Depression Clinical Trials

229 studies are recruiting for depression in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 9

1. fMRI Accelerated TMS Depression

   This study aims to investigate whether phenotypic-related brain states revealed by a novel INSCAPE ("Individualized Network-based Single-frame Coactivation Pattern Estimation") neuroimaging method in Major Depressive Disorder (MDD) patients can track brain recovery of MDD patients over an accelerat…

   Stage

   Not phased

   Ages

   18 to 65

   Site

   30 Bee Street, Charleston, South Carolina

   Run by

   Medical University of South Carolina

   See if you can join NCT06562153 on ClinicalTrials.gov

2. Effect of Vagal Nerve Stimulation on Gastric Motor Functions

   The specific aim of this study is to compare simultaneous assessment of gastric emptying and gastric accommodation in response to a caloric meal In patients who have previously undergone activation of left cervical VNS for the treatment of medication-resistant depression. Our hypothesis is that cer…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Minnesota, Minneapolis, Minnesota

   Locations

   2 in total

   Run by

   Mayo Clinic

   See if you can join NCT06038929 on ClinicalTrials.gov

3. Hybrid Type 1 Randomized Pilot Trial of a Peer-led Family and Social Strengthening Group Intervention for Refugee Families

   The proposed study draws on prior research to evaluate the feasibility, acceptability and explore preliminary effectiveness of Coffee and Family Education and Support, Version (CAFES2) using a pilot randomized type 1 hybrid effectiveness-implementation design. CAFES2 is a peer-led family and social…

   Stage

   Not phased

   Ages

   12 to 55

   Site

   University of Illinios Chicago, Chicago, Illinois

   Run by

   University of Illinois at Chicago

   See if you can join NCT06261463 on ClinicalTrials.gov

4. Cognitive Behavioral and Faith Fellowship to Improve Thy Health

   Investigators will examine the efficacy of a faith-based depression intervention, in reducing symptoms of depression among African American adults in Wisconsin. Twelve church groups, each with 10 people (N=120) will be invited to participate. This intervention will be the first evidence-based, fait…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Wisconsin - Madison, Madison, Wisconsin

   Locations

   3 in total

   Run by

   University of Wisconsin, Madison

   See if you can join NCT06292637 on ClinicalTrials.gov

5. M-O-M-S on the Bayou: Implementation of an Intervention for Mental Health in Pregnancy

   Disasters have negative effects in the short term (physical trauma, adverse environmental exposures, and unstable housing) and the long term (relocation, changes in family functioning, and negative economic effects), which interact with social determinants to worsen health among the most vulnerable…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Tulane University, New Orleans, Louisiana

   Run by

   Tulane University

   See if you can join NCT05838404 on ClinicalTrials.gov

6. Evaluation of the PACE/PACENET BHL Clinical Program

   The SUpporting Seniors Receiving Treatment And INtervention (SUSTAIN) program is a telephone-based clinical service designed to help identify and manage behavioral health issues among PACE/PACENET enrollees. The purpose of the current project is to a) explore moderators of treatment response among …

   Stage

   Not phased

   Ages

   65 and older

   Site

   Department of Psychiatry (Center for Psychotherapy Research), University of Pennsylvania, Philadelphia, Pennsylvania

   Run by

   University of Pennsylvania

   See if you can join NCT02463266 on ClinicalTrials.gov

7. Evaluating the Impact of Focused Muscle Contraction Therapy in U.S. Veterans

   This research study is being done to investigate if the GH Method exercise program positively affects body composition, improves physical abilities and can improve the overall sense of wellbeing (e.g. depression, PTSD, etc.) in U.S. Veterans. Subjects will be asked to complete 94 total visits (four…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Illinois at Chicago, Chicago, Illinois

   Run by

   University of Illinois at Chicago

   See if you can join NCT05094297 on ClinicalTrials.gov

8. Comparing Cognitive-Behavioral Therapy Versus Mindfulness-Based Therapy for Autistic Adults

   Autistic adults are at a greater risk for mental health problems compared to the general population, with 50% meeting criteria for a co-occurring psychiatric condition. Depression and anxiety are the most common of these conditions among autistic adults, contributing to long-term detrimental effect…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

