Cardiovascular Diseases Clinical Trials

125 studies are recruiting for cardiovascular diseases in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Improving the Collaborative Health of Adult Dyads

   This study tests the efficacy of a dyadic intervention to mitigate the adverse health consequences of adults with pre-existing chronic health conditions and their informal carepartners (IC). Socioeconomically disadvantaged, older, and people from rural regions are more likely burdened with greater …

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of South Carolina, Columbia, South Carolina

   Run by

   University of South Carolina

   See if you can join NCT05370014 on ClinicalTrials.gov

2. Fibrotic Disease Activity in Cardiopulmonary Disorders Using 18F-Fibroblast Activation Protein Inhibitor (18F-FAPI-74) PET/CT Imaging

   Background: Injury or diseases of the heart and lung can sometimes cause scar tissue (fibrosis) to build up in those organs. Current imaging scans can see this scar tissue once it has formed, but researchers want to find a way to detect the fibrosis in its earliest stages, while there might still b…

   Stage

   Phase 3

   Ages

   18 to 100

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Heart, Lung, and Blood Institute (NHLBI)

   See if you can join NCT07613099 on ClinicalTrials.gov

3. Diabetes and Heart Disease Risk in Blacks

   It is unknown if obesity contributes to the development of heart disease in African American men and women. This study was created to determine whether there is a relationship between sex and body size and the incidence of heart disease in African American men and women. Researchers will attempt to…

   Stage

   Not phased

   Ages

   18 to 70

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

   See if you can join NCT00001853 on ClinicalTrials.gov

4. Cerebrovascular Health and Resilience in Midlife

   This study examines cardiovascular responses to a brief psychological challenge under laboratory conditions among adult volunteers. The study volunteers are asked to complete two study sessions. In one session, the volunteers are asked to provide demographic and health-related information via quest…

   Stage

   Not phased

   Ages

   40 to 59

   Site

   University of Pittsburgh, Pittsburgh, Pennsylvania

   Run by

   University of Pittsburgh

   See if you can join NCT06029348 on ClinicalTrials.gov

5. EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease

   This study is open to adults with type 2 diabetes, high blood pressure, and cardiovascular disease. People can join the study if they have these conditions and do not have a history of heart failure. The purpose of this study is to find out if a medicine called vicadrostat, when taken with empaglif…

   Stage

   Phase 3

   Ages

   18 and older

   Site

   Pinnacle Research Group, LLC, Anniston, Alabama

   Locations

   1143 in total

   Run by

   Boehringer Ingelheim

   See if you can join NCT07064473 on ClinicalTrials.gov

6. Observational Pharmaco-Epidemiology Research & Analysis

   Greater advances are needed in two separate but related areas in healthcare: 1) the Clinical Decision Support Systems that complement the EHR use in support of routine patient care, population management and disease management; and 2) the use of the point-of-care observational data from the provide…

   Stage

   Not phased

   Ages

   0 and older

   Site

   Epividian, Durham, North Carolina

   Run by

   Epividian

   See if you can join NCT03813862 on ClinicalTrials.gov

7. A Phase 3 Trial of Inhaled Mosliciguat in PH-ILD (PHrontier)

   A Phase 3, Multicenter, Randomized, Double-Blind Placebo-Controlled Trial to Evaluate the Safety and Efficacy of Inhaled Mosliciguat in Participants with Pulmonary Hypertension Associated with Interstitial Lung Disease

   Stage

   Phase 3

   Ages

   18 to 85

   Site

   Clinical Research Site, Kissimmee, Florida

   Locations

   3 in total

   Run by

   Pulmovant, Inc.

   See if you can join NCT07816185 on ClinicalTrials.gov

8. Thrombosis and Inflammation in Vessels Initiative (TIVI)

   Background: Diseases related to the immune system, blood clots, and blood vessels can affect every part of the body. These diseases are now known to be interrelated: People who have strokes, blood clots in their legs, or autoimmune disease, for example, are at greater risk of complications in the h…

   Stage

   Not phased

   Ages

   5 to 100

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Heart, Lung, and Blood Institute (NHLBI)

   See if you can join NCT06552767 on ClinicalTrials.gov

9. Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failure

   The goal of this study is to evaluate the safety and efficacy of the BrioVAD System by demonstrating non-inferiority to the HeartMate 3 Left Ventricular Assist System when used for the treatment of advanced, refractory, left ventricular heart failure.

   Stage

   Not phased

   Ages

   18 to 100

   Site

   University of Alabama at Birmingham Hospital, Birmingham, Alabama

   Locations

   47 in total

   Run by

   BrioHealth Solutions, Inc.

