Cardiovascular Diseases Clinical Trials in Boston, Massachusetts

19 studies are recruiting for cardiovascular diseases in Boston, Massachusetts right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

Search these by distance from you

Studies now recruiting

1. Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failure

   The goal of this study is to evaluate the safety and efficacy of the BrioVAD System by demonstrating non-inferiority to the HeartMate 3 Left Ventricular Assist System when used for the treatment of advanced, refractory, left ventricular heart failure.

   Stage

   Not phased

   Ages

   18 to 100

   Site

   Tufts Medical Center, Boston, Massachusetts

   Locations

   47 in total

   Run by

   BrioHealth Solutions, Inc.

   See if you can join NCT06310031 on ClinicalTrials.gov

2. A Prospective, Multicenter, Randomized Controlled Trial to Investigate the Value of Coronary CT Angiography in the Understanding and Management of Coronary Calcium (The Optimal Trial)

   The OPTIMAL randomized clinical trial has been designed to compare two imaging strategies and to test the hypothesis that a calcium modification strategy informed by coronary CT angiography (CCTA) will improve procedural efficiency and effectiveness compared with the current standard of care (IVUS-…

   Stage

   Not phased

   Ages

   18 to 85

   Site

   Bringham and Women's Hospital, Boston, Massachusetts

   Locations

   14 in total

   Run by

   Fundación EPIC

   See if you can join NCT07286578 on ClinicalTrials.gov

3. A Study to See if Lepodisiran Can Reduce Plaque in Coronary Arteries of Adults With Elevated Lp(a) Who Have Had Heart Events or Are at High Risk

   Lipoprotein(a), also known as Lp(a), is a protein that carries cholesterol and proteins in your blood. People with high Lp(a) have a higher risk for heart disease. The main purpose of the study is to investigate how lepodisiran, compared to a placebo, affects the amount and type of plaque in the he…

   Stage

   Phase 3

   Ages

   45 to 80

   Site

   Massachusetts General Hospital, Boston, Massachusetts

   Locations

   58 in total

   Run by

   Eli Lilly and Company

   See if you can join NCT07613294 on ClinicalTrials.gov

4. A Study of Mosliciguat in Combination With Inhaled Treprostinil in PH-ILD

   This is a Phase 2, open-label, multi-center clinical study to evaluate the safety and tolerability of inhaled mosliciguat in participants with pulmonary hypertension associated with interstitial lung disease (PH-ILD) on a background inhaled treprostinil.

   Stage

   Phase 2

   Ages

   18 to 85

   Site

   Clinical Research Site, Boston, Massachusetts

   Locations

   13 in total

   Run by

   Pulmovant, Inc.

   See if you can join NCT07333183 on ClinicalTrials.gov

5. Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults

   PREVENTABLE is a multi-center, randomized, parallel group, placebo-controlled superiority study. Participants will be randomized 1:1 to atorvastatin 40 mg or placebo. This large study conducted in community-dwelling older adults without cardiovascular disease (CVD) or dementia will demonstrate the …

   Stage

   Phase 4

   Ages

   75 and older

   Site

   VA Boston Healthcare System, Boston, Massachusetts

   Locations

   106 in total

   Run by

   Duke University

   See if you can join NCT04262206 on ClinicalTrials.gov

6. Groceries for Residents of Southeastern USA to Stop Hypertension

   GoFreshSE is a randomized control trial, testing the effects of a home-delivered, dietitian-assisted, DASH-patterned grocery intervention on blood pressure in adults with high blood pressure in Florida, Georgia, and Tennessee.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Beth Israel Deaconess Medical Center, Boston, Massachusetts

   Run by

   Beth Israel Deaconess Medical Center

   See if you can join NCT06891911 on ClinicalTrials.gov

7. Global Paradise System US Post Approval Study

   The objective of the Global Paradise® System US Post Approval Study (US GPS) is to evaluate the real-world use of the Paradise Ultrasound Renal Denervation System indicated for patients who are unable to lower their blood pressure with lifestyle changes and medication. This system is comprised of a…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Massachusetts General Hospital, Boston, Massachusetts

   Locations

   43 in total

   Run by

   ReCor Medical, Inc.

   See if you can join NCT06297291 on ClinicalTrials.gov

8. The Oxford Risk Factors And Non-Invasive Imaging Study

   ORFAN is a prospective, multi-centre, multi-ethnic cohort observational study collecting CT scans, biological material and outcomes data, to develop and validate novel biomarkers of cardiometabolic and other disease risk.

   Stage

   Not phased

   Ages

   18 to 99

   Site

   Brigham and Women's Hospital, Boston, Massachusetts

   Locations

   45 in total

   Run by

   University of Oxford

   See if you can join NCT05169333 on ClinicalTrials.gov

9. CV CARE: CardioVascular Care in PC Patients

   This research is being done to test a program to assess and manage reversible cardiovascular (CV) risk factors in participants with prostate cancer starting androgen deprivation therapy (ADT), with the goal of integrating a standardized method into Dana-Farber Cancer Institute clinics for all such …

   Stage

   Not phased

   Ages

   18 and older

   Site

   Brigham and Women's Hospital, Boston, Massachusetts

   Locations

   2 in total

   Run by

   Dana-Farber Cancer Institute

   See if you can join NCT06202820 on ClinicalTrials.gov

10. SPYRAL GEMINI Pilot Study

    The purpose of the SPYRAL GEMINI Pilot Study is to evaluate that multi-organ denervation with the Gemini System is safe and provide evidence of blood pressure reduction when studied in an uncontrolled hypertensive population with and without high cardiovascular risk.

