Hypertension Clinical Trials

143 studies are recruiting for hypertension in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 4

1. Remote Fetal Monitoring in High Risk Pregnancies

   Antenatal nonstress tests (NSTs) are performed to assess fetal health and are used as a cost-effective test that can be widely administered. However, an NST is operator-dependent due to the nature of Doppler ultrasound and is primarily performed in a clinic and hospital setting. The ability to cond…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Beth Israel Deaconess Medical Center, Boston, Massachusetts

   Run by

   Beth Israel Deaconess Medical Center

   See if you can join NCT06822439 on ClinicalTrials.gov

2. PILI 'Āina Household

   Native Hawaiians' traditional lifestyles and diets ensured the mutual health and well-being of the land and its inhabitants, which stand in stark contrast to the disproportionately high prevalence of diet-related, cardiometabolic diseases they experience today. In this project, the investigators wi…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Kula no nā Po'e Hawai'i, Honolulu, Hawaii

   Locations

   2 in total

   Run by

   University of Hawaii

   See if you can join NCT06526273 on ClinicalTrials.gov

3. 'Ai Pono Cooking Demonstrations

   Native Hawaiians' traditional lifestyles and diets ensured the mutual health and well-being of the land and its inhabitants, which stand in stark contrast to the disproportionately high prevalence of diet-related, cardiometabolic diseases they experience today. In this project, the investigators wi…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Kula no na Poe Hawaii, Honolulu, Hawaii

   Locations

   2 in total

   Run by

   University of Hawaii

   See if you can join NCT06526650 on ClinicalTrials.gov

4. Imaging the Pathogenesis of Cerebral Small Vessel Disease

   Cerebral small vessel disease (CSVD) can lead to vascular cognitive impairment and dementia (VCID). The hallmark of CSVD is the appearance and progression of white matter hyperintensities (WMH) on MRI. The goal of this study it to recruit and follow individuals at risk for WMH progression and use s…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Kennedy Krieger Institute, Baltimore, Maryland

   Run by

   Johns Hopkins University

   See if you can join NCT05703386 on ClinicalTrials.gov

5. Sympathetic Mechanisms in Obesity-Crossover Design

   We will study obese hypertensive subjects in a randomized, crossover study to determine if two weeks sympathetic blockade improves endogenous glucose production. Subjects will be studied on 3 different occasions after two weeks of receiving either placebo, amlodipine (vasodilator arm) or moxonidine…

   Stage

   Phase 1

   Ages

   18 to 65

   Site

   Vanderbilt University Medical Center, Nashville, Tennessee

   Run by

   Vanderbilt University Medical Center

   See if you can join NCT05312892 on ClinicalTrials.gov

6. HTN App for HTN Control and Cardiovascular Health Among African-Americans

   The purpose of this study is to test the hypertension (HTN) app-based intervention to see if it is more effective in improving uncontrolled HTN and HTN self-care among Africian-Americans from baseline to post-intervention (immediate, 3 months and 6 months post-intervention) as compared to the stand…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Mayo Clinic, Rochester, Minnesota

   Run by

   Mayo Clinic

   See if you can join NCT06346886 on ClinicalTrials.gov

7. Evaluation of Efficacy and Safety of Iloperidone for the Treatment of Participants With Uncontrolled Hypertension

   A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Iloperidone for the Treatment of Participants with Uncontrolled Hypertension

   Stage

   Phase 2

   Ages

   18 to 65

   Site

   Vanda Investigative Site, Tempe, Arizona

   Locations

   28 in total

   Run by

   Vanda Pharmaceuticals

   See if you can join NCT07090161 on ClinicalTrials.gov

8. Colorado Community Engagement Alliance

   The Colorado Community Engagement Alliance (CO-CEAL) is a partnership between the University of Colorado Anschutz Medical Campus, several community-based organizations, and dozens of trusted local community members. Its mission is to address disproportionate impacts on health through active communi…

   Stage

   Not phased

   Ages

   18 to 90

   Site

   University of Colorado - Anschutz Medical Campus, Aurora, Colorado

   Run by

   University of Colorado, Denver

   See if you can join NCT07440316 on ClinicalTrials.gov

9. Jackson Heart Study Women's Hypertension Study

   High blood pressure is a powerful risk factor for heart disease. Black women are more likely to have high blood pressure than white women or Hispanic women. Even when they are aware they have high blood pressure, many people struggle to keep their blood pressure controlled. Research shows a connect…

