Ulcerative Colitis Clinical Trials in Orlando, Florida

12 studies are recruiting for ulcerative colitis in Orlando, Florida right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. A Study to Evaluate Efficacy and Safety of MK-8690 in Participants With Moderately to Severely Active Ulcerative Colitis (MK-8690-002)

   The purpose of this protocol is to evaluate the efficacy of MK-8690 in participants with moderately to severely active ulcerative colitis. The primary hypothesis is that MK-8690 is superior to placebo with respect to the proportion of participants achieving clinical remission per Modified Mayo Scor…

   Stage

   Phase 2

   Ages

   18 to 75

   Site

   AdventHealth Orlando ( Site 1074), Orlando, Florida

   Locations

   35 in total

   Run by

   Merck Sharp & Dohme LLC

   See if you can join NCT07463183 on ClinicalTrials.gov

2. Study of Advanced Therapies for the Treatment of Adult Participants With Moderately to Severely Active Crohn's Disease or Ulcerative Colitis

   Crohn's disease (CD) and Ulcerative colitis (UC) are 2 types of inflammatory bowel diseases which cause long-lasting, severe inflammation (redness, swelling) in the digestive tract. CD can affect any part of the digestive tract causing many different symptoms including belly pain, diarrhea, tiredne…

   Stage

   Phase 2

   Ages

   18 to 75

   Site

   Digestive And Liver Center Of Florida - Orlando /ID# 280924, Orlando, Florida

   Locations

   36 in total

   Run by

   AbbVie

   See if you can join NCT07697456 on ClinicalTrials.gov

3. A Study of Vedolizumab in Adults With Ulcerative Colitis (UC) or Crohn's Disease (CD) in the Community Setting

   Ulcerative Colitis (UC) and Crohn's Disease (CD) are long-term conditions in the gut that can cause diarrhea, swelling (inflammation), bleeding from the anus, and belly pain. The main aim of this study is to check for how many participants with UC and CD signs and symptoms disappear after 3.5 month…

   Stage

   Phase 4

   Ages

   18 to 80

   Site

   Endoscopic Research, Inc., Orlando, Florida

   Locations

   101 in total

   Run by

   Takeda

   See if you can join NCT06581328 on ClinicalTrials.gov

4. LY4268989 (MORF-057) Co-Administered With Mirikizumab in Adults With Moderately to Severely Active Ulcerative Colitis:

   The main purpose of the study is to evaluate the effectiveness and safety of LY4268989 when given with mirikizumab compared to mirikizumab alone in adult participants with moderately to severely active ulcerative colitis (UC). Study participation will last approximately 118 weeks, including 104 wee…

   Stage

   Phase 2

   Ages

   18 to 80

   Site

   Digestive and Liver Center of Florida, Orlando, Florida

   Locations

   147 in total

   Run by

   Eli Lilly and Company

   See if you can join NCT07186101 on ClinicalTrials.gov

5. Mirikizumab Administered at the Same Time as Tirzepatide in Adult Participants With Moderately to Severely Active Ulcerative Colitis and Obesity or Overweight: Phase 3b Study

   The main purpose of this study is to show whether in these individuals, treatment with both mirikizumab and tirzepatide, compared with treatment with mirikizumab and placebo, leads to decrease or disappearance of UC symptoms, and loss of at least one-tenth of the overall body weight. Participation …

   Stage

   Phase 3

   Ages

   18 to 70

   Site

   Orlando Health, Orlando, Florida

   Locations

   187 in total

   Run by

   Eli Lilly and Company

   See if you can join NCT06937086 on ClinicalTrials.gov

6. An Induction Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Ulcerative Colitis

   This is a multinational, multicenter, randomized, double-blind, placebo-controlled, Phase 3 induction study to evaluate the efficacy and safety of duvakitug in participants with moderately to severely active Ulcerative Colitis (UC). Study details include: The study duration may be up to 35 weeks wi…

