Cardiovascular Diseases Clinical Trials

125 studies are recruiting for cardiovascular diseases in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 2

1. Global Paradise System US Post Approval Study

   The objective of the Global Paradise® System US Post Approval Study (US GPS) is to evaluate the real-world use of the Paradise Ultrasound Renal Denervation System indicated for patients who are unable to lower their blood pressure with lifestyle changes and medication. This system is comprised of a…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Tibor Rubin VA Medical Center, Long Beach, California

   Locations

   43 in total

   Run by

   ReCor Medical, Inc.

   See if you can join NCT06297291 on ClinicalTrials.gov

2. The Influence of Chardonnay Marc Intake on Gut and Cardiometabolic Health

   Recently a dietary recommendation of 400 - 600 mg/ day has been proposed for the reduced risk of developing cardiovascular disease. Dietary flavanols can be obtained from the intake of foods such as tea, cocoa, wine, berries and apples. Incorporating Chardonnay Marc (the skins and seeds of Chardonn…

   Stage

   Not phased

   Ages

   45 to 70

   Site

   University of California, Davis, Davis, California

   Run by

   University of California, Davis

   See if you can join NCT06476795 on ClinicalTrials.gov

3. The Oxford Risk Factors And Non-Invasive Imaging Study

   ORFAN is a prospective, multi-centre, multi-ethnic cohort observational study collecting CT scans, biological material and outcomes data, to develop and validate novel biomarkers of cardiometabolic and other disease risk.

   Stage

   Not phased

   Ages

   18 to 99

   Site

   Valleywise Health, Phoenix, Arizona

   Locations

   45 in total

   Run by

   University of Oxford

   See if you can join NCT05169333 on ClinicalTrials.gov

4. Longitudinal Validation of CIRC Technologies

   Cardiovascular disease is the leading cause of death worldwide. Advanced cardiovascular imaging using Magnetic Resonance Imaging (MRI) has proven to be effective in providing gold standard myocardial tissue characterization. Moreover, the intrinsic advantage of MRI's lack of exposure to ionizing ra…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Cleveland Clinic, Cleveland, Ohio

   Run by

   The Cleveland Clinic

   See if you can join NCT07081711 on ClinicalTrials.gov

5. NAUTICAL: Effect of Natriuretic Peptide Augmentation on Cardiometabolic Health in Black Individuals

   Black individuals are more likely to have decreased insulin sensitivity which results in a high risk for the development of cardiometabolic disease. The reasons for this are incompletely understood. Natriuretic peptides (NPs) are hormones produced by the heart that play a role in regulating the met…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   University of Alabama at Birmingham, Birmingham, Alabama

   Run by

   University of Alabama at Birmingham

   See if you can join NCT04055428 on ClinicalTrials.gov

6. Behavioral Activation Delivered Via Home-based Telehealth to Improve Functioning in Cardiovascular Disease Patients Recently Discharged From Inpatient Care

   The purpose of this study is to demonstrate whether Behavioral Activation for depression delivered via home based telehealth (BA-HT) is effective in improving social and role functioning in Veterans recently discharged from Cardiovascular disease (CVD-related) inpatient care. Eligible participants …

   Stage

   Not phased

   Ages

   21 and older

   Site

   Ralph H. Johnson VA Medical Center, Charleston, SC, Charleston, South Carolina

   Run by

   VA Office of Research and Development

   See if you can join NCT04877197 on ClinicalTrials.gov

7. Supporting Mental Health and Reducing Care Stress in Caregivers of Persons With Cardiovascular Disease

   The purpose of this study is to evaluate the preliminary efficacy, feasibility, acceptability, and barriers and facilitators to implementation of the Confident Caregiver intervention among family caregivers of persons with cardiovascular disease participating in cardiac rehabilitation. Caregivers r…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of California Davis Health System, Sacramento, California

   Run by

   University of California, Davis

   See if you can join NCT07717723 on ClinicalTrials.gov

8. The TRICURE EFS Study

   Prospective, multi-center study to assess safety and performance of the TRiCares Topaz Tricuspid Valve Replacement System

   Stage

   Not phased

   Ages

   18 and older

   Site

   Piedmont Healthcare Inc., Atlanta, Georgia

   Locations

   10 in total

   Run by

   TRiCares

   See if you can join NCT06506942 on ClinicalTrials.gov

9. Virtual Care Strategies to Improve Participation in Cardiac Rehabilitation Among Veterans

   Home-based CR (HBCR) is an alternative to traditional CR programs that has comparable efficacy in improving morbidity/mortality and increases access to critical services. There is major potential to improve Veteran engagement in CR by combining digital coaching (d-Coaching) with existing VA-support…