   Locations

   2 in total

   Run by

   University of North Carolina, Chapel Hill

   See if you can join NCT06060860 on ClinicalTrials.gov

9. Confirmatory Efficacy Trial of Attention Bias Modification for Depression

   The goal of this clinical trial is to compare the efficacy of two related, but different ABM (Attention Biased Modification) treatments for depression in adults with elevated symptoms of depression. The main aims are: * Aim 1:examine whether gamified ABM leads to greater change in the primary and s…

   Stage

   EARLY_Phase 1

   Ages

   18 to 70

   Site

   Institute for Mental Health Research, Austin, Texas

   Run by

   University of Texas at Austin

   See if you can join NCT06361095 on ClinicalTrials.gov

10. Implementation of Problem-Solving Treatment in Community Health Centers (PST-Aid)

    Although evidence-based clinical interventions (CI) are a preferred treatment option for patients with depression, CIs are rarely available in community primary care settings. When available, CIs are often delivered with poor fidelity and abandoned by practitioners during the initial months post-tr…

    Stage

    Not phased

    Ages

    18 and older

    Site

    OCHIN, Inc., Portland, Oregon

    Run by

    University of Washington

    See if you can join NCT06494384 on ClinicalTrials.gov

11. To Improve Depressive Symptoms Using a Web-App

    This study is being done to answer a question on whether a Web App-based Lifestyle Physical Activity Promotion Program is effective in improving depressive symptom experience of midlife Korean American women (WPAPP-K).

    Stage

    Not phased

    Ages

    40 to 60

    Site

    The University of Texas at Austin, Austin, Texas

    Run by

    University of Texas at Austin

    See if you can join NCT05405803 on ClinicalTrials.gov

12. CBT Enhanced With Social Cognitive Training vs. CBT Only With Depressed Youth

    Depression in youth is a serious public health concern for which more personalized treatments are needed. This randomized controlled trial will test the effect of an intervention aimed at enhancing social cognitive capacities (e.g., ability to take another's perspective), thereby making treatment o…

    Stage

    Not phased

    Ages

    13 to 17

    Site

    Judy Garber, Nashville, Tennessee

    Run by

    Vanderbilt University

    See if you can join NCT05456035 on ClinicalTrials.gov

13. Community Park-Based Programs for Health Promotion: Fit2Play Prospective Cohort Study

    The Fit2Play prospective cohort study examines the effects of a park-based youth physical activity afterschool program on youth participant fitness and mental health outcomes. Duke will perform a secondary analysis of the data collected as part of the Fit2Play prospective cohort study run by Miami-…

    Stage

    Not phased

    Ages

    6 to 14

    Site

    Miami-Dade County Parks, Recreation and Open Spaces Department, Miami, Florida

    Run by

    Duke University

    See if you can join NCT06595251 on ClinicalTrials.gov

14. Effects of Spirulina Supplementation on Mental Health in Healthy Adults

    Spirulina platensis is a form of cyanobacteria, a blue-green algae, and is a superfood most known for being rich in protein, vitamins and minerals, and healthful phytochemicals. Spirulina supports brain health through neuroprotection offered by its antioxidants, anti-inflammatory properties, and ho…

    Stage

    Not phased

    Ages

    16 to 65

    Site

    850 PBC, Phoenix, Arizona

    Run by

    Arizona State University

    See if you can join NCT06936202 on ClinicalTrials.gov

15. Cannabis for Palliative Care in Cancer

    Many cancer patients suffer from pain, sleep, and mood problems and are using cannabis to relieve these symptoms. Cannabis may provide such relief but may also produce negative side effects including cognitive impairment, an especially problematic issue for cancer patients, indicating more research…

    Stage

    Phase 2

    Ages

    25 and older

    Site

    Anschutz Health Sciences Building, Aurora, Colorado

    Run by

    University of Colorado, Boulder

    See if you can join NCT06266611 on ClinicalTrials.gov

16. Project 2: Optimizing Engagement and Outcomes in STAND Digital Therapy

    The goal is to optimize peer coaching in order to optimize engagement and outcomes in digital therapy. The unmet mental health needs of community college students are staggering and a growing body of research demonstrates that therapy provided digitally with the assistance of trained community memb…

    Stage

    Not phased

    Ages

    18 to 40

    Site

    East Los Angeles College, Los Angeles, California

    Run by

    University of California, Los Angeles

    See if you can join NCT05908565 on ClinicalTrials.gov

17. Amplification of Positivity for Alcohol Use

    The proposed study consists of two phases. During Phase 1, the investigators will recruit a small sample of participants to complete a psychosocial intervention termed Amplification of Positivity (AMP) for individuals experiencing comorbid depression or anxiety disorders and alcohol use disorder (A…

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Laureate Institute for Brain Research, Tulsa, Oklahoma

    Run by

    Laureate Institute for Brain Research, Inc.