   See if you can join NCT06310031 on ClinicalTrials.gov

10. A Prospective, Multicenter, Randomized Controlled Trial to Investigate the Value of Coronary CT Angiography in the Understanding and Management of Coronary Calcium (The Optimal Trial)

    The OPTIMAL randomized clinical trial has been designed to compare two imaging strategies and to test the hypothesis that a calcium modification strategy informed by coronary CT angiography (CCTA) will improve procedural efficiency and effectiveness compared with the current standard of care (IVUS-…

    Stage

    Not phased

    Ages

    18 to 85

    Site

    Minneapolis Heart Institute, Minneapolis, Minnesota

    Locations

    14 in total

    Run by

    Fundación EPIC

    See if you can join NCT07286578 on ClinicalTrials.gov

11. 100-Year Human Aging Study

    The 100-Year Human Aging Study is a prospective, pragmatic, observational trial enrolling participants across fixed clinical sites, mobile clinical sites, and an online participation pathway (current and future) to undergo comprehensive multi-system health screening and longitudinal follow-up until…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Longevity Metrics, Boulder, Colorado

    Run by

    Longevity Metrics, Inc.

    See if you can join NCT07563777 on ClinicalTrials.gov

12. A Study to See if Lepodisiran Can Reduce Plaque in Coronary Arteries of Adults With Elevated Lp(a) Who Have Had Heart Events or Are at High Risk

    Lipoprotein(a), also known as Lp(a), is a protein that carries cholesterol and proteins in your blood. People with high Lp(a) have a higher risk for heart disease. The main purpose of the study is to investigate how lepodisiran, compared to a placebo, affects the amount and type of plaque in the he…

    Stage

    Phase 3

    Ages

    45 to 80

    Site

    Valley Clinical Trials, Inc., Northridge, California

    Locations

    58 in total

    Run by

    Eli Lilly and Company

    See if you can join NCT07613294 on ClinicalTrials.gov

13. Human Observatory Study

    The Human Observatory Study is a prospective observational and ecological surveillance study building a continuously-updating world model for human health, disease, and death at the individual and population level. Individual multi-system clinical data from enrolled participants are linked to a con…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Longevity Metrics, Boulder, Colorado

    Run by

    Longevity Metrics, Inc.

    See if you can join NCT07646782 on ClinicalTrials.gov

14. Health Ahead Comparative Effectiveness Study

    The Health Ahead Comparative Effectiveness Study is a pragmatic, parallel-arm interventional platform that systematically compares successive changes to preventive health screening on the path toward a fully automated screening system deployable in any environment, including the most isolated and r…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Longevity Metrics, Boulder, Colorado

    Run by

    William Brandenburg, MD

    See if you can join NCT07669168 on ClinicalTrials.gov

15. A Study of Mosliciguat in Combination With Inhaled Treprostinil in PH-ILD

    This is a Phase 2, open-label, multi-center clinical study to evaluate the safety and tolerability of inhaled mosliciguat in participants with pulmonary hypertension associated with interstitial lung disease (PH-ILD) on a background inhaled treprostinil.

    Stage

    Phase 2

    Ages

    18 to 85

    Site

    Clinical Research Site, Santa Barbara, California

    Locations

    13 in total

    Run by

    Pulmovant, Inc.

    See if you can join NCT07333183 on ClinicalTrials.gov

16. Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults

    PREVENTABLE is a multi-center, randomized, parallel group, placebo-controlled superiority study. Participants will be randomized 1:1 to atorvastatin 40 mg or placebo. This large study conducted in community-dwelling older adults without cardiovascular disease (CVD) or dementia will demonstrate the …

    Stage

    Phase 4

    Ages

    75 and older

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Locations

    106 in total

    Run by

    Duke University

    See if you can join NCT04262206 on ClinicalTrials.gov

17. Safety and Clinical Performance of the Freesolve Resorbable Magnesium Scaffold (RMS) System in Subjects With Coronary Artery Lesions

    The objective of this study is to assess the safety and efficacy of the Freesolve resorbable magnesium scaffold (RMS) in the treatment of subjects with up to two de novo lesions in native coronary arteries compared to the Xience coronary drug-eluting stent (DES) system

    Stage

    Not phased

    Ages

    18 to 80

    Site

    MedStar Washington Hospital Center, Washington D.C., District of Columbia

    Locations

    3 in total

    Run by

    Teleflex

    See if you can join NCT07258290 on ClinicalTrials.gov

18. Microbiome Metabolites and Alcohol in HIV to Reduce CVD RCT

    Among people living with HIV, heavy drinking increases the risk of heart disease and death. Studies suggest that alcohol changes the number and kind of bacteria in your gut and these changes increase the risk of heart disease and death. This randomized controlled trial will determine whether a pill…

