Hypertension Clinical Trials

143 studies are recruiting for hypertension in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease

   The purpose of this study is to evaluate whether zilebesiran versus placebo reduces the risk of cardiovascular (CV) death, nonfatal myocardial infarction (MI), nonfatal stroke, or heart failure (HF) events. This is an event-driven study that will continue until the targeted number of positively adj…

   Stage

   Phase 3

   Ages

   18 and older

   Site

   Clinical Trial Site, Birmingham, Alabama

   Locations

   1153 in total

   Run by

   Alnylam Pharmaceuticals

   See if you can join NCT07181109 on ClinicalTrials.gov

2. Diabetes and Heart Disease Risk in Blacks

   It is unknown if obesity contributes to the development of heart disease in African American men and women. This study was created to determine whether there is a relationship between sex and body size and the incidence of heart disease in African American men and women. Researchers will attempt to…

   Stage

   Not phased

   Ages

   18 to 70

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

   See if you can join NCT00001853 on ClinicalTrials.gov

3. Clinical and Molecular Characteristics of Primary Aldosteronism in Blacks

   Background: The adrenal gland makes the hormone aldosterone. This helps regulate blood pressure. An adrenal gland tumor that makes too much aldosterone can cause high blood pressure and low potassium. The cause of these tumors is unknown, but sometimes they are inherited. Objective: To study the ge…

   Stage

   Not phased

   Ages

   7 to 70

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

   See if you can join NCT03374215 on ClinicalTrials.gov

4. EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease

   This study is open to adults with type 2 diabetes, high blood pressure, and cardiovascular disease. People can join the study if they have these conditions and do not have a history of heart failure. The purpose of this study is to find out if a medicine called vicadrostat, when taken with empaglif…

   Stage

   Phase 3

   Ages

   18 and older

   Site

   Pinnacle Research Group, LLC, Anniston, Alabama

   Locations

   1143 in total

   Run by

   Boehringer Ingelheim

   See if you can join NCT07064473 on ClinicalTrials.gov

5. Study of Disrupted Sleep in Somali Americans

   The aims of this study are to determine the types and severity of previously undiagnosed sleep deficiencies in otherwise healthy Somali Americans, apply a research framework to define psychosocial, behavioral, environmental, and biological mechanisms mediating sleep deficiencies in Somali Americans…

   Stage

   Not phased

   Ages

   18 to 70

   Site

   Mayo Clinic in Rochester, Rochester, Minnesota

   Run by

   Mayo Clinic

   See if you can join NCT05411029 on ClinicalTrials.gov

6. OBPM_PANDA2026: Evaluation of the Performance and Safety of the Aktiia Periodic Optical Blood Pressure Monitoring Device

   This study, with N = 85 participants minimum over 3 visits spread over 7 days, has been designed to assess the accuracy and precision of the Blood Pressure and pulse rate values as generated by Aktiia.product-G1-US for up to 7 days after initialization in a cohort of subjects representative of the …

   Stage

   Not phased

   Ages

   22 to 59

   Site

   Parameters Research Laboratory, Broomfield, Colorado

   Run by

   Aktiia SA

   See if you can join NCT07507903 on ClinicalTrials.gov

7. A Study to Evaluate ALN-AGT01 RVR in Adult Patients With Mild to Moderate Hypertension Pretreated With Zilebesiran

   The purpose of this study is to evaluate the efficacy, pharmacodynamics (PD), and safety of ALN-AGT01 RVR in participants with mild to moderate hypertension pretreated with zilebesiran.

   Stage

   Phase 2

   Ages

   18 to 75

   Site

   Clinical Trial Site, Lake Forest, California

   Locations

   3 in total

   Run by

   Alnylam Pharmaceuticals

   See if you can join NCT07553442 on ClinicalTrials.gov

8. Impact GLP-1 Agonists Following Bariatric

   Glucagon-like peptide 1 (GLP-1) is a hormone that helps regulate blood glucose levels through improved insulin sensitivity and release of insulin from the pancreas, control hunger, induce satiety and plays a role in the metabolic health of a person. GLP-1 receptor agonists (GLP1-RAs) have been show…

   Stage

   Phase 4

   Ages

   18 and older

   Site

   University of Missouri Hospital, Columbia, Missouri

   Run by

   University of Missouri-Columbia

   See if you can join NCT06132477 on ClinicalTrials.gov

9. Implementation of a Beauty Salon-Based Strategy for Blood Pressure Management Among Women

   CROWN is a two-arm, cluster-randomized pilot trial testing the feasibility and preliminary efficacy of a salon-based cardiovascular intervention - training stylists as Heart Health Stylists to conduct in-salon blood pressure screenings, home monitoring with telehealth support, community health-work…

