Depression Clinical Trials

229 studies are recruiting for depression in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 7

1. Ketamine for Pain, Opioid Use, and Mental Health in Orthopedic Trauma Patients

   The goal of this clinical trial is to learn if ketamine, given during surgery, can help improve recovery for adults with serious orthopedic trauma. The study will test whether ketamine reduces pain, lowers the need for opioids, and improves mental health outcomes like depression and post-traumatic …

   Stage

   Phase 4

   Ages

   18 to 65

   Site

   Texas Tech University Health Sciences Center Lubbock, Lubbock, Texas

   Locations

   2 in total

   Run by

   Texas Tech University Health Sciences Center

   See if you can join NCT06903819 on ClinicalTrials.gov

2. Cerebellar Stimulation and Cognitive Control

   The purpose of this study is to examine whether cerebellar stimulation can be used to improve cognitive deficits and mood in patients with schizophrenia, autism, bipolar disorder, Parkinson's disease, and major depression.

   Stage

   Not phased

   Ages

   18 to 90

   Site

   University of Iowa, Iowa City, Iowa

   Run by

   Krystal Parker, PhD

   See if you can join NCT03217110 on ClinicalTrials.gov

3. Readiness and Progress in Emotion Regulation Therapy

   This study is an open trial designed to examine individual changes that occur before, during, and after 6 modules of Emotion Regulation Therapy (ERT) delivered via telehealth for individuals in New York State who are experiencing elevated worry, rumination, or self-criticism.

   Stage

   Not phased

   Ages

   18 to 65

   Site

   Teachers College, Columbia University, New York, New York

   Run by

   Teachers College, Columbia University

   See if you can join NCT07478393 on ClinicalTrials.gov

4. Concurrent TMS-fMRI

   The goal of this clinical trial is to examine the neural mechanisms underlying transcranial magnetic stimulation (TMS) using concurrent functional magnetic resonance imaging (fMRI) in both healthy controls (HCs) and patients with high negative affect symptoms, such as depression. Approximately half…

   Stage

   Not phased

   Ages

   18 to 65

   Site

   University of Iowa Carver College of Medicine, Iowa City, Iowa

   Run by

   Jing Jiang

   See if you can join NCT06633913 on ClinicalTrials.gov

5. ACE-D Aim 3 Clinical Cognitive Trial to Enhance Translation in Depression

   The purpose of this study is to understand how a psychotropic medication called guanfacine affects brain network functioning in humans, and how this function interacts with cognitive impairments in people experiencing depressive symptoms.

   Stage

   Phase 2

   Ages

   18 to 60

   Site

   Stanford Psychiatry and Behavioral Sciences Department, Palo Alto, California

   Locations

   2 in total

   Run by

   Stanford University

   See if you can join NCT06408246 on ClinicalTrials.gov

6. Treatment of Depression Post-SCI

   Depression is more common after a spinal cord injury (SCI) than in the general population. Unfortunately, it is unknown how depression is typically treated in individuals with SCI or if commonly used treatment methods are effective. This study will investigate the safety and impact of a novel metho…

   Stage

   Not phased

   Ages

   18 to 70

   Site

   Medical University of South Carolina, Charleston, South Carolina

   Run by

   Medical University of South Carolina

   See if you can join NCT04263285 on ClinicalTrials.gov

7. Intracranial Investigation of Neural Circuity Underlying Human Mood

   Depression is one of the most common disorders of mental health, affecting 7-8% of the population and causing tremendous disability to afflicted individuals and economic burden to society. In order to optimize existing treatments and develop improved ones, the investigators need a deeper understand…

   Stage

   Not phased

   Ages

   21 to 70

   Site

   Baylor College of Medicine, Houston, Texas

   Run by

   Baylor College of Medicine

   See if you can join NCT05871372 on ClinicalTrials.gov

8. Cannabis, Linked Emotions, and Adolescent Risk Study

   The goal of this study is to disentangle relationships between acute cannabis use and withdrawal on proximal depression and suicide risk and recovery in adolescents ages 12-18 years by incorporating time-varying patterns of substance use, mood, and SI. This project aims to guide the development of …

   Stage

   Not phased

   Ages

   12 to 18

   Site

   Massachusetts General Hopsital, Boston, Massachusetts

   Run by

   Massachusetts General Hospital

   See if you can join NCT06576076 on ClinicalTrials.gov

9. Personalized Brain Stimulation to Treat Chronic Concussive Symptoms

   The goal of this study is to investigate a new treatment for chronic symptoms after concussion or mild traumatic brain injury in people aged 18-65 years old. Chronic symptoms could include dizziness, headache, fatigue, brain fog, memory difficulty, sleep disruption, irritability, or anxiety that oc…