    Stage

    Not phased

    Ages

    18 to 80

    Site

    Beth Israel Deaconess Medical Center, Boston, Massachusetts

    Locations

    18 in total

    Run by

    Medtronic Vascular

    See if you can join NCT06907147 on ClinicalTrials.gov

11. EVOC - EVs in Obesity and Cardiometabolic Disease

    The goal of this observational study is to research the impact of molecular signals from the heart, liver and fat tissue on cardiovascular disease risk, and the presentation of Type II Diabetes and diseases that affect the heart, blood vessels and metabolism (Cardiometabolic Disease). Specifically,…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT06408961 on ClinicalTrials.gov

12. Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure

    The purpose of TEAM-HF IDE clinical trial is to evaluate safety and effectiveness of the HeartMate 3 LVAS compared to guideline directed medical therapy (GDMT) in a population of ambulatory advanced heart failure patients who are not dependent on intravenous inotrope.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Locations

    68 in total

    Run by

    Abbott Medical Devices

    See if you can join NCT06526195 on ClinicalTrials.gov

13. Longitudinal Real-world Clinical Outcomes Study on Symplicity Renal Denervation

    This observational study will assess the long-term effectiveness of the RDN procedure for lowering blood pressure in Medicare patients with uncontrolled hypertension. This research will be conducted using de-identified electronic health records (EHR) and administrative health insurance claims data.…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Beth Israel Deaconess Medical Center, Boston, Massachusetts

    Run by

    Medtronic Vascular

    See if you can join NCT07174622 on ClinicalTrials.gov

14. The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR

    The objective of this prospective, randomized, double- blinded (patient and assessors), sham-controlled clinical trial is to assess the safety and efficacy of the CMCS in treating heart failure with functional regurgitation (FMR).

    Stage

    Not phased

    Ages

    18 and older

    Site

    St Elizabeth's Medical Center, Boston, Massachusetts

    Locations

    92 in total

    Run by

    Cardiac Dimensions, Inc.

    See if you can join NCT03142152 on ClinicalTrials.gov

15. PKP2-ACM Natural History Study

    The goal of this study is to describe the natural history and clinical events for patients who have Arrhythmogenic Cardiomyopathy with Pathogenic Plakophilin-2 Variants (PKP2-ACM) managed with standard of care.

    Stage

    Not phased

    Ages

    12 and older

    Site

    Boston Children's Hospital, Boston, Massachusetts

    Locations

    3 in total

    Run by

    Rocket Pharmaceuticals Inc.

    See if you can join NCT06644742 on ClinicalTrials.gov

16. Effects of Whole vs. Nonfat Milk Consumption on Body Composition in Children

    This study will evaluate the effects of whole vs. nonfat milk consumption on body composition, cardiometabolic disease risk factors, and dietary quality.

    Stage

    Not phased

    Ages

    9 to 12

    Site

    New Balance Foundation Obesity Prevention Center, Boston, Massachusetts

    Run by

    Boston Children's Hospital

    See if you can join NCT05464186 on ClinicalTrials.gov

17. Transition to Cardiac Rehabilitation (T2CR) to Address Barriers of Multimorbidity and Frailty

    Cardiac rehabilitation (CR) is a secondary prevention program for patients with cardiovascular disease (CVD). It is especially valuable as CVD increasingly occurs in combination with comorbidity, frailty, and complexities of care that predispose patients to functional decline, disability, and high …

    Stage

    Not phased

    Ages

    18 and older

    Site

    VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA, Boston, Massachusetts

    Locations

    2 in total

    Run by

    VA Office of Research and Development

    See if you can join NCT06244199 on ClinicalTrials.gov

18. Mindfulness and Behavior Change to Improve Cardiovascular Health of Older People With HIV

    Older people with HIV (OPWH) are disproportionately impacted by cardiovascular disease (CVD) attributable to behavioral risk factors, and chronic HIV immune dysregulation resulting inflammation. Systemic inflammation is exacerbated by psychological distress via activating the immune response and dr…

    Stage

    Not phased

    Ages

    50 and older

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT06001814 on ClinicalTrials.gov

19. MagicTouch for Treatment of In-Stent Restenosis in Coronary Artery Lesions

    A Prospective, Multicenter, Randomized, Two-Arm, Single-blind Superiority Trial to Evaluate the Safety and Efficacy of the MagicTouch™ Sirolimus- Coated Balloon in the Treatment of Coronary Drug-Eluting Stent In-Stent Restenosis. Subjects with prior DES implantation presenting with ISR lesions unde…

    Stage

    Not phased

    Ages

    18 to 110

    Site

    Beth Israel Deaconess Medical Center, Boston, Massachusetts

    Locations

    28 in total

    Run by

    Concept Medical Inc.

    See if you can join NCT05908331 on ClinicalTrials.gov