Hypertension Clinical Trials

143 studies are recruiting for hypertension in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

Search these by distance from you

By city

Studies, page 2

1. Sleep Restriction and Parental History of Hypertension

   The purpose of this study is to research the effects of partial sleep deprivation (sleep restriction) in a group of individuals whose parents have high blood pressure compared to a group of individuals whose parents have normal blood pressure.

   Stage

   Not phased

   Ages

   18 to 35

   Site

   Mayo Clinic in Rochester, Rochester, Minnesota

   Run by

   Mayo Clinic

   See if you can join NCT06482814 on ClinicalTrials.gov

2. Melatonin Effects on Cardiovascular Disease Mechanisms in Midlife Women: A Randomized Clinical Trial

   The purpose of this research is to study the effects of 12 weeks of melatonin supplementation compared to placebo in women who are in the menopause transition (perimenopause) and have high blood pressure.

   Stage

   Not phased

   Ages

   40 to 55

   Site

   Mayo Clinic in Rochester, Rochester, Minnesota

   Run by

   Mayo Clinic

   See if you can join NCT06826755 on ClinicalTrials.gov

3. Global Paradise System US Post Approval Study

   The objective of the Global Paradise® System US Post Approval Study (US GPS) is to evaluate the real-world use of the Paradise Ultrasound Renal Denervation System indicated for patients who are unable to lower their blood pressure with lifestyle changes and medication. This system is comprised of a…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Tibor Rubin VA Medical Center, Long Beach, California

   Locations

   43 in total

   Run by

   ReCor Medical, Inc.

   See if you can join NCT06297291 on ClinicalTrials.gov

4. A Novel Digital Tool Physicians Can Use to Prescribe Exercise to Patients With Cardiovascular Disease Risk Factors

   The investigators will conduct a feasibility and pilot efficacy randomized controlled trial to test the usability and user satisfaction of an evidence-based digital health tool the investigators developed for physicians to use to Prioritize Personalize Prescribe EXercise (P3-EX) to patients with ca…

   Stage

   Not phased

   Ages

   18 to 64

   Site

   Hartford HealthCare, Hartford, Connecticut

   Locations

   3 in total

   Run by

   University of Connecticut

   See if you can join NCT07238556 on ClinicalTrials.gov

5. Study of the Progression of Chronic Cardiovascular Conditions

   This study will collect physiologic data in patients with cardiovascular conditions and observe the natural history of those conditions for research purposes.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Prolaio, Chicago, Illinois

   Run by

   Prolaio

   See if you can join NCT07420907 on ClinicalTrials.gov

6. Optimizing Sustainable Cuff Access and Training Pathways for Self-Measured Blood Pressure Monitoring in Primary Care

   The goal of this study is to identify what cuff delivery and BP log return modality most effectively achieve successful delivery of a self-measured blood pressure (SMBP) intervention in routine care, among adult primary care patients with uncontrolled hypertension?

   Stage

   Not phased

   Ages

   18 and older

   Site

   Advocate Medical Group Chicago (Southeast), Chicago, Illinois

   Locations

   6 in total

   Run by

   Wake Forest University Health Sciences

   See if you can join NCT07693699 on ClinicalTrials.gov

7. Therapeutic Mechanisms of Epidural Spinal Cord Stimulation

   The purpose of this study in patients undergoing routine care epidural spinal cord stimulation (SCS) is to determine 1) whether SCS reduces arterial blood pressure (BP) in patients which chronic low back pain and hypertension, 2) whether higher baseline BP (i.e., hypertension) predicts reductions i…

   Stage

   Not phased

   Ages

   18 to 89

   Site

   University of Alabama at Birmingham, Birmingham, Alabama

   Run by

   University of Alabama at Birmingham

   See if you can join NCT05556902 on ClinicalTrials.gov

8. A Trial Evaluating Safety, Tolerability and Efficacy of CTX340 in Participants With Hypertension

   A Study of CTX340 in Participants with Uncontrolled Hypertension.

   Stage

   Phase 1

   Ages

   18 to 75

   Site

   Research Site 1, Port Orange, Florida

   Locations

   2 in total

   Run by

   CRISPR Therapeutics AG

   See if you can join NCT07758634 on ClinicalTrials.gov

9. Clevidipine for the Antihypertensive Treatment of Acute Intracerebral Hemorrhage

   The aim is to compare the rate of hypertensive subjects with ICH who reach SBP target with stability within 60 minutes of enrollment, among patients treated with IV clevidipine with those treated with alternate IV antihypertensive regimen.