   Stage

   Phase 2

   Ages

   18 to 65

   Site

   UCLA, Westwood, Los Angeles, California

   Run by

   University of California, Los Angeles

   See if you can join NCT06073886 on ClinicalTrials.gov

10. The Exhale Study: Treating Maternal Depression in an Urban Pediatric Asthma Clinic

    The goal of this clinical trial is to test the effectiveness and implementation of delivering Enhanced Brief Interpersonal Psychotherapy (IPT-B), an evidence-based maternal depression treatment, to mothers of children under the age of 18 in an urban pediatric asthma clinic. Researchers will compare…

    Stage

    Not phased

    Ages

    Any age

    Site

    Children's National Hospital, Washington D.C., District of Columbia

    Run by

    Children's National Research Institute

    See if you can join NCT06623981 on ClinicalTrials.gov

11. The BEAR Program for Women With Trauma Who Have Suicidal Thoughts

    The current study aims to test the feasibility of a new form of group therapy for women who have a history of interpersonal trauma and current suicidal ideation. The Building Empowerment and Resilience (BEAR) Therapeutic group has been adapted for women who have experienced trauma and have current …

    Stage

    Not phased

    Ages

    18 to 75

    Site

    Stanford University School of Medicine, Stanford, California

    Run by

    Stanford University

    See if you can join NCT07346638 on ClinicalTrials.gov

12. Computerized Cognitive Behavioral Therapies for Suicide Prevention and Depression

    This study plans to learn more about the use of one of two self-guided online cognitive behavioral therapy courses. One is focused on symptoms of depression and one is focused on history of suicidal thoughts and behaviors.

    Stage

    Phase 2

    Ages

    18 to 65

    Site

    Eastern Colorado Health Care System, Aurora, Colorado

    Run by

    VA Eastern Colorado Health Care System

    See if you can join NCT06375083 on ClinicalTrials.gov

13. Potential Benefits of Parent Child Interaction Therapy (PCIT)

    The goal of this study is to explore possible benefits of Parent-Child Interaction Therapy (PCIT). The main goals of the study are: * To investigate whether pre-survey measures of autonomic reactivity relate to the overall functioning of participants. * To examine the effects of PCIT To identify in…

    Stage

    Not phased

    Ages

    18 to 89

    Site

    UF Health Child Psychiatry, Gainesville, Florida

    Locations

    2 in total

    Run by

    University of Florida

    See if you can join NCT06827951 on ClinicalTrials.gov

14. Bringing the Outdoors In: Virtual Nature Walks for Depression in Multiple Sclerosis (MS) Patients

    This trial explores the use of immersive virtual reality (VR) nature-based experiences as a supplementary treatment for depression in individuals with progressive multiple sclerosis (MS). This study will evaluate the feasibility and efficacy of at-home VR deployment using the Apple Vision Pro, an a…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Michigan, Ann Arbor, Michigan

    Run by

    University of Michigan

    See if you can join NCT07392879 on ClinicalTrials.gov

15. Family Acceptance Project Online (Pilot RCT)

    Research shows that sexual and gender minority youth (SGMY) experience high rates of mental health problems and other challenges (e.g., social, academic). A major factor that leads to these challenges is family rejection (family behaviors and reactions that minimize, deny, ridicule and attempt to p…

    Stage

    Phase 2

    Ages

    14 and older

    Site

    University of Michigan, Ann Arbor, Michigan

    Run by

    University of Michigan

    See if you can join NCT06839859 on ClinicalTrials.gov

16. Treatment Research Investigating Depression Effects on Neuroimmune Targets (TRIDENT)

    The purpose of this randomized controlled trial is to understand how a cognitive-behavioral treatment (a form of psychological treatment) for depression changes the gut microbiome (micro-organisms that regulate the health of the gut), immune system, and the brain functioning in people living with H…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Miami Neuroimaging Facility, Coral Gables, Florida

    Locations

    2 in total

    Run by

    Florida International University

    See if you can join NCT05136703 on ClinicalTrials.gov

17. S.T.A.N.D. Alacrity Center Signature Project

    The purpose of this study is to evaluate clinical decision-making algorithms for (a) triaging to level of care and (b) adapting level of care in a low income, highly diverse sample of community college students at East Los Angeles College (ELAC). The target enrollment is 200 participants per year, …

