Hypertension Clinical Trials

137 studies are recruiting for hypertension in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. A Study of Clazakizumab (LY5724886) in Adults With Elevated hsCRP and at Increased Risk for Cardiovascular Event

   The purpose of this study is to measure the change in high-sensitivity C-reactive protein (hsCRP), a marker of inflammation in the body, with clazakizumab compared with placebo in adults who have elevated hsCRP and at increased risk for cardiovascular event. Participation in the study will last abo…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Heart Center Research, LLC, Huntsville, Alabama

   Locations

   46 in total

   Run by

   Eli Lilly and Company

   See if you can join NCT07783802 on ClinicalTrials.gov

2. Osilodrostat in Patients With Hypertension Caused by Hypercortisolaemia Due to Cushing's Syndrome

   Osilodrostat has proven to be a safe and efficacious treatment for patients with CS. Demonstrating normalisation of hypercortisolaemia and in patients with hypertension and/or dysglycaemia clinically relevant and statistically significant reductions in blood pressure and glycaemia. This study aims …

   Stage

   Phase 4

   Ages

   18 and older

   Site

   NOLA Care, LLC, Jacksonville, Florida

   Locations

   3 in total

   Run by

   RECORDATI GROUP

   See if you can join NCT07247162 on ClinicalTrials.gov

3. Autonomic and Renal Contributions to Hypertension With ADT

   This study plans to learn more about contributors to high blood pressure in men who undergo androgen deprivation therapy (ADT) to treat prostate cancer. Prostate cancer is the most common non-skin cancer in men, affecting approximately 1 in 8 American men and its primary treatment is through the us…

   Stage

   Phase 4

   Ages

   40 and older

   Site

   Virginia Commonwealth University, Richmond, Virginia

   Run by

   Virginia Commonwealth University

   See if you can join NCT07848828 on ClinicalTrials.gov

4. Clevidipine for the Antihypertensive Treatment of Acute Intracerebral Hemorrhage

   The aim is to compare the rate of hypertensive subjects with ICH who reach SBP target with stability within 60 minutes of enrollment, among patients treated with IV clevidipine with those treated with alternate IV antihypertensive regimen.

   Stage

   Not phased

   Ages

   18 to 100

   Site

   University of California, Irvine, California

   Locations

   21 in total

   Run by

   Zeenat Qureshi Stroke Institute

   See if you can join NCT06402968 on ClinicalTrials.gov

5. Diabetes and Heart Disease Risk in Blacks

   It is unknown if obesity contributes to the development of heart disease in African American men and women. This study was created to determine whether there is a relationship between sex and body size and the incidence of heart disease in African American men and women. Researchers will attempt to…

   Stage

   Not phased

   Ages

   18 to 70

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

   See if you can join NCT00001853 on ClinicalTrials.gov

6. EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease

   This study is open to adults with type 2 diabetes, high blood pressure, and cardiovascular disease. People can join the study if they have these conditions and do not have a history of heart failure. The purpose of this study is to find out if a medicine called vicadrostat, when taken with empaglif…

   Stage

   Phase 3

   Ages

   18 and older

   Site

   Pinnacle Research Group, LLC, Anniston, Alabama

   Locations

   1142 in total

   Run by

   Boehringer Ingelheim

   See if you can join NCT07064473 on ClinicalTrials.gov

7. Clinical and Molecular Characteristics of Primary Aldosteronism in Blacks

   Background: The adrenal gland makes the hormone aldosterone. This helps regulate blood pressure. An adrenal gland tumor that makes too much aldosterone can cause high blood pressure and low potassium. The cause of these tumors is unknown, but sometimes they are inherited. Objective: To study the ge…

   Stage

   Not phased

   Ages

   7 to 70

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

   See if you can join NCT03374215 on ClinicalTrials.gov

8. Impact GLP-1 Agonists Following Bariatric

   Glucagon-like peptide 1 (GLP-1) is a hormone that helps regulate blood glucose levels through improved insulin sensitivity and release of insulin from the pancreas, control hunger, induce satiety and plays a role in the metabolic health of a person. GLP-1 receptor agonists (GLP1-RAs) have been show…

   Stage

   Phase 4

   Ages

   18 and older

   Site

   University of Missouri Hospital, Columbia, Missouri

   Run by

   University of Missouri-Columbia

   See if you can join NCT06132477 on ClinicalTrials.gov

9. Effect of Empagliflozin on Left Atrial Function in Adults at Risk for Heart Failure

   Sodium-glucose cotransporter 2 inhibitors (SGLT2i) reduce CVD events, including incident HF. SGLT2 is a glucose transport protein in the kidneys. Inhibition of this protein results in glucosuria and lower serum blood sugar. The SGLT2i medications were initially approved to treat type 2 diabetes (T2…

   Stage

   EARLY_Phase 1

   Ages

   60 and older

   Site

   University of Minnesota, Minneapolis, Minnesota

   Run by

   University of Minnesota

   See if you can join NCT06507657 on ClinicalTrials.gov

10. SPYRAL GEMINI Pilot Study

    The purpose of the SPYRAL GEMINI Pilot Study is to evaluate that multi-organ denervation with the Gemini System is safe and provide evidence of blood pressure reduction when studied in an uncontrolled hypertensive population with and without high cardiovascular risk.