   Stage

   Not phased

   Ages

   18 to 100

   Site

   University of California, Irvine, California

   Locations

   20 in total

   Run by

   Zeenat Qureshi Stroke Institute

   See if you can join NCT06402968 on ClinicalTrials.gov

10. Cardiovascular Protection After Preeclampsia With Enalapril

    The purpose of this study is to learn if postpartum women are willing to be randomized to different blood pressure medicines after delivery and how that affects blood pressure in women with hypertensive disorders of pregnancy.

    Stage

    Phase 3

    Ages

    18 and older

    Site

    Women and Infants Hospital, Providence, Rhode Island

    Run by

    Women and Infants Hospital of Rhode Island

    See if you can join NCT07222852 on ClinicalTrials.gov

11. Nifedipine and Enalapril vs Nifedipine and Labetalol for the Treatment of Postpartum Hypertension Study

    To determine if nifedipine and enalapril will have better blood pressure control in the postpartum setting compared to nifedipine and labetalol.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Cleveland Clinic, Cleveland, Ohio

    Run by

    The Cleveland Clinic

    See if you can join NCT07363343 on ClinicalTrials.gov

12. WEAVE NM: Heart Health and Nutrition for Life

    WEAVE NM (Wide Engagement for Assessing Vaccine Equity in New Mexico) is a community-based research initiative working to improve health outcomes in underserved populations, with a current focus on hypertension and food justice. The project centers on the lived experiences of Native American, Afric…

    Stage

    Not phased

    Ages

    18 to 84

    Site

    First Nations Community HealthSource, Albuquerque, New Mexico

    Run by

    University of New Mexico

    See if you can join NCT07074145 on ClinicalTrials.gov

13. A Pivotal Study to Evaluate the Effectiveness of Isometric Handgrip Therapy in Elevated Blood Pressure and Hypertensive Subjects

    The study will be a multi-center, randomized clinical trial to evaluate the safety and efficacy of using the Zona Plus handgrip therapy device compared to the use of an auditory relaxation therapy for treatment of high blood pressure and hypertension in subjects who are not currently taking antihyp…

    Stage

    Not phased

    Ages

    22 and older

    Site

    Bayview Research Group, Valley Village, California

    Locations

    10 in total

    Run by

    Zona Health, Inc

    See if you can join NCT06843577 on ClinicalTrials.gov

14. Behavioral Interventions Combining AI/ML and Personalized Medicine to Reduce Cardiovascular Risk - Randomized Controlled Trial

    This study evaluates a new digital health program that uses artificial intelligence (AI) to help patients lower their blood pressure through personalized lifestyle recommendations. The program collects information about patients' daily habits and blood pressure readings, then uses AI to suggest lif…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of California, San Diego, La Jolla, California

    Run by

    National Bureau of Economic Research, Inc.

    See if you can join NCT07725250 on ClinicalTrials.gov

15. Delivering Food Resources & Kitchen Skills (FoRKS) to Adults With Food Insecurity and Hypertension

    The goal of this clinical trial is to determine the impact of a home-delivered foods and kitchen skills program on health and nutrition in adults with high blood pressure and food insecurity. Researchers will compare Food Resources \& Kitchen Skills (FoRKS) and Enhanced Usual Care (EUC) to evaluate…

    Stage

    Not phased

    Ages

    35 to 75

    Site

    Eskenazi Health, Indianapolis, Indiana

    Run by

    Indiana University

    See if you can join NCT05856591 on ClinicalTrials.gov

16. MIND Foods and Aerobic Training in Black Adults With HTN

    The goal of this randomized controlled trial is to determine the impact of Mediterranean-Dash Intervention for Neurodegenerative Delay (MIND) diet and aerobic training on cognition in Black adults with high systolic blood pressure. Researchers will compare Food Delivery and Cooking PLUS Aerobic Tra…

    Stage

    Not phased

    Ages

    35 to 75

    Site

    Eskenazi Health, Indianapolis, Indiana

    Run by

    Indiana University

    See if you can join NCT06152614 on ClinicalTrials.gov

17. Blood Pressure Slopes and Ultrafiltration in Hemodialysis Patients

    Kidney failure has been recognized as one of the most costly chronic conditions among United States Veterans. Approximately 13,000 Veterans develop kidney failure each year, and most require hemodialysis initiation. Hemodialysis patients suffer significantly increased risk of death and hospitalizat…

