Cardiovascular Diseases Clinical Trials

121 studies are recruiting for cardiovascular diseases in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. A Prospective, Multicenter, Randomized Controlled Trial to Investigate the Value of Coronary CT Angiography in the Understanding and Management of Coronary Calcium (The Optimal Trial)

   The OPTIMAL randomized clinical trial has been designed to compare two imaging strategies and to test the hypothesis that a calcium modification strategy informed by coronary CT angiography (CCTA) will improve procedural efficiency and effectiveness compared with the current standard of care (IVUS-…

   Stage

   Not phased

   Ages

   18 to 85

   Site

   Minneapolis Heart Institute, Minneapolis, Minnesota

   Locations

   15 in total

   Run by

   Fundación EPIC

   See if you can join NCT07286578 on ClinicalTrials.gov

2. Diabetes and Heart Disease Risk in Blacks

   It is unknown if obesity contributes to the development of heart disease in African American men and women. This study was created to determine whether there is a relationship between sex and body size and the incidence of heart disease in African American men and women. Researchers will attempt to…

   Stage

   Not phased

   Ages

   18 to 70

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

   See if you can join NCT00001853 on ClinicalTrials.gov

3. The TRICURE EFS Study

   Prospective, multi-center study to assess safety and performance of the TRiCares Topaz Tricuspid Valve Replacement System

   Stage

   Not phased

   Ages

   18 and older

   Site

   Piedmont Healthcare Inc., Atlanta, Georgia

   Locations

   10 in total

   Run by

   TRiCares

   See if you can join NCT06506942 on ClinicalTrials.gov

4. EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease

   This study is open to adults with type 2 diabetes, high blood pressure, and cardiovascular disease. People can join the study if they have these conditions and do not have a history of heart failure. The purpose of this study is to find out if a medicine called vicadrostat, when taken with empaglif…

   Stage

   Phase 3

   Ages

   18 and older

   Site

   Pinnacle Research Group, LLC, Anniston, Alabama

   Locations

   1142 in total

   Run by

   Boehringer Ingelheim

   See if you can join NCT07064473 on ClinicalTrials.gov

5. Fibrotic Disease Activity in Cardiopulmonary Disorders Using 18F-Fibroblast Activation Protein Inhibitor (18F-FAPI-74) PET/CT Imaging

   Background: Injury or diseases of the heart and lung can sometimes cause scar tissue (fibrosis) to build up in those organs. Current imaging scans can see this scar tissue once it has formed, but researchers want to find a way to detect the fibrosis in its earliest stages, while there might still b…

   Stage

   Phase 3

   Ages

   18 to 100

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Heart, Lung, and Blood Institute (NHLBI)

   See if you can join NCT07613099 on ClinicalTrials.gov

6. TRIFORMIS RESILIA Real-world Study Assessing Safety and Performance (TRIBLAZE Study)

   TRIBLAZE is a prospective, observational, single-arm, multicenter study designed to collect real-world clinical outcomes in a minimum of 75 participants who will receive the Edwards Lifesciences TRIFORMIS RESILIA surgical tricuspid heart valve, Model 11300T.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Ascension St. Vincent's Hospital, Carmel, Indiana

   Run by

   Edwards Lifesciences

   See if you can join NCT07684313 on ClinicalTrials.gov

7. Effect of Empagliflozin on Left Atrial Function in Adults at Risk for Heart Failure

   Sodium-glucose cotransporter 2 inhibitors (SGLT2i) reduce CVD events, including incident HF. SGLT2 is a glucose transport protein in the kidneys. Inhibition of this protein results in glucosuria and lower serum blood sugar. The SGLT2i medications were initially approved to treat type 2 diabetes (T2…

   Stage

   EARLY_Phase 1

   Ages

   60 and older

   Site

   University of Minnesota, Minneapolis, Minnesota

   Run by

   University of Minnesota

   See if you can join NCT06507657 on ClinicalTrials.gov

8. SPYRAL GEMINI Pilot Study

   The purpose of the SPYRAL GEMINI Pilot Study is to evaluate that multi-organ denervation with the Gemini System is safe and provide evidence of blood pressure reduction when studied in an uncontrolled hypertensive population with and without high cardiovascular risk.

