Stroke Clinical Trials

216 studies are recruiting for stroke in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 7

1. Constraint-Induced Movement Therapy for Adults Post-Stroke With Mild Upper Extremity Impairment

   Constraint-Induced Therapy (CI Therapy) is a behavioral approach to neurorehabilitation and consists of multi-components that have been applied in a systematic method to improve the use of the limb or function addressed in the intensive treatment. CI Therapy for the more-affected upper extremity (U…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Alabama at Birmingham, Birmingham, Alabama

   Run by

   University of Alabama at Birmingham

   See if you can join NCT05492513 on ClinicalTrials.gov

2. Psychedelic Healing: Adjunct Therapy Harnessing Opened Malleability

   The main purpose of the current studies is to evaluate the safety and tolerability of psilocybin in patients with chronic stroke.

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Johns Hopkins, Baltimore, Maryland

   Run by

   Johns Hopkins University

   See if you can join NCT07053917 on ClinicalTrials.gov

3. Compass 3: A Novel Transition Program to Reduce Disability After Stroke

   This study evaluates a program designed to help individuals transition from inpatient rehabilitation to home following an ischemic or hemorrhagic stroke. Half of the participants will receive a stroke education program while the other half will receive an environmental modifications program.

   Stage

   Not phased

   Ages

   55 and older

   Site

   Washington University in St. Louis, St Louis, Missouri

   Locations

   2 in total

   Run by

   Washington University School of Medicine

   See if you can join NCT07069660 on ClinicalTrials.gov

4. Early Robotic Gait Training After Stroke

   The ERA Stroke project will compare the effects of robotic gait training (RGT) and usual care (UC) gait training in patients in the subacute phase of stroke recovery undergoing inpatient rehabilitation at the Baylor Scott \& White Institute for Rehabilitation (BSWIR).

   Stage

   Not phased

   Ages

   18 to 85

   Site

   Baylor Scott & White Institute for Rehabilitation, Dallas, Texas

   Run by

   Baylor Research Institute

   See if you can join NCT06430632 on ClinicalTrials.gov

5. Real-time Personalized Brain State-dependent TMS After Stroke

   Transcranial magnetic stimulation (TMS) interventions could feasibly strengthen residual corticospinal tract (CST) connections and enhance recovery of paretic upper extremity function after stroke. This project will test whether personalized brain state-dependent TMS can activate the residual corti…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Iowa, Iowa City, Iowa

   Run by

   Sara Hussain

   See if you can join NCT06533176 on ClinicalTrials.gov

6. Pharmacy-led Transitions of Care Intervention to Improve Medication Adherence

   Socioeconomically disadvantaged populations with multiple chronic conditions have high rates of nonadherence to essential chronic disease medications after hospital discharge. Medication nonadherence after hospital discharge is significantly associated with increased mortality and higher rates of r…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Tennessee Health Science Center/Regional One Health, Memphis, Tennessee

   Locations

   2 in total

   Run by

   University of Tennessee

   See if you can join NCT06374277 on ClinicalTrials.gov

7. High vs Low-frequency of High-intensity Training in Chronic Stroke

   The purpose of this pilot study is to investigate the potential role of training frequency on locomotor outcomes following high-intensity gait training and provision of a home walking program.

   Stage

   Not phased

   Ages

   18 to 85

   Site

   Rehabilitation Hospital of Indiana, Indianapolis, Indiana

   Run by

   Indiana University

   See if you can join NCT06612723 on ClinicalTrials.gov

8. Efficacy of a Telehealth Delivered Group Lifestyle Balance for People Post Stroke (tGLB-CVA)

   Investigators will conduct a randomized controlled trial (RCT) to assess intervention efficacy of telehealth delivery of the GLB-CVA (tGLB-CVA) compared to a 6-month wait-list control (WLC) in partnership with a diverse group of patient partners and peer mentors.

   Stage

   Not phased

   Ages

   18 to 85

   Site

   Baylor Scott & White Research Institute, Dallas, Texas

   Run by

   Baylor Research Institute

   See if you can join NCT06569121 on ClinicalTrials.gov

9. The Neuralert Stroke Monitor Pilot Trial

   This trial aims to demonstrate that the Neuralert Monitoring System will detect strokes before they would be identified by current standard of care. Each patient will be monitored for up to five days, depending on device connectivity or battery duration. Each monitoring session will consist of wear…

   Stage

   Not phased

   Ages

   22 and older

   Site

   Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania

   Run by

   Neuralert Technologies LLC

   See if you can join NCT06368193 on ClinicalTrials.gov

10. Anticoagulation for Stroke Prevention In Patients With Recent Episodes of Atrial Fibrillation Occurring Transiently With Stress

    Multinational, investigator-initiated study of oral anticoagulation versus no anticoagulation for the prevention of stroke and other adverse cardiovascular events in patients with transient atrial fibrillation occurring transiently with stress and additional stroke risk factors.