    Stage

    Not phased

    Ages

    18 and older

    Site

    VA North Texas Health Care System Dallas VA Medical Center, Dallas, TX, Dallas, Texas

    Run by

    VA Office of Research and Development

    See if you can join NCT04163614 on ClinicalTrials.gov

18. The RADIANCE CED Study

    The RADIANCE CED study is a prospective observational study designed to evaluate the long-term effectiveness of ultrasound renal denervation in lowering blood pressure among patients with uncontrolled hypertension. Data will be collected from electronic health records (EHRs) of Medicare-eligible pa…

    Stage

    Not phased

    Ages

    65 and older

    Site

    Henry Ford Hospital, Detroit, Michigan

    Locations

    2 in total

    Run by

    ReCor Medical, Inc.

    See if you can join NCT07231757 on ClinicalTrials.gov

19. Reach Out 2: Emergency Department-Initiated Hypertension Mobile Health Intervention Connecting Multiple Health Systems

    Emergency department visits provide an opportunity to identify people with undiagnosed, untreated, or uncontrolled high blood pressure. In Reach Out, we will test whether a mobile health intervention yields a greater reduction in blood pressure than usual care among individuals identified with high…

    Stage

    Not phased

    Ages

    18 to 99

    Site

    Hurley Medical Center, Flint, Michigan

    Run by

    Northwestern University

    See if you can join NCT06391073 on ClinicalTrials.gov

20. Facilitated Transitions From Postpartum to Primary Care Coordination for People With Chronic Conditions

    The lack of postpartum primary care coordination is a missed opportunity to increase primary care engagement and manage chronic conditions early in life, especially for the >30% of pregnant people who have or are at risk for these conditions. This study aims to increase postpartum primary care enga…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT06557005 on ClinicalTrials.gov

21. Cardiac Effects of Mineralocorticoid Receptor Antagonism After Preeclampsia

    The goal of this clinical trial is to determine if the medication eplerenone yields greater improvements in coronary microvascular function than chlorthalidone in women who experienced preeclampsia during pregnancy and subsequently developed chronic hypertension. The main Aims are: * To test the hy…

    Stage

    Phase 2

    Ages

    18 to 65

    Site

    Brigham and Women's Hospital, Boston, Massachusetts

    Locations

    2 in total

    Run by

    Massachusetts General Hospital

    See if you can join NCT07238400 on ClinicalTrials.gov

22. FIM+DASH: Food is Medicine Intervention to Promote Healthy Eating and Blood Pressure Control

    The goal of this clinical trial is to treat both hypertension and obesity in adults using a food is medicine framework. Participants will be randomized 1:1 to FIM+DASH or usual-care control. The 24-week trial includes a 12-week FIM+DASH intervention followed by a 12-week maintenance period and leve…

    Stage

    Phase 2

    Ages

    Any age

    Site

    Mile Square Health Center - South Shore, Chicago, Illinois

    Locations

    4 in total

    Run by

    University of Illinois at Chicago

    See if you can join NCT07332741 on ClinicalTrials.gov

23. Integrating Free-choice Marketplace, dieTitian coacHing, cultuRally Tailored messagIng to improVE Blood Pressure

    iTHRIVE intervention is a 2-arm randomized controlled trial testing the effects of digital FARMacy, personalized dietitian coaching with produce prescriptions, and home blood pressure measurement in 100 hypertensive adults living in high food priority areas in counties in Maryland.

    Stage

    Not phased

    Ages

    21 to 70

    Site

    Johns Hopkins Community Physicians, Baltimore, Maryland

    Locations

    3 in total

    Run by

    Johns Hopkins University

    See if you can join NCT07075588 on ClinicalTrials.gov

24. SPYRAL GEMINI Pilot Study

    The purpose of the SPYRAL GEMINI Pilot Study is to evaluate that multi-organ denervation with the Gemini System is safe and provide evidence of blood pressure reduction when studied in an uncontrolled hypertensive population with and without high cardiovascular risk.

    Stage

    Not phased

    Ages

    18 to 80

    Site

    Stanford Hospital and Clinics, Stanford, California

    Locations

    18 in total

    Run by

    Medtronic Vascular

    See if you can join NCT06907147 on ClinicalTrials.gov

25. Early Time-Restricted Eating in Older Adults With Hypertension

    The purpose of this study is to find out how early time-restricted eating affects body rhythms and improves cardiometabolic health in older adults.

    Stage

    Not phased

    Ages

    60 and older

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Run by

    University of Alabama at Birmingham

    See if you can join NCT07135505 on ClinicalTrials.gov