Cardiovascular Diseases Clinical Trials

121 studies are recruiting for cardiovascular diseases in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 2

1. Improving the Collaborative Health of Adult Dyads

   This study tests the efficacy of a dyadic intervention to mitigate the adverse health consequences of adults with pre-existing chronic health conditions and their informal carepartners (IC). Socioeconomically disadvantaged, older, and people from rural regions are more likely burdened with greater …

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of South Carolina, Columbia, South Carolina

   Run by

   University of South Carolina

   See if you can join NCT05370014 on ClinicalTrials.gov

2. Cerebrovascular Health and Resilience in Midlife

   This study examines cardiovascular responses to a brief psychological challenge under laboratory conditions among adult volunteers. The study volunteers are asked to complete two study sessions. In one session, the volunteers are asked to provide demographic and health-related information via quest…

   Stage

   Not phased

   Ages

   40 to 59

   Site

   University of Pittsburgh, Pittsburgh, Pennsylvania

   Run by

   University of Pittsburgh

   See if you can join NCT06029348 on ClinicalTrials.gov

3. Observational Pharmaco-Epidemiology Research & Analysis

   Greater advances are needed in two separate but related areas in healthcare: 1) the Clinical Decision Support Systems that complement the EHR use in support of routine patient care, population management and disease management; and 2) the use of the point-of-care observational data from the provide…

   Stage

   Not phased

   Ages

   0 and older

   Site

   Epividian, Durham, North Carolina

   Run by

   Epividian

   See if you can join NCT03813862 on ClinicalTrials.gov

4. A Phase 3 Trial of Inhaled Mosliciguat in PH-ILD (PHrontier)

   A Phase 3, Multicenter, Randomized, Double-Blind Placebo-Controlled Trial to Evaluate the Safety and Efficacy of Inhaled Mosliciguat in Participants with Pulmonary Hypertension Associated with Interstitial Lung Disease

   Stage

   Phase 3

   Ages

   18 to 85

   Site

   Clinical Research Site, Kissimmee, Florida

   Locations

   3 in total

   Run by

   Pulmovant, Inc.

   See if you can join NCT07816185 on ClinicalTrials.gov

5. Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failure

   The goal of this study is to evaluate the safety and efficacy of the BrioVAD System by demonstrating non-inferiority to the HeartMate 3 Left Ventricular Assist System when used for the treatment of advanced, refractory, left ventricular heart failure.

   Stage

   Not phased

   Ages

   18 to 100

   Site

   University of Alabama at Birmingham Hospital, Birmingham, Alabama

   Locations

   47 in total

   Run by

   BrioHealth Solutions, Inc.

   See if you can join NCT06310031 on ClinicalTrials.gov

6. 100-Year Human Aging Study

   The 100-Year Human Aging Study is a prospective, pragmatic, observational trial enrolling participants across fixed clinical sites, mobile clinical sites, and an online participation pathway (current and future) to undergo comprehensive multi-system health screening and longitudinal follow-up until…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Longevity Metrics, Boulder, Colorado

   Run by

   Longevity Metrics, Inc.

   See if you can join NCT07563777 on ClinicalTrials.gov

7. Human Observatory Study

   The Human Observatory Study is a prospective observational and ecological surveillance study building a continuously-updating world model for human health, disease, and death at the individual and population level. Individual multi-system clinical data from enrolled participants are linked to a con…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Longevity Metrics, Boulder, Colorado

   Run by

   Longevity Metrics, Inc.

   See if you can join NCT07646782 on ClinicalTrials.gov

8. Health Ahead Comparative Effectiveness Study

   The Health Ahead Comparative Effectiveness Study is a pragmatic, parallel-arm interventional platform that systematically compares successive changes to preventive health screening on the path toward a fully automated screening system deployable in any environment, including the most isolated and r…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Longevity Metrics, Boulder, Colorado

   Run by

   William Brandenburg, MD

   See if you can join NCT07669168 on ClinicalTrials.gov

9. A Study of Mosliciguat in Combination With Inhaled Treprostinil in PH-ILD

   This is a Phase 2, open-label, multi-center clinical study to evaluate the safety and tolerability of inhaled mosliciguat in participants with pulmonary hypertension associated with interstitial lung disease (PH-ILD) on a background inhaled treprostinil.

   Stage

   Phase 2

   Ages

   18 to 85

   Site

   Clinical Research Site, Santa Barbara, California

   Locations

   13 in total

   Run by

   Pulmovant, Inc.