    Stage

    Phase 4

    Ages

    55 and older

    Site

    Cedars-Sinai Medical Center, Los Angeles, California

    Locations

    105 in total

    Run by

    Population Health Research Institute

    See if you can join NCT03968393 on ClinicalTrials.gov

11. Exercise Primed Stroke Rehabilitation

    Stroke is a leading cause of disability in the U.S. and many Veteran stroke survivors live with severe disability. Despite recent advances in rehabilitation treatments many stroke survivors have persistent physical and mental difficulties such as reduced physical and cognitive function and depressi…

    Stage

    EARLY_Phase 1

    Ages

    50 to 90

    Site

    Ralph H. Johnson VA Medical Center, Charleston, SC, Charleston, South Carolina

    Run by

    VA Office of Research and Development

    See if you can join NCT04877444 on ClinicalTrials.gov

12. Multisensory Augmentation for Post-stroke Standing Balance

    Many individuals who experience a stroke have problems with their balance. In part, these balance problems may be due to sensory issues. This study will test whether sensory augmentation has the potential to improve post-stroke balance. Sensory augmentation is a method by which non-invasive vibrati…

    Stage

    EARLY_Phase 1

    Ages

    21 and older

    Site

    Ralph H. Johnson VA Medical Center, Charleston, SC, Charleston, South Carolina

    Run by

    VA Office of Research and Development

    See if you can join NCT05760885 on ClinicalTrials.gov

13. Inpatient Stroke Recovery Using Sensors

    This observational trial seeks to assess the feasibility of using non-invasive, portable, real-time body-worn sensors to continuously monitor, quantify, and interpret recovery during inpatient treatment of stroke

    Stage

    Not phased

    Ages

    18 and older

    Site

    Shirley Ryan AbilityLab, Chicago, Illinois

    Run by

    Shirley Ryan AbilityLab

    See if you can join NCT04219670 on ClinicalTrials.gov

14. Stroke Thrombectomy and Aneurysm Registry

    This international multi-center registry is used to collect existing information and outcomes for patients undergoing an operation for treatment of injuries to the brain including the blockage of blood flow to an area of the brain, an abnormal ballooning of an artery, abnormal tangling of blood ves…

    Stage

    Not phased

    Ages

    1 to 120

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Locations

    63 in total

    Run by

    Medical University of South Carolina

    See if you can join NCT04994756 on ClinicalTrials.gov

15. Reliability and Validity of the PReFS

    This study is testing the psychometric properties of a new tool to determine recommendations for pressure relief frequency in wheelchair users.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Baylor University, Waco, Texas

    Run by

    Baylor University

    See if you can join NCT07280923 on ClinicalTrials.gov

16. Determine the Effect of Targeted High-definition Transcranial Direct Current Stimulation (tDCS) on Reducing Post-stroke Upper Limb Motor Impairments

    Significant motor impairments occur in 80% of individuals after moderate to severe stroke and impact the body side to the lesioned hemisphere. Typical motor impairments involve loss of dexterity with highly prevalent upper limb flexion synergy. Advances in treating flexion synergy impairments have …

    Stage

    Not phased

    Ages

    18 to 90

    Site

    Carle Foundation Hospital, Urbana, Illinois

    Run by

    Carle Foundation Hospital

    See if you can join NCT05479006 on ClinicalTrials.gov

17. Hybrid Robot+FES Stroke Rehabilitation

    The investigators have developed a novel robot-guided stretching under intelligent control and combine it with active movement training, which helped increase joint ROM, reduce spasticity and joint stiffness, increase muscle force output, and improve locomotion. However, for stroke survivors with s…

    Stage

    Phase 1

    Ages

    18 to 85

    Site

    University of Maryland School of Medicine, Baltimore, Maryland

    Run by

    University of Maryland, Baltimore

    See if you can join NCT04550728 on ClinicalTrials.gov

18. Human/Machine Interface: What the HeartMate 3 ® Device Tells Us About the Future

    Durable left ventricular assist devices (dLVAD) have been increasingly utilized since the mid to late 1990s, with an uptick of utility starting in 2010 following expanded indications for therapy to not only include a bridge to transplantation strategy, but also for those individuals who suffer from…