   Stage

   Phase 3

   Ages

   16 to 80

   Site

   Orlando Health, Inc. - Site Number: 8400084, Orlando, Florida

   Locations

   219 in total

   Run by

   Sanofi

   See if you can join NCT07184996 on ClinicalTrials.gov

7. A Study of Vedolizumab With Tofacitinib in Adults With Ulcerative Colitis (UC)

   The main aim of this study is to learn about the effect of treatment with vedolizumab IV (vedolizumab) together with tofacitinib in adults with moderate and severe ulcerative colitis (UC). Another aim is to learn about treatment with Vedolizumab alone after the double treatment. All participants wi…

   Stage

   Phase 4

   Ages

   18 to 65

   Site

   Endoscopic Research Inc, Orlando, Florida

   Locations

   46 in total

   Run by

   Takeda

   See if you can join NCT06095128 on ClinicalTrials.gov

8. Treat-to-Target of Endoscopic Remission in Patients With IBD in Symptomatic Remission

   The purpose of this study is to compare the effectiveness and safety of a strategy of switching to an alternative targeted immunomodulator (TIM) therapy to treat to a target of endoscopic remission, versus continuing index TIM in patients with inflammatory bowel disease (IBD) (Crohn's disease or ul…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Advent Health, Orlando, Florida

   Locations

   24 in total

   Run by

   Mayo Clinic

   See if you can join NCT05230173 on ClinicalTrials.gov

9. A Study of Eltrekibart and Mirikizumab in Adult Patients With Moderately to Severely Active Ulcerative Colitis

   The main purpose of this study is to determine the safety and efficacy of eltrekibart and mirikizumab in adult participants with moderately to severely active ulcerative colitis (UC).

   Stage

   Phase 2

   Ages

   18 to 75

   Site

   Orlando Health Digestive Health Institute, Orlando, Florida

   Locations

   207 in total

   Run by

   Eli Lilly and Company

   See if you can join NCT06598943 on ClinicalTrials.gov

10. A Study to Evaluate Etrasimod Treatment in Adolescents With Ulcerative Colitis

    The purpose of this study is to determine the safety, efficacy, and pharmacokinetics (PK) of etrasimod for the treatment of moderately to severely active ulcerative colitis in adolescents (≥ 12 years up to < 18 years of age). Participants who will complete the total 52-week treatment period will ha…

    Stage

    Phase 2

    Ages

    12 to 17

    Site

    Arnold Palmer Hospital - Center for Digestive Health and Nutrition, Orlando, Florida

    Locations

    45 in total

    Run by

    Pfizer

    See if you can join NCT05287126 on ClinicalTrials.gov

11. Hyperbaric Oxygen Therapy for Ulcerative Colitis (HBOT-UC)

    Chronic intestinal hypoxia and accompanying mucosal inflammation is a hallmark of ulcerative colitis (UC). Hyperbaric oxygen therapy (HBOT) involves breathing 100% oxygen under increased atmospheric pressure to increase tissue oxygenation. Two small prospective randomized controlled trials have dem…

    Stage

    Not phased

    Ages

    18 to 85

    Site

    Orlando Health, Orlando, Florida

    Locations

    13 in total

    Run by

    Northwestern University

    See if you can join NCT05987852 on ClinicalTrials.gov

12. Mirikizumab Real World Protocol

    The goal of this observational study is to learn about how effective mirikizumab (Omvoh) is when treating patients with ulcerative colitis (UC) Does mirikizumab (Omvoh) lead to a reduction in symptoms at intervals throughout one year? Participants being prescribed mirikizumab (Omvoh) as part of the…

    Stage

    Not phased

    Ages

    18 and older

    Site

    AdventHealth, Orlando, Florida

    Locations

    9 in total

    Run by

    University of North Carolina, Chapel Hill

    See if you can join NCT06696014 on ClinicalTrials.gov