   See if you can join NCT07333183 on ClinicalTrials.gov

10. Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults

    PREVENTABLE is a multi-center, randomized, parallel group, placebo-controlled superiority study. Participants will be randomized 1:1 to atorvastatin 40 mg or placebo. This large study conducted in community-dwelling older adults without cardiovascular disease (CVD) or dementia will demonstrate the …

    Stage

    Phase 4

    Ages

    75 and older

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Locations

    106 in total

    Run by

    Duke University

    See if you can join NCT04262206 on ClinicalTrials.gov

11. Safety and Clinical Performance of the Freesolve Resorbable Magnesium Scaffold (RMS) System in Subjects With Coronary Artery Lesions

    The objective of this study is to assess the safety and efficacy of the Freesolve resorbable magnesium scaffold (RMS) in the treatment of subjects with up to two de novo lesions in native coronary arteries compared to the Xience coronary drug-eluting stent (DES) system

    Stage

    Not phased

    Ages

    18 to 80

    Site

    MedStar Washington Hospital Center, Washington D.C., District of Columbia

    Locations

    3 in total

    Run by

    Teleflex

    See if you can join NCT07258290 on ClinicalTrials.gov

12. Microbiome Metabolites and Alcohol in HIV to Reduce CVD RCT

    Among people living with HIV, heavy drinking increases the risk of heart disease and death. Studies suggest that alcohol changes the number and kind of bacteria in your gut and these changes increase the risk of heart disease and death. This randomized controlled trial will determine whether a pill…

    Stage

    Phase 2

    Ages

    18 to 89

    Site

    Vanderbilt University Medical Center, Nashville, Tennessee

    Run by

    Vanderbilt University Medical Center

    See if you can join NCT05288790 on ClinicalTrials.gov

13. Cardiovascular Biorepository

    Use biospecimens procured from patients and organ donors to improve understanding of molecular, cellular, and tissue-level processes produced by cardiovascular disease and therapeutic interventions

    Stage

    Not phased

    Ages

    Any age

    Site

    University of Kentucky, Department of Internal Medicine, Division of Cardiovascular Medicine, Lexington, Kentucky

    Run by

    Kenneth S. Campbell

    See if you can join NCT00753974 on ClinicalTrials.gov

14. Exercise Activity Intervention With Sensor-Based Engagement in Patients With Atrial Fibrillation

    Atrial fibrillation (AF) affects 1 in 4 individuals during their lifetime and continues to increase in frequency and impact. Exercise intervention has established benefits to improve AF symptoms and burden in clinical studies. However, lack of access to exercise programs has limited therapeutic ado…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Icahn School of Medicine at Mount Sinai, New York, New York

    Run by

    Icahn School of Medicine at Mount Sinai

    See if you can join NCT06938412 on ClinicalTrials.gov

15. NOrthwestern Tempus AI-enaBLed Electrocardiography (NOTABLE) Trial

    The goal of this clinical trial is to determine if a machine learning/artificial intelligence (AI)-based electrocardiogram (ECG) algorithm (rECHOmmend and ECG-AF) can identify undiagnosed cardiovascular disease in patients. It will also examine the safety and effectiveness of using this AI-based to…

    Stage

    Not phased

    Ages

    40 and older

    Site

    Northwestern University, Chicago, Illinois

    Run by

    Northwestern University

    See if you can join NCT06511505 on ClinicalTrials.gov

16. Secondhand Tobacco Smoke and Cardiovascular Disease

    This is a double-blind randomized placebo-controlled crossover clinical trial of efficacy and safety of an FDA-approved angiotensin receptor blocker (losartan) to improve cardiopulmonary outcomes in individuals with pre-Chronic Obstructive Pulmonary Disease (COPD) due to prolonged exposure to secon…

    Stage

    Phase 4

    Ages

    40 and older

    Site

    San Francisco Veterans' Affairs Medical Center, San Francisco, California

    Run by

    University of California, San Francisco

    See if you can join NCT04715568 on ClinicalTrials.gov

17. Groceries for Residents of Southeastern USA to Stop Hypertension

    GoFreshSE is a randomized control trial, testing the effects of a home-delivered, dietitian-assisted, DASH-patterned grocery intervention on blood pressure in adults with high blood pressure in Florida, Georgia, and Tennessee.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Beth Israel Deaconess Medical Center, Boston, Massachusetts

