Hypertension Clinical Trials

143 studies are recruiting for hypertension in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 6

1. Polygenic Risk Score Implementation and Stratification for Managing Blood Pressure

   In a multi-ethnic population, a genome-wide polygenic risk score (PRS) for systolic blood pressure (SBP), incorporating over one million common genetic variants, predicts blood pressure (BP) traits and the risk of adverse cardiovascular events beyond traditional risk factors. Delivering SBP PRS inf…

   Stage

   Not phased

   Ages

   18 to 55

   Site

   University of Alabama at Birmingham, Birmingham, Alabama

   Run by

   University of Alabama at Birmingham

   See if you can join NCT06962488 on ClinicalTrials.gov

2. Vascular Mechanisms, Functional Outcomes, & Exercise Among Persons With Multiple Sclerosis With Hypertension

   The goal of this study is to determine if 12 weeks of cycling exercise training at home will improve three parameters: 1) blood pressure, 2) cognition, and 3) walking ability among persons with multiple sclerosis who have high blood pressure, when compared to a group that engages in a 12-week home-…

   Stage

   Not phased

   Ages

   18 and older

   Site

   UMass Boston, Boston, Massachusetts

   Run by

   University of Massachusetts, Boston

   See if you can join NCT06554340 on ClinicalTrials.gov

3. Examining the Circadian Timing Effects of the Hypotensive Response to Exercise

   The goal of this study is to learn how exercise timing affects blood pressure in adults with elevated or high blood pressure. Exercise can influence the body's natural 24-hour rhythms, including blood pressure patterns. A single exercise session can lower blood pressure for up to 24 hours, but it i…

   Stage

   Not phased

   Ages

   18 to 39

   Site

   University of Delaware, Newark, Delaware

   Run by

   Freda Patterson

   See if you can join NCT07049783 on ClinicalTrials.gov

4. Technology-enabled Management Versus Usual Care for Blood Pressure

   Two arm parallel randomized clinical trial

   Stage

   Not phased

   Ages

   30 to 90

   Site

   Stanford Health Care, Palo Alto, California

   Locations

   3 in total

   Run by

   Stanford University

   See if you can join NCT05479461 on ClinicalTrials.gov

5. Lifestyle Medicine: Establishing Clinical Approaches to Chronic Disease for Rural Patients

   Developed nations worldwide are currently enduring a health crisis, as chronic diseases continue to decrease quality of life and promote additional disease states or even death for much of the population. Rural populations are at a particular disadvantage, as they lack access to health clubs, welln…

   Stage

   Not phased

   Ages

   18 to 64

   Site

   West Virginia School of Osteopathic Medicine, Lewisburg, West Virginia

   Run by

   West Virginia School of Osteopathic Medicine

   See if you can join NCT06049420 on ClinicalTrials.gov

6. Addressing Barriers to Achieving Cardiometabolic Disorders Prevention and Treatment Goals for PLWH in the SE US

   This study has 3 aims. Aim 1: Identify social determinants of cardiometabolic health and determine facilitators and modifiable barriers in achieving treatment goals. Aim 2: Assess PLWH knowledge, skills, and confidence for self-management of cardiometabolic disorders. Aim 3: Tailor a self-managemen…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Duke University - Charlotte Study Sites, Charlotte, North Carolina

   Locations

   2 in total

   Run by

   Duke University

   See if you can join NCT05129345 on ClinicalTrials.gov

7. Examining the Feasibility of Implementing a Hypertension Storytelling Intervention Among African Americans

   The purpose of this study is to assess if storytelling is an effective approach for promoting lifestyle and behavioral change among individuals managing hypertension and to determine if storytelling interventions can help to reduce blood pressure and improve medication adherence.

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Delaware, Newark, Delaware

   Run by

   University of Delaware

   See if you can join NCT07071077 on ClinicalTrials.gov

8. Addressing Cardiometabolic Health In Populations Through Early Prevention in the Great Lakes Region Project 1 - Epidemiology (ACHIEVE P1-EPI)

   This project is part of the ACHIEVE GREATER (Addressing Cardiometabolic Health In Populations Through Early PreVEntion in the GREAT LakEs Region) Center (IRB# 100221MP2A), the purpose of which is to improve cardiometabolic health in two uniquely comparable cities: Detroit, Michigan, and Cleveland, …

   Stage

   Not phased

   Ages

   18 and older

   Site

   Wayne Health Mobile Units, Detroit, Michigan

   Run by

   Wayne State University

   See if you can join NCT06593496 on ClinicalTrials.gov

9. Sympathetic-vascular Dysfunction in Obesity and Insulin Resistance (Vitamin C Study)

   The main purpose of research is to examine and understanding the development of hypertension in obese adults with insulin resistance. Findings from our studies will identify unique mechanisms that can be targeted to limit increases in vascular dysfunction and reduce the excessively high prevalence …

   Stage

   Phase 1

   Ages

   35 to 65

   Site

   University of Kansas Medical Center, Kansas City, Kansas

   Run by

   University of Kansas Medical Center

   See if you can join NCT04715022 on ClinicalTrials.gov

10. Reversing Glucose and Lipid-mediated Vascular Dysfunction

    The purpose of our study is to understand the extent to which the blood vessels are affected by glucose and fat (lipids) in lean healthy adults and if these changes in the blood vessels contribute to the development of high blood pressure.