    Stage

    Not phased

    Ages

    18 to 40

    Site

    East Los Angeles College, Los Angeles, California

    Run by

    University of California, Los Angeles

    See if you can join NCT05591937 on ClinicalTrials.gov

18. Filipino Family Health Initiative 1.0

    The goal of this clinical trial is to test the effectiveness of an online parenting program on Filipino parents living in California. The main aims are to: * Test the effectiveness of the online Incredible Years® model of parent training and its impact on primary outcomes. * Determine the impact of…

    Stage

    Not phased

    Ages

    8 and older

    Site

    Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, California

    Run by

    Kaiser Permanente

    See if you can join NCT06569303 on ClinicalTrials.gov

19. Impact of Depression on Thermoregulation

    The purpose of this study is to determine if, compared to non-depressed adults, differences exist in skin blood flow and sweating responses to passive heat stress in adults with clinically diagnosed depression, those with depression who are prescribed and taking SSRIs and those with depression who …

    Stage

    Not phased

    Ages

    18 to 40

    Site

    Noll Laboratory, University Park, Pennsylvania

    Run by

    Penn State University

    See if you can join NCT06805851 on ClinicalTrials.gov

20. Pharmacy-led Transitions of Care Intervention to Improve Medication Adherence

    Socioeconomically disadvantaged populations with multiple chronic conditions have high rates of nonadherence to essential chronic disease medications after hospital discharge. Medication nonadherence after hospital discharge is significantly associated with increased mortality and higher rates of r…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Tennessee Health Science Center/Regional One Health, Memphis, Tennessee

    Locations

    2 in total

    Run by

    University of Tennessee

    See if you can join NCT06374277 on ClinicalTrials.gov

21. Dopaminergic Therapy for Anhedonia - 2

    The purpose of this 8-week, double-blind, placebo-controlled, study is to explore new treatment options for people with depression who have high inflammation and anhedonia. Seventy male and female participants with depression, between 25-55 years of age, with higher levels of inflammation and anhed…

    Stage

    Phase 4

    Ages

    25 to 55

    Site

    Emory University Hospital, Atlanta, Georgia

    Run by

    Emory University

    See if you can join NCT06075771 on ClinicalTrials.gov

22. Parent Encouragement And Coaching of Happiness in Youth

    The goal of this mechanistic clinical trial is to examine whether parent-coaching aimed at increasing child positive affect will increase child neural response to reward. The main questions it aims to answer are: Aim 1. Characterize child neural reward response and its relation to maternal socializ…

    Stage

    Not phased

    Ages

    4 to 99

    Site

    University of Pittsburgh, Pittsburgh, Pennsylvania

    Run by

    University of Pittsburgh

    See if you can join NCT06725160 on ClinicalTrials.gov

23. Amplitude Titration to Improve ECT Clinical Outcomes

    A randomized controlled trial will compare hippocampal neuroplasticity, antidepressant, and cognitive outcomes between individualized amplitude and fixed 800 mA amplitude ECT in older depressed subjects (n = 25 per group, n = 50 total). Relative to fixed 800 mA ECT: H1: Individualized amplitude arm…

    Stage

    Not phased

    Ages

    50 and older

    Site

    University of New Mexico Health Science Center, Albuquerque, New Mexico

    Run by

    University of New Mexico

    See if you can join NCT05699226 on ClinicalTrials.gov

24. Effectiveness, Implementation, and Cost of Cognitive Processing Therapy in Prisons

    Addiction and trauma exposure are common among the 5.5 million people (1 in 47 adults) in the U.S. who are in prison or under supervision. About 85% of people in prison have a substance use disorder or are there for a drug-related crime, and many have experienced serious trauma before being incarce…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Northeast Arkansas Community Corrections Center (NEACC), Osceola, Arkansas

    Locations

    6 in total

    Run by

    University of Arkansas

    See if you can join NCT06923423 on ClinicalTrials.gov

25. Mindfulness and Meditation Based Lactation Education on Maternal Breastmilk in the Neonatal ICU

    The purpose of this research is to investigate associations between mindfulness and meditation techniques and changes in maternal breastmilk in the mother pumping for her NICU infant.

    Stage

    Not phased

    Ages

    20 and older

    Site

    Mayo Clinic in Rochester, Rochester, Minnesota

    Run by

    Mayo Clinic

    See if you can join NCT07351799 on ClinicalTrials.gov