   Stage

   Not phased

   Ages

   21 and older

   Site

   San Francisco VA Medical Center, San Francisco, CA, San Francisco, California

   Locations

   2 in total

   Run by

   VA Office of Research and Development

   See if you can join NCT05423158 on ClinicalTrials.gov

10. Evaluation of a Novel Technology to Support Tailored Health Behavior Counseling in Rural Primary Care Clinics

    This project will conduct a pilot hybrid study that examines the implementation (Aims 1 \& 2) and preliminary effectiveness (Aim 3) of PREVENT, a digital health intervention, among patients with overweight/obesity (N=100) using a clinic-randomized design. The central hypothesis of the study is that…

    Stage

    Not phased

    Ages

    18 to 64

    Site

    Washington University in St. Louis, St Louis, Missouri

    Run by

    Washington University School of Medicine

    See if you can join NCT06397729 on ClinicalTrials.gov

11. Adapting and Testing a Novel Digital Health Tool (PREVENT) to Improve Health Behavior Counseling and Cardiovascular Health in Rural Primary Care Clinics

    The focus on this application is low-income, rural patients, since cardiovascular disease (CVD) prevalence is 40% higher among rural than urban residents. Health behavior counseling and follow-up care are required for patients with an elevated body mass index who have increased risk for CVD. Counse…

    Stage

    Not phased

    Ages

    18 to 64

    Site

    Washington University in St. Louis, St Louis, Missouri

    Run by

    Washington University School of Medicine

    See if you can join NCT06063564 on ClinicalTrials.gov

12. The RADIANCE CED Study

    The RADIANCE CED study is a prospective observational study designed to evaluate the long-term effectiveness of ultrasound renal denervation in lowering blood pressure among patients with uncontrolled hypertension. Data will be collected from electronic health records (EHRs) of Medicare-eligible pa…

    Stage

    Not phased

    Ages

    65 and older

    Site

    Henry Ford Hospital, Detroit, Michigan

    Locations

    2 in total

    Run by

    ReCor Medical, Inc.

    See if you can join NCT07231757 on ClinicalTrials.gov

13. Self Expanding Coronary Sinus Reducer for Treatment of Symptomatic Coronary Microvascular Dysfunction (CMD)

    VahatiCor's Coronary Sinus Reducer (A-FLUX) has been designed to improve angina or angina-like symptoms in patients with CMD. SERRA-I is an early feasibility study that evaluates the safety and clinical performance of the A-FLUX Reducer in this population.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Yale University, New Haven, Connecticut

    Locations

    3 in total

    Run by

    VahatiCor, Inc.

    See if you can join NCT07449325 on ClinicalTrials.gov

14. Aging, Geriatric Syndromes and Clonal Hematopoiesis

    In this study the investigators will incorporate a wide range of clinical variables associated with aging and cardiovascular disease to determine whether they are associated with mutation status independent of chronologic age. Clinically, aging can be operationalized using geriatric assessment, whi…

    Stage

    Not phased

    Ages

    50 and older

    Site

    Washington University School of Medicine, St Louis, Missouri

    Run by

    Washington University School of Medicine

    See if you can join NCT02604563 on ClinicalTrials.gov

15. Healthy School Recognized Campus: A Hybrid Type 2 Implementation-Effectiveness Trial

    Healthy School Recognized Campus is a Texas A\&M AgriLife Extension initiative that supports the delivery of school-based physical activity and nutrition programs for diverse youth across Texas. The purpose of this study is to conduct a type 2 hybrid implementation-effectiveness, cluster dual rando…

    Stage

    Not phased

    Ages

    8 to 16

    Site

    Texas A&M AgriLife Dallas Center, Dallas, Texas

    Run by

    Texas A&M University

    See if you can join NCT07079995 on ClinicalTrials.gov

16. CV CARE: CardioVascular Care in PC Patients

    This research is being done to test a program to assess and manage reversible cardiovascular (CV) risk factors in participants with prostate cancer starting androgen deprivation therapy (ADT), with the goal of integrating a standardized method into Dana-Farber Cancer Institute clinics for all such …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Brigham and Women's Hospital, Boston, Massachusetts