   Stage

   Not phased

   Ages

   18 to 79

   Site

   Johns Hopkins University, Baltimore, Maryland

   Run by

   Johns Hopkins University

   See if you can join NCT07042386 on ClinicalTrials.gov

10. Sympathetic Transduction in Obesity-associated Hypertension (OB-HTN)

    The purpose of this study is to understand how the nervous system communicates to blood vessels to increase blood pressure during stress. The study will also investigate how hypertension and obesity influence the nervous system and vascular function. The study will involve measuring sympathetic ner…

    Stage

    EARLY_Phase 1

    Ages

    18 to 55

    Site

    University of Texas Southwestern Medical Center, Dallas, Texas

    Run by

    University of Texas Southwestern Medical Center

    See if you can join NCT04838678 on ClinicalTrials.gov

11. Childhood-Onset Essential Hypertension Natural History Study

    Background: Childhood-onset essential hypertension (COEH) is high blood pressure that develops in children and teens. High blood pressure is a major risk factor for heart disease. COEH is more likely to be caused by changes in genes rather than by factors like stress or diet. Researchers want to le…

    Stage

    Not phased

    Ages

    2 to 99

    Site

    National Institutes of Health Clinical Center, Bethesda, Maryland

    Run by

    National Human Genome Research Institute (NHGRI)

    See if you can join NCT06778239 on ClinicalTrials.gov

12. THRIVE- THerapeutic IntravasculaR Ultrasound (TIVUS™) REnal Denervation System Versus Sham for the Adjunctive Treatment of Hypertension

    The primary objective of the THRIVE Pivotal study is to demonstrate the adjunctive effectiveness and the safety of the TIVUS system in: 1. subjects with uncontrolled hypertension (HTN) receiving 0 - 2 anti-hypertensive drugs of different classes in whom the anti-hypertensive medications will be sto…

    Stage

    Not phased

    Ages

    22 to 75

    Site

    Cardiology, PC, Birmingham, Alabama

    Locations

    50 in total

    Run by

    SoniVie Inc.

    See if you can join NCT06559891 on ClinicalTrials.gov

13. Study of Efficacy and Safety of Tonlamarsen in Participants With a Recent Hospitalization and a Concurrent Episode of Acute Severe Hypertension

    The purpose of this study is to evaluate the blood pressure-lowering effect of tonlamarsen in adult participants who were recently hospitalized and concurrently experienced an episode of acute severe hypertension.

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Western Nephrology and Metabolic Bone Disease, PC - Arvada, Arvada, Colorado

    Locations

    11 in total

    Run by

    Kardigan, Inc.

    See if you can join NCT07511361 on ClinicalTrials.gov

14. Arizona CEAL: Linking Social Care With Healthcare Systems to Address SDOH

    The goal of the Arizona Community Engagement Alliance (AZ-CEAL) will be to combine social care with healthcare programs. The study will be connecting selected patients from clinics with trained community health workers (CHW) who will assist participants in getting the help that is needed for their …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Banner University Medical Center South, Tucson, Arizona

    Locations

    2 in total

    Run by

    Sairam Parthasarathy

    See if you can join NCT07799961 on ClinicalTrials.gov

15. MegaNatural BP® GSE on Blood Pressure and Cardiometabolic Risk Factors

    Inflammation and stressors can interfere with the function of the lining of blood vessels and insulin activity, therefore, investigators are aiming to see how the Grape seed Extract (GSE) called MegaNatural BP can help with limiting the effects of these factors. This research will study the effects…

    Stage

    Not phased

    Ages

    40 to 60

    Site

    Clinical Nutrition Research Center, Chicago, Illinois

    Run by

    Clinical Nutrition Research Center, Illinois Institute of Technology

    See if you can join NCT06555952 on ClinicalTrials.gov

16. Sleep Promotion and Pediatric Hypertension

    Determine the effectiveness and feasibility of a mobile health sleep extension approach in the pediatric nephrology setting, to increase sleep duration and reduce systolic and diastolic blood pressure.

    Stage

    Not phased

    Ages

    13 to 18

    Site

    Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

    Run by

    Children's Hospital of Philadelphia

    See if you can join NCT06642246 on ClinicalTrials.gov

17. BradycArdia paCemaKer With AV Interval Modulation for Blood prEssure treAtmenT

    A prospective, multinational, randomized, double-blind, clinical trial evaluating the safety and effectiveness of a novel atrioventricular interval modulation (AVIM) algorithm downloaded into a dual-chamber Medtronic Astra/Azure pacemaker.

