Ulcerative Colitis Clinical Trials

47 studies are recruiting for ulcerative colitis in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. A Study to Evaluate Efficacy and Safety of MK-8690 in Participants With Moderately to Severely Active Ulcerative Colitis (MK-8690-002)

   The purpose of this protocol is to evaluate the efficacy of MK-8690 in participants with moderately to severely active ulcerative colitis. The primary hypothesis is that MK-8690 is superior to placebo with respect to the proportion of participants achieving clinical remission per Modified Mayo Scor…

   Stage

   Phase 2

   Ages

   18 to 75

   Site

   Clinnova Research ( Site 1042), Anaheim, California

   Locations

   35 in total

   Run by

   Merck Sharp & Dohme LLC

   See if you can join NCT07463183 on ClinicalTrials.gov

2. Study of Advanced Therapies for the Treatment of Adult Participants With Moderately to Severely Active Crohn's Disease or Ulcerative Colitis

   Crohn's disease (CD) and Ulcerative colitis (UC) are 2 types of inflammatory bowel diseases which cause long-lasting, severe inflammation (redness, swelling) in the digestive tract. CD can affect any part of the digestive tract causing many different symptoms including belly pain, diarrhea, tiredne…

   Stage

   Phase 2

   Ages

   18 to 75

   Site

   Digestive Health Specialists /ID# 280827, Dothan, Alabama

   Locations

   36 in total

   Run by

   AbbVie

   See if you can join NCT07697456 on ClinicalTrials.gov

3. A Study to Learn More About How Risankizumab Works in Young Participants With Ulcerative Colitis

   Ulcerative colitis (UC) is a type of inflammatory bowel disease that causes inflammation and bleeding from the lining of the rectum and colon (large intestine). This study will assess how Risankizumab moves through the body as well as how safe and effective it is in treating pediatric participants …

   Stage

   Phase 3

   Ages

   2 to 17

   Site

   Phoenix Children's Hospital /ID# 273015, Phoenix, Arizona

   Locations

   64 in total

   Run by

   AbbVie

   See if you can join NCT07071519 on ClinicalTrials.gov

4. Immune Regulation in Ulcerative Colitis or Crohn s Disease

   This study will investigate in patients with Crohn s disease and ulcerative colitis how the body s immune system controls inflammation in the gastrointestinal tract (stomach and intestines)-specifically, how lymphocytes (a type of white blood cell) function in inflammatory responses. This protocol …

   Stage

   Not phased

   Ages

   0 to 75

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Allergy and Infectious Diseases (NIAID)

   See if you can join NCT00001184 on ClinicalTrials.gov

5. Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO

   This phase Ib trial studies the side effects of nivolumab and to see how well it works alone and in combination with other treatments, such as ipilimumab, cabozantinib, platinum containing therapy, and fluoropyrimidine, in treating patients with autoimmune disorders and cancer that has spread from …

   Stage

   Phase 1

   Ages

   18 and older

   Site

   University of California Davis Comprehensive Cancer Center, Sacramento, California

   Locations

   52 in total

   Run by

   National Cancer Institute (NCI)

   See if you can join NCT03816345 on ClinicalTrials.gov

6. A Study of Vedolizumab in Adults With Ulcerative Colitis (UC) or Crohn's Disease (CD) in the Community Setting

   Ulcerative Colitis (UC) and Crohn's Disease (CD) are long-term conditions in the gut that can cause diarrhea, swelling (inflammation), bleeding from the anus, and belly pain. The main aim of this study is to check for how many participants with UC and CD signs and symptoms disappear after 3.5 month…

   Stage

   Phase 4

   Ages

   18 to 80

   Site

   Gastro Health, Birmingham, Alabama

   Locations

   101 in total

   Run by

   Takeda

   See if you can join NCT06581328 on ClinicalTrials.gov

7. A Maintenance Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Ulcerative Colitis

   This is a multicenter, randomized, double-blind, placebo-controlled Phase 3 maintenance study to evaluate the efficacy and safety of duvakitug in participants with moderately to severely active Ulcerative Colitis (UC). Study details include: The study duration may be up to 286 weeks including: * 40…

   Stage

   Phase 3

   Ages

   16 to 80

   Site

   Del Sol Research Management, LLC - Site Number: 8400012, Tucson, Arizona

   Locations

   55 in total

   Run by

   Sanofi

   See if you can join NCT07185009 on ClinicalTrials.gov

8. Microbiome-targeted Diet Therapy in Ulcerative Colitis

   The central objective of this proposal is to test a novel diet capable of meeting the elevated protein requirements in ulcerative colitis (UC), while simultaneously decreasing microbial hydrogen sulfide (H2S) production in the colon with fiber.