    Stage

    Phase 2

    Ages

    18 to 89

    Site

    Vanderbilt University Medical Center, Nashville, Tennessee

    Run by

    Vanderbilt University Medical Center

    See if you can join NCT05288790 on ClinicalTrials.gov

19. Cardiovascular Biorepository

    Use biospecimens procured from patients and organ donors to improve understanding of molecular, cellular, and tissue-level processes produced by cardiovascular disease and therapeutic interventions

    Stage

    Not phased

    Ages

    Any age

    Site

    University of Kentucky, Department of Internal Medicine, Division of Cardiovascular Medicine, Lexington, Kentucky

    Run by

    Kenneth S. Campbell

    See if you can join NCT00753974 on ClinicalTrials.gov

20. Exercise Activity Intervention With Sensor-Based Engagement in Patients With Atrial Fibrillation

    Atrial fibrillation (AF) affects 1 in 4 individuals during their lifetime and continues to increase in frequency and impact. Exercise intervention has established benefits to improve AF symptoms and burden in clinical studies. However, lack of access to exercise programs has limited therapeutic ado…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Icahn School of Medicine at Mount Sinai, New York, New York

    Run by

    Icahn School of Medicine at Mount Sinai

    See if you can join NCT06938412 on ClinicalTrials.gov

21. NOrthwestern Tempus AI-enaBLed Electrocardiography (NOTABLE) Trial

    The goal of this clinical trial is to determine if a machine learning/artificial intelligence (AI)-based electrocardiogram (ECG) algorithm (rECHOmmend and ECG-AF) can identify undiagnosed cardiovascular disease in patients. It will also examine the safety and effectiveness of using this AI-based to…

    Stage

    Not phased

    Ages

    40 and older

    Site

    Northwestern University, Chicago, Illinois

    Run by

    Northwestern University

    See if you can join NCT06511505 on ClinicalTrials.gov

22. Secondhand Tobacco Smoke and Cardiovascular Disease

    This is a double-blind randomized placebo-controlled crossover clinical trial of efficacy and safety of an FDA-approved angiotensin receptor blocker (losartan) to improve cardiopulmonary outcomes in individuals with pre-Chronic Obstructive Pulmonary Disease (COPD) due to prolonged exposure to secon…

    Stage

    Phase 4

    Ages

    40 and older

    Site

    San Francisco Veterans' Affairs Medical Center, San Francisco, California

    Run by

    University of California, San Francisco

    See if you can join NCT04715568 on ClinicalTrials.gov

23. Groceries for Residents of Southeastern USA to Stop Hypertension

    GoFreshSE is a randomized control trial, testing the effects of a home-delivered, dietitian-assisted, DASH-patterned grocery intervention on blood pressure in adults with high blood pressure in Florida, Georgia, and Tennessee.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Beth Israel Deaconess Medical Center, Boston, Massachusetts

    Run by

    Beth Israel Deaconess Medical Center

    See if you can join NCT06891911 on ClinicalTrials.gov

24. A Randomized Placebo-procedure Controlled Trial of the Enhancor System (PULmonary Artery Denervation) to Evaluate Safety and Efficacy in Patients With Combined Pre- and Post-capillary Pulmonary Hypertension Associated With Left Heart Disease

    The goal of this clinical study is to evaluate the safety and efficacy of percutaneous pulmonary artery denervation with the Multi-Pole Pulmonary Artery Radiofrequency Ablation Enhancor System in patients with combined pre- and post-capillary pulmonary hypertension (CpcPH) associated with left hear…

    Stage

    Not phased

    Ages

    18 to 85

    Site

    Banner - University Medical Center Tucson, Tucson, Arizona

    Locations

    6 in total

    Run by

    Pulnovo Medical, Inc.

    See if you can join NCT07214376 on ClinicalTrials.gov

25. Role of Adiposomes in Endothelial Dysfunction

    The development of type II diabetes (T2D) is strongly associated with obesity and both are well-established risk factors for cardiovascular disease. Knowing that vascular dysfunction is an early event in the development of cardiovascular disease in obese diabetic (OB-T2D) patients, The investigator…

    Stage

    Not phased

    Ages

    18 to 50

    Site

    University of Illinois at Chicago, Chicago, Illinois

    Run by

    University of Illinois at Chicago

    See if you can join NCT05199454 on ClinicalTrials.gov