    Stage

    Not phased

    Ages

    18 to 100

    Site

    UCSF, San Francisco, California

    Locations

    7 in total

    Run by

    International Consortium of Circulatory Assist Clinicians

    See if you can join NCT06039176 on ClinicalTrials.gov

19. Adaptive Trial Scheduling in Naming Treatment for Aphasia

    Aphasia is a language disorder caused by stroke and other acquired brain injuries that affects over two million people in the United States and which interferes with life participation and quality of life. Anomia (i.e., word- finding difficulty) is a primary frustration for people with aphasia. Pic…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Language Rehab and Cognition Lab, Department of Communication Sciences and Disorders, School of Health and Rehabilitation Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania

    Run by

    University of Pittsburgh

    See if you can join NCT05653466 on ClinicalTrials.gov

20. Physical Capacity Building for Chronic Stroke

    Cardiac rehabilitation is the standard-of-care treatment option for patients with cardiovascular disease and has been shown to improve many aspects critical to patient recovery. Investigators believe that individuals who have had a stroke need to be treated similarly. Investigators will study the e…

    Stage

    Not phased

    Ages

    18 to 80

    Site

    Medical University of South Carolina, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT07039305 on ClinicalTrials.gov

21. Novel Wrist Sensor System to Promote Hemiparetic Arm Use in Home Daily Life of Chronic Stroke Survivors

    The proposed study is a two-arm randomized clinical trial designed to assess the effects of the StrokeWear system on clinical outcomes over a period of 6-months in chronic stroke survivors. The Intervention group will use StrokeWear system in combination to a motor and behavioral home intervention …

    Stage

    Phase 2

    Ages

    18 to 85

    Site

    Spaulding Rehabilitation Hospital Boston, Boston, Massachusetts

    Run by

    Spaulding Rehabilitation Hospital

    See if you can join NCT05626894 on ClinicalTrials.gov

22. A Novel Wrist Wearable Sensor System to Promote Hemiparetic Upper Extremity Use in Subacute Stroke Survivors

    The proposed study is a two-arm randomized clinical trial designed to assess the effects of the StrokeWear system on clinical outcomes over a period of 6-months in subacute stroke survivors. The Intervention group will use StrokeWear system in combination to a motor and behavioral home intervention…

    Stage

    Not phased

    Ages

    18 to 85

    Site

    Spaulding Rehabilitation Hospital, Boston, Massachusetts

    Run by

    Spaulding Rehabilitation Hospital

    See if you can join NCT06797154 on ClinicalTrials.gov

23. Dysphagia Study Using Novel Microphone Device

    This study aims to collect swallowing acoustics with a novel non-invasive wearable surface microphone device during routine work-up, videofluoroscopic swallow study (VFSS), of patients with dysphagia (swallowing trouble). The collected microphone data will be analyzed to find the pattern of abnorma…

    Stage

    Not phased

    Ages

    40 to 85

    Site

    Emory University Hospital Midtown, Atlanta, Georgia

    Locations

    2 in total

    Run by

    Emory University

    See if you can join NCT07251140 on ClinicalTrials.gov

24. Xeomin® and Gait Related Mobility After Stroke

    The aim of the present pilot study is to evaluate the association between change in gait related mobility in ambulatory male and female adult hemiparetic patients before and 4-6-weeks after Xeomin® injection into the upper limb, using two standardized tests of physical function in outpatient rehabi…

    Stage

    Phase 4

    Ages

    18 to 79

    Site

    Carolinas Rehabilitation, Charlotte, North Carolina

    Run by

    Wake Forest University Health Sciences

    See if you can join NCT04908423 on ClinicalTrials.gov

25. Passive Robots for Stroke Rehabilitation: A Feasibility Study

    The purpose of this study is to examine the feasibility and effectiveness of a novel, multimodal approach that combines passive devices with noninvasive neuromuscular stimulation for upper extremity rehabilitation after stroke.

    Stage

    Not phased

    Ages

    18 to 75

    Site

    University of Michigan - NeuRRo Lab, Ann Arbor, Michigan

    Run by

    University of Michigan

    See if you can join NCT07218276 on ClinicalTrials.gov