   Stage

   Not phased

   Ages

   18 to 80

   Site

   Stanford Hospital and Clinics, Stanford, California

   Locations

   18 in total

   Run by

   Medtronic Vascular

   See if you can join NCT06907147 on ClinicalTrials.gov

9. Longitudinal Real-world Clinical Outcomes Study on Symplicity Renal Denervation

   This observational study will assess the long-term effectiveness of the RDN procedure for lowering blood pressure in Medicare patients with uncontrolled hypertension. This research will be conducted using de-identified electronic health records (EHR) and administrative health insurance claims data.…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Beth Israel Deaconess Medical Center, Boston, Massachusetts

   Run by

   Medtronic Vascular

   See if you can join NCT07174622 on ClinicalTrials.gov

10. A Randomized Placebo-procedure Controlled Trial of the Enhancor System (PULmonary Artery Denervation) to Evaluate Safety and Efficacy in Patients With Combined Pre- and Post-capillary Pulmonary Hypertension Associated With Left Heart Disease

    The goal of this clinical study is to evaluate the safety and efficacy of percutaneous pulmonary artery denervation with the Multi-Pole Pulmonary Artery Radiofrequency Ablation Enhancor System in patients with combined pre- and post-capillary pulmonary hypertension (CpcPH) associated with left hear…

    Stage

    Not phased

    Ages

    18 to 85

    Site

    Banner - University Medical Center Tucson, Tucson, Arizona

    Locations

    18 in total

    Run by

    Pulnovo Medical, Inc.

    See if you can join NCT07214376 on ClinicalTrials.gov

11. Global Paradise System US Post Approval Study

    The objective of the Global Paradise® System US Post Approval Study (US GPS) is to evaluate the real-world use of the Paradise Ultrasound Renal Denervation System indicated for patients who are unable to lower their blood pressure with lifestyle changes and medication. This system is comprised of a…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Tibor Rubin VA Medical Center, Long Beach, California

    Locations

    46 in total

    Run by

    ReCor Medical, Inc.

    See if you can join NCT06297291 on ClinicalTrials.gov

12. Community Park-Based Programs for Health Promotion: Active Older Adults Prospective Cohort Study

    The Active Older Adults prospective cohort study examines the effects of a park-based fitness program on cardiovascular fitness outcomes for older adults (aged 50 years and older). Duke will perform a secondary analysis of the data collected as part of the Active Older Adults prospective cohort stu…

    Stage

    Not phased

    Ages

    50 to 95

    Site

    Miami-Dade County Parks, Recreation and Open Spaces Department, Miami, Florida

    Run by

    Duke University

    See if you can join NCT06604650 on ClinicalTrials.gov

13. PKP2-ACM Natural History Study

    The goal of this study is to describe the natural history and clinical events for patients who have Arrhythmogenic Cardiomyopathy with Pathogenic Plakophilin-2 Variants (PKP2-ACM) managed with standard of care.

    Stage

    Not phased

    Ages

    12 and older

    Site

    Boston Children's Hospital, Boston, Massachusetts

    Locations

    3 in total

    Run by

    Rocket Pharmaceuticals Inc.

    See if you can join NCT06644742 on ClinicalTrials.gov

14. American Indian Chronic Renal Insufficiency Cohort Study (AI-CRIC Study)

    Despite many advances in our understanding of the natural history and progression of chronic kidney disease (CKD) and cardio vascular disease (CVD) in the parent CRIC study over the past 15 years, important questions about key risk factors for these diseases remain unanswered in the AI population. …

    Stage

    Not phased

    Ages

    21 to 80

    Site

    First Nations Community Health Source, Albuquerque, New Mexico

    Locations

    3 in total

    Run by

    University of New Mexico

    See if you can join NCT04185844 on ClinicalTrials.gov

15. NightWare and Cardiovascular Health in Veterans With PTSD

    The purpose of this study is to learn more about the effectiveness of a prescription wrist-wearable device called NightWare (NW) on improving sleep in Veterans with nightmares related to posttraumatic stress disorder (PTSD). The investigators also want to learn whether it improves cardiovascular he…

    Stage

    Not phased

    Ages

    22 to 88

    Site

    Rocky Mountain Regional VA Medical Center, Aurora, CO, Aurora, Colorado

    Run by

    VA Office of Research and Development

    See if you can join NCT06419959 on ClinicalTrials.gov

16. A Study to See if Lepodisiran Can Reduce Plaque in Coronary Arteries of Adults With Elevated Lp(a) Who Have Had Heart Events or Are at High Risk

    Lipoprotein(a), also known as Lp(a), is a protein that carries cholesterol and proteins in your blood. People with high Lp(a) have a higher risk for heart disease. The main purpose of the study is to investigate how lepodisiran, compared to a placebo, affects the amount and type of plaque in the he…

    Stage

    Phase 3

    Ages

    45 to 80

    Site

    Valley Clinical Trials, Inc., Northridge, California

    Locations

    58 in total

    Run by

    Eli Lilly and Company

    See if you can join NCT07613294 on ClinicalTrials.gov

17. Philly CEAL- DECIDE+ Adaptation

    Cardiovascular disease (CVD) disproportionately affects racial/ethnic minorities and underserved populations in Philadelphia. This study aims to evaluate the effectiveness of an enhanced community health worker (CHW) program that combines the evidence-based DECIDE self-management intervention with …

