Hypertension Clinical Trials

137 studies are recruiting for hypertension in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 5

1. Improving Hypertension Control in Rheumatoid Arthritis

   Rheumatoid arthritis (RA) is a autoimmune disease associated with an increased risk of developing coronary artery disease (CAD) and premature death,. Traditional CAD risk factors like hypertension (HTN) are both very common and poorly controlled among RA patients. Patients with RA face significant …

   Stage

   Not phased

   Ages

   18 and older

   Site

   Duke Health System, Durham, North Carolina

   Run by

   Duke University

   See if you can join NCT05760898 on ClinicalTrials.gov

2. Pharmacy-led Transitions of Care Intervention to Improve Medication Adherence

   Socioeconomically disadvantaged populations with multiple chronic conditions have high rates of nonadherence to essential chronic disease medications after hospital discharge. Medication nonadherence after hospital discharge is significantly associated with increased mortality and higher rates of r…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Tennessee Health Science Center/Regional One Health, Memphis, Tennessee

   Locations

   2 in total

   Run by

   University of Tennessee

   See if you can join NCT06374277 on ClinicalTrials.gov

3. RCT of Sensor-controlled Digital Game for Hypertension Self-care in a Native American Community

   This study evaluates a sensor-controlled digital game (SCDG) to motivate self-management behaviors of physical activity in Native American adults with hypertension (HTN). Half of the participants will receive the SCDG app and physical activity sensors and the other half will receive only the physic…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of North Carolina Chapel Hill, Chapel Hill, North Carolina

   Run by

   University of Texas at Austin

   See if you can join NCT05671406 on ClinicalTrials.gov

4. Overnight Trials With Heat Stress in Autonomic Failure Patients With Supine Hypertension

   Patients with autonomic failure are characterized by disabling orthostatic hypotension (low blood pressure on standing), and at least half of them also have high blood pressure while lying down (supine hypertension). Exposure to heat, such as in hot environments, often worsens their orthostatic hyp…

   Stage

   Not phased

   Ages

   18 to 80

   Site

   Autonomic Dysfunction Center/ Vanderbilt University Medical Center, Nashville, Tennessee

   Run by

   Vanderbilt University Medical Center

   See if you can join NCT03042988 on ClinicalTrials.gov

5. Inspiratory Muscle Strength Training for Lowering Blood Pressure and Improving Endothelial Function in Postmenopausal Women: Comparison With "Standard of Care" Aerobic Exercise

   High blood pressure (BP) is the major modifiable risk factor for cardiovascular diseases (CVD) and related health conditions, particularly among postmenopausal (PM) women. In adults age ≥50 years this risk is primarily driven by above-normal systolic BP (SBP ≥120 mmHg), as diastolic BP plateaus, th…

   Stage

   Not phased

   Ages

   50 and older

   Site

   Integrative Physiology of Aging Laboratory, Boulder, Colorado

   Run by

   University of Colorado, Boulder

   See if you can join NCT05000515 on ClinicalTrials.gov

6. Addressing Hypertension Care in Africa Program

   The ADHINCRA Program is a bundle of multilevel evidence-based interventions that address multiple predictors of controlled hypertension, including patient-, provider-, and health system-level factors. The successful implementation of the ADHINCRA program will provide a rigorous and scalable model f…

   Stage

   Not phased

   Ages

   18 to 70

   Site

   Manhyia Government Hospital, Kumasi, Ashanti Region

   Locations

   17 in total

   Run by

   Johns Hopkins University

   See if you can join NCT06986590 on ClinicalTrials.gov

7. HOPE-BP 2.0: Evaluating the Optimal Duration of Postpartum Remote Blood Pressure Monitoring

   Postpartum remote blood pressure monitoring programs for patients with hypertensive disorders of pregnancy (HDP) are becoming part of standard postpartum management. Existing programs range in duration from 2 to 6 weeks but there has not been any evaluation as to what program duration is optimal. T…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Minnesota, Minneapolis, Minnesota

   Run by

   University of Minnesota

   See if you can join NCT07204756 on ClinicalTrials.gov

8. Autonomic Regulation of Blood Pressure in Premature and Early Menopausal Women

   This is a cross-sectional study in which the investigators will determine the impact of premature/early menopause on MSNA, BP and baroreflex sensitivity in younger (≤49 yr old) and older (≥50 yr old) women. Specifically, aim one will determine mechanisms driving autonomic dysregulation of BP in pre…

   Stage

   Not phased

   Ages

   35 to 70

   Site

   University of Minnesota, Minneapolis, Minnesota

   Run by

   University of Minnesota

   See if you can join NCT04439370 on ClinicalTrials.gov

9. Inspire HER: Inspiring the Heart and Emotions for Radical Health

   Poor heart health puts Black women at risk for a shorter life with more illness than people of any other non-indigenous racial group. We will refine and conduct a randomized, wait-list controlled trial of Inspire HER (a heart health lifestyle intervention for Black women that provides health educat…

