you can join NCT05282277 on ClinicalTrials.gov

4. Investigating Dynamic Interactions in Distributed Cognitive Control Networks

   The purpose of this study is to investigate the brain activity associated with cognitive tasks (thinking, reasoning, remembering) in order to understand how the brain works during certain tasks and to improve treatment for diseases like dementia and attention deficit disorders. Cognitive (thinking)…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Alabama at Birmingham, Birmingham, Alabama

   Run by

   University of Alabama at Birmingham

   See if you can join NCT05927974 on ClinicalTrials.gov

5. Stress and Pain in People Living With HIV

   This is a basic human experimental study utilizing 4 groups of individuals with and without HIV and complex morbidities of cannabis use disorder and major depression who will participate in 2 sessions of the Yale Pain Stress Task (YPST) and follow-up phase to assess drug use and mood symptoms.

   Stage

   Not phased

   Ages

   18 to 68

   Site

   The Yale Stress Center, New Haven, Connecticut

   Run by

   Yale University

   See if you can join NCT06784908 on ClinicalTrials.gov

6. Virtual Patient Groups for Sarcoidosis Associated Fatigue

   This research study is testing whether Mindfulness-Based Stress Reduction (MBSR) can help reduce fatigue in people with sarcoidosis. The study will also look at whether MBSR can improve symptoms of anxiety and depression. Participants will be placed into one of two groups: * One group will take par…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Cleveland Clinic, Cleveland, Ohio

   Run by

   The Cleveland Clinic

   See if you can join NCT07073963 on ClinicalTrials.gov

7. Just-in-Time Training for Youth Mentors

   This study will evaluate the usability, feasibility, and acceptability of a novel multi-level Just-In-Time Training (JITT) implementation strategy (JITT-EBP) that aims to equip mentors and mentor supervisors to implement evidence-based practices (EBPs) with fidelity using methods that are sustainab…

   Stage

   Not phased

   Ages

   12 and older

   Site

   University of Minnesota, Minneapolis, Minnesota

   Run by

   University of Minnesota

   See if you can join NCT07129070 on ClinicalTrials.gov

8. Cognitive-Behavioral Therapy and Exercise Training in Adolescents At-Risk for Type 2 Diabetes

   The investigators are doing this study to learn more about how to prevent type 2 diabetes in teenage girls. The purpose of this study is to find out if taking part in a cognitive-behavioral therapy group, exercise training group, or a combination of cognitive-behavioral therapy and exercise trainin…

   Stage

   Not phased

   Ages

   12 to 17

   Site

   Children's Hospital Colorado, Aurora, Colorado

   Locations

   2 in total

   Run by

   Colorado State University

   See if you can join NCT05543083 on ClinicalTrials.gov

9. Positive Processes and Transition to Health - Single-Session (PATH-SS)

   The goal of this clinical trial is to test a brief, new psychotherapy (called Positive Processes and Transition to Health - Single Session, or PATH-SS) that aims to provide relief for people who are suffering after experiencing a sexual assault. This research will explore whether this new psychothe…

   Stage

   Not phased

   Ages

   18 to 65

   Site

   Case Western Reserve University, Cleveland, Ohio

   Run by

   Case Western Reserve University

   See if you can join NCT06900712 on ClinicalTrials.gov

10. Neural and Psychiatric Consequences of Cannabis Use in Adolescents

    The goal of this study is to investigate the effects of cannabis on brain function among adolescents with depression.

    Stage

    Not phased

    Ages

    14 to 20

    Site

    University of Miami Clinical Research Building, Miami, Florida

    Locations

    2 in total

    Run by

    University of Miami

    See if you can join NCT06941298 on ClinicalTrials.gov

11. Evaluation of a Keto-Like Supplement on Brain Responses to Emotional Stimuli in Depression

    This study aims to determine whether a keto-like supplement relative to placebo results in functional brain changes during fMRI tasks evaluating positive and negative valence in individuals with moderate to severe depression. In this double-blind randomized placebo-controlled trial, 75 individuals …

    Stage

    Phase 2

    Ages

    18 to 65

    Site

    Laureate Institute for Brain Research, Tulsa, Oklahoma

    Run by

    Laureate Institute for Brain Research, Inc.