   Stage

   Not phased

   Ages

   18 and older

   Site

   University Of Minnesota, Minneapolis, Minnesota

   Run by

   University of Minnesota

   See if you can join NCT07520461 on ClinicalTrials.gov

9. Aquamin® for Prevention of Ulcerative Colitis J-Pouch-associate Intestinal Inflammation

   Ulcerative colitis (UC) is a disease that causes long-term inflammation in the digestive tract, and many people with this condition require surgery to remove the colon and create a new J-pouch for stool. Some patients develop a problem called pouchitis, where this pouch becomes inflamed. Current tr…

   Stage

   Phase 2

   Ages

   18 to 80

   Site

   University of Michigan, Ann Arbor, Michigan

   Run by

   Muhammad N Aslam, MD

   See if you can join NCT07501078 on ClinicalTrials.gov

10. LY4268989 (MORF-057) Co-Administered With Mirikizumab in Adults With Moderately to Severely Active Ulcerative Colitis:

    The main purpose of the study is to evaluate the effectiveness and safety of LY4268989 when given with mirikizumab compared to mirikizumab alone in adult participants with moderately to severely active ulcerative colitis (UC). Study participation will last approximately 118 weeks, including 104 wee…

    Stage

    Phase 2

    Ages

    18 to 80

    Site

    Mayo Clinic in Arizona - Scottsdale, Scottsdale, Arizona

    Locations

    147 in total

    Run by

    Eli Lilly and Company

    See if you can join NCT07186101 on ClinicalTrials.gov

11. Mirikizumab Administered at the Same Time as Tirzepatide in Adult Participants With Moderately to Severely Active Ulcerative Colitis and Obesity or Overweight: Phase 3b Study

    The main purpose of this study is to show whether in these individuals, treatment with both mirikizumab and tirzepatide, compared with treatment with mirikizumab and placebo, leads to decrease or disappearance of UC symptoms, and loss of at least one-tenth of the overall body weight. Participation …

    Stage

    Phase 3

    Ages

    18 to 70

    Site

    Digestive Health Specialists, Dothan, Alabama

    Locations

    187 in total

    Run by

    Eli Lilly and Company

    See if you can join NCT06937086 on ClinicalTrials.gov

12. Piloting an Insomnia Treatment in Patients With Ulcerative Colitis

    The goal of this clinical trial is to learn if telehealth-based Cognitive Behavioral Therapy for Insomnia (CBT-I) adapted for Ulcerative Colitis (UC) works to treat insomnia in adults with UC. The main questions it aims to answer are: * Is telehealth-based CBT-I adapted for UC feasible and acceptab…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire

    Run by

    Dartmouth-Hitchcock Medical Center

    See if you can join NCT07428629 on ClinicalTrials.gov

13. A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics (PK) of RO7837195 in Participants With Moderately to Severely Active Ulcerative Colitis (UC)

    The purpose of this study is to evaluate the efficacy of RO7837195 compared with placebo in participants with moderately to severely active ulcerative colitis for whom prior treatment with conventional and/or advanced therapies has failed.

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Gastro Care Institute, Lancaster, California

    Locations

    106 in total

    Run by

    Genentech, Inc.

    See if you can join NCT06979336 on ClinicalTrials.gov

14. A Study of Long-acting Antibodies Alone and in Combinations for Moderate to Severe Ulcerative Colitis

    This is a Phase 2, multicenter, proof-of-concept platform study in adult participants with moderately to severely active ulcerative colitis (UC). The primary goal of the study is to assess the efficacy and safety of multiple interventions following intravenous (IV) induction and subcutaneous (SC) m…

    Stage

    Phase 2

    Ages

    18 to 75

    Site

    Site 024, Canoga Park, California

    Locations

    267 in total

    Run by

    Spyre Therapeutics, Inc.

    See if you can join NCT07012395 on ClinicalTrials.gov

15. A Master Protocol (AMAZ): A Study of Mirikizumab (LY3074828) in Pediatric Participants With Ulcerative Colitis or Crohn's Disease (SHINE-ON)

    The main purpose of this study is to evaluate the long-term efficacy of mirikizumab in pediatric participants with ulcerative colitis (UC) or Crohn's disease (CD). The study will last about 172 weeks and may include up to 44 visits. Additional treatment may be available to participants via a Contin…

    Stage

    Phase 3

    Ages

    2 to 19

    Site

    UCSF Medical Center at Mission Bay, San Francisco, California

    Locations

    68 in total

    Run by

    Eli Lilly and Company

    See if you can join NCT04844606 on ClinicalTrials.gov

16. A Study to Test Whether BI 3032950 Helps People With Ulcerative Colitis

    Adults between 18 and 80 years of age with ulcerative colitis can participate in this study. This is a study for people for whom previous treatment was not successful or who stopped previous treatment. The purpose of this study is to find out whether BI 3032950 helps people with ulcerative colitis.…

    Stage

    Phase 2

    Ages

    18 to 80

    Site

    Peak Gastroenterology Associates, Colorado Springs, Colorado

    Locations

    41 in total

    Run by

    Boehringer Ingelheim

    See if you can join NCT06636656 on ClinicalTrials.gov

17. An Induction Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Ulcerative Colitis

    This is a multinational, multicenter, randomized, double-blind, placebo-controlled, Phase 3 induction study to evaluate the efficacy and safety of duvakitug in participants with moderately to severely active Ulcerative Colitis (UC). Study details include: The study duration may be up to 35 weeks wi…