   Stage

   Not phased

   Ages

   18 to 99

   Site

   University of Mississippi Medical Center, Jackson, Mississippi

   Run by

   NYU Langone Health

   See if you can join NCT06511479 on ClinicalTrials.gov

10. Assessment of Risks of Perinephric Fat Thickness to Adverse Renal Outcomes Post Donor Nephrectomy

    The goal of this observational study is to learn if PRAT thickness is a marker of visceral obesity and its influence on donors' kidney function and blood pressure in living kidney donors. Population includes male/female, 18 years and up, living kidney donors scheduled for nephrectomy within 6 month…

    Stage

    Not phased

    Ages

    18 to 80

    Site

    Mayo Clinic, Rochester, Minnesota

    Run by

    Mayo Clinic

    See if you can join NCT06886087 on ClinicalTrials.gov

11. CARBON: UAB Cardiovascular Research Biobank

    The UAB Cardiovascular Research Biobank (CARBON) will be a resource that contains biological materials, such as DNA samples, in addition to health and personal information on a large number of people over time. It will be set up so that it can be used in the future as a resource for researchers und…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Run by

    University of Alabama at Birmingham

    See if you can join NCT05067231 on ClinicalTrials.gov

12. Sleep and Circadian Mechanisms in Hypertension

    This study is a mechanistic clinical trial designed to investigate the effects of the circadian system and sleep on non-dipping blood pressure (BP) in people with hypertension (HTN).

    Stage

    Not phased

    Ages

    25 to 64

    Site

    Oregon Health and Science University, Portland, Oregon

    Run by

    Oregon Health and Science University

    See if you can join NCT05184933 on ClinicalTrials.gov

13. Assessing the Efficacy of Targeted Home Visits in the Management of Chronic Conditions

    The purpose of study is to evaluate whether home visit programs are an effective method for HTN and T2DM management as compared to standard of care clinic visits.

    Stage

    Not phased

    Ages

    18 to 60

    Site

    UT Southwestern Medical Center, Dallas, Texas

    Run by

    University of Texas Southwestern Medical Center

    See if you can join NCT05168605 on ClinicalTrials.gov

14. Blood Pressure Care for Advancing Real-World Evidence (BPCARE)

    The goal of this randomized clinical trial is to determine whether a community health worker-delivered, multi-component behavioral intervention can improve antihypertensive medication adherence and blood pressure control among adult refugees with hypertension who are prescribed antihypertensive med…

    Stage

    Not phased

    Ages

    21 and older

    Site

    Family Health Centers of San Diego, San Diego, California

    Locations

    2 in total

    Run by

    University of California, San Diego

    See if you can join NCT07398391 on ClinicalTrials.gov

15. Improving Hypertension Control in Rheumatoid Arthritis

    Rheumatoid arthritis (RA) is a autoimmune disease associated with an increased risk of developing coronary artery disease (CAD) and premature death,. Traditional CAD risk factors like hypertension (HTN) are both very common and poorly controlled among RA patients. Patients with RA face significant …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Duke Health System, Durham, North Carolina

    Run by

    Duke University

    See if you can join NCT05760898 on ClinicalTrials.gov

16. Pharmacy-led Transitions of Care Intervention to Improve Medication Adherence

    Socioeconomically disadvantaged populations with multiple chronic conditions have high rates of nonadherence to essential chronic disease medications after hospital discharge. Medication nonadherence after hospital discharge is significantly associated with increased mortality and higher rates of r…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Tennessee Health Science Center/Regional One Health, Memphis, Tennessee

    Locations

    2 in total

    Run by

    University of Tennessee

    See if you can join NCT06374277 on ClinicalTrials.gov

17. RCT of Sensor-controlled Digital Game for Hypertension Self-care in a Native American Community

    This study evaluates a sensor-controlled digital game (SCDG) to motivate self-management behaviors of physical activity in Native American adults with hypertension (HTN). Half of the participants will receive the SCDG app and physical activity sensors and the other half will receive only the physic…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of North Carolina Chapel Hill, Chapel Hill, North Carolina

    Run by

    University of Texas at Austin

    See if you can join NCT05671406 on ClinicalTrials.gov

18. Overnight Trials With Heat Stress in Autonomic Failure Patients With Supine Hypertension

    Patients with autonomic failure are characterized by disabling orthostatic hypotension (low blood pressure on standing), and at least half of them also have high blood pressure while lying down (supine hypertension). Exposure to heat, such as in hot environments, often worsens their orthostatic hyp…