    See if you can join NCT06263660 on ClinicalTrials.gov

12. Sleep Mechanisms Of Regulating Emotions

    This project is the second phase of a two-phased project investigating the impact of a proven sleep intervention, Cognitive Behavioral Therapy for Insomnia (CBT-I) on engagement of the emotion regulation brain network as a putative mechanistic target.

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Stanford University, Palo Alto, California

    Run by

    Stanford University

    See if you can join NCT06373718 on ClinicalTrials.gov

13. Sleep to Reduce Incident Depression Effectively in Peripartum

    Perinatal depression (PND) is the most common complication in pregnancy and postpartum, which increases risk for adverse perinatal outcomes such as preterm birth, maternal suicidal thoughts, and impaired mother-infant bonding. Insomnia often precedes PND cases and may serve as an entry point for in…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Henry Ford Medical Center, Novi, Michigan

    Run by

    Henry Ford Health System

    See if you can join NCT06430333 on ClinicalTrials.gov

14. Sleep Health in U.S. Marines

    The goal of this study is to test a sleep health program designed specifically for U.S. Marine Corps personnel. Researchers want to determine if this program helps Marines improve the participants sleep quality and overall mental health. The study will evaluate whether the program improves sleep qu…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    San Diego State University, San Diego, California

    Run by

    San Diego State University

    See if you can join NCT07420205 on ClinicalTrials.gov

15. Feasibility and Safety of Ketamine for Suicidal Patients in the Emergency Department

    There is currently no readily available pharmacologic intervention for suicidal ideation, a true psychiatric emergency, in the Emergency Department (ED). Investigators aim to trial low-dose, intravenous ketamine, a drug with well-established use in treatment-resistant depression, for patients who p…

    Stage

    Phase 1

    Ages

    18 to 65

    Site

    University of Kansas Medical Center Emergency Department, Kansas City, Kansas

    Locations

    2 in total

    Run by

    Lindsay Maguire, MD

    See if you can join NCT06085937 on ClinicalTrials.gov

16. External Trigeminal Nerve Stimulation for Migraine Treatment in Pregnancy

    This online registry aims to understand the potential benefits and safety of external trigeminal nerve stimulation for the treatment of migraine in pregnant women. Women do not need to use external trigeminal nerve stimulation or any other form of migraine treatment to participate in the registry. …

    Stage

    Not phased

    Ages

    18 to 44

    Site

    https://public.smart-trial.co/#/public/649d77f0e8f8d0fb993d0c61/6626f6a04f0a3c7dd0860e14/662726d84f0a3c7dd08aeaa0/signup?lang=en-us&enforceLanguage=true, Darien, Connecticut

    Run by

    Cefaly Technology

    See if you can join NCT06788977 on ClinicalTrials.gov

17. Development of a College Student-Delivered Cognitive-Behavioral Therapy (CBT) Intervention for Rural High School Students

    This research is being done to find out the effectiveness, feasibility, and acceptability of a college student-delivered cognitive-behavioral therapy (CBT) intervention in high schools in rural Schuylkill County, Pennsylvania to treat mental health problems (i.e. depression and anxiety) in adolesce…

    Stage

    Not phased

    Ages

    13 to 18

    Site

    Penn State College of Medicine, Hershey, Pennsylvania

    Run by

    Milton S. Hershey Medical Center

    See if you can join NCT07240792 on ClinicalTrials.gov

18. Community-based Approach to Lowering Stress Through Mindfulness

    The goal of this clinical trial is to test a culturally adapted mindfulness-based stress reduction intervention in a community setting for African American adults with high blood pressure (hypertension) and depression. The main questions it aims to answer are: * Does participation in a culturally a…

