Hypertension Clinical Trials

137 studies are recruiting for hypertension in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 2

1. BradycArdia paCemaKer With AV Interval Modulation for Blood prEssure treAtmenT

   A prospective, multinational, randomized, double-blind, clinical trial evaluating the safety and effectiveness of a novel atrioventricular interval modulation (AVIM) algorithm downloaded into a dual-chamber Medtronic Astra/Azure pacemaker.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Adventist Health Glendale, Glendale, California

   Locations

   131 in total

   Run by

   Orchestra BioMed, Inc

   See if you can join NCT06059638 on ClinicalTrials.gov

2. AM vs PM Exercise Training

   The treatment of high blood pressure, or hypertension, is multifaceted and can include pharmacological therapies (i.e., medications) and lifestyle modifications such as physical activity. Chronotherapy, which describes timing of a treatment with the body's daily rhythms, has recently been used with…

   Stage

   Not phased

   Ages

   55 to 80

   Site

   Michigan State University, East Lansing, Michigan

   Run by

   Michigan State University

   See if you can join NCT06042439 on ClinicalTrials.gov

3. Blood Pressure Lowering Strategies to Eliminate Hypertension Disparities (BLESSED)

   The burden of hypertension and related cardiovascular diseases, stroke, and end-stage kidney disease is disproportionately high in Black populations, especially in the South. The Blood Pressure Lowering Strategies to Eliminate Hypertension Disparities (BLESSED) cluster randomized trial aims to test…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Tulane University, New Orleans, Louisiana

   Run by

   Tulane University

   See if you can join NCT06133322 on ClinicalTrials.gov

4. Improving Hypertension Control in Safety-Net Settings: The Boston Hypertension Equity Alliance in Treatment

   High blood pressure (BP) or hypertension (HTN) affects over 100 million individuals in the US, increasing the risk of adverse outcomes, including stroke, myocardial infarction (MI), and chronic kidney disease (CKD). Effective therapies include non-pharmacologic approaches and multiple medication cl…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Boston Healthcare for the Homeless (BHCHP), Boston, Massachusetts

   Locations

   7 in total

   Run by

   Boston Medical Center

   See if you can join NCT06948838 on ClinicalTrials.gov

5. : Vascular Function in Health and Disease

   Many control mechanisms exist which successfully match the supply of blood with the metabolic demand of various tissues under wide-ranging conditions. One primary regulator of vasomotion and thus perfusion to the muscle tissue is the host of chemical factors originating from the vascular endotheliu…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   University of Utah, Salt Lake City, Utah

   Run by

   D. Walter Wray

   See if you can join NCT02966665 on ClinicalTrials.gov

6. Cardiovascular Effects of Angiotensin-(1-7) in Obesity Hypertension

   Obesity is a global health concern that is associated with high blood pressure and an increased risk for developing cardiovascular disease. The purpose of this study is to find out if the investigational drug angiotensin-(1-7) can improve cardiovascular health in people with obesity and high blood …

   Stage

   EARLY_Phase 1

   Ages

   18 to 65

   Site

   Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania

   Run by

   Milton S. Hershey Medical Center

   See if you can join NCT06482853 on ClinicalTrials.gov

7. THRIVE- THerapeutic IntravasculaR Ultrasound (TIVUS™) REnal Denervation System Versus Sham for the Adjunctive Treatment of Hypertension

   The primary objective of the THRIVE Pivotal study is to demonstrate the adjunctive effectiveness and the safety of the TIVUS system in: 1. subjects with uncontrolled hypertension (HTN) receiving 0 - 2 anti-hypertensive drugs of different classes in whom the anti-hypertensive medications will be sto…

   Stage

   Not phased

   Ages

   22 to 75

   Site

   Cardiology, PC, Birmingham, Alabama

   Locations

   51 in total

   Run by

   SoniVie Inc.