   Stage

   Not phased

   Ages

   30 to 79

   Site

   University of Alabama at Birmingham, Birmingham, Alabama

   Run by

   University of Alabama at Birmingham

   See if you can join NCT06966258 on ClinicalTrials.gov

10. Human/Machine Interface: What the HeartMate 3 ® Device Tells Us About the Future

    Durable left ventricular assist devices (dLVAD) have been increasingly utilized since the mid to late 1990s, with an uptick of utility starting in 2010 following expanded indications for therapy to not only include a bridge to transplantation strategy, but also for those individuals who suffer from…

    Stage

    Not phased

    Ages

    18 to 100

    Site

    UCSF, San Francisco, California

    Locations

    7 in total

    Run by

    International Consortium of Circulatory Assist Clinicians

    See if you can join NCT06039176 on ClinicalTrials.gov

11. Pediatric Hypertension and the Renin-Angiotensin SystEm (PHRASE)

    Studying the causal roles of components of the renin-angiotensin-aldosterone system (including angiotensin-(1-7) (Ang-(1-7)), angiotensin-converting enzyme 2 (ACE2), Ang II, and ACE), uric acid, and klotho in pediatric hypertension and related target organ injury, including in the heart, kidneys, v…

    Stage

    Not phased

    Ages

    7 to 18

    Site

    Wake Forest Health Sciences, Winston-Salem, North Carolina

    Run by

    Wake Forest University Health Sciences

    See if you can join NCT04752293 on ClinicalTrials.gov

12. Positron Emission Tomography (PET) Imaging of Cholesterol Trafficking: Clinical Evaluation of [18F]FNP-59 in Normal Human Subjects (Group 1)

    This exploratory, first-in-man, phase 0 study will evaluate the feasibility of using a sub-therapeutic dose of a fluorine-18 analogue of NP-59 ([18F]FNP-59) to image the adrenal gland in healthy normal subjects. The researchers believe that [18F]FNP-59 would greatly improve the imaging characterist…

    Stage

    EARLY_Phase 1

    Ages

    18 and older

    Site

    University of Michigan, Ann Arbor, Michigan

    Run by

    Benjamin Viglianti

    See if you can join NCT04532489 on ClinicalTrials.gov

13. Positron Emission Tomography (PET) Imaging of Cholesterol Trafficking: Clinical Evaluation of [18F]FNP-59 in Normal Human Subjects (Groups 2, 3 & 4)

    This study will evaluate the feasibility of using a sub-therapeutic dose of a fluorine-18 analogue of NP-59 ([18F]FNP-59) to image the adrenal gland. Some participants are healthy normal subjects but have undergone interventions to manipulate hormones while other participants have known adrenal pat…

    Stage

    EARLY_Phase 1

    Ages

    18 and older

    Site

    University of Michigan, Ann Arbor, Michigan

    Locations

    2 in total

    Run by

    Benjamin Viglianti

    See if you can join NCT04546126 on ClinicalTrials.gov

14. Partners in Control, Phase II: Using Remote Monitoring Technology With Community Health Workers to Support Hypertension Management for Latinx Patients

    This study seeks to evaluate the impact of a remote patient monitoring (RPM)-specific tech-enabled community health worker workforce on the use of RPM for the management of hypertension among Latinx patients. This study is a step-wedge randomized controlled trial that aims to assess the effectivene…

    Stage

    Not phased

    Ages

    18 and older

    Site

    NYU Langone Health, New York, New York

    Run by

    NYU Langone Health

    See if you can join NCT06730230 on ClinicalTrials.gov

15. Preventing Cognitive Decline by Reducing BP Target Trial

    The PCOT study is a multi-site randomized trial of patients 70 years or older with high BP. The main goal of the study Preventing Cognitive Decline by Reducing BP Target Trial (PCOT) is to conduct a large pragmatic clinical trial (PCT) to test the hypothesis that patients who receive care with a co…

    Stage

    Not phased

    Ages

    70 and older

    Site

    UT Southwestern Medical Center, Dallas, Texas

    Run by

    University of Texas Southwestern Medical Center

    See if you can join NCT05106036 on ClinicalTrials.gov

16. Intensive Patient Referral and Education Program Prior to Renal Replacement Therapy

    Intensive Patient Referral and Education Program prior to Renal Replacement Therapy (iPREP-RRT) is a 12-week intervention that identifies hospitalized African Americans with advanced chronic kidney disease (CKD) and provides them with hospital- and community-based education, navigation and self-man…

    Stage

    Not phased

    Ages

    18 to 70

    Site

    University of Chicago Medical Center, Chicago, Illinois

    Run by

    University of Chicago

    See if you can join NCT06397456 on ClinicalTrials.gov

17. Gut Microbiota in Metabolic Surgery

    Metabolic surgery is an emerging option to treat obesity-related metabolic diseases (e.g., type 2 diabetes) and prevent cardiovascular disease (CVD). Metabolic surgery can profoundly alter the gut microbiota; meanwhile, gut microbiota may affect surgical outcomes. Longitudinal studies that examined…