    Stage

    Not phased

    Ages

    18 to 80

    Site

    Stanford Hospital and Clinics, Stanford, California

    Locations

    18 in total

    Run by

    Medtronic Vascular

    See if you can join NCT06907147 on ClinicalTrials.gov

11. Longitudinal Real-world Clinical Outcomes Study on Symplicity Renal Denervation

    This observational study will assess the long-term effectiveness of the RDN procedure for lowering blood pressure in Medicare patients with uncontrolled hypertension. This research will be conducted using de-identified electronic health records (EHR) and administrative health insurance claims data.…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Beth Israel Deaconess Medical Center, Boston, Massachusetts

    Run by

    Medtronic Vascular

    See if you can join NCT07174622 on ClinicalTrials.gov

12. A Randomized Placebo-procedure Controlled Trial of the Enhancor System (PULmonary Artery Denervation) to Evaluate Safety and Efficacy in Patients With Combined Pre- and Post-capillary Pulmonary Hypertension Associated With Left Heart Disease

    The goal of this clinical study is to evaluate the safety and efficacy of percutaneous pulmonary artery denervation with the Multi-Pole Pulmonary Artery Radiofrequency Ablation Enhancor System in patients with combined pre- and post-capillary pulmonary hypertension (CpcPH) associated with left hear…

    Stage

    Not phased

    Ages

    18 to 85

    Site

    Banner - University Medical Center Tucson, Tucson, Arizona

    Locations

    18 in total

    Run by

    Pulnovo Medical, Inc.

    See if you can join NCT07214376 on ClinicalTrials.gov

13. Cardiac Effects of Mineralocorticoid Receptor Antagonism After Hypertensive Disorders of Pregnancy

    The goal of this clinical trial is to determine if the medication eplerenone yields greater improvements in coronary microvascular function than chlorthalidone in women who experienced hypertension during pregnancy and subsequently developed chronic hypertension. The main Aims are: * To test the hy…

    Stage

    Phase 2

    Ages

    18 to 65

    Site

    Brigham and Women's Hospital, Boston, Massachusetts

    Locations

    2 in total

    Run by

    Massachusetts General Hospital

    See if you can join NCT07238400 on ClinicalTrials.gov

14. Global Paradise System US Post Approval Study

    The objective of the Global Paradise® System US Post Approval Study (US GPS) is to evaluate the real-world use of the Paradise Ultrasound Renal Denervation System indicated for patients who are unable to lower their blood pressure with lifestyle changes and medication. This system is comprised of a…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Tibor Rubin VA Medical Center, Long Beach, California

    Locations

    46 in total

    Run by

    ReCor Medical, Inc.

    See if you can join NCT06297291 on ClinicalTrials.gov

15. A Novel Digital Tool Clinicians Can Use to Prescribe Exercise to Patients With Cardiovascular Disease Risk Factors

    The investigators will conduct a feasibility and pilot efficacy randomized controlled trial to test the usability and user satisfaction of an evidence-based digital health tool the investigators developed for clinicians to use to Prioritize Personalize Prescribe EXercise (P3-EX) to patients with ca…

    Stage

    Not phased

    Ages

    18 to 64

    Site

    Hartford HealthCare, Hartford, Connecticut

    Locations

    3 in total

    Run by

    University of Connecticut

    See if you can join NCT07238556 on ClinicalTrials.gov

16. Cardiovascular Manifestations of MR Activation in Primary Aldosteronism: Pilot Clinical Study

    This research study aims to learn more about the impact the hormone aldosterone on the heart. Primary aldosteronism is a condition where the body's adrenal glands make too much of the hormone aldosterone, which can cause high blood pressure and increase the risk of heart and kidney disease. Treatme…

    Stage

    Phase 4

    Ages

    18 to 85

    Site

    Brigham and Women's Hospital, Boston, Massachusetts

    Run by

    Brigham and Women's Hospital

    See if you can join NCT05030545 on ClinicalTrials.gov

17. Community Park-Based Programs for Health Promotion: Active Older Adults Prospective Cohort Study

    The Active Older Adults prospective cohort study examines the effects of a park-based fitness program on cardiovascular fitness outcomes for older adults (aged 50 years and older). Duke will perform a secondary analysis of the data collected as part of the Active Older Adults prospective cohort stu…