    Stage

    Not phased

    Ages

    18 and older

    Site

    HonorHealth, Scottsdale, Arizona

    Locations

    131 in total

    Run by

    Orchestra BioMed, Inc

    See if you can join NCT06059638 on ClinicalTrials.gov

18. Preventative Screening and Health Coaching in a Food Insecure Population

    The goal of this longitudinal study is to investigate the role of virtual health coaching on mitigation of cardiometabolic disease risk in an underserved, food insecure population. The main questions it aims to answer are: * Does longitudinal, individualized health coaching directed at lifestyle mo…

    Stage

    Not phased

    Ages

    40 to 75

    Site

    Rush University Medical Center, Chicago, Illinois

    Run by

    Rush University Medical Center

    See if you can join NCT06907524 on ClinicalTrials.gov

19. Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)

    The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the most safe and effective dose for children. The primary objective of this study is to evaluate the PK…

    Stage

    Not phased

    Ages

    0 to 20

    Site

    Lucile Packard Children's Hospital, Palo Alto, California

    Locations

    52 in total

    Run by

    Duke University

    See if you can join NCT04278404 on ClinicalTrials.gov

20. REFOCUS-HTN US-WEST: A Data Infrastructure to Characterize Individuals With Hypertension

    The goal of the REFOCUS-HTN US-WEST program is to gain a better understanding of the role of a hormone called aldosterone in the development of hypertension. The SCALED sub-study is an observational cohort study that will enroll from REFOCUS-HTN cohort for prospective data collection.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Kaiser Permanente Northern California, Oakland, California

    Run by

    Kaiser Permanente

    See if you can join NCT07780500 on ClinicalTrials.gov

21. Secondhand Tobacco Smoke and Cardiovascular Disease

    This is a double-blind randomized placebo-controlled crossover clinical trial of efficacy and safety of an FDA-approved angiotensin receptor blocker (losartan) to improve cardiopulmonary outcomes in individuals with pre-Chronic Obstructive Pulmonary Disease (COPD) due to prolonged exposure to secon…

    Stage

    Phase 4

    Ages

    40 and older

    Site

    San Francisco Veterans' Affairs Medical Center, San Francisco, California

    Run by

    University of California, San Francisco

    See if you can join NCT04715568 on ClinicalTrials.gov

22. Ketone Ester and Salt (KEAS) in Young Adults

    Most Americans consume excess dietary salt based on the recommendations set by the American Heart Association and Dietary Guidelines for Americans. High dietary salt impairs the ability of systemic blood vessels and the kidneys to control blood pressure, which contributes to excess salt consumption…

    Stage

    Not phased

    Ages

    19 to 39

    Site

    Indiana University, School of Public Health, Bloomington, Indiana

    Run by

    Indiana University

    See if you can join NCT05545501 on ClinicalTrials.gov

23. Ketone Ester And Salt (KEAS) in Older Adults

    Most Americans consume excess dietary salt based on the recommendations set by the American Heart Association and Dietary Guidelines for Americans. High dietary salt impairs blood pressure control by affecting systemic blood vessels and the kidneys. These changes contribute to excess salt consumpti…

    Stage

    Not phased

    Ages

    50 to 85

    Site

    School of Public Health, Bloomington, Indiana

    Run by

    Indiana University

    See if you can join NCT06868719 on ClinicalTrials.gov

24. Groceries for Residents of Southeastern USA to Stop Hypertension

    GoFreshSE is a randomized control trial, testing the effects of a home-delivered, dietitian-assisted, DASH-patterned grocery intervention on blood pressure in adults with high blood pressure in Florida, Georgia, and Tennessee.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Beth Israel Deaconess Medical Center, Boston, Massachusetts

    Run by

    Beth Israel Deaconess Medical Center

    See if you can join NCT06891911 on ClinicalTrials.gov

25. A Randomized Placebo-procedure Controlled Trial of the Enhancor System (PULmonary Artery Denervation) to Evaluate Safety and Efficacy in Patients With Combined Pre- and Post-capillary Pulmonary Hypertension Associated With Left Heart Disease

    The goal of this clinical study is to evaluate the safety and efficacy of percutaneous pulmonary artery denervation with the Multi-Pole Pulmonary Artery Radiofrequency Ablation Enhancor System in patients with combined pre- and post-capillary pulmonary hypertension (CpcPH) associated with left hear…

    Stage

    Not phased

    Ages

    18 to 85

    Site

    Banner - University Medical Center Tucson, Tucson, Arizona

    Locations

    6 in total

    Run by

    Pulnovo Medical, Inc.

    See if you can join NCT07214376 on ClinicalTrials.gov