    Stage

    Not phased

    Ages

    35 to 75

    Site

    University of Pennsylvania, Philadelphia, Pennsylvania

    Run by

    University of Pennsylvania

    See if you can join NCT06732102 on ClinicalTrials.gov

18. Thrombosis and Inflammation in Vessels Initiative (TIVI)

    Background: Diseases related to the immune system, blood clots, and blood vessels can affect every part of the body. These diseases are now known to be interrelated: People who have strokes, blood clots in their legs, or autoimmune disease, for example, are at greater risk of complications in the h…

    Stage

    Not phased

    Ages

    5 to 100

    Site

    National Institutes of Health Clinical Center, Bethesda, Maryland

    Run by

    National Heart, Lung, and Blood Institute (NHLBI)

    See if you can join NCT06552767 on ClinicalTrials.gov

19. GENESIS: Genotype Guided - Natriuretic Peptides - Cardiometabolic Health Study

    Natriuretic Peptides (NP) are hormones produced by the heart, and they have a wide range of favorable metabolic benefits. Lower levels of these hormones are associated with an increased likelihood of the development of diabetes and poor cardiometabolic health. Obese and Black individuals have ~30% …

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Run by

    University of Alabama at Birmingham

    See if you can join NCT05216042 on ClinicalTrials.gov

20. Strong Teens for Healthy Schools Change Club: A Civic Engagement Approach to Improving Physical Activity and Healthy Eating Environments

    Strong Teens for Healthy Schools (STHS) is a school-based, civic engagement program that empowers middle school students to improve their physical activity and healthy eating behaviors, improve their cardiovascular disease outcomes, and create positive change in their school health environments.

    Stage

    Not phased

    Ages

    8 and older

    Site

    Texas A&M AgriLife Dallas Center, Dallas, Texas

    Run by

    Texas A&M University

    See if you can join NCT05867433 on ClinicalTrials.gov

21. Transition to Cardiac Rehabilitation (T2CR) to Address Barriers of Multimorbidity and Frailty

    Cardiac rehabilitation (CR) is a secondary prevention program for patients with cardiovascular disease (CVD). It is especially valuable as CVD increasingly occurs in combination with comorbidity, frailty, and complexities of care that predispose patients to functional decline, disability, and high …

    Stage

    Not phased

    Ages

    18 and older

    Site

    VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA, Boston, Massachusetts

    Locations

    2 in total

    Run by

    VA Office of Research and Development

    See if you can join NCT06244199 on ClinicalTrials.gov

22. ADAPT Micro-Randomized Trial

    The goal of this study is to collect quantitative and qualitative data that can be used to optimize the HeartSteps mHealth intervention for physical activity. The current version of the intervention is intended to help patients with heart disease increase and maintain their physical activity long-t…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Michigan, Ann Arbor, Michigan

    Run by

    University of Michigan

    See if you can join NCT06915220 on ClinicalTrials.gov

23. Capitalizing on AI to CapTure Undiagnosed Structural Heart Disease

    Doctors are testing a new tool called EchoNext to see if it can help find heart problems earlier. EchoNext looks at the heart's electrical test, called an ECG, and uses artificial intelligence (AI) to check for signs of structural heart disease (SHD). SHD includes conditions like weak heart pumping…

    Stage

    Not phased

    Ages

    40 and older

    Site

    Columbia University Irving Medical Center / NewYork-Presbyterian, New York, New York

    Run by

    Pierre Elias

    See if you can join NCT07843004 on ClinicalTrials.gov

24. CV CARE: CardioVascular Care in PC Patients

    This research is being done to test a program to assess and manage reversible cardiovascular (CV) risk factors in participants with prostate cancer starting androgen deprivation therapy (ADT), with the goal of integrating a standardized method into Dana-Farber Cancer Institute clinics for all such …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Brigham and Women's Hospital, Boston, Massachusetts

    Locations

    2 in total

    Run by

    Dana-Farber Cancer Institute

    See if you can join NCT06202820 on ClinicalTrials.gov

25. Treatment With Aspirin After Preeclampsia: TAP Trial

    The objective of this research project is to conduct a single-site pilot trial to assess the feasibility and effect of low-dose aspirin to augment vascular recovery in the immediate postpartum period after preeclampsia through two specific aims: 1) to pilot test the feasibility of conducting a rand…

    Stage

    Phase 4

    Ages

    18 to 55

    Site

    University of Pittsburgh Magee-Womens Hospital, Pittsburgh, Pennsylvania

    Run by

    Malamo Countouris

    See if you can join NCT06281665 on ClinicalTrials.gov