    Stage

    Not phased

    Ages

    18 and older

    Site

    The Salvation Army Ray and Joan Kroc Corps Community Center Chicago, Chicago, Illinois

    Run by

    Northwestern University

    See if you can join NCT06987799 on ClinicalTrials.gov

19. SER Familia: A Family-Based Intervention Addressing Syndemic Conditions Among Latino Immigrant Families

    This study aims to prevent syndemic health conditions by decreasing acculturative stress and promoting resilience via SER Familia (Salud, Estrés y Resilencia en Familias/ Health, Stress, and Resilience in Families), a family-based intervention. SER Familia is a six-session intervention co-developed…

    Stage

    Not phased

    Ages

    12 to 100

    Site

    Duke School of Nursing, Durham, North Carolina

    Run by

    Duke University

    See if you can join NCT06627764 on ClinicalTrials.gov

20. Retrospective Analyses of TrakStar Database

    In this study, real-world data will be used to better understand the effects patient characteristics, symptoms and TMS protocol parameters have on clinical outcomes with NeuroStar TMS.

    Stage

    Not phased

    Ages

    5 to 120

    Site

    Neuronetics, Malvern, Pennsylvania

    Run by

    Neuronetics

    See if you can join NCT06917339 on ClinicalTrials.gov

21. Retrospective Analyses of the Greenbrook Database Evaluating Mental Health Treatments

    The study involves multiple retrospective analyses to understand the utilization of mental health treatments provided at Greenbrook and their effectiveness

    Stage

    Not phased

    Ages

    5 to 100

    Site

    Neuronetics, Malvern, Pennsylvania

    Run by

    Neuronetics

    See if you can join NCT06997549 on ClinicalTrials.gov

22. Transcranial Magnetic Stimulation for MCI

    The goal of this phase II study is to establish the dose-response curves of a safe and clinically feasible non-invasive brain stimulation technique (accelerated Transcranial Magnetic Stimulation (TMS)) to improve both depression and cognitive function in Mild Cognitive Impairment (MCI) patients wit…

    Stage

    Not phased

    Ages

    60 to 85

    Site

    Medical University of South Carolina, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT05992831 on ClinicalTrials.gov

23. Virtual Reality Intervention to Improve Psychological Symptom Burden for Cancer Patients Undergoing Treatment

    This clinical trial tests the safety, tolerability, and effectiveness of a virtual reality intervention to improve psychological symptom burden for cancer patients undergoing treatment. Virtual reality (VR) is a technology that allows users to experience and interact with three-dimensional, compute…

    Stage

    Not phased

    Ages

    18 to 90

    Site

    Mayo Clinic in Florida, Jacksonville, Florida

    Run by

    Mayo Clinic

    See if you can join NCT07221409 on ClinicalTrials.gov

24. SilverCloud as a School-Based Intervention for Vulnerable Youth

    The goal of this study is to test the efficacy and feasibility of a clinician-guided, app-based cognitive behavioral therapy (CBT) program, SilverCloud, as a school-based mental health intervention for vulnerable youth. An open trial of SilverCloud will be conducted to determine preliminary efficac…

    Stage

    Not phased

    Ages

    13 to 22

    Site

    NYU Langone Health, Brooklyn, New York

    Locations

    3 in total

    Run by

    NYU Langone Health

    See if you can join NCT06004414 on ClinicalTrials.gov

25. Brain Changes During Social Reward Psychotherapy for Mid- and Late-Life Suicidality

    The investigators hypothesized that during the 9-week course of Engage \& Connect treatment there will be an increase in brain functions of the Positive Valence System which in turn will lead to reduction in suicidality.

    Stage

    Not phased

    Ages

    50 to 80

    Site

    Weill Cornell Medicine, New York, New York

    Run by

    Weill Medical College of Cornell University

    See if you can join NCT05925322 on ClinicalTrials.gov