    Run by

    Beth Israel Deaconess Medical Center

    See if you can join NCT06891911 on ClinicalTrials.gov

18. Role of Adiposomes in Endothelial Dysfunction

    The development of type II diabetes (T2D) is strongly associated with obesity and both are well-established risk factors for cardiovascular disease. Knowing that vascular dysfunction is an early event in the development of cardiovascular disease in obese diabetic (OB-T2D) patients, The investigator…

    Stage

    Not phased

    Ages

    18 to 50

    Site

    University of Illinois at Chicago, Chicago, Illinois

    Run by

    University of Illinois at Chicago

    See if you can join NCT05199454 on ClinicalTrials.gov

19. The Influence of Chardonnay Marc Intake on Gut and Cardiometabolic Health

    Recently a dietary recommendation of 400 - 600 mg/ day has been proposed for the reduced risk of developing cardiovascular disease. Dietary flavanols can be obtained from the intake of foods such as tea, cocoa, wine, berries and apples. Incorporating Chardonnay Marc (the skins and seeds of Chardonn…

    Stage

    Not phased

    Ages

    45 to 70

    Site

    University of California, Davis, Davis, California

    Run by

    University of California, Davis

    See if you can join NCT06476795 on ClinicalTrials.gov

20. The Oxford Risk Factors And Non-Invasive Imaging Study

    ORFAN is a prospective, multi-centre, multi-ethnic cohort observational study collecting CT scans, biological material and outcomes data, to develop and validate novel biomarkers of cardiometabolic and other disease risk.

    Stage

    Not phased

    Ages

    18 to 99

    Site

    Valleywise Health, Phoenix, Arizona

    Locations

    45 in total

    Run by

    University of Oxford

    See if you can join NCT05169333 on ClinicalTrials.gov

21. Longitudinal Validation of CIRC Technologies

    Cardiovascular disease is the leading cause of death worldwide. Advanced cardiovascular imaging using Magnetic Resonance Imaging (MRI) has proven to be effective in providing gold standard myocardial tissue characterization. Moreover, the intrinsic advantage of MRI's lack of exposure to ionizing ra…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Cleveland Clinic, Cleveland, Ohio

    Run by

    The Cleveland Clinic

    See if you can join NCT07081711 on ClinicalTrials.gov

22. NAUTICAL: Effect of Natriuretic Peptide Augmentation on Cardiometabolic Health in Black Individuals

    Black individuals are more likely to have decreased insulin sensitivity which results in a high risk for the development of cardiometabolic disease. The reasons for this are incompletely understood. Natriuretic peptides (NPs) are hormones produced by the heart that play a role in regulating the met…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Run by

    University of Alabama at Birmingham

    See if you can join NCT04055428 on ClinicalTrials.gov

23. Behavioral Activation Delivered Via Home-based Telehealth to Improve Functioning in Cardiovascular Disease Patients Recently Discharged From Inpatient Care

    The purpose of this study is to demonstrate whether Behavioral Activation for depression delivered via home based telehealth (BA-HT) is effective in improving social and role functioning in Veterans recently discharged from Cardiovascular disease (CVD-related) inpatient care. Eligible participants …

    Stage

    Not phased

    Ages

    21 and older

    Site

    Ralph H. Johnson VA Medical Center, Charleston, SC, Charleston, South Carolina

    Run by

    VA Office of Research and Development

    See if you can join NCT04877197 on ClinicalTrials.gov

24. Supporting Mental Health and Reducing Care Stress in Caregivers of Persons With Cardiovascular Disease

    The purpose of this study is to evaluate the preliminary efficacy, feasibility, acceptability, and barriers and facilitators to implementation of the Confident Caregiver intervention among family caregivers of persons with cardiovascular disease participating in cardiac rehabilitation. Caregivers r…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of California Davis Health System, Sacramento, California

    Run by

    University of California, Davis

    See if you can join NCT07717723 on ClinicalTrials.gov

25. Virtual Care Strategies to Improve Participation in Cardiac Rehabilitation Among Veterans

    Home-based CR (HBCR) is an alternative to traditional CR programs that has comparable efficacy in improving morbidity/mortality and increases access to critical services. There is major potential to improve Veteran engagement in CR by combining digital coaching (d-Coaching) with existing VA-support…

    Stage

    Not phased

    Ages

    21 and older

    Site

    San Francisco VA Medical Center, San Francisco, CA, San Francisco, California

    Locations

    2 in total

    Run by

    VA Office of Research and Development

    See if you can join NCT05423158 on ClinicalTrials.gov