    Stage

    EARLY_Phase 1

    Ages

    18 to 79

    Site

    University of Kansas Medical Center, Kansas City, Kansas

    Run by

    University of Kansas Medical Center

    See if you can join NCT04832009 on ClinicalTrials.gov

11. Inspiratory Muscle Strength Training in Chronic Kidney Disease

    More than 80% of individuals with chronic kidney disease have concomitant hypertension and the majority fail to achieve blood pressure control <130/80 mmHg, leading to high risk of cardiovascular diseases and end-stage kidney disease. A stepwise combination of lifestyle modifications and drug thera…

    Stage

    Not phased

    Ages

    50 and older

    Site

    University of Colorado - Anschutz Medical Campus, Aurora, Colorado

    Run by

    University of Colorado, Denver

    See if you can join NCT04911491 on ClinicalTrials.gov

12. Examining Digital Health Care Delivery Models Through Medicaid Collaborative

    The purpose of this study is to examine the intervention effectiveness and dissemination of digital health care delivery models for improving selected health outcomes in the Medicaid population.

    Stage

    Not phased

    Ages

    18 and older

    Site

    OSF HealthCare System, Peoria, Illinois

    Run by

    OSF Healthcare System

    See if you can join NCT05555095 on ClinicalTrials.gov

13. Effect of Electro-Acupuncture on Blood Pressure

    Based on previous published research in animals and human, the investigators hypothesize that electroacupuncture (EA) will have a positive effect on hypertension.

    Stage

    Not phased

    Ages

    18 to 85

    Site

    Susan Samueli Integrative Health Institute, Irvine, California

    Locations

    2 in total

    Run by

    University of California, Irvine

    See if you can join NCT00932139 on ClinicalTrials.gov

14. Targeting Endoplasmic Reticulum Stress in Human Hypertension

    There is strong evidence suggesting that endoplasmic reticulum stress contributes to neurogenic and vascular hypertension in various animal models, however this has never been explored in humans. Therefore, this project will fill this gap by performing a single-blind, placebo-controlled trial in hu…

    Stage

    Phase 1

    Ages

    18 to 80

    Site

    University of North Texas Health Science Center, Fort Worth, Texas

    Run by

    University of North Texas Health Science Center

    See if you can join NCT06025630 on ClinicalTrials.gov

15. Blood Pressure Lowering Strategies to Eliminate Hypertension Disparities (BLESSED)

    The burden of hypertension and related cardiovascular diseases, stroke, and end-stage kidney disease is disproportionately high in Black populations, especially in the South. The Blood Pressure Lowering Strategies to Eliminate Hypertension Disparities (BLESSED) cluster randomized trial aims to test…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Tulane University, New Orleans, Louisiana

    Run by

    Tulane University

    See if you can join NCT06133322 on ClinicalTrials.gov

16. Nicotinamide Riboside for Treating Elevated Systolic Blood Pressure and Arterial Stiffness in Middle-aged and Older Adults

    Aging is the primary risk factor for cardiovascular diseases (CVD), the number one cause of death in developed societies. Systolic blood pressure (SBP) increase with age and is a key intermediary factor linking aging to increased CVD risk. The primary mechanisms underlying the age-associated increa…

    Stage

    Phase 2

    Ages

    50 and older

    Site

    Integrative Physiology of Aging Laboratory, Boulder, Colorado

    Run by

    Douglas Seals

    See if you can join NCT03821623 on ClinicalTrials.gov

17. Cardiovascular Manifestations of MR Activation in Primary Aldosteronism: Pilot Clinical Study

    This research study aims to learn more about the impact the hormone aldosterone on the heart. Primary aldosteronism is a condition where the body's adrenal glands make too much of the hormone aldosterone, which can cause high blood pressure and increase the risk of heart and kidney disease. Treatme…

    Stage

    Phase 4

    Ages

    18 to 85

    Site

    Brigham and Women's Hospital, Boston, Massachusetts

    Run by

    Brigham and Women's Hospital

    See if you can join NCT05030545 on ClinicalTrials.gov

18. Interactive Computer-adaptive Chronic Kidney Disease Education Program

    The goal of this pilot clinical trial is to evaluate a culturally tailored computerized education program in hospitalized African-American patients with advanced chronic kidney disease (CKD). The main question it aims to answer are: does computerized adaptive education (CAE) increase patients' know…

    Stage

    Not phased

    Ages

    18 to 70

    Site

    University of Chicago Medical Center, Chicago, Illinois

    Run by

    University of Chicago

    See if you can join NCT06364358 on ClinicalTrials.gov