   See if you can join NCT06559891 on ClinicalTrials.gov

8. Treatment With Aspirin After Preeclampsia: TAP Trial

   The objective of this research project is to conduct a single-site pilot trial to assess the feasibility and effect of low-dose aspirin to augment vascular recovery in the immediate postpartum period after preeclampsia through two specific aims: 1) to pilot test the feasibility of conducting a rand…

   Stage

   Phase 4

   Ages

   18 to 55

   Site

   University of Pittsburgh Magee-Womens Hospital, Pittsburgh, Pennsylvania

   Run by

   Malamo Countouris

   See if you can join NCT06281665 on ClinicalTrials.gov

9. Lifestyle Intervention In CKD

   This research study will test whether a 12-week healthy lifestyle program offered through a cardiac rehabilitation center can help lower blood pressure and improve kidney health in adults with advanced chronic kidney disease. Participants will be randomly assigned to either routine kidney health ed…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Sarah W Stedman Nutrition & Metabolism Center, Durham, North Carolina

   Run by

   Duke University

   See if you can join NCT07633145 on ClinicalTrials.gov

10. Study of Disrupted Sleep in Somali Americans

    The aims of this study are to determine the types and severity of previously undiagnosed sleep deficiencies in otherwise healthy Somali Americans, apply a research framework to define psychosocial, behavioral, environmental, and biological mechanisms mediating sleep deficiencies in Somali Americans…

    Stage

    Not phased

    Ages

    18 to 70

    Site

    Mayo Clinic in Rochester, Rochester, Minnesota

    Run by

    Mayo Clinic

    See if you can join NCT05411029 on ClinicalTrials.gov

11. OBPM_PANDA2026: Evaluation of the Performance and Safety of the Aktiia Periodic Optical Blood Pressure Monitoring Device

    This study, with N = 85 participants minimum over 3 visits spread over 7 days, has been designed to assess the accuracy and precision of the Blood Pressure and pulse rate values as generated by Aktiia.product-G1-US for up to 7 days after initialization in a cohort of subjects representative of the …

    Stage

    Not phased

    Ages

    22 to 59

    Site

    Parameters Research Laboratory, Broomfield, Colorado

    Run by

    Aktiia SA

    See if you can join NCT07507903 on ClinicalTrials.gov

12. Implementation of a Beauty Salon-Based Strategy for Blood Pressure Management Among Women

    CROWN is a two-arm, cluster-randomized pilot trial testing the feasibility and preliminary efficacy of a salon-based cardiovascular intervention - training stylists as Heart Health Stylists to conduct in-salon blood pressure screenings, home monitoring with telehealth support, community health-work…

    Stage

    Not phased

    Ages

    18 to 79

    Site

    Johns Hopkins University, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT07042386 on ClinicalTrials.gov

13. Sympathetic Transduction in Obesity-associated Hypertension (OB-HTN)

    The purpose of this study is to understand how the nervous system communicates to blood vessels to increase blood pressure during stress. The study will also investigate how hypertension and obesity influence the nervous system and vascular function. The study will involve measuring sympathetic ner…

    Stage

    EARLY_Phase 1

    Ages

    18 to 55

    Site

    University of Texas Southwestern Medical Center, Dallas, Texas

    Run by

    University of Texas Southwestern Medical Center

    See if you can join NCT04838678 on ClinicalTrials.gov

14. Childhood-Onset Essential Hypertension Natural History Study

    Background: Childhood-onset essential hypertension (COEH) is high blood pressure that develops in children and teens. High blood pressure is a major risk factor for heart disease. COEH is more likely to be caused by changes in genes rather than by factors like stress or diet. Researchers want to le…

    Stage

    Not phased

    Ages

    2 to 99

    Site

    National Institutes of Health Clinical Center, Bethesda, Maryland

    Run by

    National Human Genome Research Institute (NHGRI)

    See if you can join NCT06778239 on ClinicalTrials.gov

15. Arizona CEAL: Linking Social Care With Healthcare Systems to Address SDOH

    The goal of the Arizona Community Engagement Alliance (AZ-CEAL) will be to combine social care with healthcare programs. The study will be connecting selected patients from clinics with trained community health workers (CHW) who will assist participants in getting the help that is needed for their …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Banner University Medical Center South, Tucson, Arizona

    Locations

    2 in total

    Run by

    Sairam Parthasarathy

    See if you can join NCT07799961 on ClinicalTrials.gov

16. MegaNatural BP® GSE on Blood Pressure and Cardiometabolic Risk Factors

    Inflammation and stressors can interfere with the function of the lining of blood vessels and insulin activity, therefore, investigators are aiming to see how the Grape seed Extract (GSE) called MegaNatural BP can help with limiting the effects of these factors. This research will study the effects…

    Stage

    Not phased

    Ages

    40 to 60

    Site

    Clinical Nutrition Research Center, Chicago, Illinois

    Run by

    Clinical Nutrition Research Center, Illinois Institute of Technology

    See if you can join NCT06555952 on ClinicalTrials.gov

17. Sleep Promotion and Pediatric Hypertension

    Determine the effectiveness and feasibility of a mobile health sleep extension approach in the pediatric nephrology setting, to increase sleep duration and reduce systolic and diastolic blood pressure.