    Stage

    Not phased

    Ages

    18 to 80

    Site

    Autonomic Dysfunction Center/ Vanderbilt University Medical Center, Nashville, Tennessee

    Run by

    Vanderbilt University Medical Center

    See if you can join NCT03042988 on ClinicalTrials.gov

19. Inspiratory Muscle Strength Training for Lowering Blood Pressure and Improving Endothelial Function in Postmenopausal Women: Comparison With "Standard of Care" Aerobic Exercise

    High blood pressure (BP) is the major modifiable risk factor for cardiovascular diseases (CVD) and related health conditions, particularly among postmenopausal (PM) women. In adults age ≥50 years this risk is primarily driven by above-normal systolic BP (SBP ≥120 mmHg), as diastolic BP plateaus, th…

    Stage

    Not phased

    Ages

    50 and older

    Site

    Integrative Physiology of Aging Laboratory, Boulder, Colorado

    Run by

    University of Colorado, Boulder

    See if you can join NCT05000515 on ClinicalTrials.gov

20. Addressing Hypertension Care in Africa Program

    The ADHINCRA Program is a bundle of multilevel evidence-based interventions that address multiple predictors of controlled hypertension, including patient-, provider-, and health system-level factors. The successful implementation of the ADHINCRA program will provide a rigorous and scalable model f…

    Stage

    Not phased

    Ages

    18 to 70

    Site

    Manhyia Government Hospital, Kumasi, Ashanti Region

    Locations

    17 in total

    Run by

    Johns Hopkins University

    See if you can join NCT06986590 on ClinicalTrials.gov

21. HOPE-BP 2.0: Evaluating the Optimal Duration of Postpartum Remote Blood Pressure Monitoring

    Postpartum remote blood pressure monitoring programs for patients with hypertensive disorders of pregnancy (HDP) are becoming part of standard postpartum management. Existing programs range in duration from 2 to 6 weeks but there has not been any evaluation as to what program duration is optimal. T…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Minnesota, Minneapolis, Minnesota

    Run by

    University of Minnesota

    See if you can join NCT07204756 on ClinicalTrials.gov

22. Autonomic Regulation of Blood Pressure in Premature and Early Menopausal Women

    This is a cross-sectional study in which the investigators will determine the impact of premature/early menopause on MSNA, BP and baroreflex sensitivity in younger (≤49 yr old) and older (≥50 yr old) women. Specifically, aim one will determine mechanisms driving autonomic dysregulation of BP in pre…

    Stage

    Not phased

    Ages

    35 to 70

    Site

    University of Minnesota, Minneapolis, Minnesota

    Run by

    University of Minnesota

    See if you can join NCT04439370 on ClinicalTrials.gov

23. Inspire HER: Inspiring the Heart and Emotions for Radical Health

    Poor heart health puts Black women at risk for a shorter life with more illness than people of any other non-indigenous racial group. We will refine and conduct a randomized, wait-list controlled trial of Inspire HER (a heart health lifestyle intervention for Black women that provides health educat…

    Stage

    Not phased

    Ages

    30 to 79

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Run by

    University of Alabama at Birmingham

    See if you can join NCT06966258 on ClinicalTrials.gov

24. Human/Machine Interface: What the HeartMate 3 ® Device Tells Us About the Future

    Durable left ventricular assist devices (dLVAD) have been increasingly utilized since the mid to late 1990s, with an uptick of utility starting in 2010 following expanded indications for therapy to not only include a bridge to transplantation strategy, but also for those individuals who suffer from…

    Stage

    Not phased

    Ages

    18 to 100

    Site

    UCSF, San Francisco, California

    Locations

    7 in total

    Run by

    International Consortium of Circulatory Assist Clinicians

    See if you can join NCT06039176 on ClinicalTrials.gov

25. Pediatric Hypertension and the Renin-Angiotensin SystEm (PHRASE)

    Studying the causal roles of components of the renin-angiotensin-aldosterone system (including angiotensin-(1-7) (Ang-(1-7)), angiotensin-converting enzyme 2 (ACE2), Ang II, and ACE), uric acid, and klotho in pediatric hypertension and related target organ injury, including in the heart, kidneys, v…

    Stage

    Not phased

    Ages

    7 to 18

    Site

    Wake Forest Health Sciences, Winston-Salem, North Carolina

    Run by

    Wake Forest University Health Sciences

    See if you can join NCT04752293 on ClinicalTrials.gov