    See if you can join NCT06030154 on ClinicalTrials.gov

18. Cocooned Moms Study

    The Cocooned Moms Study is a pre- and post-design study primarily aimed at reducing stress, depressive symptoms, and blood pressure among expectant Black women by providing them with free access to the InovCares mobile app. InovCares is a culturally-sensitive telehealth platform designed for commun…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University Of Miami, Miami, Florida

    Locations

    2 in total

    Run by

    InovCares Connected Comprehensive Healthcare Corporation

    See if you can join NCT06968650 on ClinicalTrials.gov

19. Brain Connectivity in Depression

    This study originally included 140 subjects with medication-refractory depression undergoing 10 Hz transcranial magnetic stimulation (10Hz-TMS) to the left dorsal lateral prefrontal cortex (DLPFC), with the goal of having 60 completers with good quality data. Subjects were recruited from the TMS cl…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Brigham and Women's Hospital, Boston, Massachusetts

    Locations

    4 in total

    Run by

    Brigham and Women's Hospital

    See if you can join NCT03276793 on ClinicalTrials.gov

20. Functional Connectivity Alterations in Suicidal Patients Among Opioid Users

    Suicide is the 10th leading cause of death for Americans of all ages and more people in the United States now die from suicide than die from car accidents. Although death by firearm remains the most common cause of suicide in the United States, an intentional overdose of substance usage such as pre…

    Stage

    Not phased

    Ages

    18 to 64

    Site

    The Menninger Clinic, Houston, Texas

    Run by

    Baylor College of Medicine

    See if you can join NCT05489042 on ClinicalTrials.gov

21. Glucose Variability and Cognition in Prediabetes

    This study examines the association of variability in glucose values over a 10-day period with cognitive function and functional status among individuals with prediabetes, aged 50 or older.

    Stage

    Not phased

    Ages

    50 and older

    Site

    Baltimore VA Geriatric Research Education and Clinical Center (GRECC), Baltimore, Maryland

    Run by

    University of Maryland, Baltimore

    See if you can join NCT04201600 on ClinicalTrials.gov

22. Veteran's Perceptions of Ketamine-Assisted Psychotherapy for Depression and End-of-Life

    The goal of this exploratory, mixed-method design study is to gather qualitative and quantitative data obtained through interviews and questionnaires with veterans who are currently enrolled at the VA for healthcare. The main question this study aims to answer is: How do veterans aged 65+ who are e…

    Stage

    Not phased

    Ages

    65 and older

    Site

    Stratton VA Medical Center, Albany, New York

    Run by

    Albany Research Institute, Inc.

    See if you can join NCT06824532 on ClinicalTrials.gov

23. Combined Transcranial Magnetic Stimulation and Therapy for MTBI Related Headaches

    This study will assess the combined effectiveness of repetitive transcranial magnetic stimulation (rTMS) and telehealth based therapy in helping manage mild traumatic brain injury (mTBI) related headaches. The investigators hypothesize that active rTMS combined with telehealth therapy will provide …

    Stage

    Not phased

    Ages

    18 to 65

    Site

    VA San Diego Healthcare System, San Diego, California

    Run by

    Veterans Medical Research Foundation

    See if you can join NCT05176392 on ClinicalTrials.gov

24. Brief Interventions for Coping with Distress

    This study is being done to compare the effectiveness of three different skills trainings to cope with distress. These three trainings are: 1) an attention skills training, 2) an attention and reflective thought skills training, and 3) a health and wellness education training.

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Teachers College, Columbia University, New York, New York

    Run by

    Teachers College, Columbia University

    See if you can join NCT05779761 on ClinicalTrials.gov

25. Lay-Delivered Behavioral Activation in Senior Centers

    In response to large numbers of senior center clients who suffer untreated depression and the dearth of geriatric mental health providers, the investigators have simplified Behavioral Activation to be delivered by lay volunteers ("Do More, Feel Better"; DMFB). The focus of Behavioral Activation is …

    Stage

    Not phased

    Ages

    60 and older

    Site

    Brandon Senior Center, Brandon, Florida

    Locations

    25 in total

    Run by

    University of Washington

    See if you can join NCT04621877 on ClinicalTrials.gov