    Stage

    Not phased

    Ages

    21 to 65

    Site

    Vanderbilt_University MC, Nashville, Tennessee

    Run by

    Vanderbilt University Medical Center

    See if you can join NCT05000996 on ClinicalTrials.gov

18. Prescription of Step Counts for Targeted Changes in Body Composition and Cardiometabolic Risk in Overweight/Obese Adults

    The prevalence of overweight and obesity remains epidemic in the United States, with some of the highest rates seen in older adults. While this phenomenon is certainly multifactorial, a good deal of evidence suggests that insufficient physical activity (PA) contributes significantly. Pilot data rec…

    Stage

    Not phased

    Ages

    20 and older

    Site

    Kennesaw State Universityh, Kennesaw, Georgia

    Run by

    Kennesaw State University

    See if you can join NCT07221279 on ClinicalTrials.gov

19. bpMedManage: Digital Technology to Support Adherence to Hypertension Medications

    The purpose of the bpMedManage study is to rigorously test the efficacy of a smartphone technology to help improve high blood pressure medication adherence among older adults with mild cognitive impairment (MCI) in a 16-week randomized controlled trial. A total of 100 older adults will be recruited…

    Stage

    Not phased

    Ages

    60 and older

    Site

    University of Arizona, Tucson, Arizona

    Locations

    2 in total

    Run by

    University of Arizona

    See if you can join NCT06307574 on ClinicalTrials.gov

20. SMBP Study: Improving High Blood Pressure in Older Adults With Multiple Chronic Diseases

    Nearly half of adults in the United States (47 percent, or 116 million) have hypertension, also known as high blood pressure (BP). Uncontrolled high BP can be devasting as it can lead to stroke, heart attack and kidney failure, as well as other numerous health conditions. Hypertension can be contro…

    Stage

    Not phased

    Ages

    65 and older

    Site

    University of Iowa Health Care, Iowa City, Iowa

    Locations

    2 in total

    Run by

    Korey Kennelty

    See if you can join NCT06932029 on ClinicalTrials.gov

21. Black Impact: The Mechanisms Underlying Psychosocial Stress Reduction in a Cardiovascular Health Intervention

    Lower attainment of cardiovascular health (CVH), indicated by the American Heart Association's Life's Simple 7 (LS7; physical activity, diet, cholesterol, blood pressure, body mass index, smoking, glycemia) and Life's Essential 8 (LE8; LS7+sleep) metrics, is a major contributor to Black men having …

    Stage

    Not phased

    Ages

    18 and older

    Site

    The Ohio State University, Columbus, Ohio

    Run by

    Ohio State University

    See if you can join NCT06055036 on ClinicalTrials.gov

22. Team Lifestyle Immersion Hypertension Control Project

    This project is focuses on reducing the risk and progression of hypertension among a population that records high incidence of hypertension and other chronic ailments such as heart disease, diabetes, kidney failure, and obesity, with similar control measures. Several clinical trials over the last f…

    Stage

    Not phased

    Ages

    30 to 80

    Site

    Meharry Medical College, Nashville, Tennessee

    Run by

    Meharry Medical College

    See if you can join NCT07201948 on ClinicalTrials.gov

23. BRIDGE: Blood Pressure Reduction and Intervention Delivery Via Group Engagement

    The investigators want to improve care for people who have had a stroke. High blood pressure is the leading cause for having a second stroke and can lead to poor brain health. The goal of this study is to compare two new ways of lowering blood pressure. The first way is to help people check their b…

    Stage

    Not phased

    Ages

    35 and older

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT07091851 on ClinicalTrials.gov

24. Community Park-Based Programs for Health Promotion: The Fit2Lead Prospective Cohort Study

    The Fit2Lead prospective cohort study examines the effects of a park-based youth mental health and resilience afterschool program on youth participant mental health, resilience, physical fitness, and violence prevention outcomes. Duke will perform a secondary analysis of the data collected as part …

    Stage

    Not phased

    Ages

    12 to 17

    Site

    Miami-Dade County Parks, Recreation and Open Spaces Department, Miami, Florida

    Run by

    Duke University

    See if you can join NCT06596265 on ClinicalTrials.gov

25. Comparison of Cuff-Less Wrist Wearable Blood Pressure Device to Cuff Based Blood Pressure Measuring Devices

    (1) To compare cuff-less wrist wearable radial artery blood pressure measurements utilizing ViTrack(developed by Dynocardia) to the cuff based commercially available blood pressure device, in healthy volunteers with normal or high blood pressure.

    Stage

    Not phased

    Ages

    18 to 90

    Site

    Dynocardia Inc, Newton, Massachusetts

    Run by

    Dynocardia, Inc

    See if you can join NCT04835857 on ClinicalTrials.gov