    Stage

    Phase 3

    Ages

    16 to 80

    Site

    Onyx Clinical Research - Site Number: 8400021, Peoria, Arizona

    Locations

    219 in total

    Run by

    Sanofi

    See if you can join NCT07184996 on ClinicalTrials.gov

18. A Study of Vedolizumab With Tofacitinib in Adults With Ulcerative Colitis (UC)

    The main aim of this study is to learn about the effect of treatment with vedolizumab IV (vedolizumab) together with tofacitinib in adults with moderate and severe ulcerative colitis (UC). Another aim is to learn about treatment with Vedolizumab alone after the double treatment. All participants wi…

    Stage

    Phase 4

    Ages

    18 to 65

    Site

    Digestive Health Specialsits, Dothan, Alabama

    Locations

    46 in total

    Run by

    Takeda

    See if you can join NCT06095128 on ClinicalTrials.gov

19. Treat-to-Target of Endoscopic Remission in Patients With IBD in Symptomatic Remission

    The purpose of this study is to compare the effectiveness and safety of a strategy of switching to an alternative targeted immunomodulator (TIM) therapy to treat to a target of endoscopic remission, versus continuing index TIM in patients with inflammatory bowel disease (IBD) (Crohn's disease or ul…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Mayo Clinic Arizona, Scottsdale, Arizona

    Locations

    24 in total

    Run by

    Mayo Clinic

    See if you can join NCT05230173 on ClinicalTrials.gov

20. BOOM-IBD2 Pivotal Clinical Trial

    Ulcerative colitis is a long-lasting condition that causes swelling and sores in the large intestine. This study tests whether a small device placed under the skin can help reduce bowel urgency in people with ulcerative colitis. The investigational device sends mild signals to a nerve near the tail…

    Stage

    Not phased

    Ages

    18 to 85

    Site

    Gastroenterology Medical Clinic (Objective Health), Folsom, California

    Locations

    19 in total

    Run by

    Boomerang Medical

    See if you can join NCT06571669 on ClinicalTrials.gov

21. A Study of Vedolizumab in Children and Teenagers With Ulcerative Colitis or Crohn's Disease

    The main aim of this study is to learn how the body of a child or teenager with moderately to severely active ulcerative colitis (UC) or Crohn's disease (CD) processes vedolizumab (pharmacokinetics) given just under the skin subcutaneously (SC). The participants will be treated with vedolizumab for…

    Stage

    Phase 3

    Ages

    2 to 17

    Site

    Children's Hospital Of Orange County, Orange, California

    Locations

    54 in total

    Run by

    Takeda

    See if you can join NCT06100289 on ClinicalTrials.gov

22. A Study of Eltrekibart and Mirikizumab in Adult Patients With Moderately to Severely Active Ulcerative Colitis

    The main purpose of this study is to determine the safety and efficacy of eltrekibart and mirikizumab in adult participants with moderately to severely active ulcerative colitis (UC).

    Stage

    Phase 2

    Ages

    18 to 75

    Site

    Applied Research Center of Arkansas, Little Rock, Arkansas

    Locations

    207 in total

    Run by

    Eli Lilly and Company

    See if you can join NCT06598943 on ClinicalTrials.gov

23. Developing a Self-Management Intervention to Improve Health Outcomes for Patients With Inflammatory Bowel Disease

    This research is studying whether changing an individual's behaviors may have an impact as a treatment or outcome for inflammatory bowel disease. This research will increase the understanding of the role of a self-management program in improving health and health-related quality of life for patient…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Micigan, Ann Arbor, Michigan

    Run by

    University of Michigan

    See if you can join NCT07456566 on ClinicalTrials.gov

24. Treatment of UC With Novel Therapeutics

    This study is a clinical trial being done to investigate the efficacy of drug BRS201 as a treatment in patients with active mild ulcerative colitis. Participation in this study will take 12 weeks long and the study is structured as a crossover study in which participants will take the study drug fo…

    Stage

    Phase 2

    Ages

    18 to 75

    Site

    Brigham and Women's Hospital, Chestnut Hill, Massachusetts

    Run by

    Brigham and Women's Hospital

    See if you can join NCT06420375 on ClinicalTrials.gov

25. A Study to Evaluate Etrasimod Treatment in Adolescents With Ulcerative Colitis

    The purpose of this study is to determine the safety, efficacy, and pharmacokinetics (PK) of etrasimod for the treatment of moderately to severely active ulcerative colitis in adolescents (≥ 12 years up to < 18 years of age). Participants who will complete the total 52-week treatment period will ha…

    Stage

    Phase 2

    Ages

    12 to 17

    Site

    Valley View Wellness Medical Center, Garden Grove, California

    Locations

    45 in total

    Run by

    Pfizer

    See if you can join NCT05287126 on ClinicalTrials.gov