    Stage

    Not phased

    Ages

    50 to 95

    Site

    Miami-Dade County Parks, Recreation and Open Spaces Department, Miami, Florida

    Run by

    Duke University

    See if you can join NCT06604650 on ClinicalTrials.gov

18. E3 Hypertension - A Team-based, Multidisciplinary Model in Addressing Barriers to Hypertension Control

    This study aims to compare a multidisciplinary clinical hypertension and social needs intervention to enhanced standard of care for hypertension management in primary care clinics with regards to hypertension control outcomes.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Rush University Medical Center, Chicago, Illinois

    Run by

    Rush University Medical Center

    See if you can join NCT06899750 on ClinicalTrials.gov

19. Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease

    The purpose of this study is to evaluate whether zilebesiran versus placebo reduces the risk of cardiovascular (CV) death, nonfatal myocardial infarction (MI), nonfatal stroke, or heart failure (HF) events. This is an event-driven study that will continue until the targeted number of positively adj…

    Stage

    Phase 3

    Ages

    18 and older

    Site

    Clinical Trial Site, Birmingham, Alabama

    Locations

    1190 in total

    Run by

    Alnylam Pharmaceuticals

    See if you can join NCT07181109 on ClinicalTrials.gov

20. Study of Efficacy and Safety of Tonlamarsen in Participants With a Recent Hospitalization and a Concurrent Episode of Acute Severe Hypertension

    The purpose of this study is to evaluate the blood pressure-lowering effect of tonlamarsen in adult participants who were recently hospitalized and concurrently experienced an episode of acute severe hypertension.

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Western Nephrology and Metabolic Bone Disease, PC - Arvada, Arvada, Colorado

    Locations

    13 in total

    Run by

    Kardigan, Inc.

    See if you can join NCT07511361 on ClinicalTrials.gov

21. Polygenic Risk Score Implementation and Stratification for Managing Blood Pressure

    In a multi-ethnic population, a genome-wide polygenic risk score (PRS) for systolic blood pressure (SBP), incorporating over one million common genetic variants, predicts blood pressure (BP) traits and the risk of adverse cardiovascular events beyond traditional risk factors. Delivering SBP PRS inf…

    Stage

    Not phased

    Ages

    18 to 55

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Run by

    University of Alabama at Birmingham

    See if you can join NCT06962488 on ClinicalTrials.gov

22. A Study to Evaluate ALN-AGT01 RVR in Adult Patients With Mild to Moderate Hypertension Pretreated With Zilebesiran

    The purpose of this study is to evaluate the efficacy, pharmacodynamics (PD), and safety of ALN-AGT01 RVR in participants with mild to moderate hypertension pretreated with zilebesiran.

    Stage

    Phase 2

    Ages

    18 to 75

    Site

    Clinical Trial Site, Lake Forest, California

    Locations

    3 in total

    Run by

    Alnylam Pharmaceuticals

    See if you can join NCT07553442 on ClinicalTrials.gov

23. How a Mediterranean Diet With Potatoes Impacts Heart and Metabolic Health in Adults With Pre-Diabetes

    The goal of this clinical trial is to is to determine the effects of baked potato with the skin (BP) + nutrition education focused on adherence for a Mediterranean Dietary Pattern (MEDNE) on glycemic control, cardiometabolic health, and dietary quality in individuals with pre-diabetes from differen…

    Stage

    Not phased

    Ages

    45 to 80

    Site

    University of Nevada Las Vegas, Las Vegas, Nevada

    Locations

    2 in total

    Run by

    University of Nevada, Las Vegas

    See if you can join NCT06817252 on ClinicalTrials.gov

24. The REACH-OUT Trial

    Test the effectiveness of a technology-enabled strategy to optimize blood pressure among reproductive-aged women with hypertension receiving care in Federally Qualified Health Centers.

    Stage

    Not phased

    Ages

    18 to 44

    Site

    Northwestern University, Chicago, Illinois

    Run by

    Northwestern University

    See if you can join NCT07540143 on ClinicalTrials.gov

25. REFOCUS-HTN US-WEST: A Data Infrastructure to Characterize Individuals With Hypertension

    The goal of the REFOCUS-HTN US-WEST program is to gain a better understanding of the role of a hormone called aldosterone in the development of hypertension. The SCALED sub-study is an observational cohort study that will enroll from REFOCUS-HTN cohort for prospective data collection.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Kaiser Permanente Northern California, Oakland, California

    Run by

    Kaiser Permanente

    See if you can join NCT07780500 on ClinicalTrials.gov