    Locations

    2 in total

    Run by

    Dana-Farber Cancer Institute

    See if you can join NCT06202820 on ClinicalTrials.gov

17. Cardiovascular and Metabolic Sciences Biorepository

    The purpose of the Cardiovascular and Metabolic Sciences Biorepository is to collect and store information and biospecimens (blood, urine, stool, and heart tissue) from patients with and without cardiovascular and metabolic diseases to create a readily available biorepository of samples and related…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Cleveland Clinic Main Campus, Cleveland, Ohio

    Run by

    The Cleveland Clinic

    See if you can join NCT06560424 on ClinicalTrials.gov

18. SPYRAL GEMINI Pilot Study

    The purpose of the SPYRAL GEMINI Pilot Study is to evaluate that multi-organ denervation with the Gemini System is safe and provide evidence of blood pressure reduction when studied in an uncontrolled hypertensive population with and without high cardiovascular risk.

    Stage

    Not phased

    Ages

    18 to 80

    Site

    Stanford Hospital and Clinics, Stanford, California

    Locations

    18 in total

    Run by

    Medtronic Vascular

    See if you can join NCT06907147 on ClinicalTrials.gov

19. Optimizing Cardiovascular Preventive Care for Women Following Hypertensive Disorders of Pregnancy

    Cardiovascular disease is the leading cause of death among women in the United States, and women with hypertensive disorders of pregnancy have a 2-fold higher risk for cardiovascular disease later in life compared to women with uncomplicated pregnancies. This research investigates a patient-centere…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Utah Hospital, Salt Lake City, Utah

    Run by

    University of Utah

    See if you can join NCT05826925 on ClinicalTrials.gov

20. EVOC - EVs in Obesity and Cardiometabolic Disease

    The goal of this observational study is to research the impact of molecular signals from the heart, liver and fat tissue on cardiovascular disease risk, and the presentation of Type II Diabetes and diseases that affect the heart, blood vessels and metabolism (Cardiometabolic Disease). Specifically,…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT06408961 on ClinicalTrials.gov

21. Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure

    The purpose of TEAM-HF IDE clinical trial is to evaluate safety and effectiveness of the HeartMate 3 LVAS compared to guideline directed medical therapy (GDMT) in a population of ambulatory advanced heart failure patients who are not dependent on intravenous inotrope.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Banner-University Medical Center Phoenix, Phoenix, Arizona

    Locations

    68 in total

    Run by

    Abbott Medical Devices

    See if you can join NCT06526195 on ClinicalTrials.gov

22. Treatment With Aspirin After Preeclampsia: TAP Trial

    The objective of this research project is to conduct a single-site pilot trial to assess the feasibility and effect of low-dose aspirin to augment vascular recovery in the immediate postpartum period after preeclampsia through two specific aims: 1) to pilot test the feasibility of conducting a rand…

    Stage

    Phase 4

    Ages

    18 to 55

    Site

    University of Pittsburgh Magee-Womens Hospital, Pittsburgh, Pennsylvania

    Run by

    Malamo Countouris

    See if you can join NCT06281665 on ClinicalTrials.gov

23. Brain Connections for Arm Movement After Stroke

    The purpose of this study is to use Transcranial Magnetic Stimulation (TMS) while subjects are making reaching movements in a robotic arm device in order to discover how different brain areas control movement before and after stroke and when these brain areas are most sensitive to TMS.

    Stage

    Not phased

    Ages

    45 to 90

    Site

    VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA, Pittsburgh, Pennsylvania

    Run by

    VA Office of Research and Development

    See if you can join NCT04286516 on ClinicalTrials.gov

24. ADAPT Micro-Randomized Trial

    The goal of this study is to collect quantitative and qualitative data that can be used to optimize the HeartSteps mHealth intervention for physical activity. The current version of the intervention is intended to help patients with heart disease increase and maintain their physical activity long-t…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Michigan, Ann Arbor, Michigan

    Run by

    University of Michigan

    See if you can join NCT06915220 on ClinicalTrials.gov

25. American Indian Chronic Renal Insufficiency Cohort Study (AI-CRIC Study)

    Despite many advances in our understanding of the natural history and progression of chronic kidney disease (CKD) and cardio vascular disease (CVD) in the parent CRIC study over the past 15 years, important questions about key risk factors for these diseases remain unanswered in the AI population. …

    Stage

    Not phased

    Ages

    21 to 80

    Site

    First Nations Community Health Source, Albuquerque, New Mexico

    Locations

    3 in total

    Run by

    University of New Mexico

    See if you can join NCT04185844 on ClinicalTrials.gov