    Stage

    Not phased

    Ages

    13 to 18

    Site

    Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

    Run by

    Children's Hospital of Philadelphia

    See if you can join NCT06642246 on ClinicalTrials.gov

18. Preventative Screening and Health Coaching in a Food Insecure Population

    The goal of this longitudinal study is to investigate the role of virtual health coaching on mitigation of cardiometabolic disease risk in an underserved, food insecure population. The main questions it aims to answer are: * Does longitudinal, individualized health coaching directed at lifestyle mo…

    Stage

    Not phased

    Ages

    40 to 75

    Site

    Rush University Medical Center, Chicago, Illinois

    Run by

    Rush University Medical Center

    See if you can join NCT06907524 on ClinicalTrials.gov

19. Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)

    The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the most safe and effective dose for children. The primary objective of this study is to evaluate the PK…

    Stage

    Not phased

    Ages

    0 to 20

    Site

    Lucile Packard Children's Hospital, Palo Alto, California

    Locations

    52 in total

    Run by

    Duke University

    See if you can join NCT04278404 on ClinicalTrials.gov

20. Secondhand Tobacco Smoke and Cardiovascular Disease

    This is a double-blind randomized placebo-controlled crossover clinical trial of efficacy and safety of an FDA-approved angiotensin receptor blocker (losartan) to improve cardiopulmonary outcomes in individuals with pre-Chronic Obstructive Pulmonary Disease (COPD) due to prolonged exposure to secon…

    Stage

    Phase 4

    Ages

    40 and older

    Site

    San Francisco Veterans' Affairs Medical Center, San Francisco, California

    Run by

    University of California, San Francisco

    See if you can join NCT04715568 on ClinicalTrials.gov

21. Ketone Ester and Salt (KEAS) in Young Adults

    Most Americans consume excess dietary salt based on the recommendations set by the American Heart Association and Dietary Guidelines for Americans. High dietary salt impairs the ability of systemic blood vessels and the kidneys to control blood pressure, which contributes to excess salt consumption…

    Stage

    Not phased

    Ages

    19 to 39

    Site

    Indiana University, School of Public Health, Bloomington, Indiana

    Run by

    Indiana University

    See if you can join NCT05545501 on ClinicalTrials.gov

22. Ketone Ester And Salt (KEAS) in Older Adults

    Most Americans consume excess dietary salt based on the recommendations set by the American Heart Association and Dietary Guidelines for Americans. High dietary salt impairs blood pressure control by affecting systemic blood vessels and the kidneys. These changes contribute to excess salt consumpti…

    Stage

    Not phased

    Ages

    50 to 85

    Site

    School of Public Health, Bloomington, Indiana

    Run by

    Indiana University

    See if you can join NCT06868719 on ClinicalTrials.gov

23. Groceries for Residents of Southeastern USA to Stop Hypertension

    GoFreshSE is a randomized control trial, testing the effects of a home-delivered, dietitian-assisted, DASH-patterned grocery intervention on blood pressure in adults with high blood pressure in Florida, Georgia, and Tennessee.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Beth Israel Deaconess Medical Center, Boston, Massachusetts

    Run by

    Beth Israel Deaconess Medical Center

    See if you can join NCT06891911 on ClinicalTrials.gov

24. Sleep Restriction and Parental History of Hypertension

    The purpose of this study is to research the effects of partial sleep deprivation (sleep restriction) in a group of individuals whose parents have high blood pressure compared to a group of individuals whose parents have normal blood pressure.

    Stage

    Not phased

    Ages

    18 to 35

    Site

    Mayo Clinic in Rochester, Rochester, Minnesota

    Run by

    Mayo Clinic

    See if you can join NCT06482814 on ClinicalTrials.gov

25. Melatonin Effects on Cardiovascular Disease Mechanisms in Midlife Women: A Randomized Clinical Trial

    The purpose of this research is to study the effects of 12 weeks of melatonin supplementation compared to placebo in women who are in the menopause transition (perimenopause) and have high blood pressure.

    Stage

    Not phased

    Ages

    40 to 55

    Site

    Mayo Clinic in Rochester, Rochester, Minnesota

    Run by

    Mayo Clinic

    See if you can join NCT06826755 on ClinicalTrials.gov